Concomitant, sequential, and 7-day triple therapy in first-line treatment of Helicobacter pylori infection in Korea: study protocol for a randomized ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-11-17

AUTHORS

Hyuk Lee, Beom Jin Kim, Sang Gyun Kim, Jin Il Kim, Il Ju Choi, Yong Chan Lee, Jae G. Kim, Jae J. Kim, Korean College of Helicobacter and Upper Gastrointestinal Research

ABSTRACT

BackgroundMost international guidelines recommend triple-therapy regimens consisting of a proton pump inhibitor, clarithromycin, and amoxicillin/metronidazole for at least 7 days for the eradication of Helicobacter pylori. However, the efficacy of 7-day clarithromycin-based standard triple therapy for H. pylori infection is currently unacceptable in Korea. In this study, we will compare the efficacy and safety of 7-day standard triple therapy, 10-day sequential therapy, and 10-day concomitant therapy for the first-line treatment of H. pylori infection in Korea.Methods/designIn this multicenter, investigator-blinded, randomized trial we are recruiting adult patients with H. pylori infection from 15 hospitals in Korea to determine whether sequential or concomitant treatment is superior to standard triple therapy. Patients are randomly assigned to receive either standard triple therapy (lansoprazole, amoxicillin, and clarithromycin) for 7 days, or sequential treatment (lansoprazole and amoxicillin for the first 5 days, followed by lansoprazole, clarithromycin, and metronidazole for another 5 days) for 10 days, or concomitant therapy (lansoprazole, amoxicillin, clarithromycin, and metronidazole) for 10 days. The primary outcome is the rate of H. pylori eradication in the intention-to-treat population.DiscussionThe results of this study will be crucial for determining the optimal regimen for the primary treatment of H. pylori infection in Korea. This study will produce vital evidence that will lead to revisions to guidelines concerning first-line treatment regimens for H. pylori infection.Trial registrationClinical Research Information Service (CRIS), Republic of Korea, KCT0001980. Registered on 25 July 2016. More... »

PAGES

549

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13063-017-2281-0

DOI

http://dx.doi.org/10.1186/s13063-017-2281-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092753674

