A new phototherapy regimen during winter as an add-on therapy, coupled with oral vitamin D supplementation, for the long-term control ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-03-25

AUTHORS

Catherine Droitcourt, Sébastien Barbarot, Annabel Maruani, Laure Darrieux, Laurent Misery, Emilie Brenaut, Henri Adamski, Cécile Chabbert, Annie Vermersch, Marie Weiborn, Julien Seneschal, Alain Taïeb, Patrice Plantin, Hervé Maillard, Alice Phan, François Skowron, Manuelle Viguier, Delphine Staumont-Salle, Audrey Nosbaum, Angèle Soria, Annick Barbaud, Emmanuel Oger, Alain Dupuy,

ABSTRACT

BACKGROUND: Atopic dermatitis is a highly prevalent, chronic, relapsing disease in both adults and children. On the severity spectrum, lower-end patients benefit from small amounts of topical anti-inflammatory treatments (TAT), whereas higher-end patients need systemic immunosuppressants; in-between patients are treated with TAT and phototherapy. The major therapeutic challenge in this population is the long-term control of disease activity, and the current TAT-based pro-active strategy does not meet all their needs. Immunosuppressants are used as long-term control add-on treatments, but they are restricted to the most severely affected patients because of safety concerns. In addition, neither immunosuppressants nor other strategies have been properly evaluated in the long term despite long-term control having been acknowledged as one of the most important core outcome domains to be targeted in atopic dermatitis trials. Safe add-on therapies, rigorously evaluated for long-term control of the disease, are therefore needed. Phototherapy and vitamin D supplementation are both good candidates. METHODS: This is a multicenter, national, randomized, superiority, crossover trial testing add-on phototherapy (one winter under spaced sessions of phototherapy and one winter under observation) among subjects receiving standard care (i.e., TAT). On the same population, we will test the long-term control provided by oral supplementation of vitamin D versus placebo in a randomized, superiority, double-blind, parallel-group trial. The primary outcomes are (1) repeat measures of the PO-SCORAD severity score over 1 year and (2) cumulate consumption of TAT (number of tubes) during the winter. They will be tested following a hierarchical testing procedure. The secondary outcomes will be measures repeated over 2 years of investigator-based severity scores, patient-reported severity and quality of life scores, serum vitamin D levels, weeks during which the disease is well-controlled, inter-visit cumulate consumption of TAT, and synthetic patient-reported satisfaction at the end of each winter. DISCUSSION: This study includes two separate 2-year pragmatic trials designed to evaluate the efficacy of vitamin D supplementation and pro-active phototherapy for primary care atopic dermatitis patients receiving TAT on long-term control of disease activity. The experimental design enables the study of both interventions and exploration of the interaction between vitamin D and phototherapy. A pragmatic trial is particularly suited to the assessment of long-term control. This study explores the possibility of new and safe therapeutic strategies for the control of long-term atopic dermatitis, and is an example of efficacy research that is unlikely to be sponsored by industrialists. A potentially effective low-cost therapeutic strategy for long-term control is essential for patients and public health. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02537509 , first received: 1 September 2015. More... »

PAGES

184

References to SciGraph publications

  • 2013-08-28. Willingness to pay and quality of life in patients with atopic dermatitis in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • Journal

    TITLE

    Trials

    ISSUE

    1

    VOLUME

    20

    Author Affiliations

  • EA 7449 REPERES “Pharmaco-epidemiology and Health Services Research”, Univ Rennes, 35000 Rennes, France
  • Department of Dermatology, University Hospital Center of Nantes, 44000 Nantes, France
  • Department of Dermatology, University Hospital Center of Tours, 37000 Tours, France
  • Department of Dermatology, Hospital Center of Saint-Brieuc, 22000 Saint-Brieuc, France
  • Department of Dermatology, University Hospital Center of Brest, 29000 Brest, France
  • Department of Dermatology, University Hospital Center of Rennes, Pontchaillou Hospital, 2 rue Henri le Guilloux, 35000 Rennes, France
  • Department of Dermatology, Hospital Center of Perigueux, 24000 Perigueux, France
  • Department of Dermatology, Hospital Center of Valenciennes, 62000 Valenciennes, France
  • Department of Dermatology, University Hospital Center of Bordeaux, 33000 Bordeaux, France
  • Department of Dermatology, Hospital Center of Quimper, 29000 Quimper, France
  • Department of Dermatology, Hospital Center of Le Mans, 72000 Angers, France
  • Department of Dermatology, University Hospital Center of Lyon, 69000 Lyon-Bron, France
  • Department of Dermatology, Hospital Center of Valence, 26000 Valence, France
  • Department of Dermatology, University Hospital Center of Reims, 51000 Reims, France
  • Department of Dermatology, University Hospital Center of Lille, 59000 Lille, France
  • Department of Dermatology, University Hospital Center of Lyon, 69000 Lyon Sud, France
  • Department of Dermatology and Allergology, University Hospital Center of Paris-Tenon, 75020 Paris, France
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13063-019-3276-9

    DOI

    http://dx.doi.org/10.1186/s13063-019-3276-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112981871

