Azithromycin versus placebo for the treatment of HIV-associated chronic lung disease in children and adolescents (BREATHE trial): study protocol for ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Carmen Gonzalez-Martinez, Katharina Kranzer, Grace McHugh, Elizabeth L. Corbett, Hilda Mujuru, Mark P. Nicol, Sarah Rowland-Jones, Andrea M. Rehman, Tore J. Gutteberg, Trond Flaegstad, Jon O. Odland, Rashida A. Ferrand, the BREATHE study team

ABSTRACT

BACKGROUND: Human immunodeficiency virus (HIV)-related chronic lung disease (CLD) among children is associated with substantial morbidity, despite antiretroviral therapy. This may be a consequence of repeated respiratory tract infections and/or dysregulated immune activation that accompanies HIV infection. Macrolides have anti-inflammatory and antimicrobial properties, and we hypothesised that azithromycin would reduce decline in lung function and morbidity through preventing respiratory tract infections and controlling systemic inflammation. METHODS/DESIGN: We are conducting a multicentre (Malawi and Zimbabwe), double-blind, randomised controlled trial of a 12-month course of weekly azithromycin versus placebo. The primary outcome is the mean change in forced expiratory volume in 1 second (FEV1) z-score at 12 months. Participants are followed up to 18 months to explore the durability of effect. Secondary outcomes are FEV1 z-score at 18 months, time to death, time to first acute respiratory exacerbation, number of exacerbations, number of hospitalisations, weight for age z-score at 12 and 18 months, number of adverse events, number of malaria episodes, number of bloodstream Salmonella typhi infections and number of gastroenteritis episodes. Participants will be followed up 3-monthly, and lung function will be assessed every 6 months. Laboratory substudies will be done to investigate the impact of azithromycin on systemic inflammation and on development of antimicrobial resistance as well as impact on the nasopharyngeal, lung and gut microbiome. DISCUSSION: The results of this trial will be of clinical relevance because there are no established guidelines on the treatment and management of HIV-associated CLD in children in sub-Saharan Africa, where 80% of the world's HIV-infected children live and where HIV-associated CLD is highly prevalent. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02426112 . Registered on 21 April 2015. More... »

PAGES

622

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13063-017-2344-2

DOI

http://dx.doi.org/10.1186/s13063-017-2344-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100090966

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29282143


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Malawi", 
          "id": "https://www.grid.ac/institutes/grid.10595.38", 
          "name": [
            "Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK", 
            "Malawi-Liverpool Wellcome Trust Clinical Research Programme, Chichiri, PO Box 30096, Blantyre 3, Malawi", 
            "Department of Paediatrics and Child Health, College of Medicine, University of Malawi, Private Bag 360, Chichiri, Blantyre 3, Malawi"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonzalez-Martinez", 
        "givenName": "Carmen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "London School of Hygiene & Tropical Medicine", 
          "id": "https://www.grid.ac/institutes/grid.8991.9", 
          "name": [
            "Department of Clinical Research, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kranzer", 
        "givenName": "Katharina", 
        "id": "sg:person.01305645042.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305645042.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biomedical Research and Training Institute", 
          "id": "https://www.grid.ac/institutes/grid.418347.d", 
          "name": [
            "Biomedical Research and Training Institute, 10 Seagrave Road, Harare, Zimbabwe"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McHugh", 
        "givenName": "Grace", 
        "id": "sg:person.01245711007.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245711007.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "London School of Hygiene & Tropical Medicine", 
          "id": "https://www.grid.ac/institutes/grid.8991.9", 
          "name": [
            "Malawi-Liverpool Wellcome Trust Clinical Research Programme, Chichiri, PO Box 30096, Blantyre 3, Malawi", 
            "Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Corbett", 
        "givenName": "Elizabeth L.", 
        "id": "sg:person.01147267105.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147267105.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Zimbabwe", 
          "id": "https://www.grid.ac/institutes/grid.13001.33", 
          "name": [
            "Department of Paediatrics, University of Zimbabwe, Avondale, PO Box A178, Harare, Zimbabwe"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mujuru", 
        "givenName": "Hilda", 
        "id": "sg:person.01233505401.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233505401.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Health Laboratory Service", 
          "id": "https://www.grid.ac/institutes/grid.416657.7", 
          "name": [
            "Division of Clinical Microbiology, University of Cape Town, Anzio Road, Cape Town, South Africa", 
            "National Health Laboratory Service, Johannesburg, South Africa"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nicol", 
        "givenName": "Mark P.", 
        "id": "sg:person.01255430366.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255430366.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Nuffield Department of Medicine, Old Road Campus, University of Oxford, Roosevelt Drive, OX3 7FZ, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rowland-Jones", 
