Resource implications of preparing individual participant data from a clinical trial to share with external researchers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-07-17

AUTHORS

Catrin Tudur Smith, Sarah Nevitt, Duncan Appelbe, Richard Appleton, Pete Dixon, Janet Harrison, Anthony Marson, Paula Williamson, Elizabeth Tremain

ABSTRACT

BackgroundDemands are increasingly being made for clinical trialists to actively share individual participant data (IPD) collected from clinical trials using responsible methods that protect the confidentiality and privacy of clinical trial participants. Clinical trialists, particularly those receiving public funding, are often concerned about the additional time and money that data-sharing activities will require, but few published empirical data are available to help inform these decisions. We sought to evaluate the activity and resources required to prepare anonymised IPD from a clinical trial in anticipation of a future data-sharing request.MethodsData from two UK publicly funded clinical trials were used for this exercise: 2437 participants with epilepsy recruited from 90 hospital outpatient clinics in the SANAD trial and 146 children with neuro-developmental problems recruited from 18 hospitals in the MENDS trial. We calculated the time and resources required to prepare each anonymised dataset and assemble a data pack ready for sharing.ResultsThe older SANAD trial (published 2007) required 50 hours of staff time with a total estimated associated cost of £3185 whilst the more recently completed MENDS trial (published 2012) required 39.5 hours of staff time with total estimated associated cost of £2540.ConclusionsClinical trial researchers, funders and sponsors should consider appropriate resourcing and allow reasonable time for preparing IPD ready for subsequent sharing. This process would be most efficient if prospectively built into the standard operational design and conduct of a clinical trial. Further empirical examples exploring the resource requirements in other settings is recommended.Trial registrationSANAD: International Standard Randomised Controlled Trials Registry: ISRCTN38354748. Registered on 25 April 2003. MENDS: EU Clinical Trials Register Eudract 2006-004025-28. Registered on 16 May 2007. International Standard Randomised Controlled Trials Registry: ISRCTN05534585/MREC 07/MRE08/43. Registered on 26 January 2007. More... »

PAGES

319

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13063-017-2067-4

DOI

http://dx.doi.org/10.1186/s13063-017-2067-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090643313

