Design and implementation of a large and complex trial in emergency medical services View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Maria J. Robinson, Jodi Taylor, Stephen J. Brett, Jerry P. Nolan, Matthew Thomas, Barnaby C. Reeves, Chris A. Rogers, Sarah Voss, Madeleine Clout, Jonathan R. Benger, In collaboration with the AIRWAYS-2 study team

ABSTRACT

BACKGROUND: The research study titled "Cluster randomised trial of the clinical and cost effectiveness of the i-gel supraglottic airway device versus tracheal intubation in the initial airway management of out-of-hospital cardiac arrest (AIRWAYS-2)" is a large-scale study being run in the English emergency medical (ambulance) services (EMS). It compares two airway management strategies (tracheal intubation and the i-gel) in out-of-hospital cardiac arrest. We describe the methods used to minimise bias and the challenges associated with the set-up, enrolment, and follow-up that were addressed. METHODS: AIRWAYS-2 enrols adults without capacity when there is no opportunity to seek prior consent and when the intervention must be delivered immediately. We therefore adopted a cluster randomised design where the unit of randomisation is the individual EMS provider (paramedic). However, because paramedics could not be blinded to the intervention, it was necessary to automatically enrol all eligible patients in the study to avoid bias. Effective implementation required engagement with four large EMS and 95 receiving hospitals. Very high levels of data capture were required to ensure study integrity, and this necessitated collaborative working across multiple organisations. We sought to manage these processes by using a large and comprehensive electronic study database, implementing efficient trial procedures and comprehensive training. RESULTS: Successful implementation of the study design was facilitated by the approaches used. The necessary regulatory and ethical approvals to conduct the study were secured, and benefited from strong patient and public involvement. Early and continued consultation with decision makers within the four participating EMS resulted in a coordinated approach to study set-up. All receiving hospitals gave approval and agreed to collect data. A comprehensive database and programme of training and support were implemented. More than 1500 paramedics have been recruited to the study, and patient enrolment and follow-up has proceeded as planned. CONCLUSION: Care provided by EMS needs to be based on evidence. Although participants may be experiencing life-threatening emergencies, high-quality pre-hospital research is possible in well-designed and well-managed studies. The approaches described here can be used to support successful research that will lead to improved treatment and outcomes in similar patient groups. TRIAL REGISTRATION: ISRCTN08256118 . Registered on 22 July 2014. More... »

PAGES

108

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13063-019-3203-0

DOI

http://dx.doi.org/10.1186/s13063-019-3203-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112019818

