Total thyroidectomy (Tx) versus thionamides (antithyroid drugs) in patients with moderate-to-severe Graves’ ophthalmopathy – a 1-year follow-up: study protocol for ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-09-15

AUTHORS

Lindsay Brammen, Philipp Riss, Julius Lukas, Alois Gessl, Daniela Dunkler, Shuren Li, Asha Leisser, Sandra Rezar-Dreindl, Katharina Eibenberger, Andreas Selberherr, Christian Scheuba, Andrea Papp

ABSTRACT

BackgroundGraves’ disease (GD) is characterized by thyrotoxicosis and goiter and arises through circulating autoantibodies that bind to, and stimulate, the thyroid hormone receptor (TSHR). A temporal relation between the onset of hyperthyroidism and the onset of ophthalmopathy, a common extrathyroidal manifestation, has been demonstrated. Graves’ ophthalmopathy (GO) is typically characterized by an inflammation and expansion of the extraocular muscles and an increase in retroorbital fat. There are currently three forms of therapies offered for hyperthyroidism caused by Graves’ disease: antithyroid drugs (ATD) (thionamides), radioiodine ablation (RAI) and thyroidectomy (Tx). To date, there is no clear recommendation on the treatment of Graves’ disease and GO, mainly due to the individuality of the disease in each patient. The aim of the study is to examine the difference in the outcome of GO in patients with moderate-to-severe GO who receive Tx versus further ATD after suffering their first relapse of GO, or in which GO stays the same following the initial decrease in ATD therapy after 6 months.Methods/DesignThis prospective randomized clinical trial with observer-blinded analysis will analyze 60 patients with moderate-to-severe GO who receive Tx versus ATD without surgery. Main outcome variables include: muscle index measurements via ultrasound and thyroid antibody levels. Additional outcome variables include: Clinical Activity Score (CAScore), NOSPECS score, superonasal index measurements via ultrasound, and quality of life score.DiscussionThis study should allow for better therapeutic choices in patients with moderate-to-severe GO. In addition, it should demonstrate whether the outcome of GO in patients with moderate-to-severe GO is better in those who receive early Tx versus further ATD. Furthermore, this study will aim to establish a standard glucocorticoid scheme before and after Tx in patients with moderate-to-severe EO.Trial registrationEudra-CT: 2015–003515-38; Medical University of Vienna Protocol Record 1839/2015.Date of Ethics Committee approval: 19 January 2017.Registered on 27 January 2017. More... »

PAGES

495

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13063-018-2876-0

DOI

http://dx.doi.org/10.1186/s13063-018-2876-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107037627

