The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic ... View Full Text


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Article Info

DATE

2017-06-07

AUTHORS

Milad Daneshi-Maskooni, Seyed Ali Keshavarz, Siavash Mansouri, Mostafa Qorbani, Seyed Moayed Alavian, Mahtab Badri-Fariman, Seyed Ali Jazayeri-Tehrani, Gity Sotoudeh

ABSTRACT

BackgroundThe relationship between dietary components and nonalcoholic fatty liver disease (NAFLD) needs to be further investigated. The potential health benefits of cardamom have been found in some studies. Cardamom showed beneficial effect on hepatomegaly, dyslipidemia, and fasting hyperglycemia in animals. However, some adverse effects of cardamom have been reported in animals. No previous human study had been conducted on the effects of cardamom in NAFLD. This study aims to determine the effects of green cardamom (Elettaria cardamomum) supplementation on blood glucose indices, lipids, inflammatory profiles, and liver function, especially by examining irisin, paraxonase-1 (PON1) and sirtuin-1 (Sirt1) in obese patients with NAFLD.MethodsThis trial is to be conducted at the polyclinic of the National Iranian Oil Company (NIOC) Central Hospital, Tehran. Eighty obese patients with NAFLD will be selected according to the eligibility criteria. The NAFLD diagnosis method is ultrasonography. Patients will be randomly divided into two groups by a random-number table (cardamom and placebo groups, two 500-mg capsules, three times/day, taken with meals for 3 months, follow-up monthly). General characteristics, dietary intakes (at the beginning, middle, and end), and physical activity (at the beginning and end) will be assessed using a general, 24-h food recall, and short-form International Physical Activity Questionnaires (IPAQ), respectively. Lifestyle advice will be presented to both groups identically. At the beginning and the end, anthropometrics (weight, height, and waist circumference), blood pressure, extent of fatty liver, and blood biomarkers, including serum glucose indices (fasting blood sugar (FBS)) and insulin (FBI), homeostasis model assessment-insulin resistance (HOMA-IR), Quantitative Insulin Sensitivity Check Index (QUICKI)), lipids (triglyceride (TG), low-density lipoprotein-cholesterol (LDL-c), high-density lipoprotein-cholesterol (HDL-c), total cholesterol (TC)), inflammatory markers (highly sensitive C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6)), liver enzymes (alanine transaminase (ALT), aspartate transaminase (AST)), irisin, PON1, and Sirt1, will be determined.DiscussionThis trial would be the first to assess the effects of green cardamom on several blood factors, including glucose indices, lipids, inflammatory markers, liver enzymes, irisin, PON1, and Sirt1, and blood pressure and anthropometry in obese patients with NAFLD. Further study of cardamom’s potential in improving NAFLD is suggested.Trial registrationIranian Registry of Clinical Trials (IRCT), ID number: IRCT2015121317254N4. Registered on 27 December 2015. More... »

PAGES

260

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13063-017-1979-3

DOI

http://dx.doi.org/10.1186/s13063-017-1979-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085913291

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28592311


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38 schema:description BackgroundThe relationship between dietary components and nonalcoholic fatty liver disease (NAFLD) needs to be further investigated. The potential health benefits of cardamom have been found in some studies. Cardamom showed beneficial effect on hepatomegaly, dyslipidemia, and fasting hyperglycemia in animals. However, some adverse effects of cardamom have been reported in animals. No previous human study had been conducted on the effects of cardamom in NAFLD. This study aims to determine the effects of green cardamom (Elettaria cardamomum) supplementation on blood glucose indices, lipids, inflammatory profiles, and liver function, especially by examining irisin, paraxonase-1 (PON1) and sirtuin-1 (Sirt1) in obese patients with NAFLD.MethodsThis trial is to be conducted at the polyclinic of the National Iranian Oil Company (NIOC) Central Hospital, Tehran. Eighty obese patients with NAFLD will be selected according to the eligibility criteria. The NAFLD diagnosis method is ultrasonography. Patients will be randomly divided into two groups by a random-number table (cardamom and placebo groups, two 500-mg capsules, three times/day, taken with meals for 3 months, follow-up monthly). General characteristics, dietary intakes (at the beginning, middle, and end), and physical activity (at the beginning and end) will be assessed using a general, 24-h food recall, and short-form International Physical Activity Questionnaires (IPAQ), respectively. Lifestyle advice will be presented to both groups identically. At the beginning and the end, anthropometrics (weight, height, and waist circumference), blood pressure, extent of fatty liver, and blood biomarkers, including serum glucose indices (fasting blood sugar (FBS)) and insulin (FBI), homeostasis model assessment-insulin resistance (HOMA-IR), Quantitative Insulin Sensitivity Check Index (QUICKI)), lipids (triglyceride (TG), low-density lipoprotein-cholesterol (LDL-c), high-density lipoprotein-cholesterol (HDL-c), total cholesterol (TC)), inflammatory markers (highly sensitive C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6)), liver enzymes (alanine transaminase (ALT), aspartate transaminase (AST)), irisin, PON1, and Sirt1, will be determined.DiscussionThis trial would be the first to assess the effects of green cardamom on several blood factors, including glucose indices, lipids, inflammatory markers, liver enzymes, irisin, PON1, and Sirt1, and blood pressure and anthropometry in obese patients with NAFLD. Further study of cardamom’s potential in improving NAFLD is suggested.Trial registrationIranian Registry of Clinical Trials (IRCT), ID number: IRCT2015121317254N4. Registered on 27 December 2015.
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45 Central Hospital
46 DiscussionThis trial
47 Further studies
48 ID number
49 International Physical Activity Questionnaire
50 MethodsThis trial
51 Physical Activity Questionnaire
52 SIRT1
53 Tehran
54 activity
55 adverse effects
56 advice
57 animals
58 anthropometric
59 anthropometry
60 assessment-insulin resistance
61 beginning
62 beneficial effects
63 benefits
64 biomarkers
65 blood biomarkers
66 blood factors
67 blood glucose index
68 blood pressure
69 cardamom
70 cardamom supplementation
71 characteristics
72 check index
73 clinical trials
74 components
75 criteria
76 diagnosis method
77 dietary components
78 dietary intake
79 disease
80 dyslipidemia
81 effect
82 effect of cardamom
83 eligibility criteria
84 end
85 enzyme
86 extent
87 factors
88 fatty liver
89 fatty liver disease
90 food recall
91 function
92 general characteristics
93 glucose index
94 green cardamom
95 green cardamom supplementation
96 group
97 health benefits
98 hepatomegaly
99 homeostasis model assessment-insulin resistance
100 hospital
101 human studies
102 hyperglycemia
103 index
104 inflammatory factors
105 inflammatory markers
106 inflammatory profile
107 insulin
108 insulin sensitivity check index
109 intake
110 irisin
111 lifestyle advice
112 lipids
113 liver
114 liver disease
115 liver enzymes
116 liver function
117 markers
118 method
119 model assessment-insulin resistance
120 nonalcoholic fatty liver disease
121 number
122 obese patients
123 obesity
124 paraxonase-1
125 patients
126 physical activity
127 polyclinic
128 potential
129 potential health benefits
130 pressure
131 previous human studies
132 profile
133 protocol
134 quantitative insulin sensitivity check index
135 questionnaire
136 random number table
137 recall
138 registry
139 relationship
140 resistance
141 serum glucose indices
142 short-form International Physical Activity Questionnaire
143 sirtuin 1
144 study
145 supplementation
146 table
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