Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial—PROSPECT: a pilot trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-08-02

AUTHORS

Deborah J. Cook, Jennie Johnstone, John C. Marshall, Francois Lauzier, Lehana Thabane, Sangeeta Mehta, Peter M. Dodek, Lauralyn McIntyre, Joe Pagliarello, William Henderson, Robert W. Taylor, Rodrigo Cartin-Ceba, Eyal Golan, Margaret Herridge, Gordon Wood, Daniel Ovakim, Tim Karachi, Michael G. Surette, Dawn M. E. Bowdish, Daphnee Lamarche, Chris P. Verschoor, Erick H. Duan, Diane Heels-Ansdell, Yaseen Arabi, Maureen Meade,

ABSTRACT

BACKGROUND: Probiotics are live microorganisms that may confer health benefits when ingested. Randomized trials suggest that probiotics significantly decrease the incidence of ventilator-associated pneumonia (VAP) and the overall incidence of infection in critically ill patients. However, these studies are small, largely single-center, and at risk of bias. The aim of the PROSPECT pilot trial was to determine the feasibility of conducting a larger trial of probiotics to prevent VAP in mechanically ventilated patients in the intensive care unit (ICU). METHODS: In a randomized blinded trial, patients expected to be mechanically ventilated for ≥72 hours were allocated to receive either 1 × 10(10) colony-forming units of Lactobacillus rhamnosus GG or placebo, twice daily. Patients were excluded if they were at increased risk of L. rhamnosus GG infection or had contraindications to enteral medication. Feasibility objectives were: (1) timely recruitment; (2) maximal protocol adherence; (3) minimal contamination; and (4) estimated VAP rate ≥10 %. We also measured other infections, diarrhea, ICU and hospital length of stay, and mortality. RESULTS: Overall, in 14 centers in Canada and the USA, all feasibility goals were met: (1) 150 patients were randomized in 1 year; (2) protocol adherence was 97 %; (3) no patients received open-label probiotics; and (4) the VAP rate was 19 %. Other infections included: bloodstream infection (19.3 %), urinary tract infections (12.7 %), and skin and soft tissue infections (4.0 %). Diarrhea, defined as Bristol type 6 or 7 stools, occurred in 133 (88.7 %) of patients, the median length of stay in ICU was 12 days (quartile 1 to quartile 3, 7-18 days), and in hospital was 26 days (quartile 1 to quartile 3, 14-44 days); 23 patients (15.3 %) died in the ICU. CONCLUSIONS: The PROSPECT pilot trial supports the feasibility of a larger trial to investigate the effect of L. rhamnosus GG on VAP and other nosocomial infections in critically ill patients. TRIAL REGISTRATION: Clinicaltrials.gov NCT01782755 . Registered on 29 January 2013. More... »

PAGES

377

Journal

TITLE

Trials

ISSUE

1

VOLUME

17

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13063-016-1495-x

DOI

http://dx.doi.org/10.1186/s13063-016-1495-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012552300