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30736841


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "South Western Ambulance Service NHS Foundation Trust", 
          "id": "https://www.grid.ac/institutes/grid.499043.3", 
          "name": [
            "South Western Ambulance Service NHS Foundation Trust, Exeter, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Robinson", 
        "givenName": "Maria J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bristol", 
          "id": "https://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taylor", 
        "givenName": "Jodi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial College Healthcare NHS Trust", 
          "id": "https://www.grid.ac/institutes/grid.417895.6", 
          "name": [
            "Centre for Perioperative Medicine and Critical Care Research, Imperial College Healthcare NHS Trust, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brett", 
        "givenName": "Stephen J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Anaesthesia, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nolan", 
        "givenName": "Jerry P.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospitals Bristol NHS Foundation Trust", 
          "id": "https://www.grid.ac/institutes/grid.410421.2", 
          "name": [
            "University Hospitals Bristol NHS Foundation Trust, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomas", 
        "givenName": "Matthew", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bristol", 
          "id": "https://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reeves", 
        "givenName": "Barnaby C.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bristol", 
          "id": "https://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rogers", 
        "givenName": "Chris A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of the West of England", 
          "id": "https://www.grid.ac/institutes/grid.6518.a", 
          "name": [
            "Faculty of Health and Applied Sciences, Glenside Campus, University of the West of England, BS16 1DD, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Voss", 
        "givenName": "Sarah", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bristol", 
          "id": "https://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clout", 
        "givenName": "Madeleine", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of the West of England", 
          "id": "https://www.grid.ac/institutes/grid.6518.a", 
          "name": [
            "University Hospitals Bristol NHS Foundation Trust, Bristol, UK", 
            "Faculty of Health and Applied Sciences, Glenside Campus, University of the West of England, BS16 1DD, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benger", 
        "givenName": "Jonathan R.", 
        "type": "Person"
      }, 
      {
        "familyName": "In collaboration with the AIRWAYS-2 study team", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1177/1740774516677276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003117392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1740774516677276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003117392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-007-0580-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004393698", 
          "https://doi.org/10.1007/s00134-007-0580-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-007-0580-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004393698", 
          "https://doi.org/10.1007/s00134-007-0580-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-007-0580-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004393698", 
          "https://doi.org/10.1007/s00134-007-0580-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6939-9-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014597467", 
          "https://doi.org/10.1186/1472-6939-9-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1258/jrsm.2008.070373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016429764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1258/jrsm.2008.070373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016429764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.resuscitation.2016.10.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023182357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmjopen-2014-005045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027247145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.resuscitation.2016.09.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040928740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.resuscitation.2016.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043462037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmjopen-2014-005874", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043630459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6963-10-124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047538084", 
          "https://doi.org/10.1186/1472-6963-10-124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2288-12-122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049572571", 
          "https://doi.org/10.1186/1471-2288-12-122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0300-9572(91)90061-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052018301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bja/aev477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059425003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1258/jrsm.100.5.234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064537204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074736972", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3310/hta4310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074736972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3310/hta4310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074736972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2018.11597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106419660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2018.11597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106419660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2018.11597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106419660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2018.11597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106419660"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: The research study titled \"Cluster randomised trial of the clinical and cost effectiveness of the i-gel supraglottic airway device versus tracheal intubation in the initial airway management of out-of-hospital cardiac arrest (AIRWAYS-2)\" is a large-scale study being run in the English emergency medical (ambulance) services (EMS). It compares two airway management strategies (tracheal intubation and the i-gel) in out-of-hospital cardiac arrest. We describe the methods used to minimise bias and the challenges associated with the set-up, enrolment, and follow-up that were addressed.\nMETHODS: AIRWAYS-2 enrols adults without capacity when there is no opportunity to seek prior consent and when the intervention must be delivered immediately. We therefore adopted a cluster randomised design where the unit of randomisation is the individual EMS provider (paramedic). However, because paramedics could not be blinded to the intervention, it was necessary to automatically enrol all eligible patients in the study to avoid bias. Effective implementation required engagement with four large EMS and 95 receiving hospitals. Very high levels of data capture were required to ensure study integrity, and this necessitated collaborative working across multiple organisations. We sought to manage these processes by using a large and comprehensive electronic study database, implementing efficient trial procedures and comprehensive training.\nRESULTS: Successful implementation of the study design was facilitated by the approaches used. The necessary regulatory and ethical approvals to conduct the study were secured, and benefited from strong patient and public involvement. Early and continued consultation with decision makers within the four participating EMS resulted in a coordinated approach to study set-up. All receiving hospitals gave approval and agreed to collect data. A comprehensive database and programme of training and support were implemented. More than 1500 paramedics have been recruited to the study, and patient enrolment and follow-up has proceeded as planned.\nCONCLUSION: Care provided by EMS needs to be based on evidence. Although participants may be experiencing life-threatening emergencies, high-quality pre-hospital research is possible in well-designed and well-managed studies. The approaches described here can be used to support successful research that will lead to improved treatment and outcomes in similar patient groups.\nTRIAL REGISTRATION: ISRCTN08256118 . Registered on 22 July 2014.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13063-019-3203-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5149360", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1297400", 
        "issn": [
          "1468-6708", 
          "1745-6215"
        ], 
        "name": "Trials", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "name": "Design and implementation of a large and complex trial in emergency medical services", 
    "pagination": "108", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0ff913d162a364eae43190bdc9e461c9328e307692122682df5d93d020ef684d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30736841"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101263253"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13063-019-3203-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112019818"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13063-019-3203-0", 
      "https://app.dimensions.ai/details/publication/pub.1112019818"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000338_0000000338/records_47980_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13063-019-3203-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13063-019-3203-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13063-019-3203-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13063-019-3203-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13063-019-3203-0'


 

This table displays all metadata directly associated to this object as RDF triples.