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30909923


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Public Health and Health Services", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Administration, Cutaneous", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Administration, Oral", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anti-Inflammatory Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cholecalciferol", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Combined Modality Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cross-Over Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dermatitis, Atopic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dietary Supplements", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Double-Blind Method", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "France", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multicenter Studies as Topic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pragmatic Clinical Trials as Topic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Seasons", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Time Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ultraviolet Therapy", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "EA 7449 REPERES \u201cPharmaco-epidemiology and Health Services Research\u201d, Univ Rennes, 35000 Rennes, France", 
              "id": "http://www.grid.ac/institutes/grid.410368.8", 
              "name": [
                "Univ Rennes, Rennes, France", 
                "Department of Dermatology, University Hospital Center of Rennes, Pontchaillou Hospital, 2 rue Henri le Guilloux, 35000 Rennes, France", 
                "INSERM, CIC 1414, 35000 Rennes, France", 
                "EA 7449 REPERES \u201cPharmaco-epidemiology and Health Services Research\u201d, Univ Rennes, 35000 Rennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Droitcourt", 
            "givenName": "Catherine", 
            "id": "sg:person.01212177667.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212177667.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, University Hospital Center of Nantes, 44000 Nantes, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology, University Hospital Center of Nantes, 44000 Nantes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barbarot", 
            "givenName": "S\u00e9bastien", 
            "id": "sg:person.0634163435.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634163435.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, University Hospital Center of Tours, 37000 Tours, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology, University Hospital Center of Tours, 37000 Tours, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maruani", 
            "givenName": "Annabel", 
            "id": "sg:person.01323322421.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323322421.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, Hospital Center of Saint-Brieuc, 22000 Saint-Brieuc, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology, Hospital Center of Saint-Brieuc, 22000 Saint-Brieuc, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Darrieux", 
            "givenName": "Laure", 
            "id": "sg:person.01321005562.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321005562.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, University Hospital Center of Brest, 29000 Brest, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology, University Hospital Center of Brest, 29000 Brest, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Misery", 
            "givenName": "Laurent", 
            "id": "sg:person.01212640265.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212640265.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, University Hospital Center of Brest, 29000 Brest, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology, University Hospital Center of Brest, 29000 Brest, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brenaut", 
            "givenName": "Emilie", 
            "id": "sg:person.01140011705.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140011705.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, University Hospital Center of Rennes, Pontchaillou Hospital, 2 rue Henri le Guilloux, 35000 Rennes, France", 
              "id": "http://www.grid.ac/institutes/grid.414271.5", 
              "name": [
                "Department of Dermatology, University Hospital Center of Rennes, Pontchaillou Hospital, 2 rue Henri le Guilloux, 35000 Rennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Adamski", 
            "givenName": "Henri", 
            "id": "sg:person.01050351737.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050351737.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, Hospital Center of Perigueux, 24000 Perigueux, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology, Hospital Center of Perigueux, 24000 Perigueux, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chabbert", 
            "givenName": "C\u00e9cile", 
            "id": "sg:person.01311075442.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311075442.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, Hospital Center of Valenciennes, 62000 Valenciennes, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology, Hospital Center of Valenciennes, 62000 Valenciennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vermersch", 
            "givenName": "Annie", 
            "id": "sg:person.01043751540.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043751540.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, Hospital Center of Valenciennes, 62000 Valenciennes, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology, Hospital Center of Valenciennes, 62000 Valenciennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weiborn", 
            "givenName": "Marie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, University Hospital Center of Bordeaux, 33000 Bordeaux, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology, University Hospital Center of Bordeaux, 33000 Bordeaux, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Seneschal", 
            "givenName": "Julien", 
            "id": "sg:person.0772111230.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772111230.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, University Hospital Center of Bordeaux, 33000 Bordeaux, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology, University Hospital Center of Bordeaux, 33000 Bordeaux, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ta\u00efeb", 