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27480757


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Canada", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feasibility Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hospital Mortality", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intensive Care Units", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intubation, Intratracheal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lactobacillus rhamnosus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Length of Stay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pilot Projects", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pneumonia, Bacterial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pneumonia, Ventilator-Associated", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Probiotics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trachea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "United States", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON Canada", 
          "id": "http://www.grid.ac/institutes/grid.25073.33", 
          "name": [
            "Department of Medicine, McMaster University, McMaster Health Sciences Center, Room 2C11, 1200 Main Street W, Hamilton, ON Canada", 
            "Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cook", 
        "givenName": "Deborah J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, University of Toronto, Toronto, ON Canada", 
          "id": "http://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Public Health Ontario, Toronto, ON Canada", 
            "St. Joseph\u2019s Health Center, Toronto, ON Canada", 
            "Department of Medicine, University of Toronto, Toronto, ON Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnstone", 
        "givenName": "Jennie", 
        "id": "sg:person.0710523652.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710523652.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON Canada", 
          "id": "http://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Surgery, University of Toronto, Toronto, ON Canada", 
            "Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marshall", 
        "givenName": "John C.", 
        "id": "sg:person.01064471126.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064471126.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anesthesiology and Critical Care, Universit\u00e9 Laval, Quebec City, QC Canada", 
          "id": "http://www.grid.ac/institutes/grid.23856.3a", 
          "name": [
            "Research Center of the CHU de Qu\u00e9bec \u2013 Population Health and Optimal Health Practices Research Unit, Universit\u00e9 Laval, Quebec City, QC Canada", 
            "Department of Medicine, Universit\u00e9 Laval, Quebec City, QC Canada", 
            "Department of Anesthesiology and Critical Care, Universit\u00e9 Laval, Quebec City, QC Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lauzier", 
        "givenName": "Francois", 
        "id": "sg:person.01066142337.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066142337.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON Canada", 
          "id": "http://www.grid.ac/institutes/grid.25073.33", 
          "name": [
            "Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thabane", 
        "givenName": "Lehana", 
        "id": "sg:person.01016450746.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016450746.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON Canada", 
          "id": "http://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Medicine, University of Toronto, Toronto, ON Canada", 
            "Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mehta", 
        "givenName": "Sangeeta", 
        "id": "sg:person.01244447225.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244447225.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Health Evaluation and Outcome Sciences, St. Paul\u2019s Hospital and University of British Columbia, Vancouver, BC Canada", 
          "id": "http://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Division of Critical Care Medicine, St. Paul\u2019s Hospital and University of British Columbia, Vancouver, BC Canada", 
            "Center for Health Evaluation and Outcome Sciences, St. Paul\u2019s Hospital and University of British Columbia, Vancouver, BC Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dodek", 
        "givenName": "Peter M.", 
        "id": "sg:person.01010333011.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010333011.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Critical Care, University of Ottawa, Ottawa, ON Canada", 
          "id": "http://www.grid.ac/institutes/grid.28046.38", 
          "name": [
            "Division of Critical Care, University of Ottawa, Ottawa, ON Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McIntyre", 
        "givenName": "Lauralyn", 
        "id": "sg:person.01115205001.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115205001.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Critical Care, University of Ottawa, Ottawa, ON Canada", 
          "id": "http://www.grid.ac/institutes/grid.28046.38", 
          "name": [
            "Division of Critical Care, University of Ottawa, Ottawa, ON Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pagliarello", 
        "givenName": "Joe", 
        "id": "sg:person.01045636035.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045636035.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Critical Care Medicine, Vancouver General Hospital, Vancouver, BC Canada", 
          "id": "http://www.grid.ac/institutes/grid.412541.7", 
          "name": [
            "Division of Critical Care Medicine, Vancouver General Hospital, Vancouver, BC Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Henderson", 
        "givenName": "William", 
        "id": "sg:person.01133755556.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133755556.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Critical Care Medicine, Mercy Hospital, St Louis, MO USA", 
          "id": "http://www.grid.ac/institutes/grid.416435.1", 
          "name": [
            "Department of Critical Care Medicine, Mercy Hospital, St Louis, MO USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taylor", 
        "givenName": "Robert W.", 
        "id": "sg:person.0771562350.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771562350.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN USA", 
          "id": "http://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cartin-Ceba", 
        "givenName": "Rodrigo", 
        "id": "sg:person.01065274412.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065274412.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON Canada", 
          "id": "http://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Medicine, University of Toronto, Toronto, ON Canada", 
            "Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Golan", 
        "givenName": "Eyal", 
        "id": "sg:person.01131400212.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131400212.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON Canada", 
          "id": "http://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Medicine, University of Toronto, Toronto, ON Canada", 
            "Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Herridge", 
        "givenName": "Margaret", 
        "id": "sg:person.01353230623.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353230623.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anesthesia & Critical Care, Vancouver Island Health Authority, Victoria, BC Canada", 
          "id": "http://www.grid.ac/institutes/grid.417249.d", 
          "name": [
            "Department of Anesthesia & Critical Care, Vancouver Island Health Authority, Victoria, BC Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wood", 
        "givenName": "Gordon", 
        "id": "sg:person.01213746236.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213746236.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anesthesia & Critical Care, Vancouver Island Health Authority, Victoria, BC Canada", 
          "id": "http://www.grid.ac/institutes/grid.417249.d", 
          "name": [
            "Department of Anesthesia & Critical Care, Vancouver Island Health Authority, Victoria, BC Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ovakim", 
        "givenName": "Daniel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, McMaster University, McMaster Health Sciences Center, Room 2C11, 1200 Main Street W, Hamilton, ON Canada", 
          "id": "http://www.grid.ac/institutes/grid.25073.33", 
          "name": [
            "Department of Medicine, McMaster University, McMaster Health Sciences Center, Room 2C11, 1200 Main Street W, Hamilton, ON Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karachi", 
        "givenName": "Tim", 
        "id": "sg:person.01235004225.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235004225.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, McMaster University, McMaster Health Sciences Center, Room 2C11, 1200 Main Street W, Hamilton, ON Canada", 
          "id": "http://www.grid.ac/institutes/grid.25073.33", 
          "name": [