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28712359


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clinical Trials as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Data Anonymization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Data Collection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Efficiency, Organizational", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Information Dissemination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Personnel Staffing and Scheduling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Research Design", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Research Support as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Workflow", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Street, L69 3GL, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Street, L69 3GL, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tudur Smith", 
        "givenName": "Catrin", 
        "id": "sg:person.01261374732.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261374732.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Street, L69 3GL, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Street, L69 3GL, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nevitt", 
        "givenName": "Sarah", 
        "id": "sg:person.014257575147.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014257575147.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Street, L69 3GL, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Street, L69 3GL, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Appelbe", 
        "givenName": "Duncan", 
        "id": "sg:person.011211702241.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011211702241.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Alder Hey Children\u2019s NHS Foundation Trust, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.417858.7", 
          "name": [
            "Alder Hey Children\u2019s NHS Foundation Trust, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Appleton", 
        "givenName": "Richard", 
        "id": "sg:person.01230413744.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230413744.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dixon", 
        "givenName": "Pete", 
        "id": "sg:person.01226560701.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226560701.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Street, L69 3GL, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Street, L69 3GL, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harrison", 
        "givenName": "Janet", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marson", 
        "givenName": "Anthony", 
        "id": "sg:person.01174075734.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174075734.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Street, L69 3GL, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Street, L69 3GL, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Williamson", 
        "givenName": "Paula", 
        "id": "sg:person.01002370610.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002370610.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Health Research Evaluation, Trials and Studies Coordinating Centre, University of Southampton, Southampton, UK", 
          "id": "http://www.grid.ac/institutes/grid.5491.9", 
          "name": [
            "National Institute for Health Research Evaluation, Trials and Studies Coordinating Centre, University of Southampton, Southampton, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tremain", 
        "givenName": "Elizabeth", 
        "id": "sg:person.013001137514.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013001137514.52"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s12916-015-0532-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036208262", 
          "https://doi.org/10.1186/s12916-015-0532-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12916-016-0612-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034448822", 
          "https://doi.org/10.1186/s12916-016-0612-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13063-015-0604-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050280001", 
          "https://doi.org/10.1186/s13063-015-0604-6"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-07-17", 
    "datePublishedReg": "2017-07-17", 
    "description": "BackgroundDemands are increasingly being made for clinical trialists to actively share individual participant data (IPD) collected from clinical trials using responsible methods that protect the confidentiality and privacy of clinical trial participants. Clinical trialists, particularly those receiving public funding, are often concerned about the additional time and money that data-sharing activities will require, but few published empirical data are available to help inform these decisions. We sought to evaluate the activity and resources required to prepare anonymised IPD from a clinical trial in anticipation of a future data-sharing request.MethodsData from two UK publicly funded clinical trials were used for this exercise: 2437 participants with epilepsy recruited from 90 hospital outpatient clinics in the SANAD trial and 146 children with neuro-developmental problems recruited from 18 hospitals in the MENDS trial. We calculated the time and resources required to prepare each anonymised dataset and assemble a data pack ready for sharing.ResultsThe older SANAD trial (published 2007) required 50\u00a0hours of staff time with a total estimated associated cost of \u00a33185 whilst the more recently completed MENDS trial (published 2012) required 39.5\u00a0hours of staff time with total estimated associated cost of \u00a32540.ConclusionsClinical trial researchers, funders and sponsors should consider appropriate resourcing and allow reasonable time for preparing IPD ready for subsequent sharing. This process would be most efficient if prospectively built into the standard operational design and conduct of a clinical trial. Further empirical examples exploring the resource requirements in other settings is recommended.Trial registrationSANAD: International Standard Randomised Controlled Trials Registry: ISRCTN38354748. Registered on 25 April 2003. MENDS: EU Clinical Trials Register Eudract 2006-004025-28. Registered on 16 May 2007. International Standard Randomised Controlled Trials Registry: ISRCTN05534585/MREC 07/MRE08/43. Registered on 26 January 2007.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s13063-017-2067-4", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3862178", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1297400", 
        "issn": [
          "1468-6708", 
          "1745-6215"
        ], 
        "name": "Trials", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "keywords": [
      "individual participant data", 
      "Controlled Trials Registry", 
      "clinical trials", 
      "Trials Registry", 
      "clinical trialists", 
      "SANAD trial", 
      "participant data", 
      "neuro-developmental problems", 
      "hospital outpatient clinic", 
      "EU Clinical Trials", 
      "clinical trial participants", 
      "staff time", 
      "outpatient clinic", 
      "trial participants", 
      "trial researchers", 
      "trials", 
      "registry", 
      "trialists", 
      "resource implications", 
      "hours", 
      "participants", 
      "epilepsy", 
      "MethodsData", 
      "clinic", 
      "hospital", 
      "additional time", 
      "children", 
      "activity", 
      "exercise", 
      "BackgroundDemand", 
      "subsequent sharing", 
      "data", 
      "setting", 
      "time", 
      "international standards", 
      "external researchers", 
      "standards", 
      "data-sharing activities", 
      "funders", 
      "UK", 
      "anticipation", 
      "public funding", 
      "funding", 
      "responsible method", 
      "sponsors", 
      "implications", 
      "conduct", 
      "pack", 
      "cost", 
      "decisions", 
      "researchers", 
      "method", 
      "confidentiality", 
      "requests", 
      "resources", 
      "design", 
      "requirements", 
      "process", 
      "problem", 
      "sharing", 
      "empirical data", 
      "money", 
      "operational design", 
      "resource requirements", 
      "dataset", 
      "example", 
      "privacy", 
      "reasonable time", 
      "data packs", 
      "empirical example"
    ], 
    "name": "Resource implications of preparing individual participant data from a clinical trial to share with external researchers", 
    "pagination": "319", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1090643313"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13063-017-2067-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28712359"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13063-017-2067-4", 
      "https://app.dimensions.ai/details/publication/pub.1090643313"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_723.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s13063-017-2067-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13063-017-2067-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13063-017-2067-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13063-017-2067-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13063-017-2067-4'


 

This table displays all metadata directly associated to this object as RDF triples.