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29149904


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amoxicillin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clarithromycin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clinical Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Administration Schedule", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Therapy, Combination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Helicobacter Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Helicobacter pylori", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lansoprazole", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metronidazole", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sample Size", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, 06351, Gangnam-gu, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.264381.a", 
          "name": [
            "Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, 06351, Gangnam-gu, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hyuk", 
        "id": "sg:person.01041415632.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041415632.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Chung-Ang University College of Medicine, 102 Heukseok-ro, 06973, Dongjak-gu, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.254224.7", 
          "name": [
            "Department of Internal Medicine, Chung-Ang University College of Medicine, 102 Heukseok-ro, 06973, Dongjak-gu, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Beom Jin", 
        "id": "sg:person.01035723616.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035723616.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Sang Gyun", 
        "id": "sg:person.016035435043.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016035435043.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.411947.e", 
          "name": [
            "Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jin Il", 
        "id": "sg:person.01275602615.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275602615.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Gastric Cancer, National Cancer Center Hospital, National Cancer Center, Goyang, Gyeonggi, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.410914.9", 
          "name": [
            "Center for Gastric Cancer, National Cancer Center Hospital, National Cancer Center, Goyang, Gyeonggi, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Il Ju", 
        "id": "sg:person.01123522666.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123522666.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Yong Chan", 
        "id": "sg:person.01350057705.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350057705.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Chung-Ang University College of Medicine, 102 Heukseok-ro, 06973, Dongjak-gu, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.254224.7", 
          "name": [
            "Department of Internal Medicine, Chung-Ang University College of Medicine, 102 Heukseok-ro, 06973, Dongjak-gu, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jae G.", 
        "id": "sg:person.01215567240.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215567240.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, 06351, Gangnam-gu, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.264381.a", 
          "name": [
            "Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, 06351, Gangnam-gu, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jae J.", 
        "id": "sg:person.011046517237.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011046517237.70"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Korean College of Helicobacter and Upper Gastrointestinal Research", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ajg.2009.555", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040138284", 
          "https://doi.org/10.1038/ajg.2009.555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2005.00264.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049592931", 
          "https://doi.org/10.1111/j.1572-0241.2005.00264.x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-11-17", 
    "datePublishedReg": "2017-11-17", 
    "description": "BackgroundMost international guidelines recommend triple-therapy regimens consisting of a proton pump inhibitor, clarithromycin, and amoxicillin/metronidazole for at least 7\u00a0days for the eradication of Helicobacter pylori. However, the efficacy of 7-day clarithromycin-based standard triple therapy for H. pylori infection is currently unacceptable in Korea. In this study, we will compare the efficacy and safety of 7-day standard triple therapy, 10-day sequential therapy, and 10-day concomitant therapy for the first-line treatment of H. pylori infection in Korea.Methods/designIn this multicenter, investigator-blinded, randomized trial we are recruiting adult patients with H. pylori infection from 15 hospitals in Korea to determine whether sequential or concomitant treatment is superior to standard triple therapy. Patients are randomly assigned to receive either standard triple therapy (lansoprazole, amoxicillin, and clarithromycin) for 7\u00a0days, or sequential treatment (lansoprazole and amoxicillin for the first 5\u00a0days, followed by lansoprazole, clarithromycin, and metronidazole for another 5\u00a0days) for 10\u00a0days, or concomitant therapy (lansoprazole, amoxicillin, clarithromycin, and metronidazole) for 10\u00a0days. The primary outcome is the rate of H. pylori eradication in the intention-to-treat population.DiscussionThe results of this study will be crucial for determining the optimal regimen for the primary treatment of H. pylori infection in Korea. This study will produce vital evidence that will lead to revisions to guidelines concerning first-line treatment regimens for H. pylori infection.Trial registrationClinical Research Information Service (CRIS), Republic of Korea, KCT0001980. Registered on 25 July 2016.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s13063-017-2281-0", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1297400", 
        "issn": [
          "1468-6708", 
          "1745-6215"
        ], 
        "name": "Trials", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "keywords": [
      "standard triple therapy", 
      "H. pylori infection", 
      "first-line treatment", 
      "triple therapy", 
      "pylori infection", 
      "concomitant therapy", 
      "first-line treatment regimens", 
      "triple therapy regimens", 
      "amoxicillin/metronidazole", 
      "H. pylori eradication", 
      "proton pump inhibitors", 
      "Helicobacter pylori infection", 
      "Research Information Service", 
      "treat population", 
      "sequential therapy", 
      "pylori eradication", 
      "optimal regimen", 
      "adult patients", 
      "primary outcome", 
      "concomitant treatment", 
      "treatment regimens", 
      "pump inhibitors", 
      "study protocol", 
      "primary treatment", 
      "international guidelines", 
      "therapy", 
      "Helicobacter pylori", 
      "infection", 
      "regimens", 
      "treatment", 
      "patients", 
      "sequential treatment", 
      "trials", 
      "days", 
      "efficacy", 
      "eradication", 
      "guidelines", 
      "multicenter", 
      "regimen", 
      "hospital", 
      "clarithromycin", 
      "designIn", 
      "pylori", 
      "metronidazole", 
      "study", 
      "outcomes", 
      "Republic of Korea", 
      "inhibitors", 
      "vital evidence", 
      "safety", 
      "population", 
      "evidence", 
      "Korea", 
      "protocol", 
      "rate", 
      "revision", 
      "services", 
      "intention", 
      "results", 
      "information services", 
      "Republic"
    ], 
    "name": "Concomitant, sequential, and 7-day triple therapy in first-line treatment of Helicobacter pylori infection in Korea: study protocol for a randomized controlled trial", 
    "pagination": "549", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1092753674"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13063-017-2281-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29149904"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13063-017-2281-0", 
      "https://app.dimensions.ai/details/publication/pub.1092753674"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_723.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s13063-017-2281-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13063-017-2281-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13063-017-2281-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13063-017-2281-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13063-017-2281-0'


 

This table displays all metadata directly associated to this object as RDF triples.

