Continuous wound infiltration or epidural analgesia for pain prevention after hepato-pancreato-biliary surgery within an enhanced recovery program (POP-UP trial): study ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Timothy H. Mungroop, Denise P. Veelo, Olivier R. Busch, Susan van Dieren, Thomas M. van Gulik, Tom M. Karsten, Steve M. de Castro, Marc B. Godfried, Bram Thiel, Markus W. Hollmann, Philipp Lirk, Marc G. Besselink

ABSTRACT

BACKGROUND: Postoperative pain prevention is essential for the recovery of surgical patients. Continuous (thoracic) epidural analgesia (CEA) is routinely practiced for major abdominal surgery, but evidence is conflicting on its benefits in this setting. Potential disadvantages of epidural analgesia are a) perioperative hypotension, frequently requiring additional intravenous fluid boluses or prolonged use of vasopressors; b) relatively high failure rates, with periods of inadequate analgesia; and c) the risk of rare but serious, at times persistent, neurologic complications (hematoma and abscess). In recent years, continuous (subfascial) wound infiltration (CWI) plus patient-controlled analgesia (PCA) has been suggested as a safe and reliable alternative, which does not have the previously mentioned disadvantages, but evidence from multicenter trials targeting a specific surgical population is lacking. We hypothesize that CWI+PCA is equally as effective as CEA, without the mentioned disadvantages. METHODS/DESIGN: POP-UP is a randomized controlled noninferiority multicenter trial, recruiting adult patients scheduled for elective hepato-pancreato-biliary surgery via laparotomy in an enhanced recovery setting. A total of 102 patients are being randomly allocated to CWI+PCA or (P)CEA. Our primary endpoint is the Overall Benefit of Analgesic Score (OBAS), a composite endpoint of pain intensity, opioid-related adverse effects and patient satisfaction, during postoperative days 1 to 5. Secondary endpoints include length of the hospital stay, number of patients with severe pain, and the use of rescue medication. DISCUSSION: POP-UP is a pragmatic trial that will provide evidence of whether CWI+PCA is noninferior as compared to (P)CEA after elective hepato-pancreato-biliary surgery via laparotomy in an enhanced recovery setting. If this hypothesis is confirmed, this finding could contribute to more widespread implementation of this technique, especially when the described disadvantages of epidural analgesia are less often observed with CWI+PCA. TRIAL REGISTRATION: Netherlands Trial Register NTR4948 (registry date 2 January 2015). More... »

PAGES

562

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13063-015-1075-5

DOI

http://dx.doi.org/10.1186/s13063-015-1075-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016722649