            "givenName": "Alain", 
            "id": "sg:person.0746777426.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746777426.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, Hospital Center of Quimper, 29000 Quimper, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology, Hospital Center of Quimper, 29000 Quimper, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Plantin", 
            "givenName": "Patrice", 
            "id": "sg:person.01011610150.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011610150.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, Hospital Center of Le Mans, 72000 Angers, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology, Hospital Center of Le Mans, 72000 Angers, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maillard", 
            "givenName": "Herv\u00e9", 
            "id": "sg:person.0746700570.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746700570.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, University Hospital Center of Lyon, 69000 Lyon-Bron, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology, University Hospital Center of Lyon, 69000 Lyon-Bron, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Phan", 
            "givenName": "Alice", 
            "id": "sg:person.01362550204.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362550204.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, Hospital Center of Valence, 26000 Valence, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology, Hospital Center of Valence, 26000 Valence, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Skowron", 
            "givenName": "Fran\u00e7ois", 
            "id": "sg:person.01264506043.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264506043.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, University Hospital Center of Reims, 51000 Reims, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology, University Hospital Center of Reims, 51000 Reims, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Viguier", 
            "givenName": "Manuelle", 
            "id": "sg:person.01302526630.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302526630.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, University Hospital Center of Lille, 59000 Lille, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology, University Hospital Center of Lille, 59000 Lille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Staumont-Salle", 
            "givenName": "Delphine", 
            "id": "sg:person.01316212175.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316212175.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology, University Hospital Center of Lyon, 69000 Lyon Sud, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology, University Hospital Center of Lyon, 69000 Lyon Sud, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nosbaum", 
            "givenName": "Audrey", 
            "id": "sg:person.01035026340.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035026340.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology and Allergology, University Hospital Center of Paris-Tenon, 75020 Paris, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology and Allergology, University Hospital Center of Paris-Tenon, 75020 Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Soria", 
            "givenName": "Ang\u00e8le", 
            "id": "sg:person.01020051155.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020051155.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Dermatology and Allergology, University Hospital Center of Paris-Tenon, 75020 Paris, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Dermatology and Allergology, University Hospital Center of Paris-Tenon, 75020 Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barbaud", 
            "givenName": "Annick", 
            "id": "sg:person.01033731147.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033731147.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "EA 7449 REPERES \u201cPharmaco-epidemiology and Health Services Research\u201d, Univ Rennes, 35000 Rennes, France", 
              "id": "http://www.grid.ac/institutes/grid.410368.8", 
              "name": [
                "Univ Rennes, Rennes, France", 
                "EA 7449 REPERES \u201cPharmaco-epidemiology and Health Services Research\u201d, Univ Rennes, 35000 Rennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oger", 
            "givenName": "Emmanuel", 
            "id": "sg:person.01061540055.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061540055.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "EA 7449 REPERES \u201cPharmaco-epidemiology and Health Services Research\u201d, Univ Rennes, 35000 Rennes, France", 
              "id": "http://www.grid.ac/institutes/grid.410368.8", 
              "name": [
                "Univ Rennes, Rennes, France", 
                "Department of Dermatology, University Hospital Center of Rennes, Pontchaillou Hospital, 2 rue Henri le Guilloux, 35000 Rennes, France", 
                "EA 7449 REPERES \u201cPharmaco-epidemiology and Health Services Research\u201d, Univ Rennes, 35000 Rennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dupuy", 
            "givenName": "Alain", 
            "id": "sg:person.01104353732.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104353732.54"
            ], 
            "type": "Person"
          }, 
          {}
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00403-013-1402-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011126987", 
              "https://doi.org/10.1007/s00403-013-1402-1"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-03-25", 
        "datePublishedReg": "2019-03-25", 