            "Department of Medicine, McMaster University, McMaster Health Sciences Center, Room 2C11, 1200 Main Street W, Hamilton, ON Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Surette", 
        "givenName": "Michael G.", 
        "id": "sg:person.01237160221.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237160221.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON Canada", 
          "id": "http://www.grid.ac/institutes/grid.25073.33", 
          "name": [
            "Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bowdish", 
        "givenName": "Dawn M. E.", 
        "id": "sg:person.01201465765.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201465765.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biochemistry and Biomedical Sciences Department, McMaster University, Hamilton, ON Canada", 
          "id": "http://www.grid.ac/institutes/grid.25073.33", 
          "name": [
            "Biochemistry and Biomedical Sciences Department, McMaster University, Hamilton, ON Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lamarche", 
        "givenName": "Daphnee", 
        "id": "sg:person.01315711766.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315711766.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON Canada", 
          "id": "http://www.grid.ac/institutes/grid.25073.33", 
          "name": [
            "Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verschoor", 
        "givenName": "Chris P.", 
        "id": "sg:person.01065237365.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065237365.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, McMaster University, McMaster Health Sciences Center, Room 2C11, 1200 Main Street W, Hamilton, ON Canada", 
          "id": "http://www.grid.ac/institutes/grid.25073.33", 
          "name": [
            "Department of Medicine, McMaster University, McMaster Health Sciences Center, Room 2C11, 1200 Main Street W, Hamilton, ON Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Duan", 
        "givenName": "Erick H.", 
        "id": "sg:person.0623423152.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623423152.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON Canada", 
          "id": "http://www.grid.ac/institutes/grid.25073.33", 
          "name": [
            "Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heels-Ansdell", 
        "givenName": "Diane", 
        "id": "sg:person.01010170325.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010170325.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.412149.b", 
          "name": [
            "King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arabi", 
        "givenName": "Yaseen", 
        "id": "sg:person.01233210151.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233210151.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON Canada", 
          "id": "http://www.grid.ac/institutes/grid.25073.33", 
          "name": [
            "Department of Medicine, McMaster University, McMaster Health Sciences Center, Room 2C11, 1200 Main Street W, Hamilton, ON Canada", 
            "Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meade", 
        "givenName": "Maureen", 
        "id": "sg:person.01316617337.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316617337.49"
        ], 
        "type": "Person"
      }, 
      {}
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1471-2288-10-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032642219", 
          "https://doi.org/10.1186/1471-2288-10-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc12832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029510016", 
          "https://doi.org/10.1186/cc12832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40814-015-0013-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037826788", 
          "https://doi.org/10.1186/s40814-015-0013-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002018-199410020-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042571161", 
          "https://doi.org/10.2165/00002018-199410020-00001"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-08-02", 
    "datePublishedReg": "2016-08-02", 
    "description": "BACKGROUND: Probiotics are live microorganisms that may confer health benefits when ingested. Randomized trials suggest that probiotics significantly decrease the incidence of ventilator-associated pneumonia (VAP) and the overall incidence of infection in critically ill patients. However, these studies are small, largely single-center, and at risk of bias. The aim of the PROSPECT pilot trial was to determine the feasibility of conducting a larger trial of probiotics to prevent VAP in mechanically ventilated patients in the intensive care unit (ICU).\nMETHODS: In a randomized blinded trial, patients expected to be mechanically ventilated for \u226572\u00a0hours were allocated to receive either 1\u2009\u00d7\u200910(10) colony-forming units of Lactobacillus rhamnosus GG or placebo, twice daily. Patients were excluded if they were at increased risk of L. rhamnosus GG infection or had contraindications to enteral medication. Feasibility objectives were: (1) timely recruitment; (2) maximal protocol adherence; (3) minimal contamination; and (4) estimated VAP rate \u226510\u00a0%. We also measured other infections, diarrhea, ICU and hospital length of stay, and mortality.\nRESULTS: Overall, in 14 centers in Canada and the USA, all feasibility goals were met: (1) 150 patients were randomized in 1\u00a0year; (2) protocol adherence was 97\u00a0%; (3) no patients received open-label probiotics; and (4) the VAP rate was 19\u00a0%. Other infections included: bloodstream infection (19.3\u00a0%), urinary tract infections (12.7\u00a0%), and skin and soft tissue infections (4.0\u00a0%). Diarrhea, defined as Bristol type 6 or 7 stools, occurred in 133 (88.7\u00a0%) of patients, the median length of stay in ICU was 12\u00a0days (quartile 1 to quartile 3, 7-18 days), and in hospital was 26\u00a0days (quartile 1 to quartile 3, 14-44 days); 23 patients (15.3\u00a0%) died in the ICU.\nCONCLUSIONS: The PROSPECT pilot trial supports the feasibility of a larger trial to investigate the effect of L. rhamnosus GG on VAP and other nosocomial infections in critically ill patients.\nTRIAL REGISTRATION: Clinicaltrials.gov NCT01782755 . Registered on 29 January 2013.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s13063-016-1495-x", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1297400", 
        "issn": [
          "1468-6708", 
          "1745-6215"
        ], 
        "name": "Trials", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "keywords": [
      "intensive care unit", 
      "ventilator-associated pneumonia", 
      "pilot trial", 
      "VAP rates", 
      "ill patients", 
      "large trials", 
      "protocol adherence", 
      "randomized blinded trial", 
      "urinary tract infection", 
      "soft tissue infections", 
      "risk of bias", 
      "enteral medications", 
      "hospital length", 
      "tract infections", 
      "randomized trials", 
      "overall incidence", 
      "tissue infections", 
      "care unit", 
      "bloodstream infections", 
      "severe pneumonia", 
      "median length", 
      "blinded trial", 
      "feasibility objectives", 
      "nosocomial infections", 
      "patients", 
      "feasibility goals", 
      "infection", 
      "type 6", 
      "colony-forming units", 
      "trials", 
      "health benefits", 
      "live microorganisms", 
      "probiotics", 
      "pneumonia", 
      "diarrhea", 
      "stay", 
      "incidence", 
      "timely recruitment", 
      "adherence", 
      "risk", 
      "days", 
      "placebo", 
      "contraindications", 
      "medications", 
      "stool", 
      "hospital", 
      "mortality", 
      "prevention", 
      "GG", 
      "skin", 
      "rate", 
      "hours", 
      "minimal contamination", 
      "Lactobacillus", 
      "aim", 
      "years", 
      "recruitment", 
      "study", 
      "center", 
      "feasibility", 
      "units", 
      "benefits", 
      "effect", 
      "length", 
      "objective", 
      "bias", 
      "Canada", 
      "microorganisms", 
      "goal", 
      "USA", 
      "contamination", 
      "PROSPECT pilot trial", 
      "rhamnosus GG infection", 
      "GG infection", 
      "maximal protocol adherence", 
      "open-label probiotics", 
      "Bristol type 6", 
      "NCT01782755", 
      "Endotracheal Colonization Trial\u2014PROSPECT", 
      "Colonization Trial\u2014PROSPECT", 
      "Trial\u2014PROSPECT"
    ], 
    "name": "Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial\u2014PROSPECT: a pilot trial", 
    "pagination": "377", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012552300"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13063-016-1495-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27480757"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13063-016-1495-x", 
      "https://app.dimensions.ai/details/publication/pub.1012552300"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_708.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s13063-016-1495-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13063-016-1495-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13063-016-1495-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13063-016-1495-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13063-016-1495-x'


