Determining the efficacy of guppies and pyriproxyfen (Sumilarv® 2MR) combined with community engagement on dengue vectors in Cambodia: study protocol ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-08-04

AUTHORS

John Hustedt, Dyna Doum, Vanney Keo, Sokha Ly, BunLeng Sam, Vibol Chan, Neal Alexander, John Bradley, Didot Budi Prasetyo, Agus Rachmat, Shafique Muhammad, Sergio Lopes, Rithea Leang, Jeffrey Hii

ABSTRACT

BackgroundEvidence on the effectiveness of low-cost, sustainable, biological vector-control tools for the Aedes mosquitoes is limited. Therefore, the purpose of this trial is to estimate the impact of guppy fish (guppies), in combination with the use of the larvicide pyriproxyfen (Sumilarv® 2MR), and Communication for Behavioral Impact (COMBI) activities to reduce entomological indices in Cambodia.Methods/designIn this cluster randomized controlled, superiority trial, 30 clusters comprising one or more villages each (with approximately 170 households) will be allocated, in a 1:1:1 ratio, to receive either (1) three interventions (guppies, Sumilarv® 2MR, and COMBI activities), (2) two interventions (guppies and COMBI activities), or (3) control (standard vector control). Households will be invited to participate, and entomology surveys among 40 randomly selected households per cluster will be carried out quarterly. The primary outcome will be the population density of adult female Aedes mosquitoes (i.e., number per house) trapped using adult resting collections. Secondary outcome measures will include the House Index, Container Index, Breteau Index, Pupae Per House, Pupae Per Person, mosquito infection rate, guppy fish coverage, Sumilarv® 2MR coverage, and percentage of respondents with knowledge about Aedes mosquitoes causing dengue. In the primary analysis, adult female Aedes density and mosquito infection rates will be aggregated over follow-up time points to give a single rate per cluster. This will be analyzed by negative binomial regression, yielding density ratios.DiscussionThis trial is expected to provide robust estimates of the intervention effect. A rigorous evaluation of these vector-control interventions is vital to developing an evidence-based dengue control strategy and to help direct government resources.Trial registrationCurrent Controlled Trials, ID: ISRCTN85307778. Registered on 25 October 2015. More... »

PAGES

367

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13063-017-2105-2

DOI

http://dx.doi.org/10.1186/s13063-017-2105-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091051465

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28778174


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28 schema:description BackgroundEvidence on the effectiveness of low-cost, sustainable, biological vector-control tools for the Aedes mosquitoes is limited. Therefore, the purpose of this trial is to estimate the impact of guppy fish (guppies), in combination with the use of the larvicide pyriproxyfen (Sumilarv® 2MR), and Communication for Behavioral Impact (COMBI) activities to reduce entomological indices in Cambodia.Methods/designIn this cluster randomized controlled, superiority trial, 30 clusters comprising one or more villages each (with approximately 170 households) will be allocated, in a 1:1:1 ratio, to receive either (1) three interventions (guppies, Sumilarv® 2MR, and COMBI activities), (2) two interventions (guppies and COMBI activities), or (3) control (standard vector control). Households will be invited to participate, and entomology surveys among 40 randomly selected households per cluster will be carried out quarterly. The primary outcome will be the population density of adult female Aedes mosquitoes (i.e., number per house) trapped using adult resting collections. Secondary outcome measures will include the House Index, Container Index, Breteau Index, Pupae Per House, Pupae Per Person, mosquito infection rate, guppy fish coverage, Sumilarv® 2MR coverage, and percentage of respondents with knowledge about Aedes mosquitoes causing dengue. In the primary analysis, adult female Aedes density and mosquito infection rates will be aggregated over follow-up time points to give a single rate per cluster. This will be analyzed by negative binomial regression, yielding density ratios.DiscussionThis trial is expected to provide robust estimates of the intervention effect. A rigorous evaluation of these vector-control interventions is vital to developing an evidence-based dengue control strategy and to help direct government resources.Trial registrationCurrent Controlled Trials, ID: ISRCTN85307778. Registered on 25 October 2015.
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36 Aedes density
37 Aedes mosquitoes
38 BackgroundEvidence
39 Breteau index
40 Cambodia
41 Controlled Trials
42 DiscussionThis trial
43 ID
44 Secondary outcome measures
45 Sumilarv
46 activity
47 adult female Aedes mosquitoes
48 adults
49 analysis
50 binomial regression
51 clusters
52 collection
53 combination
54 communication
55 community engagement
56 container index
57 control
58 control strategy
59 coverage
60 dengue
61 dengue control strategies
62 dengue vectors
63 density
64 density ratio
65 designIn
66 effect
67 effectiveness
68 efficacy
69 engagement
70 entomological indices
71 entomology surveys
72 estimates
73 evaluation
74 female Aedes mosquitoes
75 fish
76 government resources
77 guppies
78 guppy fish
79 house
80 house index
81 households
82 impact
83 impact activities
84 index
85 infection rate
86 intervention
87 intervention effects
88 knowledge
89 larvicide pyriproxyfen
90 measures
91 more villages
92 mosquito infection rates
93 mosquitoes
94 negative binomial regression
95 outcome measures
96 outcomes
97 percentage
98 percentage of respondents
99 persons
100 point
101 population density
102 primary analysis
103 primary outcome
104 protocol
105 pupae
106 purpose
107 pyriproxyfen
108 rate
109 ratio
110 regression
111 resources
112 respondents
113 rigorous evaluation
114 robust estimates
115 single rate
116 strategies
117 study protocol
118 superiority trial
119 survey
120 time points
121 tool
122 trials
123 use
124 vector
125 vector control interventions
126 vector control tools
127 villages
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