252 TRIPLES      21 PREDICATES      109 URIs      98 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13063-017-2067-4 schema:about N0bb083a8eed64403b360772408cf7f37
2 N208103d474cc4472a95a4b2c75fd0301
3 N2297860909104a7bb57edeec498508dc
4 N4b022744c2db4268bf07e04ef1fc2948
5 N540cc24fd6744cc28a266708d3efa112
6 N89a2619d99fa49da858f40cc34c28f83
7 Naa70e6c84f6f4b6cbb3b742f1df3e440
8 Nb5a390576e5745e7800a7880388bf252
9 Nbbf0bc0d6aec4ef18a9b4ef0d65e4532
10 Nca1321d0fc4044a291c2b719c88e2db6
11 Nd925589288614ed093528c19bfa67d73
12 anzsrc-for:11
13 anzsrc-for:1117
14 schema:author Nf48fa44f5e194c19be42d6214dd7a0f4
15 schema:citation sg:pub.10.1186/s12916-015-0532-z
16 sg:pub.10.1186/s12916-016-0612-8
17 sg:pub.10.1186/s13063-015-0604-6
18 schema:datePublished 2017-07-17
19 schema:datePublishedReg 2017-07-17
20 schema:description BackgroundDemands are increasingly being made for clinical trialists to actively share individual participant data (IPD) collected from clinical trials using responsible methods that protect the confidentiality and privacy of clinical trial participants. Clinical trialists, particularly those receiving public funding, are often concerned about the additional time and money that data-sharing activities will require, but few published empirical data are available to help inform these decisions. We sought to evaluate the activity and resources required to prepare anonymised IPD from a clinical trial in anticipation of a future data-sharing request.MethodsData from two UK publicly funded clinical trials were used for this exercise: 2437 participants with epilepsy recruited from 90 hospital outpatient clinics in the SANAD trial and 146 children with neuro-developmental problems recruited from 18 hospitals in the MENDS trial. We calculated the time and resources required to prepare each anonymised dataset and assemble a data pack ready for sharing.ResultsThe older SANAD trial (published 2007) required 50 hours of staff time with a total estimated associated cost of £3185 whilst the more recently completed MENDS trial (published 2012) required 39.5 hours of staff time with total estimated associated cost of £2540.ConclusionsClinical trial researchers, funders and sponsors should consider appropriate resourcing and allow reasonable time for preparing IPD ready for subsequent sharing. This process would be most efficient if prospectively built into the standard operational design and conduct of a clinical trial. Further empirical examples exploring the resource requirements in other settings is recommended.Trial registrationSANAD: International Standard Randomised Controlled Trials Registry: ISRCTN38354748. Registered on 25 April 2003. MENDS: EU Clinical Trials Register Eudract 2006-004025-28. Registered on 16 May 2007. International Standard Randomised Controlled Trials Registry: ISRCTN05534585/MREC 07/MRE08/43. Registered on 26 January 2007.
21 schema:genre article
22 schema:isAccessibleForFree true
23 schema:isPartOf N295d18d887294e63886b91cbd2e6787d
24 N2983f71652f34424aba17b7bc286653f
25 sg:journal.1297400
26 schema:keywords BackgroundDemand
27 Controlled Trials Registry
28 EU Clinical Trials
29 MethodsData
30 SANAD trial
31 Trials Registry
32 UK
33 activity
34 additional time
35 anticipation
36 children
37 clinic
38 clinical trial participants
39 clinical trialists
40 clinical trials
41 conduct
42 confidentiality
43 cost
44 data
45 data packs
46 data-sharing activities
47 dataset
48 decisions
49 design
50 empirical data
51 empirical example
52 epilepsy
53 example
54 exercise
55 external researchers
56 funders
57 funding
58 hospital
59 hospital outpatient clinic
60 hours
61 implications
62 individual participant data
63 international standards
64 method
65 money
66 neuro-developmental problems
67 operational design
68 outpatient clinic
69 pack
70 participant data
71 participants
72 privacy
73 problem
74 process
75 public funding
76 reasonable time
77 registry
78 requests
79 requirements
80 researchers
81 resource implications
82 resource requirements
83 resources
84 responsible method
85 setting
86 sharing
87 sponsors
88 staff time