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26654448


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analgesia, Epidural", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analgesics, Opioid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anesthetics, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bupivacaine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Catheters", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clinical Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Digestive System Surgical Procedures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infusions, Parenteral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Length of Stay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Netherlands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pain Management", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pain Measurement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pain, Postoperative", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Patient Satisfaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recovery of Function", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Research Design", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands", 
            "Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mungroop", 
        "givenName": "Timothy H.", 
        "id": "sg:person.01100761703.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100761703.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Veelo", 
        "givenName": "Denise P.", 
        "id": "sg:person.01326441562.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326441562.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Busch", 
        "givenName": "Olivier R.", 
        "id": "sg:person.01013166567.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013166567.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands", 
            "Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Dieren", 
        "givenName": "Susan", 
        "id": "sg:person.01247354752.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247354752.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Gulik", 
        "givenName": "Thomas M.", 
        "id": "sg:person.015646004657.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015646004657.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Onze Lieve Vrouwe Gasthuis", 
          "id": "https://www.grid.ac/institutes/grid.440209.b", 
          "name": [
            "Department of Surgery, Onze Lieve Vrouwe Gasthuis, Oosterpark 9, 1091, Amsterdam, AC, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karsten", 
        "givenName": "Tom M.", 
        "id": "sg:person.01000101007.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000101007.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Onze Lieve Vrouwe Gasthuis", 
          "id": "https://www.grid.ac/institutes/grid.440209.b", 
          "name": [
            "Department of Surgery, Onze Lieve Vrouwe Gasthuis, Oosterpark 9, 1091, Amsterdam, AC, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Castro", 
        "givenName": "Steve M.", 
        "id": "sg:person.011207627517.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011207627517.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Onze Lieve Vrouwe Gasthuis", 
          "id": "https://www.grid.ac/institutes/grid.440209.b", 
          "name": [
            "Department of Anesthesiology, Onze Lieve Vrouwe Gasthuis, Oosterpark 9, 1091, Amsterdam, AC, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Godfried", 
        "givenName": "Marc B.", 
        "id": "sg:person.011555425044.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011555425044.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Onze Lieve Vrouwe Gasthuis", 
          "id": "https://www.grid.ac/institutes/grid.440209.b", 
          "name": [
            "Department of Anesthesiology, Onze Lieve Vrouwe Gasthuis, Oosterpark 9, 1091, Amsterdam, AC, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thiel", 
        "givenName": "Bram", 
        "id": "sg:person.0770374403.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770374403.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hollmann", 
        "givenName": "Markus W.", 
        "id": "sg:person.01262763005.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262763005.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lirk", 
        "givenName": "Philipp", 
        "id": "sg:person.01342236547.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342236547.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Besselink", 
        "givenName": "Marc G.", 
        "id": "sg:person.01120602634.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120602634.21"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1213/ane.0b013e31826b4694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000075123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/ane.0b013e31826b4694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000075123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/ane.0b013e31826b4694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000075123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd004088.pub3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000558387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamasurg.2014.210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005025925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-200161030-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006847677", 
          "https://doi.org/10.2165/00003495-200161030-00002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-200161030-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006847677", 
          "https://doi.org/10.2165/00003495-200161030-00002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9610(02)00866-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010730778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bja/aen309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016793829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bja/aeq186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022081394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-199510000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022419894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-199510000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022419894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bja/89.3.459", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027935471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.9204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035174323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bja/aes091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037492211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.d3016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039652779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-200410000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039784305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-200410000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039784305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1477-2574.2012.00490.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040325281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1098-7339(99)90038-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042121283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/hpb.12183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043533376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2044.2001.01763-7.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049459502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpa.2006.12.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052194234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079082694", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: Postoperative pain prevention is essential for the recovery of surgical patients. Continuous (thoracic) epidural analgesia (CEA) is routinely practiced for major abdominal surgery, but evidence is conflicting on its benefits in this setting. Potential disadvantages of epidural analgesia are a) perioperative hypotension, frequently requiring additional intravenous fluid boluses or prolonged use of vasopressors; b) relatively high failure rates, with periods of inadequate analgesia; and c) the risk of rare but serious, at times persistent, neurologic complications (hematoma and abscess). In recent years, continuous (subfascial) wound infiltration (CWI) plus patient-controlled analgesia (PCA) has been suggested as a safe and reliable alternative, which does not have the previously mentioned disadvantages, but evidence from multicenter trials targeting a specific surgical population is lacking. We hypothesize that CWI+PCA is equally as effective as CEA, without the mentioned disadvantages.\nMETHODS/DESIGN: POP-UP is a randomized controlled noninferiority multicenter trial, recruiting adult patients scheduled for elective hepato-pancreato-biliary surgery via laparotomy in an enhanced recovery setting. A total of 102 patients are being randomly allocated to CWI+PCA or (P)CEA. Our primary endpoint is the Overall Benefit of Analgesic Score (OBAS), a composite endpoint of pain intensity, opioid-related adverse effects and patient satisfaction, during postoperative days 1 to 5. Secondary endpoints include length of the hospital stay, number of patients with severe pain, and the use of rescue medication.\nDISCUSSION: POP-UP is a pragmatic trial that will provide evidence of whether CWI+PCA is noninferior as compared to (P)CEA after elective hepato-pancreato-biliary surgery via laparotomy in an enhanced recovery setting. If this hypothesis is confirmed, this finding could contribute to more widespread implementation of this technique, especially when the described disadvantages of epidural analgesia are less often observed with CWI+PCA.\nTRIAL REGISTRATION: Netherlands Trial Register NTR4948 (registry date 2 January 2015).", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13063-015-1075-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1297400", 
        "issn": [
          "1468-6708", 
          "1745-6215"
        ], 
        "name": "Trials", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Continuous wound infiltration or epidural analgesia for pain prevention after hepato-pancreato-biliary surgery within an enhanced recovery program (POP-UP trial): study protocol for a randomized controlled trial", 
    "pagination": "562", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4fad451f9da86c29e3c0226569699d92993b72b875f263408e45ec8e5976fec9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26654448"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101263253"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13063-015-1075-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016722649"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13063-015-1075-5", 
      "https://app.dimensions.ai/details/publication/pub.1016722649"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000511.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs13063-015-1075-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13063-015-1075-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13063-015-1075-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13063-015-1075-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13063-015-1075-5'


 

This table displays all metadata directly associated to this object as RDF triples.