        "description": "BACKGROUND: Atopic dermatitis is a highly prevalent, chronic, relapsing disease in both adults and children. On the severity spectrum, lower-end patients benefit from small amounts of topical anti-inflammatory treatments (TAT), whereas higher-end patients need systemic immunosuppressants; in-between patients are treated with TAT and phototherapy. The major therapeutic challenge in this population is the long-term control of disease activity, and the current TAT-based pro-active strategy does not meet all their needs. Immunosuppressants are used as long-term control add-on treatments, but they are restricted to the most severely affected patients because of safety concerns. In addition, neither immunosuppressants nor other strategies have been properly evaluated in the long term despite long-term control having been acknowledged as one of the most important core outcome domains to be targeted in atopic dermatitis trials. Safe add-on therapies, rigorously evaluated for long-term control of the disease, are therefore needed. Phototherapy and vitamin D supplementation are both good candidates.\nMETHODS: This is a multicenter, national, randomized, superiority, crossover trial testing add-on phototherapy (one winter under spaced sessions of phototherapy and one winter under observation) among subjects receiving standard care (i.e., TAT). On the same population, we will test the long-term control provided by oral supplementation of vitamin D versus placebo in a randomized, superiority, double-blind, parallel-group trial. The primary outcomes are (1) repeat measures of the PO-SCORAD severity score over 1\u2009year and (2) cumulate consumption of TAT (number of tubes) during the winter. They will be tested following a hierarchical testing procedure. The secondary outcomes will be measures repeated over 2\u2009years of investigator-based severity scores, patient-reported severity and quality of life scores, serum vitamin D levels, weeks during which the disease is well-controlled, inter-visit cumulate consumption of TAT, and synthetic patient-reported satisfaction at the end of each winter.\nDISCUSSION: This study includes two separate 2-year pragmatic trials designed to evaluate the efficacy of vitamin D supplementation and pro-active phototherapy for primary care atopic dermatitis patients receiving TAT on long-term control of disease activity. The experimental design enables the study of both interventions and exploration of the interaction between vitamin D and phototherapy. A pragmatic trial is particularly suited to the assessment of long-term control. This study explores the possibility of new and safe therapeutic strategies for the control of long-term atopic dermatitis, and is an example of efficacy research that is unlikely to be sponsored by industrialists. A potentially effective low-cost therapeutic strategy for long-term control is essential for patients and public health.\nTRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02537509 , first received: 1 September 2015.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s13063-019-3276-9", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1297400", 
            "issn": [
              "1468-6708", 
              "1745-6215"
            ], 
            "name": "Trials", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "20"
          }
        ], 
        "keywords": [
          "topical anti-inflammatory treatment", 
          "vitamin D supplementation", 
          "long-term control", 
          "atopic dermatitis", 
          "pragmatic trial", 
          "disease activity", 
          "vitamin D", 
          "severity score", 
          "therapeutic strategies", 
          "serum vitamin D levels", 
          "oral vitamin D supplementation", 
          "atopic dermatitis trials", 
          "vitamin D levels", 
          "anti-inflammatory treatment", 
          "parallel-group trial", 
          "patient-reported satisfaction", 
          "atopic dermatitis patients", 
          "major therapeutic challenge", 
          "core outcome domains", 
          "patient-reported severity", 
          "safe therapeutic strategy", 
          "systemic immunosuppressants", 
          "standard care", 
          "Secondary outcomes", 
          "D levels", 
          "primary outcome", 
          "oral supplementation", 
          "dermatitis patients", 
          "therapeutic challenge", 
          "life scores", 
          "study protocol", 
          "severity spectrum", 
          "patients", 
          "hierarchical testing procedure", 
          "outcome domains", 
          "immunosuppressants", 
          "dermatitis", 
          "trial testing", 
          "phototherapy", 
          "trials", 
          "supplementation", 
          "disease", 
          "public health", 
          "therapy", 
          "safety concerns", 
          "scores", 
          "efficacy research", 
          "outcomes", 
          "treatment", 
          "same population", 
          "long term", 
          "multicenter", 
          "multicentre", 
          "placebo", 
          "regimen", 
          "control", 
          "population", 
          "years", 
          "severity", 
          "weeks", 
          "study", 
          "care", 
          "efficacy", 
          "intervention", 
          "adults", 
          "children", 
          "activity", 
          "health", 
          "subjects", 
          "measures", 
          "strategies", 
          "assessment", 
          "levels", 
          "testing", 
          "satisfaction", 
          "protocol", 
          "consumption", 
          "good candidate", 
          "procedure", 
          "pro-active strategies", 
          "need", 
          "candidates", 
          "concern", 
          "small amount", 
          "addition", 
          "quality", 
          "superiority", 
          "testing procedures", 
          "end", 
          "challenges", 
          "experimental design", 
          "possibility", 
          "amount", 
          "research", 
          "identifiers", 
          "exploration", 
          "interaction", 
          "crossover", 
          "terms", 
          "domain", 
          "design", 
          "winter", 
          "spectra", 
          "example", 
          "industrialists", 
          "lower-end patients", 
          "higher-end patients", 
          "current TAT", 
          "important core outcome domains", 
          "dermatitis trials", 
          "D supplementation", 
          "crossover trial testing", 
          "PO-SCORAD severity score", 
          "cumulate consumption", 
          "investigator-based severity scores", 
          "inter-visit cumulate consumption", 
          "synthetic patient-reported satisfaction", 
          "pro-active phototherapy", 
          "primary care atopic dermatitis patients", 
          "care atopic dermatitis patients", 
          "long-term atopic dermatitis", 
          "effective low-cost therapeutic strategy", 
          "low-cost therapeutic strategy", 
          "NCT02537509", 
          "new phototherapy regimen", 