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30219088


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antithyroid Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Austria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clinical Trials, Phase III as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Graves Ophthalmopathy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Randomized Controlled Trials as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recurrence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thyroidectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Section of Endocrine Surgery, Department of Surgery, Medical University Vienna, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Section of Endocrine Surgery, Department of Surgery, Medical University Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brammen", 
        "givenName": "Lindsay", 
        "id": "sg:person.0635130415.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635130415.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University Vienna, General Hospital Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Section of Endocrine Surgery, Department of Surgery, Medical University Vienna, Vienna, Austria", 
            "Medical University Vienna, General Hospital Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riss", 
        "givenName": "Philipp", 
        "id": "sg:person.01107211310.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107211310.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, Medical University Vienna, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Ophthalmology, Medical University Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lukas", 
        "givenName": "Julius", 
        "id": "sg:person.0730023154.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730023154.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine- Section of Endocrinology, Medical University Vienna, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Internal Medicine- Section of Endocrinology, Medical University Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gessl", 
        "givenName": "Alois", 
        "id": "sg:person.0665554447.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665554447.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Section for Clinical Biometrics, CeMSIIS, Medical University Vienna, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Section for Clinical Biometrics, CeMSIIS, Medical University Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dunkler", 
        "givenName": "Daniela", 
        "id": "sg:person.01244530216.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244530216.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear Medicine, Medical University Vienna, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Nuclear Medicine, Medical University Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Shuren", 
        "id": "sg:person.0771074626.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771074626.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear Medicine, Medical University Vienna, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Nuclear Medicine, Medical University Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leisser", 
        "givenName": "Asha", 
        "id": "sg:person.01175533330.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175533330.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, Medical University Vienna, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Ophthalmology, Medical University Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rezar-Dreindl", 
        "givenName": "Sandra", 
        "id": "sg:person.010243054425.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010243054425.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, Medical University Vienna, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Ophthalmology, Medical University Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eibenberger", 
        "givenName": "Katharina", 
        "id": "sg:person.0777714737.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777714737.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Section of Endocrine Surgery, Department of Surgery, Medical University Vienna, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Section of Endocrine Surgery, Department of Surgery, Medical University Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Selberherr", 
        "givenName": "Andreas", 
        "id": "sg:person.01365255052.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365255052.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Section of Endocrine Surgery, Department of Surgery, Medical University Vienna, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Section of Endocrine Surgery, Department of Surgery, Medical University Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scheuba", 
        "givenName": "Christian", 
        "id": "sg:person.0617351314.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617351314.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, Medical University Vienna, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Ophthalmology, Medical University Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Papp", 
        "givenName": "Andrea", 
        "id": "sg:person.01034274564.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034274564.60"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00268-008-9497-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018891589", 
          "https://doi.org/10.1007/s00268-008-9497-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03349833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035631428", 
          "https://doi.org/10.1007/bf03349833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12020-011-9559-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010170891", 
          "https://doi.org/10.1007/s12020-011-9559-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002680010216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014322481", 