302 TRIPLES      21 PREDICATES      68 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13063-015-1075-5 schema:about N13d862752adc40b1b182d36e85a31491
2 N1b59932f5271464aaa7e7487820377c2
3 N36fb7def1e03451cbd2b0150f8c9756b
4 N3cd7508fce1440c8a143fc8057842312
5 N41a1da6c7a7249a781604159ad7697f5
6 N527bbbe5880249f3b6a4488196c022d0
7 N55c7e349509f442bb66b3bec4b599788
8 N660ccce8f18543b3a0494b34cd0b1057
9 N676c80dce0964449bc2e019d3bfa04b5
10 N6d505ef41a9d4d6f899f989bcd2f8b5b
11 N7309601f65ba490dae74583462152ce4
12 N83bd3d3ab55c40bb80c3cb6430b517e2
13 N8a01188fd8f14b3580b5e6e008c3b7e5
14 N91927111611549a1b8dbccdfc042b6c1
15 Na21baf6ada0648a1b99a16b2e5dc0bca
16 Na671fc2fd9f8468a85e25e9f52cbe38e
17 Nab50e2192a8747a984d7dc1f0bab3b71
18 Nc55c9187d2cc475790dbcc2b8bef1305
19 Nc7e5c6b04ef244f9b9b535eb83c7e6f0
20 Nd4f02f3fe74842d48915213c9ad1a2e6
21 anzsrc-for:11
22 anzsrc-for:1103
23 schema:author N096dc3e3d358437c8d839695c6b10067
24 schema:citation sg:pub.10.2165/00003495-200161030-00002
25 https://app.dimensions.ai/details/publication/pub.1079082694
26 https://doi.org/10.1001/jamasurg.2014.210
27 https://doi.org/10.1002/14651858.cd004088.pub3
28 https://doi.org/10.1002/bjs.9204
29 https://doi.org/10.1016/j.bpa.2006.12.001
30 https://doi.org/10.1016/s0002-9610(02)00866-8
31 https://doi.org/10.1016/s1098-7339(99)90038-x
32 https://doi.org/10.1046/j.1365-2044.2001.01763-7.x
33 https://doi.org/10.1093/bja/89.3.459
34 https://doi.org/10.1093/bja/aen309
35 https://doi.org/10.1093/bja/aeq186
36 https://doi.org/10.1093/bja/aes091
37 https://doi.org/10.1097/00000542-199510000-00015
38 https://doi.org/10.1097/00000542-200410000-00021
39 https://doi.org/10.1111/hpb.12183
40 https://doi.org/10.1111/j.1477-2574.2012.00490.x
41 https://doi.org/10.1136/bmj.d3016
42 https://doi.org/10.1213/ane.0b013e31826b4694
43 schema:datePublished 2015-12
44 schema:datePublishedReg 2015-12-01
45 schema:description BACKGROUND: Postoperative pain prevention is essential for the recovery of surgical patients. Continuous (thoracic) epidural analgesia (CEA) is routinely practiced for major abdominal surgery, but evidence is conflicting on its benefits in this setting. Potential disadvantages of epidural analgesia are a) perioperative hypotension, frequently requiring additional intravenous fluid boluses or prolonged use of vasopressors; b) relatively high failure rates, with periods of inadequate analgesia; and c) the risk of rare but serious, at times persistent, neurologic complications (hematoma and abscess). In recent years, continuous (subfascial) wound infiltration (CWI) plus patient-controlled analgesia (PCA) has been suggested as a safe and reliable alternative, which does not have the previously mentioned disadvantages, but evidence from multicenter trials targeting a specific surgical population is lacking. We hypothesize that CWI+PCA is equally as effective as CEA, without the mentioned disadvantages. METHODS/DESIGN: POP-UP is a randomized controlled noninferiority multicenter trial, recruiting adult patients scheduled for elective hepato-pancreato-biliary surgery via laparotomy in an enhanced recovery setting. A total of 102 patients are being randomly allocated to CWI+PCA or (P)CEA. Our primary endpoint is the Overall Benefit of Analgesic Score (OBAS), a composite endpoint of pain intensity, opioid-related adverse effects and patient satisfaction, during postoperative days 1 to 5. Secondary endpoints include length of the hospital stay, number of patients with severe pain, and the use of rescue medication. DISCUSSION: POP-UP is a pragmatic trial that will provide evidence of whether CWI+PCA is noninferior as compared to (P)CEA after elective hepato-pancreato-biliary surgery via laparotomy in an enhanced recovery setting. If this hypothesis is confirmed, this finding could contribute to more widespread implementation of this technique, especially when the described disadvantages of epidural analgesia are less often observed with CWI+PCA. TRIAL REGISTRATION: Netherlands Trial Register NTR4948 (registry date 2 January 2015).
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree true
49 schema:isPartOf N83fcce7b70f14f44b9bf2be724133faa
50 Na812486ccd28462e8a799eae5a0bfdc3
51 sg:journal.1297400
52 schema:name Continuous wound infiltration or epidural analgesia for pain prevention after hepato-pancreato-biliary surgery within an enhanced recovery program (POP-UP trial): study protocol for a randomized controlled trial