 

This table displays all metadata directly associated to this object as RDF triples.

460 TRIPLES      22 PREDICATES      134 URIs      121 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13063-016-1495-x schema:about N127d6f2152f7437186f1473aea331e59
2 N2173c163122e4441ace29324503763af
3 N2e706b6a3610403f9ba6c611ebeb755d
4 N313e4fb51a574892ad53f2202440173b
5 N36d809af937340a7b1b83f745221e013
6 N4454827c1215465b89859029c352a278
7 N457d41e0d6a0404ca95732e8ecdb0b30
8 N500667d8ac58485bafec5b14d23adb59
9 N5b5db10b70e2432b91f9182e7c8ff371
10 N5ebfb6fe68a34a39811e1c8771293d62
11 N5f61e29deb4f4c16830b3e36cf224d0a
12 N6a86aeda201647df8a61d074f09a56f1
13 N872f09d341ff4bde89b9eb7170ce155c
14 N885144f3164c4b9a8c236c3438affae0
15 N9d03711a83e745d1aa34891f780ae369
16 Naa468ef1d99f42cf8fb86c72fc8a795b
17 Naad38fa4e2c34623a226ab0a116b880c
18 Nb0a40ce974344fb7ab9d81f9b1e16473
19 Nc074a7c6702f4602890c158791fa0f81
20 Ndea4494fe3cc4ce7a7e0b822f9ba6b21
21 Ne4ee330f7cb94ace9417564b60fe7742
22 Nff34152d23ba4b5097c96529acdf4bfe
23 anzsrc-for:11
24 anzsrc-for:1103
25 anzsrc-for:1117
26 schema:author N4047db893c8d45aeab18ef4a4c59e33b
27 schema:citation sg:pub.10.1186/1471-2288-10-1
28 sg:pub.10.1186/cc12832
29 sg:pub.10.1186/s40814-015-0013-3
30 sg:pub.10.2165/00002018-199410020-00001
31 schema:datePublished 2016-08-02
32 schema:datePublishedReg 2016-08-02
33 schema:description BACKGROUND: Probiotics are live microorganisms that may confer health benefits when ingested. Randomized trials suggest that probiotics significantly decrease the incidence of ventilator-associated pneumonia (VAP) and the overall incidence of infection in critically ill patients. However, these studies are small, largely single-center, and at risk of bias. The aim of the PROSPECT pilot trial was to determine the feasibility of conducting a larger trial of probiotics to prevent VAP in mechanically ventilated patients in the intensive care unit (ICU). METHODS: In a randomized blinded trial, patients expected to be mechanically ventilated for ≥72 hours were allocated to receive either 1 × 10(10) colony-forming units of Lactobacillus rhamnosus GG or placebo, twice daily. Patients were excluded if they were at increased risk of L. rhamnosus GG infection or had contraindications to enteral medication. Feasibility objectives were: (1) timely recruitment; (2) maximal protocol adherence; (3) minimal contamination; and (4) estimated VAP rate ≥10 %. We also measured other infections, diarrhea, ICU and hospital length of stay, and mortality. RESULTS: Overall, in 14 centers in Canada and the USA, all feasibility goals were met: (1) 150 patients were randomized in 1 year; (2) protocol adherence was 97 %; (3) no patients received open-label probiotics; and (4) the VAP rate was 19 %. Other infections included: bloodstream infection (19.3 %), urinary tract infections (12.7 %), and skin and soft tissue infections (4.0 %). Diarrhea, defined as Bristol type 6 or 7 stools, occurred in 133 (88.7 %) of patients, the median length of stay in ICU was 12 days (quartile 1 to quartile 3, 7-18 days), and in hospital was 26 days (quartile 1 to quartile 3, 14-44 days); 23 patients (15.3 %) died in the ICU. CONCLUSIONS: The PROSPECT pilot trial supports the feasibility of a larger trial to investigate the effect of L. rhamnosus GG on VAP and other nosocomial infections in critically ill patients. TRIAL REGISTRATION: Clinicaltrials.gov NCT01782755 . Registered on 29 January 2013.
34 schema:genre article
35 schema:inLanguage en
36 schema:isAccessibleForFree true
37 schema:isPartOf N63be0dfb599a483caf8ff4876ef01611
38 Ncebff597722c4b459d4311cf70b32a76
39 sg:journal.1297400
40 schema:keywords Bristol type 6
41 Canada
42 Colonization Trial—PROSPECT
43 Endotracheal Colonization Trial—PROSPECT
44 GG
45 GG infection
46 Lactobacillus
47 NCT01782755
48 PROSPECT pilot trial
49 Trial—PROSPECT
50 USA
51 VAP rates
52 adherence
53 aim
54 benefits
55 bias
56 blinded trial
57 bloodstream infections
58 care unit
59 center
60 colony-forming units
61 contamination
62 contraindications
63 days
64 diarrhea
65 effect
66 enteral medications
67 feasibility
68 feasibility goals
69 feasibility objectives
70 goal
71 health benefits
72 hospital
73 hospital length
74 hours
75 ill patients
76 incidence
77 infection
78 intensive care unit
79 large trials
80 length
81 live microorganisms
82 maximal protocol adherence
83 median length
84 medications
85 microorganisms
86 minimal contamination
87 mortality
88 nosocomial infections
89 objective
90 open-label probiotics
91 overall incidence
92 patients
93 pilot trial
94 placebo
95 pneumonia
96 prevention
97 probiotics
98 protocol adherence
99 randomized blinded trial
100 randomized trials