        "givenName": "Sarah", 
        "id": "sg:person.0673115154.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673115154.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "London School of Hygiene & Tropical Medicine", 
          "id": "https://www.grid.ac/institutes/grid.8991.9", 
          "name": [
            "MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rehman", 
        "givenName": "Andrea M.", 
        "id": "sg:person.01254665412.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254665412.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Arctic University of Norway", 
          "id": "https://www.grid.ac/institutes/grid.10919.30", 
          "name": [
            "Department of Microbiology and Infection Control, University Hospital of North Norway, N-9038, Troms\u00f8, Norway", 
            "Faculty of Health Sciences, Arctic University of Norway, N-9037, Troms\u00f8, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gutteberg", 
        "givenName": "Tore J.", 
        "id": "sg:person.01312242407.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312242407.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of North Norway", 
          "id": "https://www.grid.ac/institutes/grid.412244.5", 
          "name": [
            "Faculty of Health Sciences, Arctic University of Norway, N-9037, Troms\u00f8, Norway", 
            "Department of Paediatrics, University Hospital of North Norway, N-9038, Troms\u00f8, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Flaegstad", 
        "givenName": "Trond", 
        "id": "sg:person.01011575517.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011575517.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pretoria", 
          "id": "https://www.grid.ac/institutes/grid.49697.35", 
          "name": [
            "Faculty of Health Sciences, Arctic University of Norway, N-9037, Troms\u00f8, Norway", 
            "School of Health Systems and Public Health, Faculty of Health Sciences, University of Pretoria, Hatfield, South Africa"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Odland", 
        "givenName": "Jon O.", 
        "id": "sg:person.0654573673.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654573673.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "London School of Hygiene & Tropical Medicine", 
          "id": "https://www.grid.ac/institutes/grid.8991.9", 
          "name": [
            "Biomedical Research and Training Institute, 10 Seagrave Road, Harare, Zimbabwe", 
            "Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferrand", 
        "givenName": "Rashida A.", 
        "id": "sg:person.0625103201.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625103201.17"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "the BREATHE study team", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/ctr.12401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003005670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/cis271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004524377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7448/ias.16.1.18633", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004819873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.crad.2010.10.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008964258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/inf.0000000000001453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009543973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/inf.0000000000001453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009543973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jiu254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010887413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2011.161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018500041", 
          "https://doi.org/10.1038/bmt.2011.161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jpids/piv045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019049084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2213-2600(13)70185-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022031752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.5667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022395753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2016.11.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022932582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200601-071oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023897327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0000000000001249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023972987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0000000000001249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023972987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0000000000001249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023972987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2011.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025558428", 
          "https://doi.org/10.1038/bmt.2011.1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2213-2600(14)70019-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025684324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd002203.pub4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031421591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mop.0b013e328360c317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032108023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mop.0b013e328360c317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032108023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.prrv.2010.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037885587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)60953-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042773616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1705026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043738012", 