53 schema:pagination 562
54 schema:productId N0aafe18e62ef4647b98de67dba1a0f65
55 N36117d1964194583a3390552c9315fd6
56 N54650e6311f7415a99820f6e8705f045
57 N74de54e435124f4692bf2a956a949161
58 Nbb250a1b0d5c42d4a679d0b774d68d8e
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016722649
60 https://doi.org/10.1186/s13063-015-1075-5
61 schema:sdDatePublished 2019-04-11T02:00
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher Nbb6330475a4d459cb36d9b8a73ba585d
64 schema:url http://link.springer.com/10.1186%2Fs13063-015-1075-5
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N05ac28f35bb247a18607b9d487b35e8a rdf:first sg:person.0770374403.56
69 rdf:rest N7bae058422284282b3f7a186eface1ee
70 N096dc3e3d358437c8d839695c6b10067 rdf:first sg:person.01100761703.89
71 rdf:rest Nf0a5fb504d6a4dcbb97ba1e07526c5c3
72 N0a8dac947b8143958471084a99ac6830 rdf:first sg:person.01342236547.01
73 rdf:rest Na58140ef5e184a239bd03da145fc0d5c
74 N0aafe18e62ef4647b98de67dba1a0f65 schema:name doi
75 schema:value 10.1186/s13063-015-1075-5
76 rdf:type schema:PropertyValue
77 N13d862752adc40b1b182d36e85a31491 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Humans
79 rdf:type schema:DefinedTerm
80 N1b59932f5271464aaa7e7487820377c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Time Factors
82 rdf:type schema:DefinedTerm
83 N1befeefc639c40a28f45a6446b75c943 schema:name Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands
84 Department of Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands
85 rdf:type schema:Organization
86 N20633a30076e4040a4a23ddfc0ab929b rdf:first sg:person.011555425044.46
87 rdf:rest N05ac28f35bb247a18607b9d487b35e8a
88 N2846ea245a68455689994169e4f05144 schema:name Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands
89 rdf:type schema:Organization
90 N36117d1964194583a3390552c9315fd6 schema:name pubmed_id
91 schema:value 26654448
92 rdf:type schema:PropertyValue
93 N36fb7def1e03451cbd2b0150f8c9756b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Pain Measurement
95 rdf:type schema:DefinedTerm
96 N3cd7508fce1440c8a143fc8057842312 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Digestive System Surgical Procedures
98 rdf:type schema:DefinedTerm
99 N3fc9600a264c49deb25e54c2c212e65d rdf:first sg:person.01247354752.80
100 rdf:rest N87b721a583994eb0800db71fcb5134cd
101 N41a1da6c7a7249a781604159ad7697f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Catheters
103 rdf:type schema:DefinedTerm
104 N48e3df98442c4c1e9bb9e1a45848279d schema:name Department of Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands
105 rdf:type schema:Organization
106 N527bbbe5880249f3b6a4488196c022d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Anesthetics, Local
108 rdf:type schema:DefinedTerm
109 N54650e6311f7415a99820f6e8705f045 schema:name dimensions_id
110 schema:value pub.1016722649
111 rdf:type schema:PropertyValue
112 N55c7e349509f442bb66b3bec4b599788 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Netherlands
114 rdf:type schema:DefinedTerm
115 N63659629d4aa47c6a932e64fb7640d43 schema:name Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands
116 rdf:type schema:Organization
117 N660ccce8f18543b3a0494b34cd0b1057 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Research Design
119 rdf:type schema:DefinedTerm
120 N676c80dce0964449bc2e019d3bfa04b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Clinical Protocols
122 rdf:type schema:DefinedTerm
123 N6c1084fa8c4b4c6dbcef10c01e5ffba6 schema:name Department of Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands
124 rdf:type schema:Organization
125 N6d505ef41a9d4d6f899f989bcd2f8b5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Infusions, Parenteral
127 rdf:type schema:DefinedTerm
128 N7309601f65ba490dae74583462152ce4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Bupivacaine
130 rdf:type schema:DefinedTerm
131 N748f16ea38184908813d8ca6d9f7a650 schema:name Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands
132 rdf:type schema:Organization
133 N74de54e435124f4692bf2a956a949161 schema:name nlm_unique_id
134 schema:value 101263253
135 rdf:type schema:PropertyValue
136 N7bae058422284282b3f7a186eface1ee rdf:first sg:person.01262763005.31
137 rdf:rest N0a8dac947b8143958471084a99ac6830
138 N83bd3d3ab55c40bb80c3cb6430b517e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Pain Management
140 rdf:type schema:DefinedTerm