101 rate
102 recruitment
103 rhamnosus GG infection
104 risk
105 risk of bias
106 severe pneumonia
107 skin
108 soft tissue infections
109 stay
110 stool
111 study
112 timely recruitment
113 tissue infections
114 tract infections
115 trials
116 type 6
117 units
118 urinary tract infection
119 ventilator-associated pneumonia
120 years
121 schema:name Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial—PROSPECT: a pilot trial
122 schema:pagination 377
123 schema:productId N3abc65a4b7144952b3b8fe67c6bbb918
124 N58b5fd4bb6cf43ee8fd1926797b9e1ef
125 Nd84cc0effc5244ec944fc64d964c0b8f
126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012552300
127 https://doi.org/10.1186/s13063-016-1495-x
128 schema:sdDatePublished 2021-12-01T19:37
129 schema:sdLicense https://scigraph.springernature.com/explorer/license/
130 schema:sdPublisher N09a940a209a149a19ff571c09ce366d2
131 schema:url https://doi.org/10.1186/s13063-016-1495-x
132 sgo:license sg:explorer/license/
133 sgo:sdDataset articles
134 rdf:type schema:ScholarlyArticle
135 N05bc535106614d6c97a0ebbfed01117e schema:affiliation grid-institutes:grid.25073.33
136 schema:familyName Cook
137 schema:givenName Deborah J.
138 rdf:type schema:Person
139 N09a940a209a149a19ff571c09ce366d2 schema:name Springer Nature - SN SciGraph project
140 rdf:type schema:Organization
141 N0b9f3d657b0b4795ad8df2026d7edfb3 rdf:first sg:person.01010333011.45
142 rdf:rest Naca8c4e995d1418894d2a12ae82425d0
143 N0ffdb005358f461ab0b6de49fae1690b rdf:first sg:person.01016450746.82
144 rdf:rest N798943152a6742938e51bcfed2c60c72
145 N127d6f2152f7437186f1473aea331e59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Pneumonia, Ventilator-Associated
147 rdf:type schema:DefinedTerm
148 N169ab3b3c8764bc3acbe4ad9905f1b41 rdf:first N8e1081ac971544c6b7bd8c661e443e59
149 rdf:rest rdf:nil
150 N1a6800ac249644c1845ab403bb87cd31 rdf:first sg:person.01315711766.51
151 rdf:rest Ncdf1690a9645409aa73439a6fc8271a2
152 N2173c163122e4441ace29324503763af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Adult
154 rdf:type schema:DefinedTerm
155 N2842f35b224d4991b9c1a8b6fdb6a4bd rdf:first sg:person.01235004225.73
156 rdf:rest Nf50376011cd04661a773a545c62b1d5d
157 N2d3ed15fb693442f8e19fecca71db257 schema:affiliation grid-institutes:grid.417249.d
158 schema:familyName Ovakim
159 schema:givenName Daniel
160 rdf:type schema:Person
161 N2e706b6a3610403f9ba6c611ebeb755d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Probiotics
163 rdf:type schema:DefinedTerm
164 N313e4fb51a574892ad53f2202440173b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Male
166 rdf:type schema:DefinedTerm
167 N36d809af937340a7b1b83f745221e013 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Length of Stay
169 rdf:type schema:DefinedTerm
170 N3721cc1ea33846a989694ee3c8f98184 rdf:first N2d3ed15fb693442f8e19fecca71db257
171 rdf:rest N2842f35b224d4991b9c1a8b6fdb6a4bd
172 N3abc65a4b7144952b3b8fe67c6bbb918 schema:name doi
173 schema:value 10.1186/s13063-016-1495-x
174 rdf:type schema:PropertyValue
175 N4047db893c8d45aeab18ef4a4c59e33b rdf:first N05bc535106614d6c97a0ebbfed01117e
176 rdf:rest N66b2946b5b9e4538a428502c5bdd87b9
177 N43b999c95d624a1e8da11b1e6e2c3cd2 rdf:first sg:person.01131400212.25
178 rdf:rest N4e52d9a365074e11b3f857ae285cb0df
179 N4454827c1215465b89859029c352a278 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name United States
181 rdf:type schema:DefinedTerm
182 N457d41e0d6a0404ca95732e8ecdb0b30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Hospital Mortality
184 rdf:type schema:DefinedTerm
185 N4a6c7aecea8b4c96abbe7732740d34b2 rdf:first sg:person.01316617337.49
186 rdf:rest N169ab3b3c8764bc3acbe4ad9905f1b41
187 N4e52d9a365074e11b3f857ae285cb0df rdf:first sg:person.01353230623.63
188 rdf:rest N7215372af2664e6980c04821bbe25f22
189 N500667d8ac58485bafec5b14d23adb59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Aged
191 rdf:type schema:DefinedTerm
192 N55f9a673c78843019e27e9c6b02f7303 rdf:first sg:person.01066142337.60
193 rdf:rest N0ffdb005358f461ab0b6de49fae1690b
194 N58b5fd4bb6cf43ee8fd1926797b9e1ef schema:name dimensions_id
195 schema:value pub.1012552300
196 rdf:type schema:PropertyValue
197 N59589d7e141c40b7b4f0cb28ccae8b2d rdf:first sg:person.01133755556.23
198 rdf:rest Nc0f4f0bc78264362bd9184b62b98e155
199 N5b5db10b70e2432b91f9182e7c8ff371 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Lactobacillus rhamnosus
201 rdf:type schema:DefinedTerm
202 N5ebfb6fe68a34a39811e1c8771293d62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Treatment Outcome
204 rdf:type schema:DefinedTerm
205 N5f61e29deb4f4c16830b3e36cf224d0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Trachea
207 rdf:type schema:DefinedTerm