242 TRIPLES      21 PREDICATES      99 URIs      89 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13063-017-2281-0 schema:about N0e88cd85b171443db7359fd920761bed
2 N19c0381999b146429833b824bb7af96f
3 N5db35b41a2fe4754955e53b83e73e423
4 N621c5b4d19a848bbb3558faa57c5e2fc
5 N65acfd13ff3f48afafdb05011b4dd498
6 N9193af7b5b9f4a60a37847dfaea8e8bf
7 Nbbed810d9019416fbb43c007e1af3df5
8 Nc2f645d64dc54aa7b539b505af1e0add
9 Nde9657af2d7142b78248c2928298ca22
10 Ne2db269804f44389b7d6c38623a631a0
11 Neae13e91a4c3472eb0a6c03109d8ac48
12 anzsrc-for:11
13 anzsrc-for:1103
14 schema:author N61b161a8439245b090b9c4002c52b758
15 schema:citation sg:pub.10.1038/ajg.2009.555
16 sg:pub.10.1111/j.1572-0241.2005.00264.x
17 schema:datePublished 2017-11-17
18 schema:datePublishedReg 2017-11-17
19 schema:description BackgroundMost international guidelines recommend triple-therapy regimens consisting of a proton pump inhibitor, clarithromycin, and amoxicillin/metronidazole for at least 7 days for the eradication of Helicobacter pylori. However, the efficacy of 7-day clarithromycin-based standard triple therapy for H. pylori infection is currently unacceptable in Korea. In this study, we will compare the efficacy and safety of 7-day standard triple therapy, 10-day sequential therapy, and 10-day concomitant therapy for the first-line treatment of H. pylori infection in Korea.Methods/designIn this multicenter, investigator-blinded, randomized trial we are recruiting adult patients with H. pylori infection from 15 hospitals in Korea to determine whether sequential or concomitant treatment is superior to standard triple therapy. Patients are randomly assigned to receive either standard triple therapy (lansoprazole, amoxicillin, and clarithromycin) for 7 days, or sequential treatment (lansoprazole and amoxicillin for the first 5 days, followed by lansoprazole, clarithromycin, and metronidazole for another 5 days) for 10 days, or concomitant therapy (lansoprazole, amoxicillin, clarithromycin, and metronidazole) for 10 days. The primary outcome is the rate of H. pylori eradication in the intention-to-treat population.DiscussionThe results of this study will be crucial for determining the optimal regimen for the primary treatment of H. pylori infection in Korea. This study will produce vital evidence that will lead to revisions to guidelines concerning first-line treatment regimens for H. pylori infection.Trial registrationClinical Research Information Service (CRIS), Republic of Korea, KCT0001980. Registered on 25 July 2016.
20 schema:genre article
21 schema:isAccessibleForFree true
22 schema:isPartOf N6bf6e036a7c848b2bdd7ad54f0414c95
23 N7c53c9790a994f9f86cf1f4d276f5314
24 sg:journal.1297400
25 schema:keywords H. pylori eradication
26 H. pylori infection
27 Helicobacter pylori
28 Helicobacter pylori infection
29 Korea
30 Republic
31 Republic of Korea
32 Research Information Service
33 adult patients
34 amoxicillin/metronidazole
35 clarithromycin
36 concomitant therapy
37 concomitant treatment
38 days
39 designIn
40 efficacy
41 eradication
42 evidence
43 first-line treatment
44 first-line treatment regimens
45 guidelines
46 hospital
47 infection
48 information services
49 inhibitors
50 intention
51 international guidelines
52 metronidazole
53 multicenter
54 optimal regimen
55 outcomes
56 patients
57 population
58 primary outcome
59 primary treatment
60 protocol
61 proton pump inhibitors
62 pump inhibitors
63 pylori
64 pylori eradication
65 pylori infection
66 rate
67 regimen
68 regimens
69 results
70 revision
71 safety
72 sequential therapy
73 sequential treatment
74 services
75 standard triple therapy
76 study
77 study protocol
78 therapy
79 treat population
80 treatment
81 treatment regimens
82 trials
83 triple therapy
84 triple therapy regimens
85 vital evidence
86 schema:name Concomitant, sequential, and 7-day triple therapy in first-line treatment of Helicobacter pylori infection in Korea: study protocol for a randomized controlled trial
87 schema:pagination 549
