Efficacy and safety of rapid intermittent correction compared with slow continuous correction with hypertonic saline in patients with moderately severe ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03-29

AUTHORS

Anna Lee, You Hwan Jo, Kyuseok Kim, Soyeon Ahn, Yun Kyu Oh, Huijai Lee, Jonghwan Shin, Ho Jun Chin, Ki Young Na, Jung Bok Lee, Seon Ha Baek, Sejoong Kim

ABSTRACT

BACKGROUND: Hyponatremia is the most common electrolyte imbalance encountered in clinical practice, associated with increased mortality and length of hospital stay. However, no high-quality evidence regarding whether hypertonic saline is best administered as a continuous infusion or a bolus injection has been found to date. Therefore, in the current study, we will evaluate the efficacy and safety of rapid intermittent correction compared with slow continuous correction with hypertonic saline in patients with moderately severe or severe symptomatic hyponatremia. METHODS/DESIGN: This is a prospective, investigator-initiated, multicenter, open-label, randomized controlled study with two experimental therapy groups. A total of 178 patients with severe symptomatic hyponatremia will be enrolled and randomly assigned to receive either rapid intermittent bolus or slow continuous infusion management with hypertonic saline. The primary outcome is the incidence of overcorrection at any given period over 2 days. The secondary outcomes will include the efficacy and safety of two other approaches to the treatment of hyponatremia with 3% hypertonic saline. DISCUSSION: This is the first clinical trial to investigate the efficacy and safety of rapid intermittent correction compared with slow continuous correction with hypertonic saline in patients with moderately severe or severe hyponatremia. TRIAL REGISTRATION: ClinicalTrials.gov, identifier number: NCT02887469 . Registered on 1 August 2016. More... »

PAGES

147

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13063-017-1865-z

DOI

http://dx.doi.org/10.1186/s13063-017-1865-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084252102