197 TRIPLES      21 PREDICATES      46 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13063-019-3203-0 schema:about anzsrc-for:11
2 anzsrc-for:1117
3 schema:author Nb5a2ca5a935c48dc97d9fab0f5e8ae4a
4 schema:citation sg:pub.10.1007/s00134-007-0580-8
5 sg:pub.10.1186/1471-2288-12-122
6 sg:pub.10.1186/1472-6939-9-9
7 sg:pub.10.1186/1472-6963-10-124
8 https://app.dimensions.ai/details/publication/pub.1074736972
9 https://doi.org/10.1001/jama.2018.11597
10 https://doi.org/10.1016/0300-9572(91)90061-3
11 https://doi.org/10.1016/j.resuscitation.2016.08.004
12 https://doi.org/10.1016/j.resuscitation.2016.09.016
13 https://doi.org/10.1016/j.resuscitation.2016.10.030
14 https://doi.org/10.1093/bja/aev477
15 https://doi.org/10.1136/bmjopen-2014-005045
16 https://doi.org/10.1136/bmjopen-2014-005874
17 https://doi.org/10.1177/1740774516677276
18 https://doi.org/10.1258/jrsm.100.5.234
19 https://doi.org/10.1258/jrsm.2008.070373
20 https://doi.org/10.3310/hta4310
21 schema:datePublished 2019-12
22 schema:datePublishedReg 2019-12-01
23 schema:description BACKGROUND: The research study titled "Cluster randomised trial of the clinical and cost effectiveness of the i-gel supraglottic airway device versus tracheal intubation in the initial airway management of out-of-hospital cardiac arrest (AIRWAYS-2)" is a large-scale study being run in the English emergency medical (ambulance) services (EMS). It compares two airway management strategies (tracheal intubation and the i-gel) in out-of-hospital cardiac arrest. We describe the methods used to minimise bias and the challenges associated with the set-up, enrolment, and follow-up that were addressed. METHODS: AIRWAYS-2 enrols adults without capacity when there is no opportunity to seek prior consent and when the intervention must be delivered immediately. We therefore adopted a cluster randomised design where the unit of randomisation is the individual EMS provider (paramedic). However, because paramedics could not be blinded to the intervention, it was necessary to automatically enrol all eligible patients in the study to avoid bias. Effective implementation required engagement with four large EMS and 95 receiving hospitals. Very high levels of data capture were required to ensure study integrity, and this necessitated collaborative working across multiple organisations. We sought to manage these processes by using a large and comprehensive electronic study database, implementing efficient trial procedures and comprehensive training. RESULTS: Successful implementation of the study design was facilitated by the approaches used. The necessary regulatory and ethical approvals to conduct the study were secured, and benefited from strong patient and public involvement. Early and continued consultation with decision makers within the four participating EMS resulted in a coordinated approach to study set-up. All receiving hospitals gave approval and agreed to collect data. A comprehensive database and programme of training and support were implemented. More than 1500 paramedics have been recruited to the study, and patient enrolment and follow-up has proceeded as planned. CONCLUSION: Care provided by EMS needs to be based on evidence. Although participants may be experiencing life-threatening emergencies, high-quality pre-hospital research is possible in well-designed and well-managed studies. The approaches described here can be used to support successful research that will lead to improved treatment and outcomes in similar patient groups. TRIAL REGISTRATION: ISRCTN08256118 . Registered on 22 July 2014.
24 schema:genre research_article
25 schema:inLanguage en
26 schema:isAccessibleForFree true
27 schema:isPartOf N11add548bb92441986b98cf1c89fdd7b
28 Nb4ad1713d1014eaf8282c6c69f7eb613
29 sg:journal.1297400
30 schema:name Design and implementation of a large and complex trial in emergency medical services
31 schema:pagination 108
32 schema:productId N0e3346d9e62844e581683ea751106842
33 N1756e7edb4e64e5fa85933205d94dbe2
34 N3aa6d2a0e1ca4893991a430d54177bda
35 Na02424d76de54d03b29270403cc38f40
36 Nbb9fe4ca950b459d964fc61f37b40330
37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112019818
38 https://doi.org/10.1186/s13063-019-3203-0
39 schema:sdDatePublished 2019-04-11T09:12
40 schema:sdLicense https://scigraph.springernature.com/explorer/license/
41 schema:sdPublisher N6480d1c9cceb432ea47f5a6b34d4dcb3
