Efficacy and mechanisms of combined aerobic exercise and cognitive training in mild cognitive impairment: study protocol of the ACT trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Fang Yu, Feng Vankee Lin, Dereck L. Salisbury, Krupa N. Shah, Lisa Chow, David Vock, Nathaniel W. Nelson, Anton P. Porsteinsson, Clifford Jack

ABSTRACT

BACKGROUND: Developing non-pharmacological interventions with strong potential to prevent or delay the onset of Alzheimer's disease (AD) in high-risk populations is critical. Aerobic exercise and cognitive training are two promising interventions. Aerobic exercise increases aerobic fitness, which in turn improves brain structure and function, while cognitive training improves selective brain function intensively. Hence, combined aerobic exercise and cognitive training may have a synergistic effect on cognition by complementary strengthening of different neural functions. Few studies have tested the effects of such a combined intervention, and the findings have been discrepant, largely due to varying doses and formats of the interventions. METHODS/DESIGN: The purpose of this single-blinded, 2 × 2 factorial phase II randomized controlled trial is to test the efficacy and synergistic effects of a 6-month combined cycling and speed of processing training intervention on cognition and relevant mechanisms (aerobic fitness, cortical thickness, and functional connectivity in the default mode network) in older adults with amnestic mild cognitive impairment. This trial will randomize 128 participants equally to four arms: cycling and speed of processing, cycling only, speed of processing only, or attention control for 6 months, and then follow them for another 12 months. Cognition and aerobic fitness will be assessed at baseline and at 3, 6, 12, and 18 months; cortical thickness and functional connectivity at baseline and at 6, 12, and 18 months; Alzheimer's disease (AD) conversion at 6, 12, and 18 months. The specific aims are to (1) determine the efficacy and synergistic effects of the combined intervention on cognition over 6 months, (2) examine the underlying mechanisms of the combined intervention, and (3) calculate the long-term effect sizes of the combined intervention on cognition and AD conversion. The analysis will use intention-to-treat and linear mixed-effects modeling. DISCUSSION: This trial will be among the first to test the synergistic effects on cognition and mechanisms (relevant to Alzheimer's-associated neurodegeneration) of a uniquely conceptualized and rigorously designed aerobic exercise and cognitive training intervention in older adults with mild cognitive impairment. It will advance Alzheimer's prevention research by providing precise effect-size estimates of the combined intervention. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03313895 . Registered on 18 October 2017. More... »

PAGES

700

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13063-018-3054-0

DOI

http://dx.doi.org/10.1186/s13063-018-3054-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110815868

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30577848


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1701", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Psychology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/17", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Psychology and Cognitive Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bicycling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebral Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clinical Trials, Phase II as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cognition", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cognitive Aging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cognitive Behavioral Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cognitive Dysfunction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Executive Function", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Exercise Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Memory", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mental Health", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multicenter Studies as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuropsychological Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Physical Fitness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Randomized Controlled Trials as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Single-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "United States", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "University of Minnesota School of Nursing, 5-160 WDH 1331, 308 Harvard St SE, 55455, Minneapolis, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Fang", 
        "id": "sg:person.01212267437.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212267437.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Rochester Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412750.5", 
          "name": [
            "University of Rochester Medical Center, 601 Elmwood Ave, 14642, Rochester, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Feng Vankee", 
        "id": "sg:person.0720260005.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720260005.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "University of Minnesota School of Nursing, 5-160 WDH 1331, 308 Harvard St SE, 55455, Minneapolis, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salisbury", 
        "givenName": "Dereck L.", 
        "id": "sg:person.0664741204.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664741204.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Rochester Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412750.5", 
          "name": [
            "University of Rochester Medical Center, 601 Elmwood Ave, 14642, Rochester, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shah", 
        "givenName": "Krupa N.", 
        "id": "sg:person.07577171777.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07577171777.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "University of Minnesota School of Medicine, Minneapolis, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chow", 