141 N83fcce7b70f14f44b9bf2be724133faa schema:issueNumber 1
142 rdf:type schema:PublicationIssue
143 N87b721a583994eb0800db71fcb5134cd rdf:first sg:person.015646004657.26
144 rdf:rest N9f4b8ea113ef4bf596314c2b2db265e7
145 N8a01188fd8f14b3580b5e6e008c3b7e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Patient Satisfaction
147 rdf:type schema:DefinedTerm
148 N91927111611549a1b8dbccdfc042b6c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Analgesics, Opioid
150 rdf:type schema:DefinedTerm
151 N9b6a1dd616e848aaa6e50b3b5b1e989d rdf:first sg:person.01013166567.25
152 rdf:rest N3fc9600a264c49deb25e54c2c212e65d
153 N9f4b8ea113ef4bf596314c2b2db265e7 rdf:first sg:person.01000101007.88
154 rdf:rest Na63c725af7c4482aabe5b2d9e15243bf
155 Na21baf6ada0648a1b99a16b2e5dc0bca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Severity of Illness Index
157 rdf:type schema:DefinedTerm
158 Na58140ef5e184a239bd03da145fc0d5c rdf:first sg:person.01120602634.21
159 rdf:rest rdf:nil
160 Na63c725af7c4482aabe5b2d9e15243bf rdf:first sg:person.011207627517.90
161 rdf:rest N20633a30076e4040a4a23ddfc0ab929b
162 Na671fc2fd9f8468a85e25e9f52cbe38e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Recovery of Function
164 rdf:type schema:DefinedTerm
165 Na812486ccd28462e8a799eae5a0bfdc3 schema:volumeNumber 16
166 rdf:type schema:PublicationVolume
167 Nab50e2192a8747a984d7dc1f0bab3b71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Treatment Outcome
169 rdf:type schema:DefinedTerm
170 Nb64b61ebb23b4d0b8c86a52d73fda2e4 schema:name Department of Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands
171 rdf:type schema:Organization
172 Nbb250a1b0d5c42d4a679d0b774d68d8e schema:name readcube_id
173 schema:value 4fad451f9da86c29e3c0226569699d92993b72b875f263408e45ec8e5976fec9
174 rdf:type schema:PropertyValue
175 Nbb6330475a4d459cb36d9b8a73ba585d schema:name Springer Nature - SN SciGraph project
176 rdf:type schema:Organization
177 Nc55c9187d2cc475790dbcc2b8bef1305 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Analgesia, Epidural
179 rdf:type schema:DefinedTerm
180 Nc7e5c6b04ef244f9b9b535eb83c7e6f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Pain, Postoperative
182 rdf:type schema:DefinedTerm
183 Ncb78ed7f08354fc8a78b559a8205d4de schema:name Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands
184 Department of Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100, Amsterdam, DD, The Netherlands
185 rdf:type schema:Organization
186 Nd4f02f3fe74842d48915213c9ad1a2e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Length of Stay
188 rdf:type schema:DefinedTerm
189 Nf0a5fb504d6a4dcbb97ba1e07526c5c3 rdf:first sg:person.01326441562.20
190 rdf:rest N9b6a1dd616e848aaa6e50b3b5b1e989d
191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
192 schema:name Medical and Health Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
195 schema:name Clinical Sciences
196 rdf:type schema:DefinedTerm
197 sg:journal.1297400 schema:issn 1468-6708
198 1745-6215
199 schema:name Trials
200 rdf:type schema:Periodical
201 sg:person.01000101007.88 schema:affiliation https://www.grid.ac/institutes/grid.440209.b
202 schema:familyName Karsten
203 schema:givenName Tom M.
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000101007.88
205 rdf:type schema:Person
206 sg:person.01013166567.25 schema:affiliation Nb64b61ebb23b4d0b8c86a52d73fda2e4
207 schema:familyName Busch
208 schema:givenName Olivier R.
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013166567.25
210 rdf:type schema:Person
211 sg:person.01100761703.89 schema:affiliation N1befeefc639c40a28f45a6446b75c943
212 schema:familyName Mungroop
213 schema:givenName Timothy H.
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100761703.89
215 rdf:type schema:Person
216 sg:person.01120602634.21 schema:affiliation N6c1084fa8c4b4c6dbcef10c01e5ffba6
217 schema:familyName Besselink
218 schema:givenName Marc G.
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120602634.21
220 rdf:type schema:Person
221 sg:person.011207627517.90 schema:affiliation https://www.grid.ac/institutes/grid.440209.b
222 schema:familyName de Castro
223 schema:givenName Steve M.
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011207627517.90
225 rdf:type schema:Person
226 sg:person.011555425044.46 schema:affiliation https://www.grid.ac/institutes/grid.440209.b
227 schema:familyName Godfried
228 schema:givenName Marc B.