88 schema:productId N0562b3be64e4403cb81cc93aca5dc178
89 N07b88276afa04ee6a3e93ee71be304e8
90 N88e14b40f62f44c18fc1a34d6c033bd7
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092753674
92 https://doi.org/10.1186/s13063-017-2281-0
93 schema:sdDatePublished 2022-10-01T06:42
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher N13dff5a3e4554f9e833bb296fba95e34
96 schema:url https://doi.org/10.1186/s13063-017-2281-0
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N0562b3be64e4403cb81cc93aca5dc178 schema:name dimensions_id
101 schema:value pub.1092753674
102 rdf:type schema:PropertyValue
103 N07b88276afa04ee6a3e93ee71be304e8 schema:name doi
104 schema:value 10.1186/s13063-017-2281-0
105 rdf:type schema:PropertyValue
106 N0e88cd85b171443db7359fd920761bed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Helicobacter pylori
108 rdf:type schema:DefinedTerm
109 N0ec16bd22f8647b79a2dad466b6e19db schema:familyName Korean College of Helicobacter and Upper Gastrointestinal Research
110 rdf:type schema:Person
111 N13dff5a3e4554f9e833bb296fba95e34 schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 N19c0381999b146429833b824bb7af96f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Clinical Protocols
115 rdf:type schema:DefinedTerm
116 N280bc43e06784d83be65f1013ddf26e0 rdf:first sg:person.01275602615.59
117 rdf:rest N368863d37f044c51b306498e0eb27b30
118 N368863d37f044c51b306498e0eb27b30 rdf:first sg:person.01123522666.07
119 rdf:rest Nd4bf4ebba9dd4619b2ada5b6436df38a
120 N401ac08e68204b8aa7e72e9821d543d4 rdf:first sg:person.016035435043.00
121 rdf:rest N280bc43e06784d83be65f1013ddf26e0
122 N51350be0232547e588e3842943c866e6 rdf:first sg:person.01215567240.34
123 rdf:rest N689b3238c6b840bdbc9c3d2bfdc6145e
124 N5db35b41a2fe4754955e53b83e73e423 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Sample Size
126 rdf:type schema:DefinedTerm
127 N61b161a8439245b090b9c4002c52b758 rdf:first sg:person.01041415632.33
128 rdf:rest N63d22e631a1947b8aa3b4db593f3dde0
129 N621c5b4d19a848bbb3558faa57c5e2fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Drug Therapy, Combination
131 rdf:type schema:DefinedTerm
132 N63d22e631a1947b8aa3b4db593f3dde0 rdf:first sg:person.01035723616.98
133 rdf:rest N401ac08e68204b8aa7e72e9821d543d4
134 N65acfd13ff3f48afafdb05011b4dd498 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 N689b3238c6b840bdbc9c3d2bfdc6145e rdf:first sg:person.011046517237.70
138 rdf:rest Nc369ec5c2637427f9110d18bfcd8ea55
139 N6bf6e036a7c848b2bdd7ad54f0414c95 schema:volumeNumber 18
140 rdf:type schema:PublicationVolume
141 N7c53c9790a994f9f86cf1f4d276f5314 schema:issueNumber 1
142 rdf:type schema:PublicationIssue
143 N88e14b40f62f44c18fc1a34d6c033bd7 schema:name pubmed_id
144 schema:value 29149904
145 rdf:type schema:PropertyValue
146 N9193af7b5b9f4a60a37847dfaea8e8bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Clarithromycin
148 rdf:type schema:DefinedTerm
149 Nbbed810d9019416fbb43c007e1af3df5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Drug Administration Schedule
151 rdf:type schema:DefinedTerm
152 Nc2f645d64dc54aa7b539b505af1e0add schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Metronidazole
154 rdf:type schema:DefinedTerm
155 Nc369ec5c2637427f9110d18bfcd8ea55 rdf:first N0ec16bd22f8647b79a2dad466b6e19db
156 rdf:rest rdf:nil
157 Nd4bf4ebba9dd4619b2ada5b6436df38a rdf:first sg:person.01350057705.89
158 rdf:rest N51350be0232547e588e3842943c866e6
159 Nde9657af2d7142b78248c2928298ca22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Lansoprazole
161 rdf:type schema:DefinedTerm
162 Ne2db269804f44389b7d6c38623a631a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Amoxicillin
164 rdf:type schema:DefinedTerm
165 Neae13e91a4c3472eb0a6c03109d8ac48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Helicobacter Infections
167 rdf:type schema:DefinedTerm
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
172 schema:name Clinical Sciences
173 rdf:type schema:DefinedTerm