42 schema:url https://link.springer.com/10.1186%2Fs13063-019-3203-0
43 sgo:license sg:explorer/license/
44 sgo:sdDataset articles
45 rdf:type schema:ScholarlyArticle
46 N082308bdc56c48218b01bf8521112c7a rdf:first Nf29607f5a0054f66a2e96d3668edf33b
47 rdf:rest N591843df63f345559f79a441800d1cfe
48 N0e3346d9e62844e581683ea751106842 schema:name readcube_id
49 schema:value 0ff913d162a364eae43190bdc9e461c9328e307692122682df5d93d020ef684d
50 rdf:type schema:PropertyValue
51 N11add548bb92441986b98cf1c89fdd7b schema:issueNumber 1
52 rdf:type schema:PublicationIssue
53 N14fb03f8bf834080a578dbecbb9fa5b8 rdf:first Nb36db98ab8a444838ffcaed54ea6053a
54 rdf:rest N4bf42ac4275a42cd9c4bc2296494d6e6
55 N15f351340a9f419ba6181f428ce7d2de schema:affiliation https://www.grid.ac/institutes/grid.6518.a
56 schema:familyName Voss
57 schema:givenName Sarah
58 rdf:type schema:Person
59 N1756e7edb4e64e5fa85933205d94dbe2 schema:name doi
60 schema:value 10.1186/s13063-019-3203-0
61 rdf:type schema:PropertyValue
62 N38408db608cb4b12bf593b2c47f9db16 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
63 schema:familyName Clout
64 schema:givenName Madeleine
65 rdf:type schema:Person
66 N3aa6d2a0e1ca4893991a430d54177bda schema:name pubmed_id
67 schema:value 30736841
68 rdf:type schema:PropertyValue
69 N4af4bdda8fd0452aaee5746de927710f rdf:first N86e0ac9c54664a18a5faac5ae4615bbb
70 rdf:rest N6ee0c3753bb243a8a4b6038155538205
71 N4bf42ac4275a42cd9c4bc2296494d6e6 rdf:first N65b6d5e63a3341d5b2c3670a8353b46b
72 rdf:rest Nf31f3f8502af401a80248674ec0b75ce
73 N5249185774f942b683ecd591f3ec06a8 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
74 schema:familyName Taylor
75 schema:givenName Jodi
76 rdf:type schema:Person
77 N591843df63f345559f79a441800d1cfe rdf:first Nae0fae68d68b41199d8e751f5617207c
78 rdf:rest N14fb03f8bf834080a578dbecbb9fa5b8
79 N6480d1c9cceb432ea47f5a6b34d4dcb3 schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 N65b6d5e63a3341d5b2c3670a8353b46b schema:affiliation https://www.grid.ac/institutes/grid.5337.2
82 schema:familyName Rogers
83 schema:givenName Chris A.
84 rdf:type schema:Person
85 N6ee0c3753bb243a8a4b6038155538205 rdf:first Na409388885ee41f9a0a456f53084792e
86 rdf:rest rdf:nil
87 N829bfea6183f4d1fbe1a8c6cf3b8d1ee schema:affiliation https://www.grid.ac/institutes/grid.417895.6
88 schema:familyName Brett
89 schema:givenName Stephen J.
90 rdf:type schema:Person
91 N86e0ac9c54664a18a5faac5ae4615bbb schema:affiliation https://www.grid.ac/institutes/grid.6518.a
92 schema:familyName Benger
93 schema:givenName Jonathan R.
94 rdf:type schema:Person
95 N963bc4aea00b4e8d9165198901b417aa rdf:first N829bfea6183f4d1fbe1a8c6cf3b8d1ee
96 rdf:rest N082308bdc56c48218b01bf8521112c7a
97 N9a15fcc21ac745f5b12f3387b74da8ad schema:name Department of Anaesthesia, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK
98 rdf:type schema:Organization
99 N9bc70ea729fb4b63b9babaa0a43b5a8b schema:affiliation https://www.grid.ac/institutes/grid.499043.3
100 schema:familyName Robinson
101 schema:givenName Maria J.
102 rdf:type schema:Person
103 Na02424d76de54d03b29270403cc38f40 schema:name dimensions_id
104 schema:value pub.1112019818
105 rdf:type schema:PropertyValue
106 Na409388885ee41f9a0a456f53084792e schema:familyName In collaboration with the AIRWAYS-2 study team
107 rdf:type schema:Person
108 Nadbf5d1ec0214b42ae55fe80941ed26c rdf:first N5249185774f942b683ecd591f3ec06a8
109 rdf:rest N963bc4aea00b4e8d9165198901b417aa
110 Nae0fae68d68b41199d8e751f5617207c schema:affiliation https://www.grid.ac/institutes/grid.410421.2
111 schema:familyName Thomas
112 schema:givenName Matthew
113 rdf:type schema:Person
114 Nb36db98ab8a444838ffcaed54ea6053a schema:affiliation https://www.grid.ac/institutes/grid.5337.2
115 schema:familyName Reeves
116 schema:givenName Barnaby C.
117 rdf:type schema:Person
118 Nb4ad1713d1014eaf8282c6c69f7eb613 schema:volumeNumber 20
119 rdf:type schema:PublicationVolume
120 Nb5a2ca5a935c48dc97d9fab0f5e8ae4a rdf:first N9bc70ea729fb4b63b9babaa0a43b5a8b
121 rdf:rest Nadbf5d1ec0214b42ae55fe80941ed26c
122 Nbb9fe4ca950b459d964fc61f37b40330 schema:name nlm_unique_id
123 schema:value 101263253
124 rdf:type schema:PropertyValue
125 Nbde67790b2e749a0972a3a8740b9b47c rdf:first N38408db608cb4b12bf593b2c47f9db16
126 rdf:rest N4af4bdda8fd0452aaee5746de927710f
127 Nf29607f5a0054f66a2e96d3668edf33b schema:affiliation N9a15fcc21ac745f5b12f3387b74da8ad
128 schema:familyName Nolan