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28356136


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clinical Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluid Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hyponatremia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infusions, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Republic of Korea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Research Design", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saline Solution, Hypertonic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sodium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Anna", 
        "id": "sg:person.012035147023.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012035147023.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jo", 
        "givenName": "You Hwan", 
        "id": "sg:person.0664107211.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664107211.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Kyuseok", 
        "id": "sg:person.011016476477.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011016476477.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahn", 
        "givenName": "Soyeon", 
        "id": "sg:person.0612662613.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612662613.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412479.d", 
          "name": [
            "Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oh", 
        "givenName": "Yun Kyu", 
        "id": "sg:person.016536632307.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016536632307.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Emergency Medicine, Seoul National University Boramae Hospital, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412479.d", 
          "name": [
            "Department of Emergency Medicine, Seoul National University Boramae Hospital, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Huijai", 
        "id": "sg:person.01127251066.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127251066.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Emergency Medicine, Seoul National University Boramae Hospital, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412479.d", 
          "name": [
            "Department of Emergency Medicine, Seoul National University Boramae Hospital, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shin", 
        "givenName": "Jonghwan", 
        "id": "sg:person.01253534675.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253534675.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chin", 
        "givenName": "Ho Jun", 
        "id": "sg:person.01253267031.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253267031.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Na", 
        "givenName": "Ki Young", 
        "id": "sg:person.01021265615.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021265615.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jung Bok", 
        "id": "sg:person.0722451412.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722451412.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong-si, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.488450.5", 
          "name": [
            "Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea", 
            "Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong-si, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baek", 
        "givenName": "Seon Ha", 
        "id": "sg:person.01146631605.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146631605.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea", 
          "id": "http://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Sejoong", 
        "id": "sg:person.01234041164.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234041164.22"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11255-004-4770-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036520751", 
          "https://doi.org/10.1007/s11255-004-4770-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11011-010-9173-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034994259", 
          "https://doi.org/10.1007/s11011-010-9173-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-009-1323-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023158217", 
          "https://doi.org/10.1007/s00467-009-1323-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncpneph0526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010182457", 
          "https://doi.org/10.1038/ncpneph0526"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-03-29", 
    "datePublishedReg": "2017-03-29", 
    "description": "BACKGROUND: Hyponatremia is the most common electrolyte imbalance encountered in clinical practice, associated with increased mortality and length of hospital stay. However, no high-quality evidence regarding whether hypertonic saline is best administered as a continuous infusion or a bolus injection has been found to date. Therefore, in the current study, we will evaluate the efficacy and safety of rapid intermittent correction compared with slow continuous correction with hypertonic saline in patients with moderately severe or severe symptomatic hyponatremia.\nMETHODS/DESIGN: This is a prospective, investigator-initiated, multicenter, open-label, randomized controlled study with two experimental therapy groups. A total of 178 patients with severe symptomatic hyponatremia will be enrolled and randomly assigned to receive either rapid intermittent bolus or slow continuous infusion management with hypertonic saline. The primary outcome is the incidence of overcorrection at any given period over 2\u00a0days. The secondary outcomes will include the efficacy and safety of two other approaches to the treatment of hyponatremia with 3% hypertonic saline.\nDISCUSSION: This is the first clinical trial to investigate the efficacy and safety of rapid intermittent correction compared with slow continuous correction with hypertonic saline in patients with moderately severe or severe hyponatremia.\nTRIAL REGISTRATION: ClinicalTrials.gov, identifier number: NCT02887469 . Registered on 1 August 2016.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s13063-017-1865-z", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1297400", 
        "issn": [
          "1468-6708", 
          "1745-6215"
        ], 
        "name": "Trials", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "keywords": [
      "severe symptomatic hyponatremia", 
      "hypertonic saline", 
      "symptomatic hyponatremia", 
      "experimental-therapy group", 
      "incidence of overcorrection", 
      "treatment of hyponatremia", 
      "common electrolyte imbalance", 
      "high-quality evidence", 
      "first clinical trial", 
      "hospital stay", 
      "intermittent bolus", 
      "severe hyponatremia", 
      "Secondary outcomes", 
      "primary outcome", 
      "electrolyte imbalance", 
      "continuous infusion", 
      "clinical trials", 
      "therapy group", 
      "bolus injection", 
      "hyponatremia", 
      "infusion management", 
      "clinical practice", 
      "patients", 
      "identifier number", 
      "saline", 
      "efficacy", 
      "trials", 
      "safety", 
      "outcomes", 
      "current study", 
      "continuous correction", 
      "multicenter", 
      "stay", 
      "infusion", 
      "bolus", 
      "mortality", 
      "incidence", 
      "overcorrection", 
      "injection", 
      "treatment", 
      "intermittent correction", 
      "total", 
      "study", 
      "days", 
      "group", 
      "correction", 
      "evidence", 
      "imbalance", 
      "management", 
      "period", 
      "protocol", 
      "date", 
      "practice", 
      "number", 
      "length", 
      "approach", 
      "rapid intermittent correction", 
      "slow continuous correction", 
      "rapid intermittent bolus", 
      "slow continuous infusion management", 
      "continuous infusion management", 
      "NCT02887469"
    ], 
    "name": "Efficacy and safety of rapid intermittent correction compared with slow continuous correction with hypertonic saline in patients with moderately severe or severe symptomatic hyponatremia: study protocol for a randomized controlled trial (SALSA trial)", 
    "pagination": "147", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084252102"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13063-017-1865-z"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28356136"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13063-017-1865-z", 
      "https://app.dimensions.ai/details/publication/pub.1084252102"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_755.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s13063-017-1865-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13063-017-1865-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13063-017-1865-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13063-017-1865-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13063-017-1865-z'


 

This table displays all metadata directly associated to this object as RDF triples.

