Regio and stereoselective synthesis of anticancer spirooxindolopyrrolidine embedded piperidone heterocyclic hybrids derived from one-pot cascade protocol View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Natarajan Arumugam, Abdulrahman I. Almansour, Raju Suresh Kumar, Dhaifallah M. Al-thamili, Govindasami Periyasami, V. S. Periasamy, Jegan Athinarayanan, Ali A. Alshatwi, S. M. Mahalingam, J. Carlos Menéndez

ABSTRACT

BACKGROUND: Spiropyrrolidine tethered piperidone heterocyclic hybrids were synthesized with complete regio- and stereoselectively in excellent yield via a tandem three-component 1,3-dipolar cycloaddition and subsequent enamine reaction in [bmim]Br. The synthesized compounds were evaluated for their anticancer activity against FaDu hypopharyngeal tumor cells. FINDINGS: Interestingly, most compounds displayed cytotoxicities similar to the standard anticancer agent bleomycin, with two of them (5a and 5g) being slightly more active than the reference drug. CONCLUSION: Synthesized compounds have also been evaluated for their apoptosis-inducing properties in a cancer cell model, finding that treatment with compounds 5a-e led to apoptotic cell death. More... »

PAGES

95

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13065-018-0462-x

DOI

http://dx.doi.org/10.1186/s13065-018-0462-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106492109

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30173362


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