          "https://doi.org/10.1007/s002680010216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-008-9910-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023778127", 
          "https://doi.org/10.1007/s00268-008-9910-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40618-016-0484-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028057205", 
          "https://doi.org/10.1007/s40618-016-0484-y"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-09-15", 
    "datePublishedReg": "2018-09-15", 
    "description": "BackgroundGraves\u2019 disease (GD) is characterized by thyrotoxicosis and goiter and arises through circulating autoantibodies that bind to, and stimulate, the thyroid hormone receptor (TSHR). A temporal relation between the onset of hyperthyroidism and the onset of ophthalmopathy, a common extrathyroidal manifestation, has been demonstrated. Graves\u2019 ophthalmopathy (GO) is typically characterized by an inflammation and expansion of the extraocular muscles and an increase in retroorbital fat. There are currently three forms of therapies offered for hyperthyroidism caused by Graves\u2019 disease: antithyroid drugs (ATD) (thionamides), radioiodine ablation (RAI) and thyroidectomy (Tx). To date, there is no clear recommendation on the treatment of Graves\u2019 disease and GO, mainly due to the individuality of the disease in each patient. The aim of the study is to examine the difference in the outcome of GO in patients with moderate-to-severe GO who receive Tx versus further ATD after suffering their first relapse of GO, or in which GO stays the same following the initial decrease in ATD therapy after 6\u00a0months.Methods/DesignThis prospective randomized clinical trial with observer-blinded analysis will analyze 60 patients with moderate-to-severe GO who receive Tx versus ATD without surgery. Main outcome variables include: muscle index measurements via ultrasound and thyroid antibody levels. Additional outcome variables include: Clinical Activity Score (CAScore), NOSPECS score, superonasal index measurements via ultrasound, and quality of life score.DiscussionThis study should allow for better therapeutic choices in patients with moderate-to-severe GO. In addition, it should demonstrate whether the outcome of GO in patients with moderate-to-severe GO is better in those who receive early Tx versus further ATD. Furthermore, this study will aim to establish a standard glucocorticoid scheme before and after Tx in patients with moderate-to-severe EO.Trial registrationEudra-CT: 2015\u2013003515-38; Medical University of Vienna Protocol Record 1839/2015.Date of Ethics Committee approval: 19 January 2017.Registered on 27 January 2017.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s13063-018-2876-0", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1297400", 
        "issn": [
          "1468-6708", 
          "1745-6215"
        ], 
        "name": "Trials", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "severe GO", 
      "antithyroid drugs", 
      "radioiodine ablation", 
      "treatment of Graves", 
      "Methods/designThis", 
      "outcome variables", 
      "thyroid antibody levels", 
      "clinical activity score", 
      "onset of hyperthyroidism", 
      "best therapeutic choice", 
      "main outcome variables", 
      "form of therapy", 
      "ethics committee approval", 
      "additional outcome variables", 
      "retroorbital fat", 
      "ATD therapy", 
      "NOSPECS score", 
      "severe Graves", 
      "first relapse", 
      "antibody levels", 
      "activity score", 
      "life scores", 
      "therapeutic choice", 
      "study protocol", 
      "clinical trials", 
      "extraocular muscles", 
      "patients", 
      "committee approval", 
      "Medical University", 
      "thyroid hormone receptor", 
      "hormone receptors", 
      "disease", 
      "clear recommendations", 
      "DiscussionThis study", 
      "trials", 
      "hyperthyroidism", 
      "therapy", 
      "scores", 
      "ultrasound", 
      "outcomes", 
      "initial decrease", 
      "onset", 
      "Graves", 
      "BackgroundGraves", 
      "DesignThis", 
      "thyrotoxicosis", 
      "ophthalmopathy", 
      "thyroidectomy", 
      "autoantibodies", 
      "relapse", 
      "thionamides", 
      "inflammation", 
      "surgery", 
      "goiter", 
      "index measurements", 
      "months", 
      "receptors", 
      "drugs", 
      "study", 
      "muscle", 
      "manifestations", 
      "treatment", 
      "fat", 
      "temporal relations", 
      "ablation", 
      "approval", 
      "aim", 
      "TX", 
      "levels", 
      "recommendations", 
      "differences", 
      "decrease", 
      "variables", 
      "protocol", 
      "increase", 
      "date", 
      "addition", 
      "quality", 
      "GO", 
      "choice", 
      "analysis", 
      "measurements", 
      "University", 
      "form", 
      "relation", 
      "expansion", 
      "EO", 
      "individuality", 
      "scheme"
    ], 
    "name": "Total thyroidectomy (Tx) versus thionamides (antithyroid drugs) in patients with moderate-to-severe Graves\u2019 ophthalmopathy \u2013 a 1-year follow-up: study protocol for a randomized controlled trial", 
    "pagination": "495", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107037627"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13063-018-2876-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30219088"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13063-018-2876-0", 
      "https://app.dimensions.ai/details/publication/pub.1107037627"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_756.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s13063-018-2876-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13063-018-2876-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13063-018-2876-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13063-018-2876-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13063-018-2876-0'