          "phototherapy regimen", 
          "PRADA trial"
        ], 
        "name": "A new phototherapy regimen during winter as an add-on therapy, coupled with oral vitamin D supplementation, for the long-term control of atopic dermatitis: study protocol for a multicentre, randomized, crossover, pragmatic trial \u2013 the PRADA trial", 
        "pagination": "184", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112981871"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13063-019-3276-9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30909923"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13063-019-3276-9", 
          "https://app.dimensions.ai/details/publication/pub.1112981871"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-12-01T19:44", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_821.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s13063-019-3276-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13063-019-3276-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13063-019-3276-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13063-019-3276-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13063-019-3276-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    453 TRIPLES      22 PREDICATES      171 URIs      162 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13063-019-3276-9 schema:about N2884f90119d54f8db37dc8b72ac41408
    2 N289b368404744d07a099f37c806bfe36
    3 N2bcb5f22e81e482084ad132cbb36eed5
    4 N6763c16ceecd4f458cf2c72dc1eb87e4
    5 N69cfb1e7c11c4cf490e54639eea772c4
    6 N71d6292a6b4e42e8a7b967013e16d201
    7 N80799bba121447c2a49bf8054396f451
    8 N80b26a2d39124549b0c0b52e8e5d6bec
    9 N8870f91554694a86bda9748a9eab1b8e
    10 Nabd601a84a624cd4a85242d3b1346654
    11 Nb5e04a8c94454e558a09d9c75f6cbad2
    12 Nc57eaae6c588483d9f8574c4a72d281e
    13 Nc9c063d256794e54be86cd394aad3734
    14 Ndac0b727778747c48799171cc9b5224f
    15 Ndbc66b84fc984cca840133bbf53de1c6
    16 Nec98bae9b1f44b1c88e41f1917600817
    17 Nfed47829b55c475a982c8a9f46219dfd
    18 anzsrc-for:11
    19 anzsrc-for:1117
    20 schema:author Nb7bd5dca88434005bcc33176f4ec64d3
    21 schema:citation sg:pub.10.1007/s00403-013-1402-1
    22 schema:datePublished 2019-03-25
    23 schema:datePublishedReg 2019-03-25
    24 schema:description BACKGROUND: Atopic dermatitis is a highly prevalent, chronic, relapsing disease in both adults and children. On the severity spectrum, lower-end patients benefit from small amounts of topical anti-inflammatory treatments (TAT), whereas higher-end patients need systemic immunosuppressants; in-between patients are treated with TAT and phototherapy. The major therapeutic challenge in this population is the long-term control of disease activity, and the current TAT-based pro-active strategy does not meet all their needs. Immunosuppressants are used as long-term control add-on treatments, but they are restricted to the most severely affected patients because of safety concerns. In addition, neither immunosuppressants nor other strategies have been properly evaluated in the long term despite long-term control having been acknowledged as one of the most important core outcome domains to be targeted in atopic dermatitis trials. Safe add-on therapies, rigorously evaluated for long-term control of the disease, are therefore needed. Phototherapy and vitamin D supplementation are both good candidates. METHODS: This is a multicenter, national, randomized, superiority, crossover trial testing add-on phototherapy (one winter under spaced sessions of phototherapy and one winter under observation) among subjects receiving standard care (i.e., TAT). On the same population, we will test the long-term control provided by oral supplementation of vitamin D versus placebo in a randomized, superiority, double-blind, parallel-group trial. The primary outcomes are (1) repeat measures of the PO-SCORAD severity score over 1 year and (2) cumulate consumption of TAT (number of tubes) during the winter. They will be tested following a hierarchical testing procedure. The secondary outcomes will be measures repeated over 2 years of investigator-based severity scores, patient-reported severity and quality of life scores, serum vitamin D levels, weeks during which the disease is well-controlled, inter-visit cumulate consumption of TAT, and synthetic patient-reported satisfaction at the end of each winter. DISCUSSION: This study includes two separate 2-year pragmatic trials designed to evaluate the efficacy of vitamin D supplementation and pro-active phototherapy for primary care atopic dermatitis patients receiving TAT on long-term control of disease activity. The experimental design enables the study of both interventions and exploration of the interaction between vitamin D and phototherapy. A pragmatic trial is particularly suited to the assessment of long-term control. This study explores the possibility of new and safe therapeutic strategies for the control of long-term atopic dermatitis, and is an example of efficacy research that is unlikely to be sponsored by industrialists. A potentially effective low-cost therapeutic strategy for long-term control is essential for patients and public health. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02537509 , first received: 1 September 2015.
    25 schema:genre article
    26 schema:inLanguage en
    27 schema:isAccessibleForFree true
    28 schema:isPartOf N1f8ce6ed3a5a44588a7d141d8c88dedd
    29 N55a0c0eee1414f19aed72b45279fb1d1
    30 sg:journal.1297400
    31 schema:keywords D levels
    32 D supplementation
    33 NCT02537509
    34 PO-SCORAD severity score
    35 PRADA trial
    36 Secondary outcomes
    37 activity
    38 addition
    39 adults
    40 amount
    41 anti-inflammatory treatment
    42 assessment
    43 atopic dermatitis
    44 atopic dermatitis patients
    45 atopic dermatitis trials
    46 candidates
    47 care
    48 care atopic dermatitis patients
    49 challenges
    50 children
    51 concern
    52 consumption
    53 control
    54 core outcome domains
    55 crossover
    56 crossover trial testing
    57 cumulate consumption
    58 current TAT
    59 dermatitis
    60 dermatitis patients
    61 dermatitis trials
    62 design
    63 disease
    64 disease activity
    65 domain
    66 effective low-cost therapeutic strategy
    67 efficacy
    68 efficacy research
    69 end
    70 example
    71 experimental design
    72 exploration
    73 good candidate