89 standards
90 subsequent sharing
91 time
92 trial participants
93 trial researchers
94 trialists
95 trials
96 schema:name Resource implications of preparing individual participant data from a clinical trial to share with external researchers
97 schema:pagination 319
98 schema:productId N47e4e133503742a0a1920ccb242e2a62
99 N6a039a95b85b4817b38ffef3a8c73503
100 N886db6858b4449f4ade6fd73ce138c3f
101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090643313
102 https://doi.org/10.1186/s13063-017-2067-4
103 schema:sdDatePublished 2022-12-01T06:35
104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
105 schema:sdPublisher N734ed27432564bc9ae6f8a4e13d218da
106 schema:url https://doi.org/10.1186/s13063-017-2067-4
107 sgo:license sg:explorer/license/
108 sgo:sdDataset articles
109 rdf:type schema:ScholarlyArticle
110 N0bb083a8eed64403b360772408cf7f37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Data Anonymization
112 rdf:type schema:DefinedTerm
113 N1de0252236a24c76868777e3df997bf7 rdf:first Ne1e70ffbb9684999b9154b16e9625c9e
114 rdf:rest Ndaf95d3321bb48bc9c08356d0477043c
115 N208103d474cc4472a95a4b2c75fd0301 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Personnel Staffing and Scheduling
117 rdf:type schema:DefinedTerm
118 N2297860909104a7bb57edeec498508dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Workflow
120 rdf:type schema:DefinedTerm
121 N295d18d887294e63886b91cbd2e6787d schema:issueNumber 1
122 rdf:type schema:PublicationIssue
123 N2983f71652f34424aba17b7bc286653f schema:volumeNumber 18
124 rdf:type schema:PublicationVolume
125 N47e4e133503742a0a1920ccb242e2a62 schema:name pubmed_id
126 schema:value 28712359
127 rdf:type schema:PropertyValue
128 N4b022744c2db4268bf07e04ef1fc2948 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Information Dissemination
130 rdf:type schema:DefinedTerm
131 N540cc24fd6744cc28a266708d3efa112 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Research Design
133 rdf:type schema:DefinedTerm
134 N6a039a95b85b4817b38ffef3a8c73503 schema:name dimensions_id
135 schema:value pub.1090643313
136 rdf:type schema:PropertyValue
137 N734ed27432564bc9ae6f8a4e13d218da schema:name Springer Nature - SN SciGraph project
138 rdf:type schema:Organization
139 N886db6858b4449f4ade6fd73ce138c3f schema:name doi
140 schema:value 10.1186/s13063-017-2067-4
141 rdf:type schema:PropertyValue
142 N89a2619d99fa49da858f40cc34c28f83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Clinical Trials as Topic
144 rdf:type schema:DefinedTerm
145 N9d09bf9ab40c422482cd97ba849cbad5 rdf:first sg:person.013001137514.52
146 rdf:rest rdf:nil
147 Naa70e6c84f6f4b6cbb3b742f1df3e440 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Research Support as Topic
149 rdf:type schema:DefinedTerm
150 Nab0092b885b440c6a1b8fde011deefaf rdf:first sg:person.01230413744.80
151 rdf:rest Nc8dc2b3f63f746d28530bc37030801f8
152 Nb5a390576e5745e7800a7880388bf252 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Humans
154 rdf:type schema:DefinedTerm
155 Nbbf0bc0d6aec4ef18a9b4ef0d65e4532 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Efficiency, Organizational
157 rdf:type schema:DefinedTerm
158 Nc8dc2b3f63f746d28530bc37030801f8 rdf:first sg:person.01226560701.24
159 rdf:rest N1de0252236a24c76868777e3df997bf7
160 Nca1321d0fc4044a291c2b719c88e2db6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Time Factors
162 rdf:type schema:DefinedTerm
163 Nd925589288614ed093528c19bfa67d73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Data Collection
165 rdf:type schema:DefinedTerm
166 Ndaf95d3321bb48bc9c08356d0477043c rdf:first sg:person.01174075734.81
167 rdf:rest Nee12dab486224b51997d9132c97979c8
168 Ne1e70ffbb9684999b9154b16e9625c9e schema:affiliation grid-institutes:grid.10025.36
169 schema:familyName Harrison
170 schema:givenName Janet
171 rdf:type schema:Person
172 Ne9fc63ffc8124b519fb673f421b01d18 rdf:first sg:person.014257575147.70
173 rdf:rest Nf74f3b8944ee44b18ca49d6c734189f9
174 Nee12dab486224b51997d9132c97979c8 rdf:first sg:person.01002370610.91
175 rdf:rest N9d09bf9ab40c422482cd97ba849cbad5
176 Nf48fa44f5e194c19be42d6214dd7a0f4 rdf:first sg:person.01261374732.97