          "https://doi.org/10.1038/sj.bmt.1705026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1705026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043738012", 
          "https://doi.org/10.1038/sj.bmt.1705026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mop.0b013e3282ff62e9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051100919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mop.0b013e3282ff62e9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051100919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2431-14-238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051896730", 
          "https://doi.org/10.1186/1471-2431-14-238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/ciw683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054017230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0036-1572555", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057352888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.2009-2701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067828098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-158-3-201302050-00583", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073713447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00325481.2017.1285677", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079400044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0000000000001320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083839674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0000000000001320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083839674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0000000000001320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083839674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1513/annalsats.201612-1018oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084321272"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: Human immunodeficiency virus (HIV)-related chronic lung disease (CLD) among children is associated with substantial morbidity, despite antiretroviral therapy. This may be a consequence of repeated respiratory tract infections and/or dysregulated immune activation that accompanies HIV infection. Macrolides have anti-inflammatory and antimicrobial properties, and we hypothesised that azithromycin would reduce decline in lung function and morbidity through preventing respiratory tract infections and controlling systemic inflammation.\nMETHODS/DESIGN: We are conducting a multicentre (Malawi and Zimbabwe), double-blind, randomised controlled trial of a 12-month course of weekly azithromycin versus placebo. The primary outcome is the mean change in forced expiratory volume in 1 second (FEV1) z-score at 12 months. Participants are followed up to 18 months to explore the durability of effect. Secondary outcomes are FEV1 z-score at 18 months, time to death, time to first acute respiratory exacerbation, number of exacerbations, number of hospitalisations, weight for age z-score at 12 and 18 months, number of adverse events, number of malaria episodes, number of bloodstream Salmonella typhi infections and number of gastroenteritis episodes. Participants will be followed up 3-monthly, and lung function will be assessed every 6 months. Laboratory substudies will be done to investigate the impact of azithromycin on systemic inflammation and on development of antimicrobial resistance as well as impact on the nasopharyngeal, lung and gut microbiome.\nDISCUSSION: The results of this trial will be of clinical relevance because there are no established guidelines on the treatment and management of HIV-associated CLD in children in sub-Saharan Africa, where 80% of the world's HIV-infected children live and where HIV-associated CLD is highly prevalent.\nTRIAL REGISTRATION: ClinicalTrials.gov, NCT02426112 . Registered on 21 April 2015.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13063-017-2344-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3498121", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1297400", 
        "issn": [
          "1468-6708", 
          "1745-6215"
        ], 
        "name": "Trials", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Azithromycin versus placebo for the treatment of HIV-associated chronic lung disease in children and adolescents (BREATHE trial): study protocol for a randomised controlled trial", 
    "pagination": "622", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c9452aff0c456d757f9e06ea6fceec6c14553bff4b2ea37506dde24d380f4195"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29282143"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101263253"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13063-017-2344-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100090966"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13063-017-2344-2", 
      "https://app.dimensions.ai/details/publication/pub.1100090966"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000572.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186/s13063-017-2344-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13063-017-2344-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13063-017-2344-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13063-017-2344-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13063-017-2344-2'


 

This table displays all metadata directly associated to this object as RDF triples.