208 N63be0dfb599a483caf8ff4876ef01611 schema:volumeNumber 17
209 rdf:type schema:PublicationVolume
210 N66b2946b5b9e4538a428502c5bdd87b9 rdf:first sg:person.0710523652.20
211 rdf:rest Ne566316dea4a40ff8950322daf7f97e4
212 N69b4e0a6e0334ed18d05d4e2fb202293 rdf:first sg:person.01201465765.19
213 rdf:rest N1a6800ac249644c1845ab403bb87cd31
214 N6a86aeda201647df8a61d074f09a56f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Time Factors
216 rdf:type schema:DefinedTerm
217 N7215372af2664e6980c04821bbe25f22 rdf:first sg:person.01213746236.33
218 rdf:rest N3721cc1ea33846a989694ee3c8f98184
219 N798943152a6742938e51bcfed2c60c72 rdf:first sg:person.01244447225.31
220 rdf:rest N0b9f3d657b0b4795ad8df2026d7edfb3
221 N872f09d341ff4bde89b9eb7170ce155c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Pneumonia, Bacterial
223 rdf:type schema:DefinedTerm
224 N885144f3164c4b9a8c236c3438affae0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Canada
226 rdf:type schema:DefinedTerm
227 N8ca9c306f0e0474b9da30e9b79cf52c8 rdf:first sg:person.01233210151.86
228 rdf:rest N4a6c7aecea8b4c96abbe7732740d34b2
229 N9d03711a83e745d1aa34891f780ae369 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
230 schema:name Feasibility Studies
231 rdf:type schema:DefinedTerm
232 N9dfed4dd396f4b70becf176cb66a2734 rdf:first sg:person.0623423152.13
233 rdf:rest Nde444a9a958148328f45fb406e732aae
234 Naa468ef1d99f42cf8fb86c72fc8a795b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
235 schema:name Female
236 rdf:type schema:DefinedTerm
237 Naad38fa4e2c34623a226ab0a116b880c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
238 schema:name Intensive Care Units
239 rdf:type schema:DefinedTerm
240 Naca8c4e995d1418894d2a12ae82425d0 rdf:first sg:person.01115205001.21
241 rdf:rest Nbb0be8c96ad5404eb5815412643ec46f
242 Nb0a40ce974344fb7ab9d81f9b1e16473 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
243 schema:name Severity of Illness Index
244 rdf:type schema:DefinedTerm
245 Nb0dd17f8a96644cb99aa6819baf9c970 rdf:first sg:person.01065274412.96
246 rdf:rest N43b999c95d624a1e8da11b1e6e2c3cd2
247 Nbb0be8c96ad5404eb5815412643ec46f rdf:first sg:person.01045636035.15
248 rdf:rest N59589d7e141c40b7b4f0cb28ccae8b2d
249 Nc074a7c6702f4602890c158791fa0f81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
250 schema:name Pilot Projects
251 rdf:type schema:DefinedTerm
252 Nc0f4f0bc78264362bd9184b62b98e155 rdf:first sg:person.0771562350.64
253 rdf:rest Nb0dd17f8a96644cb99aa6819baf9c970
254 Ncdf1690a9645409aa73439a6fc8271a2 rdf:first sg:person.01065237365.56
255 rdf:rest N9dfed4dd396f4b70becf176cb66a2734
256 Ncebff597722c4b459d4311cf70b32a76 schema:issueNumber 1
257 rdf:type schema:PublicationIssue
258 Nd84cc0effc5244ec944fc64d964c0b8f schema:name pubmed_id
259 schema:value 27480757
260 rdf:type schema:PropertyValue
261 Nde444a9a958148328f45fb406e732aae rdf:first sg:person.01010170325.74
262 rdf:rest N8ca9c306f0e0474b9da30e9b79cf52c8
263 Ndea4494fe3cc4ce7a7e0b822f9ba6b21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
264 schema:name Middle Aged
265 rdf:type schema:DefinedTerm
266 Ne4ee330f7cb94ace9417564b60fe7742 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
267 schema:name Humans
268 rdf:type schema:DefinedTerm
269 Ne566316dea4a40ff8950322daf7f97e4 rdf:first sg:person.01064471126.24
270 rdf:rest N55f9a673c78843019e27e9c6b02f7303
271 Nf50376011cd04661a773a545c62b1d5d rdf:first sg:person.01237160221.29
272 rdf:rest N69b4e0a6e0334ed18d05d4e2fb202293
273 Nff34152d23ba4b5097c96529acdf4bfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
274 schema:name Intubation, Intratracheal
275 rdf:type schema:DefinedTerm
276 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
277 schema:name Medical and Health Sciences
278 rdf:type schema:DefinedTerm
279 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
280 schema:name Clinical Sciences
281 rdf:type schema:DefinedTerm
282 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
283 schema:name Public Health and Health Services
284 rdf:type schema:DefinedTerm
285 sg:journal.1297400 schema:issn 1468-6708
286 1745-6215
287 schema:name Trials
288 schema:publisher Springer Nature
289 rdf:type schema:Periodical
290 sg:person.01010170325.74 schema:affiliation grid-institutes:grid.25073.33
291 schema:familyName Heels-Ansdell
292 schema:givenName Diane
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010170325.74
294 rdf:type schema:Person
295 sg:person.01010333011.45 schema:affiliation grid-institutes:grid.17091.3e
296 schema:familyName Dodek
297 schema:givenName Peter M.
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010333011.45
299 rdf:type schema:Person