174 sg:journal.1297400 schema:issn 1468-6708
175 1745-6215
176 schema:name Trials
177 schema:publisher Springer Nature
178 rdf:type schema:Periodical
179 sg:person.01035723616.98 schema:affiliation grid-institutes:grid.254224.7
180 schema:familyName Kim
181 schema:givenName Beom Jin
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035723616.98
183 rdf:type schema:Person
184 sg:person.01041415632.33 schema:affiliation grid-institutes:grid.264381.a
185 schema:familyName Lee
186 schema:givenName Hyuk
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041415632.33
188 rdf:type schema:Person
189 sg:person.011046517237.70 schema:affiliation grid-institutes:grid.264381.a
190 schema:familyName Kim
191 schema:givenName Jae J.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011046517237.70
193 rdf:type schema:Person
194 sg:person.01123522666.07 schema:affiliation grid-institutes:grid.410914.9
195 schema:familyName Choi
196 schema:givenName Il Ju
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123522666.07
198 rdf:type schema:Person
199 sg:person.01215567240.34 schema:affiliation grid-institutes:grid.254224.7
200 schema:familyName Kim
201 schema:givenName Jae G.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215567240.34
203 rdf:type schema:Person
204 sg:person.01275602615.59 schema:affiliation grid-institutes:grid.411947.e
205 schema:familyName Kim
206 schema:givenName Jin Il
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275602615.59
208 rdf:type schema:Person
209 sg:person.01350057705.89 schema:affiliation grid-institutes:grid.15444.30
210 schema:familyName Lee
211 schema:givenName Yong Chan
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350057705.89
213 rdf:type schema:Person
214 sg:person.016035435043.00 schema:affiliation grid-institutes:grid.31501.36
215 schema:familyName Kim
216 schema:givenName Sang Gyun
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016035435043.00
218 rdf:type schema:Person
219 sg:pub.10.1038/ajg.2009.555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040138284
220 https://doi.org/10.1038/ajg.2009.555
221 rdf:type schema:CreativeWork
222 sg:pub.10.1111/j.1572-0241.2005.00264.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049592931
223 https://doi.org/10.1111/j.1572-0241.2005.00264.x
224 rdf:type schema:CreativeWork
225 grid-institutes:grid.15444.30 schema:alternateName Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, South Korea
226 schema:name Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, South Korea
227 rdf:type schema:Organization
228 grid-institutes:grid.254224.7 schema:alternateName Department of Internal Medicine, Chung-Ang University College of Medicine, 102 Heukseok-ro, 06973, Dongjak-gu, Seoul, South Korea
229 schema:name Department of Internal Medicine, Chung-Ang University College of Medicine, 102 Heukseok-ro, 06973, Dongjak-gu, Seoul, South Korea
230 rdf:type schema:Organization
231 grid-institutes:grid.264381.a schema:alternateName Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, 06351, Gangnam-gu, Seoul, South Korea
232 schema:name Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, 06351, Gangnam-gu, Seoul, South Korea
233 rdf:type schema:Organization
234 grid-institutes:grid.31501.36 schema:alternateName Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea
235 schema:name Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea
236 rdf:type schema:Organization
237 grid-institutes:grid.410914.9 schema:alternateName Center for Gastric Cancer, National Cancer Center Hospital, National Cancer Center, Goyang, Gyeonggi, South Korea
238 schema:name Center for Gastric Cancer, National Cancer Center Hospital, National Cancer Center, Goyang, Gyeonggi, South Korea
239 rdf:type schema:Organization
240 grid-institutes:grid.411947.e schema:alternateName Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, South Korea
241 schema:name Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, South Korea
242 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...