276 TRIPLES      21 PREDICATES      58 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13063-017-2344-2 schema:about anzsrc-for:11
2 anzsrc-for:1108
3 schema:author Nec138b2ecf18456a9a3cb3566c53aa7a
4 schema:citation sg:pub.10.1038/bmt.2011.1
5 sg:pub.10.1038/bmt.2011.161
6 sg:pub.10.1038/sj.bmt.1705026
7 sg:pub.10.1186/1471-2431-14-238
8 https://doi.org/10.1002/14651858.cd002203.pub4
9 https://doi.org/10.1002/sim.5667
10 https://doi.org/10.1016/j.crad.2010.10.009
11 https://doi.org/10.1016/j.lfs.2016.11.024
12 https://doi.org/10.1016/j.prrv.2010.07.005
13 https://doi.org/10.1016/s0140-6736(12)60953-2
14 https://doi.org/10.1016/s2213-2600(13)70185-1
15 https://doi.org/10.1016/s2213-2600(14)70019-0
16 https://doi.org/10.1055/s-0036-1572555
17 https://doi.org/10.1080/00325481.2017.1285677
18 https://doi.org/10.1093/cid/cis271
19 https://doi.org/10.1093/cid/ciw683
20 https://doi.org/10.1093/infdis/jiu254
21 https://doi.org/10.1093/jpids/piv045
22 https://doi.org/10.1097/inf.0000000000001453
23 https://doi.org/10.1097/mop.0b013e3282ff62e9
24 https://doi.org/10.1097/mop.0b013e328360c317
25 https://doi.org/10.1097/qad.0000000000001249
26 https://doi.org/10.1097/qai.0000000000001320
27 https://doi.org/10.1111/ctr.12401
28 https://doi.org/10.1164/rccm.200601-071oc
29 https://doi.org/10.1513/annalsats.201612-1018oc
30 https://doi.org/10.1542/peds.2009-2701
31 https://doi.org/10.7326/0003-4819-158-3-201302050-00583
32 https://doi.org/10.7448/ias.16.1.18633
33 schema:datePublished 2017-12
34 schema:datePublishedReg 2017-12-01
35 schema:description BACKGROUND: Human immunodeficiency virus (HIV)-related chronic lung disease (CLD) among children is associated with substantial morbidity, despite antiretroviral therapy. This may be a consequence of repeated respiratory tract infections and/or dysregulated immune activation that accompanies HIV infection. Macrolides have anti-inflammatory and antimicrobial properties, and we hypothesised that azithromycin would reduce decline in lung function and morbidity through preventing respiratory tract infections and controlling systemic inflammation. METHODS/DESIGN: We are conducting a multicentre (Malawi and Zimbabwe), double-blind, randomised controlled trial of a 12-month course of weekly azithromycin versus placebo. The primary outcome is the mean change in forced expiratory volume in 1 second (FEV1) z-score at 12 months. Participants are followed up to 18 months to explore the durability of effect. Secondary outcomes are FEV1 z-score at 18 months, time to death, time to first acute respiratory exacerbation, number of exacerbations, number of hospitalisations, weight for age z-score at 12 and 18 months, number of adverse events, number of malaria episodes, number of bloodstream Salmonella typhi infections and number of gastroenteritis episodes. Participants will be followed up 3-monthly, and lung function will be assessed every 6 months. Laboratory substudies will be done to investigate the impact of azithromycin on systemic inflammation and on development of antimicrobial resistance as well as impact on the nasopharyngeal, lung and gut microbiome. DISCUSSION: The results of this trial will be of clinical relevance because there are no established guidelines on the treatment and management of HIV-associated CLD in children in sub-Saharan Africa, where 80% of the world's HIV-infected children live and where HIV-associated CLD is highly prevalent. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02426112 . Registered on 21 April 2015.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree true
39 schema:isPartOf N36a701cc374c4438be733a91a5aaa506
40 Needdbc8eec7b458e8d593abd6b54cec6
41 sg:journal.1297400
42 schema:name Azithromycin versus placebo for the treatment of HIV-associated chronic lung disease in children and adolescents (BREATHE trial): study protocol for a randomised controlled trial
43 schema:pagination 622
44 schema:productId N05aa958c15304e5bb553df9921d7871e
45 N3a41c5ea02544b948fc82b43a7ac0d2b
46 N6030d514cdf64360aadb80b373651293
47 N8db95b4dd70a4de2884220ac84657d1e
48 Nbaae2a1cb4f0461aa814da3d7996554f