129 schema:givenName Jerry P.
130 rdf:type schema:Person
131 Nf31f3f8502af401a80248674ec0b75ce rdf:first N15f351340a9f419ba6181f428ce7d2de
132 rdf:rest Nbde67790b2e749a0972a3a8740b9b47c
133 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
134 schema:name Medical and Health Sciences
135 rdf:type schema:DefinedTerm
136 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
137 schema:name Public Health and Health Services
138 rdf:type schema:DefinedTerm
139 sg:grant.5149360 http://pending.schema.org/fundedItem sg:pub.10.1186/s13063-019-3203-0
140 rdf:type schema:MonetaryGrant
141 sg:journal.1297400 schema:issn 1468-6708
142 1745-6215
143 schema:name Trials
144 rdf:type schema:Periodical
145 sg:pub.10.1007/s00134-007-0580-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004393698
146 https://doi.org/10.1007/s00134-007-0580-8
147 rdf:type schema:CreativeWork
148 sg:pub.10.1186/1471-2288-12-122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049572571
149 https://doi.org/10.1186/1471-2288-12-122
150 rdf:type schema:CreativeWork
151 sg:pub.10.1186/1472-6939-9-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014597467
152 https://doi.org/10.1186/1472-6939-9-9
153 rdf:type schema:CreativeWork
154 sg:pub.10.1186/1472-6963-10-124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047538084
155 https://doi.org/10.1186/1472-6963-10-124
156 rdf:type schema:CreativeWork
157 https://app.dimensions.ai/details/publication/pub.1074736972 schema:CreativeWork
158 https://doi.org/10.1001/jama.2018.11597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106419660
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/0300-9572(91)90061-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052018301
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/j.resuscitation.2016.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043462037
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/j.resuscitation.2016.09.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040928740
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/j.resuscitation.2016.10.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023182357
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1093/bja/aev477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059425003
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1136/bmjopen-2014-005045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027247145
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1136/bmjopen-2014-005874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043630459
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1177/1740774516677276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003117392
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1258/jrsm.100.5.234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064537204
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1258/jrsm.2008.070373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016429764
179 rdf:type schema:CreativeWork
180 https://doi.org/10.3310/hta4310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074736972
181 rdf:type schema:CreativeWork
182 https://www.grid.ac/institutes/grid.410421.2 schema:alternateName University Hospitals Bristol NHS Foundation Trust
183 schema:name University Hospitals Bristol NHS Foundation Trust, Bristol, UK
184 rdf:type schema:Organization
185 https://www.grid.ac/institutes/grid.417895.6 schema:alternateName Imperial College Healthcare NHS Trust
186 schema:name Centre for Perioperative Medicine and Critical Care Research, Imperial College Healthcare NHS Trust, London, UK
187 rdf:type schema:Organization
188 https://www.grid.ac/institutes/grid.499043.3 schema:alternateName South Western Ambulance Service NHS Foundation Trust
189 schema:name South Western Ambulance Service NHS Foundation Trust, Exeter, UK
190 rdf:type schema:Organization
191 https://www.grid.ac/institutes/grid.5337.2 schema:alternateName University of Bristol
192 schema:name Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, UK
193 rdf:type schema:Organization
194 https://www.grid.ac/institutes/grid.6518.a schema:alternateName University of the West of England
195 schema:name Faculty of Health and Applied Sciences, Glenside Campus, University of the West of England, BS16 1DD, Bristol, UK
196 University Hospitals Bristol NHS Foundation Trust, Bristol, UK
197 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...