        "givenName": "Lisa", 
        "id": "sg:person.0736516041.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736516041.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "University of Minnesota Division of Biostatistics, Minneapolis, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vock", 
        "givenName": "David", 
        "id": "sg:person.01020150701.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020150701.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of St. Thomas", 
          "id": "https://www.grid.ac/institutes/grid.267207.6", 
          "name": [
            "University of St. Thomas, Minneapolis, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nelson", 
        "givenName": "Nathaniel W.", 
        "id": "sg:person.0750303541.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750303541.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Rochester Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412750.5", 
          "name": [
            "University of Rochester Medical Center, 601 Elmwood Ave, 14642, Rochester, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Porsteinsson", 
        "givenName": "Anton P.", 
        "id": "sg:person.016461363674.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016461363674.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Department of Radiology, Mayo Clinic, Rochester, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jack", 
        "givenName": "Clifford", 
        "id": "sg:person.01033737345.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033737345.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.neubiorev.2013.04.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000055535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neubiorev.2013.04.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000055535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hipo.20547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001158561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/13803395.2015.1132298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001287271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/neuro.22.002.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002235984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(05)70198-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003262386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpsychores.2012.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004700055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/a0037363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005007617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0708803104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005500047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bjsm.2007.044735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006124198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/gerona/glq038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006322616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamainternmed.2013.189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006394408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2948-11.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008509688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbr.2011.04.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009244471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/gerona/63.1.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011428601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2015.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011461915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wad.0b013e31815a9ddc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012161642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wad.0b013e31815a9ddc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012161642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1467-842x.1997.tb01653.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012663179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2167702613497932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013006830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2167702613497932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013006830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fnagi.2010.00032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013058757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2011.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015460770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0882-7974.7.4.643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017531201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awv283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017803622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.10262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019711215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e31828726f5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019727932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e31828726f5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019727932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.300.9.1027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020885718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gps.1010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021784001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.58.3.498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024178661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2011.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025279802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gerinurse.2012.12.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025528938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jgs.14132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025927553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep39471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028153827", 