 

This table displays all metadata directly associated to this object as RDF triples.

310 TRIPLES      22 PREDICATES      133 URIs      119 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13063-018-2876-0 schema:about N05473c462d9548e0b770bc3c04f56680
2 N2e7c750ed229464c91d28917b4d925e8
3 N7e0bf18ddc8f4cf19039bc64756287b9
4 N8d36598adf3b46cf8192570725ee956b
5 N902088fb6cc54942a1f7c73555fb8ef0
6 N9e6d3ee38da24df780ade51c32b7c759
7 Na24907950544449b98827abec28092b1
8 Nb7830402766d44fea1ac582130241ca9
9 Nc2a050360aa54cd59f2cf5c3641d69c5
10 Nc809c07e0596416e97560f703847b4f6
11 Ne66d905110b74fc687a4d8b668e535bf
12 Nf11af138fc6347dc869d869f4593c433
13 anzsrc-for:11
14 anzsrc-for:1103
15 schema:author Nfc0c67f8990b465eb6c46483c3f5afaa
16 schema:citation sg:pub.10.1007/bf03349833
17 sg:pub.10.1007/s00268-008-9497-9
18 sg:pub.10.1007/s00268-008-9910-4
19 sg:pub.10.1007/s002680010216
20 sg:pub.10.1007/s12020-011-9559-x
21 sg:pub.10.1007/s40618-016-0484-y
22 schema:datePublished 2018-09-15
23 schema:datePublishedReg 2018-09-15
24 schema:description BackgroundGraves’ disease (GD) is characterized by thyrotoxicosis and goiter and arises through circulating autoantibodies that bind to, and stimulate, the thyroid hormone receptor (TSHR). A temporal relation between the onset of hyperthyroidism and the onset of ophthalmopathy, a common extrathyroidal manifestation, has been demonstrated. Graves’ ophthalmopathy (GO) is typically characterized by an inflammation and expansion of the extraocular muscles and an increase in retroorbital fat. There are currently three forms of therapies offered for hyperthyroidism caused by Graves’ disease: antithyroid drugs (ATD) (thionamides), radioiodine ablation (RAI) and thyroidectomy (Tx). To date, there is no clear recommendation on the treatment of Graves’ disease and GO, mainly due to the individuality of the disease in each patient. The aim of the study is to examine the difference in the outcome of GO in patients with moderate-to-severe GO who receive Tx versus further ATD after suffering their first relapse of GO, or in which GO stays the same following the initial decrease in ATD therapy after 6 months.Methods/DesignThis prospective randomized clinical trial with observer-blinded analysis will analyze 60 patients with moderate-to-severe GO who receive Tx versus ATD without surgery. Main outcome variables include: muscle index measurements via ultrasound and thyroid antibody levels. Additional outcome variables include: Clinical Activity Score (CAScore), NOSPECS score, superonasal index measurements via ultrasound, and quality of life score.DiscussionThis study should allow for better therapeutic choices in patients with moderate-to-severe GO. In addition, it should demonstrate whether the outcome of GO in patients with moderate-to-severe GO is better in those who receive early Tx versus further ATD. Furthermore, this study will aim to establish a standard glucocorticoid scheme before and after Tx in patients with moderate-to-severe EO.Trial registrationEudra-CT: 2015–003515-38; Medical University of Vienna Protocol Record 1839/2015.Date of Ethics Committee approval: 19 January 2017.Registered on 27 January 2017.
25 schema:genre article
26 schema:inLanguage en
27 schema:isAccessibleForFree true
28 schema:isPartOf Na94d4ae65abf4ed48c28529936782caf
29 Ned3ef3446cd74ed18f6fa5dc45a64e14
30 sg:journal.1297400
31 schema:keywords ATD therapy
32 BackgroundGraves
33 DesignThis
34 DiscussionThis study
35 EO
36 GO
37 Graves
38 Medical University
39 Methods/designThis
40 NOSPECS score
41 TX
42 University
43 ablation
44 activity score
45 addition
46 additional outcome variables
47 aim
48 analysis
49 antibody levels
50 antithyroid drugs
51 approval
52 autoantibodies
53 best therapeutic choice
54 choice
55 clear recommendations
56 clinical activity score
57 clinical trials
58 committee approval
59 date
60 decrease
61 differences
62 disease
63 drugs
64 ethics committee approval
65 expansion
66 extraocular muscles
67 fat
68 first relapse
69 form
70 form of therapy
71 goiter
72 hormone receptors
73 hyperthyroidism
74 increase
75 index measurements
76 individuality
77 inflammation
78 initial decrease
79 levels
80 life scores
81 main outcome variables
82 manifestations
83 measurements
84 months
85 muscle
86 onset
87 onset of hyperthyroidism
88 ophthalmopathy
89 outcome variables
90 outcomes
91 patients
92 protocol
93 quality
94 radioiodine ablation
95 receptors
96 recommendations
97 relapse
98 relation
99 retroorbital fat
100 scheme
101 scores
102 severe GO
103 severe Graves
104 study
105 study protocol
106 surgery
107 temporal relations
108 therapeutic choice
109 therapy
110 thionamides
111 thyroid antibody levels
112 thyroid hormone receptor
113 thyroidectomy
114 thyrotoxicosis
115 treatment
116 treatment of Graves
117 trials
118 ultrasound
119 variables
120 schema:name Total thyroidectomy (Tx) versus thionamides (antithyroid drugs) in patients with moderate-to-severe Graves’ ophthalmopathy – a 1-year follow-up: study protocol for a randomized controlled trial