    74 health
    75 hierarchical testing procedure
    76 higher-end patients
    77 identifiers
    78 immunosuppressants
    79 important core outcome domains
    80 industrialists
    81 inter-visit cumulate consumption
    82 interaction
    83 intervention
    84 investigator-based severity scores
    85 levels
    86 life scores
    87 long term
    88 long-term atopic dermatitis
    89 long-term control
    90 low-cost therapeutic strategy
    91 lower-end patients
    92 major therapeutic challenge
    93 measures
    94 multicenter
    95 multicentre
    96 need
    97 new phototherapy regimen
    98 oral supplementation
    99 oral vitamin D supplementation
    100 outcome domains
    101 outcomes
    102 parallel-group trial
    103 patient-reported satisfaction
    104 patient-reported severity
    105 patients
    106 phototherapy
    107 phototherapy regimen
    108 placebo
    109 population
    110 possibility
    111 pragmatic trial
    112 primary care atopic dermatitis patients
    113 primary outcome
    114 pro-active phototherapy
    115 pro-active strategies
    116 procedure
    117 protocol
    118 public health
    119 quality
    120 regimen
    121 research
    122 safe therapeutic strategy
    123 safety concerns
    124 same population
    125 satisfaction
    126 scores
    127 serum vitamin D levels
    128 severity
    129 severity score
    130 severity spectrum
    131 small amount
    132 spectra
    133 standard care
    134 strategies
    135 study
    136 study protocol
    137 subjects
    138 superiority
    139 supplementation
    140 synthetic patient-reported satisfaction
    141 systemic immunosuppressants
    142 terms
    143 testing
    144 testing procedures
    145 therapeutic challenge
    146 therapeutic strategies
    147 therapy
    148 topical anti-inflammatory treatment
    149 treatment
    150 trial testing
    151 trials
    152 vitamin D
    153 vitamin D levels
    154 vitamin D supplementation
    155 weeks
    156 winter
    157 years
    158 schema:name A new phototherapy regimen during winter as an add-on therapy, coupled with oral vitamin D supplementation, for the long-term control of atopic dermatitis: study protocol for a multicentre, randomized, crossover, pragmatic trial – the PRADA trial
    159 schema:pagination 184
    160 schema:productId N2478ce6e17494dd5902dd6642cb0847d
    161 N7c98f33bcdb44e1ea2fe04bd3b2f92b8
    162 N85c6eafe8cbd4dbd853df3967a8d5892
    163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112981871
    164 https://doi.org/10.1186/s13063-019-3276-9
    165 schema:sdDatePublished 2021-12-01T19:44
    166 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    167 schema:sdPublisher N99ff89271f264a57be1fa18af04d7af0
    168 schema:url https://doi.org/10.1186/s13063-019-3276-9
    169 sgo:license sg:explorer/license/
    170 sgo:sdDataset articles
    171 rdf:type schema:ScholarlyArticle
    172 N03d1c642823747a4adcf1796aee3235f rdf:first sg:person.01302526630.97
    173 rdf:rest N4b34455e3c774acb985c7ddef67562ad
    174 N0c1dab01c12942b8bf11faa1b334d62b rdf:first sg:person.0746700570.26
    175 rdf:rest Nbb23b1cee9a74b9081d369b8979b4b3b
    176 N1f8ce6ed3a5a44588a7d141d8c88dedd schema:issueNumber 1
    177 rdf:type schema:PublicationIssue
    178 N22ed1119e56c4da4b0d80fa7f7468a94 rdf:first sg:person.01104353732.54
    179 rdf:rest Nc8911ee8d578487694a419153402ff7b
    180 N2478ce6e17494dd5902dd6642cb0847d schema:name dimensions_id
    181 schema:value pub.1112981871
    182 rdf:type schema:PropertyValue
    183 N2884f90119d54f8db37dc8b72ac41408 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Administration, Oral
    185 rdf:type schema:DefinedTerm
    186 N289b368404744d07a099f37c806bfe36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Dermatitis, Atopic
    188 rdf:type schema:DefinedTerm
    189 N2bcb5f22e81e482084ad132cbb36eed5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Cross-Over Studies
    191 rdf:type schema:DefinedTerm
    192 N31c78ae04916472c99c657ae8e2f8daa rdf:first sg:person.01043751540.39
    193 rdf:rest Nbf4f33f9a81d4cc7b3f96c2b40edb114
    194 N45dc93107f1d4d57afab68883d893181 rdf:first sg:person.01321005562.53
    195 rdf:rest Nbb59fc8444d048bea3835bda4164a2f5
    196 N4b34455e3c774acb985c7ddef67562ad rdf:first sg:person.01316212175.63
    197 rdf:rest Ne83f6f20ed5540c3ae687006f7e57784
    198 N52e2496e17d24f3fadf1b1890b2af12d schema:affiliation grid-institutes:None
    199 schema:familyName Weiborn
    200 schema:givenName Marie
    201 rdf:type schema:Person
    202 N55a0c0eee1414f19aed72b45279fb1d1 schema:volumeNumber 20
    203 rdf:type schema:PublicationVolume
    204 N589bede7829548e5972ad9b4c65d79ba rdf:first sg:person.01020051155.46
    205 rdf:rest Nbe2ac78c1c8c4ee5b4a7288b26c850ad
    206 N6763c16ceecd4f458cf2c72dc1eb87e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Anti-Inflammatory Agents
    208 rdf:type schema:DefinedTerm
    209 N69cfb1e7c11c4cf490e54639eea772c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Humans
    211 rdf:type schema:DefinedTerm
    212 N6fd796020b454983b90750c0d5314a5a rdf:first sg:person.01011610150.22
    213 rdf:rest N0c1dab01c12942b8bf11faa1b334d62b
    214 N7019b425b41a44ccb17685c9e111db2d rdf:first sg:person.01264506043.24
    215 rdf:rest N03d1c642823747a4adcf1796aee3235f
    216 N71d6292a6b4e42e8a7b967013e16d201 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name Seasons
    218 rdf:type schema:DefinedTerm
    219 N7c98f33bcdb44e1ea2fe04bd3b2f92b8 schema:name pubmed_id
    220 schema:value 30909923
    221 rdf:type schema:PropertyValue
    222 N80799bba121447c2a49bf8054396f451 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    223 schema:name Double-Blind Method
    224 rdf:type schema:DefinedTerm
    225 N80b26a2d39124549b0c0b52e8e5d6bec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    226 schema:name Cholecalciferol
    227 rdf:type schema:DefinedTerm
    228 N85c6eafe8cbd4dbd853df3967a8d5892 schema:name doi
    229 schema:value 10.1186/s13063-019-3276-9
    230 rdf:type schema:PropertyValue
    231 N87477dfcd14640ffb762cc10f9f3aebd rdf:first sg:person.0772111230.98
    232 rdf:rest Ned9d018df5e04a8a9a2984cb72a02197
    233 N8870f91554694a86bda9748a9eab1b8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    234 schema:name Pragmatic Clinical Trials as Topic
    235 rdf:type schema:DefinedTerm
    236 N8c6d374506c4422eb70d37ca83dfdc69 rdf:first sg:person.01140011705.52