177 rdf:rest Ne9fc63ffc8124b519fb673f421b01d18
178 Nf74f3b8944ee44b18ca49d6c734189f9 rdf:first sg:person.011211702241.20
179 rdf:rest Nab0092b885b440c6a1b8fde011deefaf
180 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
181 schema:name Medical and Health Sciences
182 rdf:type schema:DefinedTerm
183 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
184 schema:name Public Health and Health Services
185 rdf:type schema:DefinedTerm
186 sg:grant.3862178 http://pending.schema.org/fundedItem sg:pub.10.1186/s13063-017-2067-4
187 rdf:type schema:MonetaryGrant
188 sg:journal.1297400 schema:issn 1468-6708
189 1745-6215
190 schema:name Trials
191 schema:publisher Springer Nature
192 rdf:type schema:Periodical
193 sg:person.01002370610.91 schema:affiliation grid-institutes:grid.10025.36
194 schema:familyName Williamson
195 schema:givenName Paula
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002370610.91
197 rdf:type schema:Person
198 sg:person.011211702241.20 schema:affiliation grid-institutes:grid.10025.36
199 schema:familyName Appelbe
200 schema:givenName Duncan
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011211702241.20
202 rdf:type schema:Person
203 sg:person.01174075734.81 schema:affiliation grid-institutes:grid.10025.36
204 schema:familyName Marson
205 schema:givenName Anthony
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174075734.81
207 rdf:type schema:Person
208 sg:person.01226560701.24 schema:affiliation grid-institutes:grid.10025.36
209 schema:familyName Dixon
210 schema:givenName Pete
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226560701.24
212 rdf:type schema:Person
213 sg:person.01230413744.80 schema:affiliation grid-institutes:grid.417858.7
214 schema:familyName Appleton
215 schema:givenName Richard
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230413744.80
217 rdf:type schema:Person
218 sg:person.01261374732.97 schema:affiliation grid-institutes:grid.10025.36
219 schema:familyName Tudur Smith
220 schema:givenName Catrin
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261374732.97
222 rdf:type schema:Person
223 sg:person.013001137514.52 schema:affiliation grid-institutes:grid.5491.9
224 schema:familyName Tremain
225 schema:givenName Elizabeth
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013001137514.52
227 rdf:type schema:Person
228 sg:person.014257575147.70 schema:affiliation grid-institutes:grid.10025.36
229 schema:familyName Nevitt
230 schema:givenName Sarah
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014257575147.70
232 rdf:type schema:Person
233 sg:pub.10.1186/s12916-015-0532-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1036208262
234 https://doi.org/10.1186/s12916-015-0532-z
235 rdf:type schema:CreativeWork
236 sg:pub.10.1186/s12916-016-0612-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034448822
237 https://doi.org/10.1186/s12916-016-0612-8
238 rdf:type schema:CreativeWork
239 sg:pub.10.1186/s13063-015-0604-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050280001
240 https://doi.org/10.1186/s13063-015-0604-6
241 rdf:type schema:CreativeWork
242 grid-institutes:grid.10025.36 schema:alternateName Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Street, L69 3GL, Liverpool, UK
243 Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
244 schema:name Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Street, L69 3GL, Liverpool, UK
245 Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
246 rdf:type schema:Organization
247 grid-institutes:grid.417858.7 schema:alternateName Alder Hey Children’s NHS Foundation Trust, Liverpool, UK
248 schema:name Alder Hey Children’s NHS Foundation Trust, Liverpool, UK
249 rdf:type schema:Organization
250 grid-institutes:grid.5491.9 schema:alternateName National Institute for Health Research Evaluation, Trials and Studies Coordinating Centre, University of Southampton, Southampton, UK
251 schema:name National Institute for Health Research Evaluation, Trials and Studies Coordinating Centre, University of Southampton, Southampton, UK
252 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...