          "https://doi.org/10.1038/srep39471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2318-11-27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028990405", 
          "https://doi.org/10.1186/1471-2318-11-27"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0278-6133.23.5.443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031169939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00625068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031407261", 
          "https://doi.org/10.1007/bf00625068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00625068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031407261", 
          "https://doi.org/10.1007/bf00625068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/neuro.09.016.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033934924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0040588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035386464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(04)00767-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035990884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/a0020080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035997804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bjsports-2015-095699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038494210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fnagi.2010.00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040011497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02701367.1991.10607519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040983201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0447.2008.01326.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041394829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1355617713001094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041978171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropsychologia.2010.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043011534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd006220.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044221069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1745-6215-15-394", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044389813", 
          "https://doi.org/10.1186/1745-6215-15-394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2202-14-103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045484275", 
          "https://doi.org/10.1186/1471-2202-14-103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2009.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049326297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.47.12.1019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051064139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.47.12.1019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051064139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/aje/kwf074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051835807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropharm.2012.07.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053310717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2002-33735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057416654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0193945911420174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063769847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0193945911420174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063769847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000317094.86209.cb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064350375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000317094.86209.cb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064350375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000317094.86209.cb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064350375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000317094.86209.cb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064350375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000002415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064353391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000002415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064353391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000002415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064353391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000002415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064353391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e318296e940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064357796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e318296e940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064357796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e318296e940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064357796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/156720512803568984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069189205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/187152707783220938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069221411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-144-2-200601170-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073708530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-152-11-201006010-00232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073711230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-153-3-201008030-00260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073711708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-158-3-201302050-00583", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073713447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1567205014666170203095128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083685622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2018.02.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103192032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2018.02.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103192032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2018.02.