121 schema:pagination 495
122 schema:productId N5a0c2e971c8b4345bb5b7052b0fff884
123 N64b7f03a2e3e4cc191c5cfd6d3bfc1e3
124 N9a2b1065f27c4b89aebaf3984b40ddd6
125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107037627
126 https://doi.org/10.1186/s13063-018-2876-0
127 schema:sdDatePublished 2022-05-20T07:34
128 schema:sdLicense https://scigraph.springernature.com/explorer/license/
129 schema:sdPublisher Ne962e68b46b8475399bf99e805cf0f2b
130 schema:url https://doi.org/10.1186/s13063-018-2876-0
131 sgo:license sg:explorer/license/
132 sgo:sdDataset articles
133 rdf:type schema:ScholarlyArticle
134 N05473c462d9548e0b770bc3c04f56680 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Severity of Illness Index
136 rdf:type schema:DefinedTerm
137 N08835931f5d743178a18f5135e9d260f rdf:first sg:person.01175533330.94
138 rdf:rest Nafa99409f73e46d6ac71004de053b0da
139 N1d8baef3fe4c407789223f9e0bca7ae4 rdf:first sg:person.01034274564.60
140 rdf:rest rdf:nil
141 N1dcea1d8655a44f8a17cc9886e05c53e rdf:first sg:person.01365255052.76
142 rdf:rest N645e10ea065a44e6afabf012fd53bd42
143 N20eb274c1aa14dde8c50e1cc998a5fc8 rdf:first sg:person.0665554447.82
144 rdf:rest N53f6a5fa5d4c499e9af23518d1399195
145 N2e7c750ed229464c91d28917b4d925e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Randomized Controlled Trials as Topic
147 rdf:type schema:DefinedTerm
148 N53f6a5fa5d4c499e9af23518d1399195 rdf:first sg:person.01244530216.91
149 rdf:rest N6a4e6e1368c047c79dec9e703572e76d
150 N5a0c2e971c8b4345bb5b7052b0fff884 schema:name pubmed_id
151 schema:value 30219088
152 rdf:type schema:PropertyValue
153 N606437237dff4fd29b52fe7e7eecb91e rdf:first sg:person.01107211310.34
154 rdf:rest Ne8937d28c0774e6ea4120cf686ab22e5
155 N645e10ea065a44e6afabf012fd53bd42 rdf:first sg:person.0617351314.15
156 rdf:rest N1d8baef3fe4c407789223f9e0bca7ae4
157 N64b7f03a2e3e4cc191c5cfd6d3bfc1e3 schema:name dimensions_id
158 schema:value pub.1107037627
159 rdf:type schema:PropertyValue
160 N6a4e6e1368c047c79dec9e703572e76d rdf:first sg:person.0771074626.92
161 rdf:rest N08835931f5d743178a18f5135e9d260f
162 N7e0bf18ddc8f4cf19039bc64756287b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Recurrence
164 rdf:type schema:DefinedTerm
165 N8d36598adf3b46cf8192570725ee956b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Antithyroid Agents
167 rdf:type schema:DefinedTerm
168 N902088fb6cc54942a1f7c73555fb8ef0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Humans
170 rdf:type schema:DefinedTerm
171 N9a2b1065f27c4b89aebaf3984b40ddd6 schema:name doi
172 schema:value 10.1186/s13063-018-2876-0
173 rdf:type schema:PropertyValue
174 N9e6d3ee38da24df780ade51c32b7c759 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Prospective Studies
176 rdf:type schema:DefinedTerm
177 Na24907950544449b98827abec28092b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Treatment Outcome
179 rdf:type schema:DefinedTerm
180 Na94d4ae65abf4ed48c28529936782caf schema:volumeNumber 19
181 rdf:type schema:PublicationVolume
182 Nafa99409f73e46d6ac71004de053b0da rdf:first sg:person.010243054425.04
183 rdf:rest Nd3a763693100446cab40111d3b73b54a
184 Nb7830402766d44fea1ac582130241ca9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Clinical Trials, Phase III as Topic
186 rdf:type schema:DefinedTerm
187 Nc2a050360aa54cd59f2cf5c3641d69c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Time Factors
189 rdf:type schema:DefinedTerm
190 Nc809c07e0596416e97560f703847b4f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Graves Ophthalmopathy
192 rdf:type schema:DefinedTerm
193 Nd3a763693100446cab40111d3b73b54a rdf:first sg:person.0777714737.35
194 rdf:rest N1dcea1d8655a44f8a17cc9886e05c53e
195 Ne66d905110b74fc687a4d8b668e535bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Austria
197 rdf:type schema:DefinedTerm
198 Ne8937d28c0774e6ea4120cf686ab22e5 rdf:first sg:person.0730023154.52
199 rdf:rest N20eb274c1aa14dde8c50e1cc998a5fc8
200 Ne962e68b46b8475399bf99e805cf0f2b schema:name Springer Nature - SN SciGraph project
201 rdf:type schema:Organization
202 Ned3ef3446cd74ed18f6fa5dc45a64e14 schema:issueNumber 1
203 rdf:type schema:PublicationIssue
204 Nf11af138fc6347dc869d869f4593c433 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Thyroidectomy
206 rdf:type schema:DefinedTerm
207 Nfc0c67f8990b465eb6c46483c3f5afaa rdf:first sg:person.0635130415.60
208 rdf:rest N606437237dff4fd29b52fe7e7eecb91e
209 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
210 schema:name Medical and Health Sciences
211 rdf:type schema:DefinedTerm
212 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
213 schema:name Clinical Sciences
214 rdf:type schema:DefinedTerm
215 sg:journal.1297400 schema:issn 1468-6708
216 1745-6215
217 schema:name Trials
218 schema:publisher Springer Nature
219 rdf:type schema:Periodical
220 sg:person.010243054425.04 schema:affiliation grid-institutes:grid.22937.3d