289 TRIPLES      22 PREDICATES      106 URIs      94 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13063-017-1865-z schema:about N018615c7041a4da19cacc72c835f02cb
2 N0b4b88d11ff144debd0d5ad8b53a9722
3 N0d42c4a037ab4e7597a3c9e74691eccb
4 N1738944eba8e4402af5fd95588f8ac90
5 N1b4febc33d694e3cae86c341ee06294f
6 N466b64726b18403c8d93f0bb26aaa361
7 N6cb80b80dbc842d3b362c7ccc4755325
8 N7b1b9c6e5c6a40729039a2643cf4490a
9 N94ecfadef254447bb8f4ba5898eeef3d
10 N95eeb751a4f04ee7ae35706685d5214b
11 Nb851bd5b972f48e2993bf828d8a92b1b
12 Nbe8dfbb52f284a4fa5c3fc750ed87842
13 Neea5e7451584452a98c6eb9f4ccba3b9
14 Nf8bfab713e0f4508b75cf05bcd575e25
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N9204f67734f54aaf803232677de2cdaa
18 schema:citation sg:pub.10.1007/s00467-009-1323-6
19 sg:pub.10.1007/s11011-010-9173-2
20 sg:pub.10.1007/s11255-004-4770-9
21 sg:pub.10.1038/ncpneph0526
22 schema:datePublished 2017-03-29
23 schema:datePublishedReg 2017-03-29
24 schema:description BACKGROUND: Hyponatremia is the most common electrolyte imbalance encountered in clinical practice, associated with increased mortality and length of hospital stay. However, no high-quality evidence regarding whether hypertonic saline is best administered as a continuous infusion or a bolus injection has been found to date. Therefore, in the current study, we will evaluate the efficacy and safety of rapid intermittent correction compared with slow continuous correction with hypertonic saline in patients with moderately severe or severe symptomatic hyponatremia. METHODS/DESIGN: This is a prospective, investigator-initiated, multicenter, open-label, randomized controlled study with two experimental therapy groups. A total of 178 patients with severe symptomatic hyponatremia will be enrolled and randomly assigned to receive either rapid intermittent bolus or slow continuous infusion management with hypertonic saline. The primary outcome is the incidence of overcorrection at any given period over 2 days. The secondary outcomes will include the efficacy and safety of two other approaches to the treatment of hyponatremia with 3% hypertonic saline. DISCUSSION: This is the first clinical trial to investigate the efficacy and safety of rapid intermittent correction compared with slow continuous correction with hypertonic saline in patients with moderately severe or severe hyponatremia. TRIAL REGISTRATION: ClinicalTrials.gov, identifier number: NCT02887469 . Registered on 1 August 2016.
25 schema:genre article
26 schema:inLanguage en
27 schema:isAccessibleForFree true
28 schema:isPartOf N5c3ad3eec8fe40f6a5289a8080911c81
29 N6e911fa824834a4d924d5a41785c4698
30 sg:journal.1297400
31 schema:keywords NCT02887469
32 Secondary outcomes
33 approach
34 bolus
35 bolus injection
36 clinical practice
37 clinical trials
38 common electrolyte imbalance
39 continuous correction
40 continuous infusion
41 continuous infusion management
42 correction
43 current study
44 date
45 days
46 efficacy
47 electrolyte imbalance
48 evidence
49 experimental-therapy group
50 first clinical trial
51 group
52 high-quality evidence
53 hospital stay
54 hypertonic saline
55 hyponatremia
56 identifier number
57 imbalance
58 incidence
59 incidence of overcorrection
60 infusion
61 infusion management
62 injection
63 intermittent bolus
64 intermittent correction
65 length
66 management
67 mortality
68 multicenter
69 number
70 outcomes
71 overcorrection
72 patients
73 period
74 practice
75 primary outcome
76 protocol
77 rapid intermittent bolus
78 rapid intermittent correction
79 safety
80 saline
81 severe hyponatremia
82 severe symptomatic hyponatremia
83 slow continuous correction
84 slow continuous infusion management
85 stay
86 study
87 symptomatic hyponatremia
88 therapy group
89 total
90 treatment
91 treatment of hyponatremia
92 trials
93 schema:name Efficacy and safety of rapid intermittent correction compared with slow continuous correction with hypertonic saline in patients with moderately severe or severe symptomatic hyponatremia: study protocol for a randomized controlled trial (SALSA trial)
94 schema:pagination 147
95 schema:productId N1b3f996836b940efa6cc97093347eda7
96 N20e521ddf86d44f7aed879144ebf69d7
97 Na34ed1eba1744a48a4026481852202ef
98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084252102
99 https://doi.org/10.1186/s13063-017-1865-z
100 schema:sdDatePublished 2022-01-01T18:47
101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
102 schema:sdPublisher N33fed5b7783746498c867dc61dfc4461
103 schema:url https://doi.org/10.1186/s13063-017-1865-z
104 sgo:license sg:explorer/license/
105 sgo:sdDataset articles
106 rdf:type schema:ScholarlyArticle