    237 rdf:rest N9aaecf79456e41ddb943f7a7db622c06
    238 N96e9a957ac014d9ab4c6bd0c20ecec54 rdf:first sg:person.01061540055.97
    239 rdf:rest N22ed1119e56c4da4b0d80fa7f7468a94
    240 N99ff89271f264a57be1fa18af04d7af0 schema:name Springer Nature - SN SciGraph project
    241 rdf:type schema:Organization
    242 N9aaecf79456e41ddb943f7a7db622c06 rdf:first sg:person.01050351737.74
    243 rdf:rest Na9219ecddf0d43e28e742dfe514365e3
    244 Na74959cc49cd42aea77035134404d7cb rdf:first sg:person.0634163435.96
    245 rdf:rest Nb2b801349a88453ab174ed4e55af7eea
    246 Na9219ecddf0d43e28e742dfe514365e3 rdf:first sg:person.01311075442.71
    247 rdf:rest N31c78ae04916472c99c657ae8e2f8daa
    248 Nabd601a84a624cd4a85242d3b1346654 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    249 schema:name Administration, Cutaneous
    250 rdf:type schema:DefinedTerm
    251 Nb2b801349a88453ab174ed4e55af7eea rdf:first sg:person.01323322421.13
    252 rdf:rest N45dc93107f1d4d57afab68883d893181
    253 Nb5e04a8c94454e558a09d9c75f6cbad2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    254 schema:name Multicenter Studies as Topic
    255 rdf:type schema:DefinedTerm
    256 Nb7bd5dca88434005bcc33176f4ec64d3 rdf:first sg:person.01212177667.78
    257 rdf:rest Na74959cc49cd42aea77035134404d7cb
    258 Nbb23b1cee9a74b9081d369b8979b4b3b rdf:first sg:person.01362550204.70
    259 rdf:rest N7019b425b41a44ccb17685c9e111db2d
    260 Nbb59fc8444d048bea3835bda4164a2f5 rdf:first sg:person.01212640265.63
    261 rdf:rest N8c6d374506c4422eb70d37ca83dfdc69
    262 Nbe2ac78c1c8c4ee5b4a7288b26c850ad rdf:first sg:person.01033731147.30
    263 rdf:rest N96e9a957ac014d9ab4c6bd0c20ecec54
    264 Nbf4f33f9a81d4cc7b3f96c2b40edb114 rdf:first N52e2496e17d24f3fadf1b1890b2af12d
    265 rdf:rest N87477dfcd14640ffb762cc10f9f3aebd
    266 Nc57eaae6c588483d9f8574c4a72d281e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    267 schema:name Time Factors
    268 rdf:type schema:DefinedTerm
    269 Nc8911ee8d578487694a419153402ff7b rdf:first N0ec9ab42ab1f4a3582d8f879e77fdb1c
    270 rdf:rest rdf:nil
    271 Nc9c063d256794e54be86cd394aad3734 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    272 schema:name Dietary Supplements
    273 rdf:type schema:DefinedTerm
    274 Ndac0b727778747c48799171cc9b5224f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    275 schema:name Ultraviolet Therapy
    276 rdf:type schema:DefinedTerm
    277 Ndbc66b84fc984cca840133bbf53de1c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    278 schema:name Combined Modality Therapy
    279 rdf:type schema:DefinedTerm
    280 Ne83f6f20ed5540c3ae687006f7e57784 rdf:first sg:person.01035026340.65
    281 rdf:rest N589bede7829548e5972ad9b4c65d79ba
    282 Nec98bae9b1f44b1c88e41f1917600817 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    283 schema:name Treatment Outcome
    284 rdf:type schema:DefinedTerm
    285 Ned9d018df5e04a8a9a2984cb72a02197 rdf:first sg:person.0746777426.35
    286 rdf:rest N6fd796020b454983b90750c0d5314a5a
    287 Nfed47829b55c475a982c8a9f46219dfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    288 schema:name France
    289 rdf:type schema:DefinedTerm
    290 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    291 schema:name Medical and Health Sciences
    292 rdf:type schema:DefinedTerm
    293 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
    294 schema:name Public Health and Health Services
    295 rdf:type schema:DefinedTerm
    296 sg:journal.1297400 schema:issn 1468-6708
    297 1745-6215
    298 schema:name Trials
    299 schema:publisher Springer Nature
    300 rdf:type schema:Periodical
    301 sg:person.01011610150.22 schema:affiliation grid-institutes:None
    302 schema:familyName Plantin
    303 schema:givenName Patrice
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011610150.22
    305 rdf:type schema:Person
    306 sg:person.01020051155.46 schema:affiliation grid-institutes:None
    307 schema:familyName Soria
    308 schema:givenName Angèle
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020051155.46
    310 rdf:type schema:Person
    311 sg:person.01033731147.30 schema:affiliation grid-institutes:None
    312 schema:familyName Barbaud
    313 schema:givenName Annick
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033731147.30
    315 rdf:type schema:Person
    316 sg:person.01035026340.65 schema:affiliation grid-institutes:None
    317 schema:familyName Nosbaum
    318 schema:givenName Audrey
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035026340.65
    320 rdf:type schema:Person
    321 sg:person.01043751540.39 schema:affiliation grid-institutes:None
    322 schema:familyName Vermersch
    323 schema:givenName Annie
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043751540.39
    325 rdf:type schema:Person
    326 sg:person.01050351737.74 schema:affiliation grid-institutes:grid.414271.5
    327 schema:familyName Adamski
    328 schema:givenName Henri
    329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050351737.74
    330 rdf:type schema:Person
    331 sg:person.01061540055.97 schema:affiliation grid-institutes:grid.410368.8
    332 schema:familyName Oger
    333 schema:givenName Emmanuel
    334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061540055.97
    335 rdf:type schema:Person
    336 sg:person.01104353732.54 schema:affiliation grid-institutes:grid.410368.8
    337 schema:familyName Dupuy
    338 schema:givenName Alain
    339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104353732.54
    340 rdf:type schema:Person
    341 sg:person.01140011705.52 schema:affiliation grid-institutes:None
    342 schema:familyName Brenaut
    343 schema:givenName Emilie
    344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140011705.52
    345 rdf:type schema:Person
    346 sg:person.01212177667.78 schema:affiliation grid-institutes:grid.410368.8
    347 schema:familyName Droitcourt
    348 schema:givenName Catherine
    349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212177667.78
    350 rdf:type schema:Person
    351 sg:person.01212640265.63 schema:affiliation grid-institutes:None
    352 schema:familyName Misery
    353 schema:givenName Laurent
    354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212640265.63
    355 rdf:type schema:Person
    356 sg:person.01264506043.24 schema:affiliation grid-institutes:None
    357 schema:familyName Skowron
    358 schema:givenName François
    359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264506043.24