49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100090966
50 https://doi.org/10.1186/s13063-017-2344-2
51 schema:sdDatePublished 2019-04-10T18:29
52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
53 schema:sdPublisher N7a94723deb57401d8b28af77f5fe7a25
54 schema:url http://link.springer.com/10.1186/s13063-017-2344-2
55 sgo:license sg:explorer/license/
56 sgo:sdDataset articles
57 rdf:type schema:ScholarlyArticle
58 N05aa958c15304e5bb553df9921d7871e schema:name pubmed_id
59 schema:value 29282143
60 rdf:type schema:PropertyValue
61 N36a701cc374c4438be733a91a5aaa506 schema:issueNumber 1
62 rdf:type schema:PublicationIssue
63 N3a41c5ea02544b948fc82b43a7ac0d2b schema:name dimensions_id
64 schema:value pub.1100090966
65 rdf:type schema:PropertyValue
66 N51b7de2a5d8a496bbaad74903de97fb6 rdf:first sg:person.01254665412.93
67 rdf:rest N52bf5e9c69b74d7988f92ca679523ad9
68 N52bf5e9c69b74d7988f92ca679523ad9 rdf:first sg:person.01312242407.05
69 rdf:rest N9a8f6218629d47b79fc070735cccae4a
70 N5e3a77d15f75432399c1c94b38c20447 schema:affiliation https://www.grid.ac/institutes/grid.10595.38
71 schema:familyName Gonzalez-Martinez
72 schema:givenName Carmen
73 rdf:type schema:Person
74 N6030d514cdf64360aadb80b373651293 schema:name doi
75 schema:value 10.1186/s13063-017-2344-2
76 rdf:type schema:PropertyValue
77 N648b759837584d29aca3daae44205595 rdf:first sg:person.01255430366.85
78 rdf:rest Ne58abfc832f84dc09b7cb269054a4485
79 N67b0be5c893b4c05b9ae1c3952311bfc rdf:first sg:person.0654573673.10
80 rdf:rest N6de4ccd3acdc417583f452f57609f85e
81 N6de4ccd3acdc417583f452f57609f85e rdf:first sg:person.0625103201.17
82 rdf:rest N72167d8f3ecb4662a260648715dd2b50
83 N72167d8f3ecb4662a260648715dd2b50 rdf:first Nc37c9601ece547a6965ffcb2263a697d
84 rdf:rest rdf:nil
85 N7a94723deb57401d8b28af77f5fe7a25 schema:name Springer Nature - SN SciGraph project
86 rdf:type schema:Organization
87 N8db95b4dd70a4de2884220ac84657d1e schema:name nlm_unique_id
88 schema:value 101263253
89 rdf:type schema:PropertyValue
90 N9a8f6218629d47b79fc070735cccae4a rdf:first sg:person.01011575517.21
91 rdf:rest N67b0be5c893b4c05b9ae1c3952311bfc
92 Naba848b2b35e454d9b8c869c8f4ee3bf rdf:first sg:person.01147267105.64
93 rdf:rest Ncc2dab0d0e6744909caa5caddc5f840e
94 Nbaae2a1cb4f0461aa814da3d7996554f schema:name readcube_id
95 schema:value c9452aff0c456d757f9e06ea6fceec6c14553bff4b2ea37506dde24d380f4195
96 rdf:type schema:PropertyValue
97 Nc37c9601ece547a6965ffcb2263a697d schema:familyName the BREATHE study team
98 rdf:type schema:Person
99 Ncc2dab0d0e6744909caa5caddc5f840e rdf:first sg:person.01233505401.34
100 rdf:rest N648b759837584d29aca3daae44205595
101 Ne58abfc832f84dc09b7cb269054a4485 rdf:first sg:person.0673115154.27
102 rdf:rest N51b7de2a5d8a496bbaad74903de97fb6
103 Ne92efc0ee2d14928817ee6b47e613ead rdf:first sg:person.01305645042.57
104 rdf:rest Neb45d7aa70b94cb8a1009cd8ac8cb715
105 Neb45d7aa70b94cb8a1009cd8ac8cb715 rdf:first sg:person.01245711007.24
106 rdf:rest Naba848b2b35e454d9b8c869c8f4ee3bf
107 Nec138b2ecf18456a9a3cb3566c53aa7a rdf:first N5e3a77d15f75432399c1c94b38c20447
108 rdf:rest Ne92efc0ee2d14928817ee6b47e613ead
109 Needdbc8eec7b458e8d593abd6b54cec6 schema:volumeNumber 18
110 rdf:type schema:PublicationVolume
111 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
112 schema:name Medical and Health Sciences
113 rdf:type schema:DefinedTerm
114 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
115 schema:name Medical Microbiology
116 rdf:type schema:DefinedTerm
117 sg:grant.3498121 http://pending.schema.org/fundedItem sg:pub.10.1186/s13063-017-2344-2
118 rdf:type schema:MonetaryGrant
119 sg:journal.1297400 schema:issn 1468-6708
120 1745-6215
121 schema:name Trials
122 rdf:type schema:Periodical
123 sg:person.01011575517.21 schema:affiliation https://www.grid.ac/institutes/grid.412244.5
124 schema:familyName Flaegstad
125 schema:givenName Trond
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011575517.21
127 rdf:type schema:Person
128 sg:person.01147267105.64 schema:affiliation https://www.grid.ac/institutes/grid.8991.9
129 schema:familyName Corbett
130 schema:givenName Elizabeth L.