107 N018615c7041a4da19cacc72c835f02cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Prospective Studies
109 rdf:type schema:DefinedTerm
110 N07a2478facb54f0fa19428da863f6857 rdf:first sg:person.016536632307.50
111 rdf:rest N77b21473ad2242159b873e3c842f3fe1
112 N0b4b88d11ff144debd0d5ad8b53a9722 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Treatment Outcome
114 rdf:type schema:DefinedTerm
115 N0d42c4a037ab4e7597a3c9e74691eccb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Severity of Illness Index
117 rdf:type schema:DefinedTerm
118 N1738944eba8e4402af5fd95588f8ac90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Republic of Korea
120 rdf:type schema:DefinedTerm
121 N1b3f996836b940efa6cc97093347eda7 schema:name dimensions_id
122 schema:value pub.1084252102
123 rdf:type schema:PropertyValue
124 N1b4febc33d694e3cae86c341ee06294f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Sodium
126 rdf:type schema:DefinedTerm
127 N20e521ddf86d44f7aed879144ebf69d7 schema:name pubmed_id
128 schema:value 28356136
129 rdf:type schema:PropertyValue
130 N2f490b579faa4775ba880559d2d84c64 rdf:first sg:person.011016476477.19
131 rdf:rest Na0a3ff6dbb9c4eee892b6fa215fd7410
132 N33fed5b7783746498c867dc61dfc4461 schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 N466b64726b18403c8d93f0bb26aaa361 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Clinical Protocols
136 rdf:type schema:DefinedTerm
137 N4d0ab1c0f0eb4fe8a4b3aae5a735358a rdf:first sg:person.0664107211.23
138 rdf:rest N2f490b579faa4775ba880559d2d84c64
139 N551c469a36d04810bcc994e33aaac84f rdf:first sg:person.01234041164.22
140 rdf:rest rdf:nil
141 N55ad0520987f465b98e56f4c078a0c18 rdf:first sg:person.01253534675.01
142 rdf:rest N59062a0c1a5f4e4a8ec6534b37d80518
143 N59062a0c1a5f4e4a8ec6534b37d80518 rdf:first sg:person.01253267031.10
144 rdf:rest N95da80d79444450dbbfbe8f6b7bce5f4
145 N5c3ad3eec8fe40f6a5289a8080911c81 schema:volumeNumber 18
146 rdf:type schema:PublicationVolume
147 N6cb80b80dbc842d3b362c7ccc4755325 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Biomarkers
149 rdf:type schema:DefinedTerm
150 N6e911fa824834a4d924d5a41785c4698 schema:issueNumber 1
151 rdf:type schema:PublicationIssue
152 N77b21473ad2242159b873e3c842f3fe1 rdf:first sg:person.01127251066.57
153 rdf:rest N55ad0520987f465b98e56f4c078a0c18
154 N7b1b9c6e5c6a40729039a2643cf4490a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Saline Solution, Hypertonic
156 rdf:type schema:DefinedTerm
157 N7c50024d2d4e4dedabb2c34cfecea090 rdf:first sg:person.01146631605.34
158 rdf:rest N551c469a36d04810bcc994e33aaac84f
159 N9204f67734f54aaf803232677de2cdaa rdf:first sg:person.012035147023.58
160 rdf:rest N4d0ab1c0f0eb4fe8a4b3aae5a735358a
161 N94ecfadef254447bb8f4ba5898eeef3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Hyponatremia
163 rdf:type schema:DefinedTerm
164 N95da80d79444450dbbfbe8f6b7bce5f4 rdf:first sg:person.01021265615.43
165 rdf:rest Nf57fd3e8c9cc4d41950c04f4cb56efcd
166 N95eeb751a4f04ee7ae35706685d5214b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Time Factors
168 rdf:type schema:DefinedTerm
169 Na0a3ff6dbb9c4eee892b6fa215fd7410 rdf:first sg:person.0612662613.04
170 rdf:rest N07a2478facb54f0fa19428da863f6857
171 Na34ed1eba1744a48a4026481852202ef schema:name doi
172 schema:value 10.1186/s13063-017-1865-z
173 rdf:type schema:PropertyValue
174 Nb851bd5b972f48e2993bf828d8a92b1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Humans
176 rdf:type schema:DefinedTerm
177 Nbe8dfbb52f284a4fa5c3fc750ed87842 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Infusions, Intravenous
179 rdf:type schema:DefinedTerm
180 Neea5e7451584452a98c6eb9f4ccba3b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Research Design
182 rdf:type schema:DefinedTerm
183 Nf57fd3e8c9cc4d41950c04f4cb56efcd rdf:first sg:person.0722451412.90
184 rdf:rest N7c50024d2d4e4dedabb2c34cfecea090
185 Nf8bfab713e0f4508b75cf05bcd575e25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Fluid Therapy
187 rdf:type schema:DefinedTerm
188 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
189 schema:name Medical and Health Sciences
190 rdf:type schema:DefinedTerm
191 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
192 schema:name Clinical Sciences
193 rdf:type schema:DefinedTerm
194 sg:journal.1297400 schema:issn 1468-6708
195 1745-6215
196 schema:name Trials
197 schema:publisher Springer Nature
198 rdf:type schema:Periodical
199 sg:person.01021265615.43 schema:affiliation grid-institutes:grid.412480.b
200 schema:familyName Na
201 schema:givenName Ki Young
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021265615.43
203 rdf:type schema:Person