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103192032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.31189/2165-6193-6.2.22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105582614"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Developing non-pharmacological interventions with strong potential to prevent or delay the onset of Alzheimer's disease (AD) in high-risk populations is critical. Aerobic exercise and cognitive training are two promising interventions. Aerobic exercise increases aerobic fitness, which in turn improves brain structure and function, while cognitive training improves selective brain function intensively. Hence, combined aerobic exercise and cognitive training may have a synergistic effect on cognition by complementary strengthening of different neural functions. Few studies have tested the effects of such a combined intervention, and the findings have been discrepant, largely due to varying doses and formats of the interventions.\nMETHODS/DESIGN: The purpose of this single-blinded, 2\u2009\u00d7\u20092 factorial phase II randomized controlled trial is to test the efficacy and synergistic effects of a 6-month combined cycling and speed of processing training intervention on cognition and relevant mechanisms (aerobic fitness, cortical thickness, and functional connectivity in the default mode network) in older adults with amnestic mild cognitive impairment. This trial will randomize 128 participants equally to four arms: cycling and speed of processing, cycling only, speed of processing only, or attention control for 6\u2009months, and then follow them for another 12\u2009months. Cognition and aerobic fitness will be assessed at baseline and at 3, 6, 12, and 18\u2009months; cortical thickness and functional connectivity at baseline and at 6, 12, and 18\u2009months; Alzheimer's disease (AD) conversion at 6, 12, and 18\u2009months. The specific aims are to (1) determine the efficacy and synergistic effects of the combined intervention on cognition over 6\u2009months, (2) examine the underlying mechanisms of the combined intervention, and (3) calculate the long-term effect sizes of the combined intervention on cognition and AD conversion. The analysis will use intention-to-treat and linear mixed-effects modeling.\nDISCUSSION: This trial will be among the first to test the synergistic effects on cognition and mechanisms (relevant to Alzheimer's-associated neurodegeneration) of a uniquely conceptualized and rigorously designed aerobic exercise and cognitive training intervention in older adults with mild cognitive impairment. It will advance Alzheimer's prevention research by providing precise effect-size estimates of the combined intervention.\nTRIAL REGISTRATION: ClinicalTrials.gov, NCT03313895 . Registered on 18 October 2017.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13063-018-3054-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7026878", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2705213", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1297400", 
        "issn": [
          "1468-6708", 
          "1745-6215"
        ], 
        "name": "Trials", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Efficacy and mechanisms of combined aerobic exercise and cognitive training in mild cognitive impairment: study protocol of the ACT trial", 
    "pagination": "700", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13063-018-3054-0"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "129e54e63e415a1b9f9ab100784b32dc695a8714ee2a8d892a9be907546c5203"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110815868"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101263253"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30577848"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13063-018-3054-0", 
      "https://app.dimensions.ai/details/publication/pub.1110815868"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91447_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13063-018-3054-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13063-018-3054-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13063-018-3054-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13063-018-3054-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13063-018-3054-0'


 

This table displays all metadata directly associated to this object as RDF triples.

440 TRIPLES      21 PREDICATES      119 URIs      46 LITERALS      34 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13063-018-3054-0 schema:about N067ba6d33dd3480394ef478657bf24e5
2 N16570db54a324795ab461683d6975da0
3 N1f5c4841e7d64f5db47e4f50415e80a4
4 N23c18523e5c6445d86410e17cf7ade13
5 N2f246286f48a484685dd0188f8491d8f
6 N43b8f3d4cb374b4e91e6e1f9a67d3fb1
7 N4f4fb9af74ab42da95f073e3ccac96a8
8 N50b2261247244b4e8d75cb7201475503
9 N5391e94db4d8400299887d7904d6cf41
10 N557a4231b1c3443cae5a5e442325c837
11 N58b392ffeadc486b859f908ce9bed60c
12 N69c0fa902020496c914d12b6f8300f01
13 N6a97f4a3b40e4c2ba2cf4837b09fced4
14 N7152c343cab74a75b752f676c666c468
15 N7cded741185b4a98bcf746cfe483cb16
16 N7e873ff1c41b4ce9ad714fd7d82176f8
17 N947317ea584540439bb3dbe2888fbf59
18 N999fe59f92c444608b3c2253226438bb
19 Na982d778ece7471c970dfcc71ee73f02
20 Nad62218139e7460abff53f25f0c9fb7c
21 Nb986ed81460d4a00a43dcab37b78b5e0
22 Ne02fd44aef9747d6ac63fd42e0d5f2bd
23 Ne1bb2b8f83614f45a2e582eafdcbb82d
24 Nf27989a8e7f644949a78fa0fb708494d
25 Nf49e85d674e44fcebf3851d62ff93a68
26 anzsrc-for:17
27 anzsrc-for:1701
28 schema:author Nb0f4bae17d03465e9f00e89d6a6585ce
29 schema:citation sg:pub.10.1007/bf00625068
30 sg:pub.10.1038/srep39471
31 sg:pub.10.1186/1471-2202-14-103
32 sg:pub.10.1186/1471-2318-11-27
33 sg:pub.10.1186/1745-6215-15-394
34 https://doi.org/10.1001/archneur.58.3.498
35 https://doi.org/10.1001/jama.300.9.1027
36 https://doi.org/10.1001/jamainternmed.2013.189
37 https://doi.org/10.1002/14651858.cd006220.pub2
38 https://doi.org/10.1002/ana.10262
39 https://doi.org/10.1002/gps.1010
40 https://doi.org/10.1002/hipo.20547
41 https://doi.org/10.1016/j.bbr.2011.04.023
42 https://doi.org/10.1016/j.gerinurse.2012.12.014