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147267105.64
132 rdf:type schema:Person
133 sg:person.01233505401.34 schema:affiliation https://www.grid.ac/institutes/grid.13001.33
134 schema:familyName Mujuru
135 schema:givenName Hilda
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233505401.34
137 rdf:type schema:Person
138 sg:person.01245711007.24 schema:affiliation https://www.grid.ac/institutes/grid.418347.d
139 schema:familyName McHugh
140 schema:givenName Grace
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245711007.24
142 rdf:type schema:Person
143 sg:person.01254665412.93 schema:affiliation https://www.grid.ac/institutes/grid.8991.9
144 schema:familyName Rehman
145 schema:givenName Andrea M.
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254665412.93
147 rdf:type schema:Person
148 sg:person.01255430366.85 schema:affiliation https://www.grid.ac/institutes/grid.416657.7
149 schema:familyName Nicol
150 schema:givenName Mark P.
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255430366.85
152 rdf:type schema:Person
153 sg:person.01305645042.57 schema:affiliation https://www.grid.ac/institutes/grid.8991.9
154 schema:familyName Kranzer
155 schema:givenName Katharina
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305645042.57
157 rdf:type schema:Person
158 sg:person.01312242407.05 schema:affiliation https://www.grid.ac/institutes/grid.10919.30
159 schema:familyName Gutteberg
160 schema:givenName Tore J.
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312242407.05
162 rdf:type schema:Person
163 sg:person.0625103201.17 schema:affiliation https://www.grid.ac/institutes/grid.8991.9
164 schema:familyName Ferrand
165 schema:givenName Rashida A.
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625103201.17
167 rdf:type schema:Person
168 sg:person.0654573673.10 schema:affiliation https://www.grid.ac/institutes/grid.49697.35
169 schema:familyName Odland
170 schema:givenName Jon O.