221 schema:familyName Rezar-Dreindl
222 schema:givenName Sandra
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010243054425.04
224 rdf:type schema:Person
225 sg:person.01034274564.60 schema:affiliation grid-institutes:grid.22937.3d
226 schema:familyName Papp
227 schema:givenName Andrea
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034274564.60
229 rdf:type schema:Person
230 sg:person.01107211310.34 schema:affiliation grid-institutes:grid.22937.3d
231 schema:familyName Riss
232 schema:givenName Philipp
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107211310.34
234 rdf:type schema:Person
235 sg:person.01175533330.94 schema:affiliation grid-institutes:grid.22937.3d
236 schema:familyName Leisser
237 schema:givenName Asha
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175533330.94
239 rdf:type schema:Person
240 sg:person.01244530216.91 schema:affiliation grid-institutes:grid.22937.3d
241 schema:familyName Dunkler
242 schema:givenName Daniela
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244530216.91
244 rdf:type schema:Person
245 sg:person.01365255052.76 schema:affiliation grid-institutes:grid.22937.3d
246 schema:familyName Selberherr
247 schema:givenName Andreas
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365255052.76
249 rdf:type schema:Person
250 sg:person.0617351314.15 schema:affiliation grid-institutes:grid.22937.3d
251 schema:familyName Scheuba
252 schema:givenName Christian
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617351314.15
254 rdf:type schema:Person
255 sg:person.0635130415.60 schema:affiliation grid-institutes:grid.22937.3d
256 schema:familyName Brammen
257 schema:givenName Lindsay
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635130415.60
259 rdf:type schema:Person
260 sg:person.0665554447.82 schema:affiliation grid-institutes:grid.22937.3d
261 schema:familyName Gessl
262 schema:givenName Alois
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665554447.82
264 rdf:type schema:Person
265 sg:person.0730023154.52 schema:affiliation grid-institutes:grid.22937.3d
266 schema:familyName Lukas
267 schema:givenName Julius
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730023154.52
269 rdf:type schema:Person
270 sg:person.0771074626.92 schema:affiliation grid-institutes:grid.22937.3d
271 schema:familyName Li
272 schema:givenName Shuren
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771074626.92
274 rdf:type schema:Person
275 sg:person.0777714737.35 schema:affiliation grid-institutes:grid.22937.3d
276 schema:familyName Eibenberger
277 schema:givenName Katharina
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777714737.35
279 rdf:type schema:Person
280 sg:pub.10.1007/bf03349833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035631428
281 https://doi.org/10.1007/bf03349833
282 rdf:type schema:CreativeWork
283 sg:pub.10.1007/s00268-008-9497-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018891589
284 https://doi.org/10.1007/s00268-008-9497-9
285 rdf:type schema:CreativeWork
286 sg:pub.10.1007/s00268-008-9910-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023778127
287 https://doi.org/10.1007/s00268-008-9910-4
288 rdf:type schema:CreativeWork
289 sg:pub.10.1007/s002680010216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014322481
290 https://doi.org/10.1007/s002680010216
291 rdf:type schema:CreativeWork
292 sg:pub.10.1007/s12020-011-9559-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010170891
293 https://doi.org/10.1007/s12020-011-9559-x
294 rdf:type schema:CreativeWork
295 sg:pub.10.1007/s40618-016-0484-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1028057205
296 https://doi.org/10.1007/s40618-016-0484-y
297 rdf:type schema:CreativeWork
298 grid-institutes:grid.22937.3d schema:alternateName Department of Internal Medicine- Section of Endocrinology, Medical University Vienna, Vienna, Austria
299 Department of Nuclear Medicine, Medical University Vienna, Vienna, Austria
300 Department of Ophthalmology, Medical University Vienna, Vienna, Austria
301 Medical University Vienna, General Hospital Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria
302 Section for Clinical Biometrics, CeMSIIS, Medical University Vienna, Vienna, Austria
303 Section of Endocrine Surgery, Department of Surgery, Medical University Vienna, Vienna, Austria
304 schema:name Department of Internal Medicine- Section of Endocrinology, Medical University Vienna, Vienna, Austria
305 Department of Nuclear Medicine, Medical University Vienna, Vienna, Austria
306 Department of Ophthalmology, Medical University Vienna, Vienna, Austria
307 Medical University Vienna, General Hospital Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria
308 Section for Clinical Biometrics, CeMSIIS, Medical University Vienna, Vienna, Austria
309 Section of Endocrine Surgery, Department of Surgery, Medical University Vienna, Vienna, Austria
310 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...