43 https://doi.org/10.1016/j.jalz.2011.03.005
44 https://doi.org/10.1016/j.jalz.2011.03.008
45 https://doi.org/10.1016/j.jalz.2015.05.002
46 https://doi.org/10.1016/j.jalz.2018.02.018
47 https://doi.org/10.1016/j.jpsychores.2012.01.008
48 https://doi.org/10.1016/j.neubiorev.2013.04.005
49 https://doi.org/10.1016/j.neurobiolaging.2009.03.008
50 https://doi.org/10.1016/j.neuropharm.2012.07.027
51 https://doi.org/10.1016/j.neuropsychologia.2010.01.005
52 https://doi.org/10.1016/s1474-4422(04)00767-7
53 https://doi.org/10.1016/s1474-4422(05)70198-8
54 https://doi.org/10.1017/s1355617713001094
55 https://doi.org/10.1037/0278-6133.23.5.443
56 https://doi.org/10.1037/0882-7974.7.4.643
57 https://doi.org/10.1037/a0020080
58 https://doi.org/10.1037/a0037363
59 https://doi.org/10.1055/s-2002-33735
60 https://doi.org/10.1073/pnas.0708803104
61 https://doi.org/10.1080/02701367.1991.10607519
62 https://doi.org/10.1080/13803395.2015.1132298
63 https://doi.org/10.1093/aje/kwf074
64 https://doi.org/10.1093/brain/awv283
65 https://doi.org/10.1093/gerona/63.1.62
66 https://doi.org/10.1093/gerona/glq038
67 https://doi.org/10.1097/wad.0b013e31815a9ddc
68 https://doi.org/10.1111/j.1467-842x.1997.tb01653.x
69 https://doi.org/10.1111/j.1600-0447.2008.01326.x
70 https://doi.org/10.1111/jgs.14132
71 https://doi.org/10.1136/bjsm.2007.044735
72 https://doi.org/10.1136/bjsports-2015-095699
73 https://doi.org/10.1136/thx.47.12.1019
74 https://doi.org/10.1177/0193945911420174
75 https://doi.org/10.1177/2167702613497932
76 https://doi.org/10.1212/01.wnl.0000317094.86209.cb
77 https://doi.org/10.1212/wnl.0000000000002415
78 https://doi.org/10.1212/wnl.0b013e31828726f5
79 https://doi.org/10.1212/wnl.0b013e318296e940
80 https://doi.org/10.1371/journal.pone.0040588
81 https://doi.org/10.1523/jneurosci.2948-11.2011
82 https://doi.org/10.2174/1567205014666170203095128
83 https://doi.org/10.2174/156720512803568984
84 https://doi.org/10.2174/187152707783220938
85 https://doi.org/10.31189/2165-6193-6.2.22
86 https://doi.org/10.3389/fnagi.2010.00023
87 https://doi.org/10.3389/fnagi.2010.00032
88 https://doi.org/10.3389/neuro.09.016.2010
89 https://doi.org/10.3389/neuro.22.002.2009
90 https://doi.org/10.7326/0003-4819-144-2-200601170-00004
91 https://doi.org/10.7326/0003-4819-152-11-201006010-00232
92 https://doi.org/10.7326/0003-4819-153-3-201008030-00260
93 https://doi.org/10.7326/0003-4819-158-3-201302050-00583
94 schema:datePublished 2018-12
95 schema:datePublishedReg 2018-12-01
96 schema:description BACKGROUND: Developing non-pharmacological interventions with strong potential to prevent or delay the onset of Alzheimer's disease (AD) in high-risk populations is critical. Aerobic exercise and cognitive training are two promising interventions. Aerobic exercise increases aerobic fitness, which in turn improves brain structure and function, while cognitive training improves selective brain function intensively. Hence, combined aerobic exercise and cognitive training may have a synergistic effect on cognition by complementary strengthening of different neural functions. Few studies have tested the effects of such a combined intervention, and the findings have been discrepant, largely due to varying doses and formats of the interventions. METHODS/DESIGN: The purpose of this single-blinded, 2 × 2 factorial phase II randomized controlled trial is to test the efficacy and synergistic effects of a 6-month combined cycling and speed of processing training intervention on cognition and relevant mechanisms (aerobic fitness, cortical thickness, and functional connectivity in the default mode network) in older adults with amnestic mild cognitive impairment. This trial will randomize 128 participants equally to four arms: cycling and speed of processing, cycling only, speed of processing only, or attention control for 6 months, and then follow them for another 12 months. Cognition and aerobic fitness will be assessed at baseline and at 3, 6, 12, and 18 months; cortical thickness and functional connectivity at baseline and at 6, 12, and 18 months; Alzheimer's disease (AD) conversion at 6, 12, and 18 months. The specific aims are to (1) determine the efficacy and synergistic effects of the combined intervention on cognition over 6 months, (2) examine the underlying mechanisms of the combined intervention, and (3) calculate the long-term effect sizes of the combined intervention on cognition and AD conversion. The analysis will use intention-to-treat and linear mixed-effects modeling. DISCUSSION: This trial will be among the first to test the synergistic effects on cognition and mechanisms (relevant to Alzheimer's-associated neurodegeneration) of a uniquely conceptualized and rigorously designed aerobic exercise and cognitive training intervention in older adults with mild cognitive impairment. It will advance Alzheimer's prevention research by providing precise effect-size estimates of the combined intervention. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03313895 . Registered on 18 October 2017.
97 schema:genre research_article
98 schema:inLanguage en
99 schema:isAccessibleForFree true
100 schema:isPartOf N23e0a063b35d4a3d9056cb08adc95c7a
101 Ncab9d1e7f995473f91545f293b5c3e72
102 sg:journal.1297400
103 schema:name Efficacy and mechanisms of combined aerobic exercise and cognitive training in mild cognitive impairment: study protocol of the ACT trial
104 schema:pagination 700
105 schema:productId N3e94219c35ec4967971f919b1ec3e388
106 N69a6f43f85124d8fa26a67962734ad88
107 N935ca11bcdeb477ca1bf32c40054313c
108 Nc421f831546346d1ae963b391fac2ef8
109 Nd1cf7a9cfa34474b95fa0265b500026e
110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110815868
111 https://doi.org/10.1186/s13063-018-3054-0
112 schema:sdDatePublished 2019-04-15T09:01
113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
114 schema:sdPublisher N80f5b23d178e4c5b89e77a49a701e148
115 schema:url https://link.springer.com/10.1186%2Fs13063-018-3054-0
116 sgo:license sg:explorer/license/
117 sgo:sdDataset articles
118 rdf:type schema:ScholarlyArticle
119 N067ba6d33dd3480394ef478657bf24e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Randomized Controlled Trials as Topic