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654573673.10
172 rdf:type schema:Person
173 sg:person.0673115154.27 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
174 schema:familyName Rowland-Jones
175 schema:givenName Sarah
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673115154.27
177 rdf:type schema:Person
178 sg:pub.10.1038/bmt.2011.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025558428
179 https://doi.org/10.1038/bmt.2011.1
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/bmt.2011.161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018500041
182 https://doi.org/10.1038/bmt.2011.161
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/sj.bmt.1705026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043738012
185 https://doi.org/10.1038/sj.bmt.1705026
186 rdf:type schema:CreativeWork
187 sg:pub.10.1186/1471-2431-14-238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051896730
188 https://doi.org/10.1186/1471-2431-14-238
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1002/14651858.cd002203.pub4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031421591
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1002/sim.5667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022395753
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.crad.2010.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008964258
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.lfs.2016.11.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022932582
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.prrv.2010.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037885587
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/s0140-6736(12)60953-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042773616
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/s2213-2600(13)70185-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022031752
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/s2213-2600(14)70019-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025684324
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1055/s-0036-1572555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057352888
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1080/00325481.2017.1285677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079400044
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1093/cid/cis271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004524377
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1093/cid/ciw683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054017230
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1093/infdis/jiu254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010887413
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1093/jpids/piv045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019049084
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1097/inf.0000000000001453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009543973
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1097/mop.0b013e3282ff62e9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051100919
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1097/mop.0b013e328360c317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032108023
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1097/qad.0000000000001249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023972987
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1097/qai.0000000000001320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083839674
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1111/ctr.12401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003005670
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1164/rccm.200601-071oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1023897327
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1513/annalsats.201612-1018oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1084321272
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1542/peds.2009-2701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067828098
235 rdf:type schema:CreativeWork
236 https://doi.org/10.7326/0003-4819-158-3-201302050-00583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073713447
237 rdf:type schema:CreativeWork
238 https://doi.org/10.7448/ias.16.1.18633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004819873
239 rdf:type schema:CreativeWork
240 https://www.grid.ac/institutes/grid.10595.38 schema:alternateName University of Malawi
241 schema:name Department of Paediatrics and Child Health, College of Medicine, University of Malawi, Private Bag 360, Chichiri, Blantyre 3, Malawi
242 Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK
243 Malawi-Liverpool Wellcome Trust Clinical Research Programme, Chichiri, PO Box 30096, Blantyre 3, Malawi
244 rdf:type schema:Organization
245 https://www.grid.ac/institutes/grid.10919.30 schema:alternateName The Arctic University of Norway
246 schema:name Department of Microbiology and Infection Control, University Hospital of North Norway, N-9038, Tromsø, Norway
247 Faculty of Health Sciences, Arctic University of Norway, N-9037, Tromsø, Norway
248 rdf:type schema:Organization
249 https://www.grid.ac/institutes/grid.13001.33 schema:alternateName University of Zimbabwe
250 schema:name Department of Paediatrics, University of Zimbabwe, Avondale, PO Box A178, Harare, Zimbabwe
251 rdf:type schema:Organization
252 https://www.grid.ac/institutes/grid.412244.5 schema:alternateName University Hospital of North Norway
253 schema:name Department of Paediatrics, University Hospital of North Norway, N-9038, Tromsø, Norway
254 Faculty of Health Sciences, Arctic University of Norway, N-9037, Tromsø, Norway
255 rdf:type schema:Organization
256 https://www.grid.ac/institutes/grid.416657.7 schema:alternateName National Health Laboratory Service
257 schema:name Division of Clinical Microbiology, University of Cape Town, Anzio Road, Cape Town, South Africa
258 National Health Laboratory Service, Johannesburg, South Africa
259 rdf:type schema:Organization
260 https://www.grid.ac/institutes/grid.418347.d schema:alternateName Biomedical Research and Training Institute
261 schema:name Biomedical Research and Training Institute, 10 Seagrave Road, Harare, Zimbabwe
262 rdf:type schema:Organization
263 https://www.grid.ac/institutes/grid.49697.35 schema:alternateName University of Pretoria
264 schema:name Faculty of Health Sciences, Arctic University of Norway, N-9037, Tromsø, Norway
265 School of Health Systems and Public Health, Faculty of Health Sciences, University of Pretoria, Hatfield, South Africa
266 rdf:type schema:Organization
267 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
268 schema:name Nuffield Department of Medicine, Old Road Campus, University of Oxford, Roosevelt Drive, OX3 7FZ, Oxford, UK
269 rdf:type schema:Organization
270 https://www.grid.ac/institutes/grid.8991.9 schema:alternateName London School of Hygiene & Tropical Medicine
271 schema:name Biomedical Research and Training Institute, 10 Seagrave Road, Harare, Zimbabwe
272 Department of Clinical Research, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK
273 Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK
274 MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK
275 Malawi-Liverpool Wellcome Trust Clinical Research Programme, Chichiri, PO Box 30096, Blantyre 3, Malawi
276 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...