    360 rdf:type schema:Person
    361 sg:person.01302526630.97 schema:affiliation grid-institutes:None
    362 schema:familyName Viguier
    363 schema:givenName Manuelle
    364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302526630.97
    365 rdf:type schema:Person
    366 sg:person.01311075442.71 schema:affiliation grid-institutes:None
    367 schema:familyName Chabbert
    368 schema:givenName Cécile
    369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311075442.71
    370 rdf:type schema:Person
    371 sg:person.01316212175.63 schema:affiliation grid-institutes:None
    372 schema:familyName Staumont-Salle
    373 schema:givenName Delphine
    374 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316212175.63
    375 rdf:type schema:Person
    376 sg:person.01321005562.53 schema:affiliation grid-institutes:None
    377 schema:familyName Darrieux
    378 schema:givenName Laure
    379 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321005562.53
    380 rdf:type schema:Person
    381 sg:person.01323322421.13 schema:affiliation grid-institutes:None
    382 schema:familyName Maruani
    383 schema:givenName Annabel
    384 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323322421.13
    385 rdf:type schema:Person
    386 sg:person.01362550204.70 schema:affiliation grid-institutes:None
    387 schema:familyName Phan
    388 schema:givenName Alice
    389 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362550204.70
    390 rdf:type schema:Person
    391 sg:person.0634163435.96 schema:affiliation grid-institutes:None
    392 schema:familyName Barbarot
    393 schema:givenName Sébastien
    394 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634163435.96
    395 rdf:type schema:Person
    396 sg:person.0746700570.26 schema:affiliation grid-institutes:None
    397 schema:familyName Maillard
    398 schema:givenName Hervé
    399 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746700570.26
    400 rdf:type schema:Person
    401 sg:person.0746777426.35 schema:affiliation grid-institutes:None
    402 schema:familyName Taïeb
    403 schema:givenName Alain
    404 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746777426.35
    405 rdf:type schema:Person
    406 sg:person.0772111230.98 schema:affiliation grid-institutes:None
    407 schema:familyName Seneschal
    408 schema:givenName Julien
    409 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772111230.98
    410 rdf:type schema:Person
    411 sg:pub.10.1007/s00403-013-1402-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011126987
    412 https://doi.org/10.1007/s00403-013-1402-1
    413 rdf:type schema:CreativeWork
    414 grid-institutes:None schema:alternateName Department of Dermatology and Allergology, University Hospital Center of Paris-Tenon, 75020 Paris, France
    415 Department of Dermatology, Hospital Center of Le Mans, 72000 Angers, France
    416 Department of Dermatology, Hospital Center of Perigueux, 24000 Perigueux, France
    417 Department of Dermatology, Hospital Center of Quimper, 29000 Quimper, France
    418 Department of Dermatology, Hospital Center of Saint-Brieuc, 22000 Saint-Brieuc, France
    419 Department of Dermatology, Hospital Center of Valence, 26000 Valence, France
    420 Department of Dermatology, Hospital Center of Valenciennes, 62000 Valenciennes, France
    421 Department of Dermatology, University Hospital Center of Bordeaux, 33000 Bordeaux, France
    422 Department of Dermatology, University Hospital Center of Brest, 29000 Brest, France
    423 Department of Dermatology, University Hospital Center of Lille, 59000 Lille, France
    424 Department of Dermatology, University Hospital Center of Lyon, 69000 Lyon Sud, France
    425 Department of Dermatology, University Hospital Center of Lyon, 69000 Lyon-Bron, France
    426 Department of Dermatology, University Hospital Center of Nantes, 44000 Nantes, France
    427 Department of Dermatology, University Hospital Center of Reims, 51000 Reims, France
    428 Department of Dermatology, University Hospital Center of Tours, 37000 Tours, France
    429 schema:name Department of Dermatology and Allergology, University Hospital Center of Paris-Tenon, 75020 Paris, France
    430 Department of Dermatology, Hospital Center of Le Mans, 72000 Angers, France
    431 Department of Dermatology, Hospital Center of Perigueux, 24000 Perigueux, France
    432 Department of Dermatology, Hospital Center of Quimper, 29000 Quimper, France
    433 Department of Dermatology, Hospital Center of Saint-Brieuc, 22000 Saint-Brieuc, France
    434 Department of Dermatology, Hospital Center of Valence, 26000 Valence, France
    435 Department of Dermatology, Hospital Center of Valenciennes, 62000 Valenciennes, France
    436 Department of Dermatology, University Hospital Center of Bordeaux, 33000 Bordeaux, France
    437 Department of Dermatology, University Hospital Center of Brest, 29000 Brest, France
    438 Department of Dermatology, University Hospital Center of Lille, 59000 Lille, France
    439 Department of Dermatology, University Hospital Center of Lyon, 69000 Lyon Sud, France
    440 Department of Dermatology, University Hospital Center of Lyon, 69000 Lyon-Bron, France
    441 Department of Dermatology, University Hospital Center of Nantes, 44000 Nantes, France
    442 Department of Dermatology, University Hospital Center of Reims, 51000 Reims, France
    443 Department of Dermatology, University Hospital Center of Tours, 37000 Tours, France
    444 rdf:type schema:Organization
    445 grid-institutes:grid.410368.8 schema:alternateName EA 7449 REPERES “Pharmaco-epidemiology and Health Services Research”, Univ Rennes, 35000 Rennes, France
    446 schema:name Department of Dermatology, University Hospital Center of Rennes, Pontchaillou Hospital, 2 rue Henri le Guilloux, 35000 Rennes, France
    447 EA 7449 REPERES “Pharmaco-epidemiology and Health Services Research”, Univ Rennes, 35000 Rennes, France
    448 INSERM, CIC 1414, 35000 Rennes, France
    449 Univ Rennes, Rennes, France
    450 rdf:type schema:Organization
    451 grid-institutes:grid.414271.5 schema:alternateName Department of Dermatology, University Hospital Center of Rennes, Pontchaillou Hospital, 2 rue Henri le Guilloux, 35000 Rennes, France
    452 schema:name Department of Dermatology, University Hospital Center of Rennes, Pontchaillou Hospital, 2 rue Henri le Guilloux, 35000 Rennes, France
    453 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...