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011555425044.46
230 rdf:type schema:Person
231 sg:person.01247354752.80 schema:affiliation Ncb78ed7f08354fc8a78b559a8205d4de
232 schema:familyName van Dieren
233 schema:givenName Susan
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247354752.80
235 rdf:type schema:Person
236 sg:person.01262763005.31 schema:affiliation N63659629d4aa47c6a932e64fb7640d43
237 schema:familyName Hollmann
238 schema:givenName Markus W.
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262763005.31
240 rdf:type schema:Person
241 sg:person.01326441562.20 schema:affiliation N2846ea245a68455689994169e4f05144
242 schema:familyName Veelo
243 schema:givenName Denise P.
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326441562.20
245 rdf:type schema:Person
246 sg:person.01342236547.01 schema:affiliation N748f16ea38184908813d8ca6d9f7a650
247 schema:familyName Lirk
248 schema:givenName Philipp
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342236547.01
250 rdf:type schema:Person
251 sg:person.015646004657.26 schema:affiliation N48e3df98442c4c1e9bb9e1a45848279d
252 schema:familyName van Gulik
253 schema:givenName Thomas M.
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015646004657.26
255 rdf:type schema:Person
256 sg:person.0770374403.56 schema:affiliation https://www.grid.ac/institutes/grid.440209.b
257 schema:familyName Thiel
258 schema:givenName Bram
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770374403.56
260 rdf:type schema:Person
261 sg:pub.10.2165/00003495-200161030-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006847677
262 https://doi.org/10.2165/00003495-200161030-00002
263 rdf:type schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1079082694 schema:CreativeWork
265 https://doi.org/10.1001/jamasurg.2014.210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005025925
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/14651858.cd004088.pub3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000558387
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/bjs.9204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035174323
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.bpa.2006.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052194234
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0002-9610(02)00866-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010730778
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s1098-7339(99)90038-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042121283
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1046/j.1365-2044.2001.01763-7.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049459502
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1093/bja/89.3.459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027935471
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1093/bja/aen309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016793829
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1093/bja/aeq186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022081394
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1093/bja/aes091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037492211
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1097/00000542-199510000-00015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022419894
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1097/00000542-200410000-00021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039784305
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1111/hpb.12183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043533376
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1111/j.1477-2574.2012.00490.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040325281
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1136/bmj.d3016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039652779
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1213/ane.0b013e31826b4694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000075123
298 rdf:type schema:CreativeWork
299 https://www.grid.ac/institutes/grid.440209.b schema:alternateName Onze Lieve Vrouwe Gasthuis
300 schema:name Department of Anesthesiology, Onze Lieve Vrouwe Gasthuis, Oosterpark 9, 1091, Amsterdam, AC, The Netherlands
301 Department of Surgery, Onze Lieve Vrouwe Gasthuis, Oosterpark 9, 1091, Amsterdam, AC, The Netherlands
302 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...