300 sg:person.01016450746.82 schema:affiliation grid-institutes:grid.25073.33
301 schema:familyName Thabane
302 schema:givenName Lehana
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016450746.82
304 rdf:type schema:Person
305 sg:person.01045636035.15 schema:affiliation grid-institutes:grid.28046.38
306 schema:familyName Pagliarello
307 schema:givenName Joe
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045636035.15
309 rdf:type schema:Person
310 sg:person.01064471126.24 schema:affiliation grid-institutes:grid.17063.33
311 schema:familyName Marshall
312 schema:givenName John C.
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064471126.24
314 rdf:type schema:Person
315 sg:person.01065237365.56 schema:affiliation grid-institutes:grid.25073.33
316 schema:familyName Verschoor
317 schema:givenName Chris P.
318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065237365.56
319 rdf:type schema:Person
320 sg:person.01065274412.96 schema:affiliation grid-institutes:grid.66875.3a
321 schema:familyName Cartin-Ceba
322 schema:givenName Rodrigo
323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065274412.96
324 rdf:type schema:Person
325 sg:person.01066142337.60 schema:affiliation grid-institutes:grid.23856.3a
326 schema:familyName Lauzier
327 schema:givenName Francois
328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066142337.60
329 rdf:type schema:Person
330 sg:person.01115205001.21 schema:affiliation grid-institutes:grid.28046.38
331 schema:familyName McIntyre
332 schema:givenName Lauralyn
333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115205001.21
334 rdf:type schema:Person
335 sg:person.01131400212.25 schema:affiliation grid-institutes:grid.17063.33
336 schema:familyName Golan
337 schema:givenName Eyal
338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131400212.25
339 rdf:type schema:Person
340 sg:person.01133755556.23 schema:affiliation grid-institutes:grid.412541.7
341 schema:familyName Henderson
342 schema:givenName William
343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133755556.23
344 rdf:type schema:Person
345 sg:person.01201465765.19 schema:affiliation grid-institutes:grid.25073.33
346 schema:familyName Bowdish
347 schema:givenName Dawn M. E.
348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201465765.19
349 rdf:type schema:Person
350 sg:person.01213746236.33 schema:affiliation grid-institutes:grid.417249.d
351 schema:familyName Wood
352 schema:givenName Gordon
353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213746236.33
354 rdf:type schema:Person
355 sg:person.01233210151.86 schema:affiliation grid-institutes:grid.412149.b
356 schema:familyName Arabi
357 schema:givenName Yaseen
358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233210151.86
359 rdf:type schema:Person
360 sg:person.01235004225.73 schema:affiliation grid-institutes:grid.25073.33
361 schema:familyName Karachi
362 schema:givenName Tim
363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235004225.73
364 rdf:type schema:Person
365 sg:person.01237160221.29 schema:affiliation grid-institutes:grid.25073.33
366 schema:familyName Surette
367 schema:givenName Michael G.
368 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237160221.29
369 rdf:type schema:Person
370 sg:person.01244447225.31 schema:affiliation grid-institutes:grid.17063.33
371 schema:familyName Mehta
372 schema:givenName Sangeeta
373 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244447225.31
374 rdf:type schema:Person
375 sg:person.01315711766.51 schema:affiliation grid-institutes:grid.25073.33
376 schema:familyName Lamarche
377 schema:givenName Daphnee
378 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315711766.51
379 rdf:type schema:Person
380 sg:person.01316617337.49 schema:affiliation grid-institutes:grid.25073.33
381 schema:familyName Meade
382 schema:givenName Maureen
383 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316617337.49
384 rdf:type schema:Person
385 sg:person.01353230623.63 schema:affiliation grid-institutes:grid.17063.33
386 schema:familyName Herridge
387 schema:givenName Margaret
388 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353230623.63
389 rdf:type schema:Person
390 sg:person.0623423152.13 schema:affiliation grid-institutes:grid.25073.33
391 schema:familyName Duan
392 schema:givenName Erick H.
393 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623423152.13
394 rdf:type schema:Person
395 sg:person.0710523652.20 schema:affiliation grid-institutes:grid.17063.33
396 schema:familyName Johnstone
397 schema:givenName Jennie
398 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710523652.20
399 rdf:type schema:Person
400 sg:person.0771562350.64 schema:affiliation grid-institutes:grid.416435.1