121 rdf:type schema:DefinedTerm
122 N16570db54a324795ab461683d6975da0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Bicycling
124 rdf:type schema:DefinedTerm
125 N1f5c4841e7d64f5db47e4f50415e80a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Female
127 rdf:type schema:DefinedTerm
128 N23c18523e5c6445d86410e17cf7ade13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Clinical Trials, Phase II as Topic
130 rdf:type schema:DefinedTerm
131 N23e0a063b35d4a3d9056cb08adc95c7a schema:issueNumber 1
132 rdf:type schema:PublicationIssue
133 N2482680eb6784bcb9da0164300d4eb20 rdf:first sg:person.07577171777.37
134 rdf:rest Nb8633e58565242928ae054cbd080f103
135 N2f246286f48a484685dd0188f8491d8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cognitive Behavioral Therapy
137 rdf:type schema:DefinedTerm
138 N31b71ae53a584ebfab91833b149f3d67 rdf:first sg:person.0664741204.16
139 rdf:rest N2482680eb6784bcb9da0164300d4eb20
140 N3e94219c35ec4967971f919b1ec3e388 schema:name nlm_unique_id
141 schema:value 101263253
142 rdf:type schema:PropertyValue
143 N43b8f3d4cb374b4e91e6e1f9a67d3fb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Executive Function
145 rdf:type schema:DefinedTerm
146 N4f4fb9af74ab42da95f073e3ccac96a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name United States
148 rdf:type schema:DefinedTerm
149 N50b2261247244b4e8d75cb7201475503 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Cognition
151 rdf:type schema:DefinedTerm
152 N5391e94db4d8400299887d7904d6cf41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Humans
154 rdf:type schema:DefinedTerm
155 N557a4231b1c3443cae5a5e442325c837 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Male
157 rdf:type schema:DefinedTerm
158 N58b392ffeadc486b859f908ce9bed60c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Single-Blind Method
160 rdf:type schema:DefinedTerm
161 N69a6f43f85124d8fa26a67962734ad88 schema:name doi
162 schema:value 10.1186/s13063-018-3054-0
163 rdf:type schema:PropertyValue
164 N69c0fa902020496c914d12b6f8300f01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Mental Health
166 rdf:type schema:DefinedTerm
167 N6a97f4a3b40e4c2ba2cf4837b09fced4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Cerebral Cortex
169 rdf:type schema:DefinedTerm
170 N7152c343cab74a75b752f676c666c468 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Physical Fitness
172 rdf:type schema:DefinedTerm
173 N7cded741185b4a98bcf746cfe483cb16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Age Factors
175 rdf:type schema:DefinedTerm
176 N7e873ff1c41b4ce9ad714fd7d82176f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Cognitive Aging
178 rdf:type schema:DefinedTerm
179 N80f5b23d178e4c5b89e77a49a701e148 schema:name Springer Nature - SN SciGraph project
180 rdf:type schema:Organization
181 N89c8e24e9b3f4735a6ff51911658e795 rdf:first sg:person.01033737345.96
182 rdf:rest rdf:nil
183 N935ca11bcdeb477ca1bf32c40054313c schema:name dimensions_id
184 schema:value pub.1110815868
185 rdf:type schema:PropertyValue
186 N947317ea584540439bb3dbe2888fbf59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Aged
188 rdf:type schema:DefinedTerm
189 N999fe59f92c444608b3c2253226438bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Memory
191 rdf:type schema:DefinedTerm
192 Na0d5c4a30e514961b01994a84ccd2c13 rdf:first sg:person.01020150701.96
193 rdf:rest Nc2660939303c4f58a1e6d1580084d61c
194 Na982d778ece7471c970dfcc71ee73f02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Magnetic Resonance Imaging
196 rdf:type schema:DefinedTerm
197 Nad62218139e7460abff53f25f0c9fb7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Cognitive Dysfunction
199 rdf:type schema:DefinedTerm
200 Nb0f4bae17d03465e9f00e89d6a6585ce rdf:first sg:person.01212267437.20
201 rdf:rest Nba183d7ebeaf438196fa5f94bc26e635
202 Nb8633e58565242928ae054cbd080f103 rdf:first sg:person.0736516041.39
203 rdf:rest Na0d5c4a30e514961b01994a84ccd2c13
204 Nb986ed81460d4a00a43dcab37b78b5e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Time Factors
206 rdf:type schema:DefinedTerm
207 Nba183d7ebeaf438196fa5f94bc26e635 rdf:first sg:person.0720260005.12
208 rdf:rest N31b71ae53a584ebfab91833b149f3d67
209 Nc2660939303c4f58a1e6d1580084d61c rdf:first sg:person.0750303541.98
210 rdf:rest Ne59a653804d443aaaef5ba18afff6a02
211 Nc421f831546346d1ae963b391fac2ef8 schema:name readcube_id
212 schema:value 129e54e63e415a1b9f9ab100784b32dc695a8714ee2a8d892a9be907546c5203
213 rdf:type schema:PropertyValue
214 Ncab9d1e7f995473f91545f293b5c3e72 schema:volumeNumber 19
215 rdf:type schema:PublicationVolume
216 Nd1cf7a9cfa34474b95fa0265b500026e schema:name pubmed_id
217 schema:value 30577848
218 rdf:type schema:PropertyValue
219 Ne02fd44aef9747d6ac63fd42e0d5f2bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Exercise Therapy
221 rdf:type schema:DefinedTerm
222 Ne1bb2b8f83614f45a2e582eafdcbb82d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Treatment Outcome
224 rdf:type schema:DefinedTerm
225 Ne59a653804d443aaaef5ba18afff6a02 rdf:first sg:person.016461363674.21
226 rdf:rest N89c8e24e9b3f4735a6ff51911658e795
227 Nf27989a8e7f644949a78fa0fb708494d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
228 schema:name Neuropsychological Tests
229 rdf:type schema:DefinedTerm
230 Nf49e85d674e44fcebf3851d62ff93a68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
231 schema:name Multicenter Studies as Topic
232 rdf:type schema:DefinedTerm
233 anzsrc-for:17 schema:inDefinedTermSet anzsrc-for:
234 schema:name Psychology and Cognitive Sciences
235 rdf:type schema:DefinedTerm
236 anzsrc-for:1701 schema:inDefinedTermSet anzsrc-for:
237 schema:name Psychology
238 rdf:type schema:DefinedTerm
239 sg:grant.2705213 http://pending.schema.org/fundedItem sg:pub.10.1186/s13063-018-3054-0
240 rdf:type schema:MonetaryGrant
241 sg:grant.7026878 http://pending.schema.org/fundedItem sg:pub.10.1186/s13063-018-3054-0
242 rdf:type schema:MonetaryGrant
243 sg:journal.1297400 schema:issn 1468-6708
244 1745-6215
245 schema:name Trials
246 rdf:type schema:Periodical
247 sg:person.01020150701.96 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