204 sg:person.011016476477.19 schema:affiliation grid-institutes:grid.412480.b
205 schema:familyName Kim
206 schema:givenName Kyuseok
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011016476477.19
208 rdf:type schema:Person
209 sg:person.01127251066.57 schema:affiliation grid-institutes:grid.412479.d
210 schema:familyName Lee
211 schema:givenName Huijai
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127251066.57
213 rdf:type schema:Person
214 sg:person.01146631605.34 schema:affiliation grid-institutes:grid.488450.5
215 schema:familyName Baek
216 schema:givenName Seon Ha
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146631605.34
218 rdf:type schema:Person
219 sg:person.012035147023.58 schema:affiliation grid-institutes:grid.412480.b
220 schema:familyName Lee
221 schema:givenName Anna
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012035147023.58
223 rdf:type schema:Person
224 sg:person.01234041164.22 schema:affiliation grid-institutes:grid.412480.b
225 schema:familyName Kim
226 schema:givenName Sejoong
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234041164.22
228 rdf:type schema:Person
229 sg:person.01253267031.10 schema:affiliation grid-institutes:grid.412480.b
230 schema:familyName Chin
231 schema:givenName Ho Jun
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253267031.10
233 rdf:type schema:Person
234 sg:person.01253534675.01 schema:affiliation grid-institutes:grid.412479.d
235 schema:familyName Shin
236 schema:givenName Jonghwan
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253534675.01
238 rdf:type schema:Person
239 sg:person.016536632307.50 schema:affiliation grid-institutes:grid.412479.d
240 schema:familyName Oh
241 schema:givenName Yun Kyu
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016536632307.50
243 rdf:type schema:Person
244 sg:person.0612662613.04 schema:affiliation grid-institutes:grid.412480.b
245 schema:familyName Ahn
246 schema:givenName Soyeon
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612662613.04
248 rdf:type schema:Person
249 sg:person.0664107211.23 schema:affiliation grid-institutes:grid.412480.b
250 schema:familyName Jo
251 schema:givenName You Hwan
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664107211.23
253 rdf:type schema:Person
254 sg:person.0722451412.90 schema:affiliation grid-institutes:grid.413967.e
255 schema:familyName Lee
256 schema:givenName Jung Bok
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722451412.90
258 rdf:type schema:Person
259 sg:pub.10.1007/s00467-009-1323-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023158217
260 https://doi.org/10.1007/s00467-009-1323-6
261 rdf:type schema:CreativeWork
262 sg:pub.10.1007/s11011-010-9173-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034994259
263 https://doi.org/10.1007/s11011-010-9173-2
264 rdf:type schema:CreativeWork
265 sg:pub.10.1007/s11255-004-4770-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036520751
266 https://doi.org/10.1007/s11255-004-4770-9
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/ncpneph0526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010182457
269 https://doi.org/10.1038/ncpneph0526
270 rdf:type schema:CreativeWork
271 grid-institutes:grid.412479.d schema:alternateName Department of Emergency Medicine, Seoul National University Boramae Hospital, Seoul, Republic of Korea
272 Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul, Republic of Korea
273 schema:name Department of Emergency Medicine, Seoul National University Boramae Hospital, Seoul, Republic of Korea
274 Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul, Republic of Korea
275 rdf:type schema:Organization
276 grid-institutes:grid.412480.b schema:alternateName Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
277 Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
278 Department of Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
279 schema:name Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
280 Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
281 Department of Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
282 rdf:type schema:Organization
283 grid-institutes:grid.413967.e schema:alternateName Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea
284 schema:name Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea
285 rdf:type schema:Organization
286 grid-institutes:grid.488450.5 schema:alternateName Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong-si, Republic of Korea
287 schema:name Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong-si, Republic of Korea
288 Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
289 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...