401 schema:familyName Taylor
402 schema:givenName Robert W.
403 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771562350.64
404 rdf:type schema:Person
405 sg:pub.10.1186/1471-2288-10-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032642219
406 https://doi.org/10.1186/1471-2288-10-1
407 rdf:type schema:CreativeWork
408 sg:pub.10.1186/cc12832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029510016
409 https://doi.org/10.1186/cc12832
410 rdf:type schema:CreativeWork
411 sg:pub.10.1186/s40814-015-0013-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037826788
412 https://doi.org/10.1186/s40814-015-0013-3
413 rdf:type schema:CreativeWork
414 sg:pub.10.2165/00002018-199410020-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042571161
415 https://doi.org/10.2165/00002018-199410020-00001
416 rdf:type schema:CreativeWork
417 grid-institutes:grid.17063.33 schema:alternateName Department of Medicine, University of Toronto, Toronto, ON Canada
418 Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON Canada
419 schema:name Department of Medicine, University of Toronto, Toronto, ON Canada
420 Department of Surgery, University of Toronto, Toronto, ON Canada
421 Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON Canada
422 Public Health Ontario, Toronto, ON Canada
423 St. Joseph’s Health Center, Toronto, ON Canada
424 rdf:type schema:Organization
425 grid-institutes:grid.17091.3e schema:alternateName Center for Health Evaluation and Outcome Sciences, St. Paul’s Hospital and University of British Columbia, Vancouver, BC Canada
426 schema:name Center for Health Evaluation and Outcome Sciences, St. Paul’s Hospital and University of British Columbia, Vancouver, BC Canada
427 Division of Critical Care Medicine, St. Paul’s Hospital and University of British Columbia, Vancouver, BC Canada
428 rdf:type schema:Organization
429 grid-institutes:grid.23856.3a schema:alternateName Department of Anesthesiology and Critical Care, Université Laval, Quebec City, QC Canada
430 schema:name Department of Anesthesiology and Critical Care, Université Laval, Quebec City, QC Canada
431 Department of Medicine, Université Laval, Quebec City, QC Canada
432 Research Center of the CHU de Québec – Population Health and Optimal Health Practices Research Unit, Université Laval, Quebec City, QC Canada
433 rdf:type schema:Organization
434 grid-institutes:grid.25073.33 schema:alternateName Biochemistry and Biomedical Sciences Department, McMaster University, Hamilton, ON Canada
435 Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON Canada
436 Department of Medicine, McMaster University, McMaster Health Sciences Center, Room 2C11, 1200 Main Street W, Hamilton, ON Canada
437 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON Canada
438 schema:name Biochemistry and Biomedical Sciences Department, McMaster University, Hamilton, ON Canada
439 Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON Canada
440 Department of Medicine, McMaster University, McMaster Health Sciences Center, Room 2C11, 1200 Main Street W, Hamilton, ON Canada
441 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON Canada
442 rdf:type schema:Organization
443 grid-institutes:grid.28046.38 schema:alternateName Division of Critical Care, University of Ottawa, Ottawa, ON Canada
444 schema:name Division of Critical Care, University of Ottawa, Ottawa, ON Canada
445 rdf:type schema:Organization
446 grid-institutes:grid.412149.b schema:alternateName King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia
447 schema:name King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia
448 rdf:type schema:Organization
449 grid-institutes:grid.412541.7 schema:alternateName Division of Critical Care Medicine, Vancouver General Hospital, Vancouver, BC Canada
450 schema:name Division of Critical Care Medicine, Vancouver General Hospital, Vancouver, BC Canada
451 rdf:type schema:Organization
452 grid-institutes:grid.416435.1 schema:alternateName Department of Critical Care Medicine, Mercy Hospital, St Louis, MO USA
453 schema:name Department of Critical Care Medicine, Mercy Hospital, St Louis, MO USA
454 rdf:type schema:Organization
455 grid-institutes:grid.417249.d schema:alternateName Department of Anesthesia & Critical Care, Vancouver Island Health Authority, Victoria, BC Canada
456 schema:name Department of Anesthesia & Critical Care, Vancouver Island Health Authority, Victoria, BC Canada
457 rdf:type schema:Organization
458 grid-institutes:grid.66875.3a schema:alternateName Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN USA
459 schema:name Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN USA
460 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...