248 schema:familyName Vock
249 schema:givenName David
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020150701.96
251 rdf:type schema:Person
252 sg:person.01033737345.96 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
253 schema:familyName Jack
254 schema:givenName Clifford
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033737345.96
256 rdf:type schema:Person
257 sg:person.01212267437.20 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
258 schema:familyName Yu
259 schema:givenName Fang
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212267437.20
261 rdf:type schema:Person
262 sg:person.016461363674.21 schema:affiliation https://www.grid.ac/institutes/grid.412750.5
263 schema:familyName Porsteinsson
264 schema:givenName Anton P.
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016461363674.21
266 rdf:type schema:Person
267 sg:person.0664741204.16 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
268 schema:familyName Salisbury
269 schema:givenName Dereck L.
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664741204.16
271 rdf:type schema:Person
272 sg:person.0720260005.12 schema:affiliation https://www.grid.ac/institutes/grid.412750.5
273 schema:familyName Lin
274 schema:givenName Feng Vankee
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720260005.12
276 rdf:type schema:Person
277 sg:person.0736516041.39 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
278 schema:familyName Chow
279 schema:givenName Lisa
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736516041.39
281 rdf:type schema:Person
282 sg:person.0750303541.98 schema:affiliation https://www.grid.ac/institutes/grid.267207.6
283 schema:familyName Nelson
284 schema:givenName Nathaniel W.
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750303541.98
286 rdf:type schema:Person
287 sg:person.07577171777.37 schema:affiliation https://www.grid.ac/institutes/grid.412750.5
288 schema:familyName Shah
289 schema:givenName Krupa N.
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07577171777.37
291 rdf:type schema:Person
292 sg:pub.10.1007/bf00625068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031407261
293 https://doi.org/10.1007/bf00625068
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/srep39471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028153827
296 https://doi.org/10.1038/srep39471
297 rdf:type schema:CreativeWork
298 sg:pub.10.1186/1471-2202-14-103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045484275
299 https://doi.org/10.1186/1471-2202-14-103
300 rdf:type schema:CreativeWork
301 sg:pub.10.1186/1471-2318-11-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028990405
302 https://doi.org/10.1186/1471-2318-11-27
303 rdf:type schema:CreativeWork
304 sg:pub.10.1186/1745-6215-15-394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044389813
305 https://doi.org/10.1186/1745-6215-15-394
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1001/archneur.58.3.498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024178661
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1001/jama.300.9.1027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020885718
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1001/jamainternmed.2013.189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006394408
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1002/14651858.cd006220.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044221069
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1002/ana.10262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019711215
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1002/gps.1010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021784001
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1002/hipo.20547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001158561
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.bbr.2011.04.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009244471
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/j.gerinurse.2012.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025528938
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/j.jalz.2011.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015460770
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/j.jalz.2011.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025279802
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/j.jalz.2015.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011461915
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/j.jalz.2018.02.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103192032
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/j.jpsychores.2012.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004700055
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/j.neubiorev.2013.04.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000055535
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/j.neurobiolaging.2009.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049326297
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/j.neuropharm.2012.07.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053310717
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/j.neuropsychologia.2010.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043011534
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/s1474-4422(04)00767-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035990884
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/s1474-4422(05)70198-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003262386
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1017/s1355617713001094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041978171
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1037/0278-6133.23.5.443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031169939
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1037/0882-7974.7.4.643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017531201
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1037/a0020080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035997804
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1037/a0037363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005007617
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1055/s-2002-33735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057416654
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1073/pnas.0708803104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005500047
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1080/02701367.1991.10607519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040983201
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1080/13803395.2015.1132298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001287271
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1093/aje/kwf074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051835807
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1093/brain/awv283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017803622
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1093/gerona/63.1.62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011428601
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1093/gerona/glq038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006322616
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1097/wad.0b013e31815a9ddc schema:sameAs https://app.dimensions.ai/details/publication/pub.1012161642
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1111/j.1467-842x.1997.tb01653.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012663179
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1111/j.1600-0447.2008.01326.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041394829
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1111/jgs.14132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025927553
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1136/bjsm.2007.044735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006124198
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1136/bjsports-2015-095699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038494210
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1136/thx.47.12.1019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051064139
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1177/0193945911420174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063769847
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1177/2167702613497932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013006830
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1212/01.wnl.0000317094.86209.cb schema:sameAs https://app.dimensions.ai/details/publication/pub.1064350375
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1212/wnl.0000000000002415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064353391
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1212/wnl.0b013e31828726f5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019727932
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1212/wnl.0b013e318296e940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064357796
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1371/journal.pone.0040588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035386464
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1523/jneurosci.2948-11.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008509688
402 rdf:type schema:CreativeWork
403 https://doi.org/10.2174/1567205014666170203095128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083685622
404 rdf:type schema:CreativeWork
405 https://doi.org/10.2174/156720512803568984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069189205
406 rdf:type schema:CreativeWork
407 https://doi.org/10.2174/187152707783220938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069221411
408 rdf:type schema:CreativeWork
409 https://doi.org/10.31189/2165-6193-6.2.22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105582614
410 rdf:type schema:CreativeWork
411 https://doi.org/10.3389/fnagi.2010.00023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040011497
412 rdf:type schema:CreativeWork
413 https://doi.org/10.3389/fnagi.2010.00032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013058757
414 rdf:type schema:CreativeWork
415 https://doi.org/10.3389/neuro.09.016.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033934924
416 rdf:type schema:CreativeWork
417 https://doi.org/10.3389/neuro.22.002.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002235984
418 rdf:type schema:CreativeWork
419 https://doi.org/10.7326/0003-4819-144-2-200601170-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073708530
420 rdf:type schema:CreativeWork
421 https://doi.org/10.7326/0003-4819-152-11-201006010-00232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073711230
422 rdf:type schema:CreativeWork
423 https://doi.org/10.7326/0003-4819-153-3-201008030-00260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073711708
424 rdf:type schema:CreativeWork
425 https://doi.org/10.7326/0003-4819-158-3-201302050-00583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073713447
426 rdf:type schema:CreativeWork
427 https://www.grid.ac/institutes/grid.17635.36 schema:alternateName University of Minnesota
428 schema:name University of Minnesota Division of Biostatistics, Minneapolis, MN, USA
429 University of Minnesota School of Medicine, Minneapolis, MN, USA
430 University of Minnesota School of Nursing, 5-160 WDH 1331, 308 Harvard St SE, 55455, Minneapolis, MN, USA
431 rdf:type schema:Organization
432 https://www.grid.ac/institutes/grid.267207.6 schema:alternateName University of St. Thomas
433 schema:name University of St. Thomas, Minneapolis, MN, USA
434 rdf:type schema:Organization
435 https://www.grid.ac/institutes/grid.412750.5 schema:alternateName University of Rochester Medical Center
436 schema:name University of Rochester Medical Center, 601 Elmwood Ave, 14642, Rochester, NY, USA
437 rdf:type schema:Organization
438 https://www.grid.ac/institutes/grid.66875.3a schema:alternateName Mayo Clinic
439 schema:name Department of Radiology, Mayo Clinic, Rochester, MN, USA
440 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...