Ontology type: schema:ScholarlyArticle Open Access: True
2015-09-15
AUTHORSJoo Myung Lee, Ji-Hyun Jung, Kyung Woo Park, Eun-Seok Shin, Seok Kyu Oh, Jang-Whan Bae, Jay Young Rhew, Namho Lee, Dong-Bin Kim, Ung Kim, Jung-Kyu Han, Sang Eun Lee, Han-Mo Yang, Hyun-Jae Kang, Bon-Kwon Koo, Sanghyun Kim, Yun Kyeong Cho, Won-Yong Shin, Young-Hyo Lim, Seung-Woon Rha, Seok-Yeon Kim, Sung Yun Lee, Young-Dae Kim, In-Ho Chae, Kwang Soo Cha, Hyo-Soo Kim
ABSTRACTBackgroundAntiplatelet treatment is an important component in optimizing the clinical outcomes after percutaneous coronary intervention (PCI) especially in patients with acute coronary syndrome (ACS). Prasugrel, which is a new P2Y12 inhibitor, has been confirmed as efficacious in a large trial in Western countries, and a similar trial is also to be launched in Asian countries. Although a 60-mg loading dose of prasugrel followed by 10 mg per day should be acceptable, there have been no data regarding the optimal dose in Asian patients. Furthermore, serum levels of prasugrel and the rates of platelet inhibition are known to be higher in Asians than Caucasians with the same dose of the drug.Polymer, a key component of drug-eluting stents (DES), has been suggested as the cause of inflammation leading to late complications, and has driven many companies to develop biodegradable-polymer DES. Currently, there are limited data regarding the head-to-head comparison between BP-BES and the biostable polymer CoCr-EES or the newest platinum-chromium everolimus-eluting stent (PtCr-EES). Furthermore, the polymer issue may be more important in ACS where there is ruptured thrombotic plaque where polymer-induced inflammation may affect the local milieu of the stented artery.Therefore, the present study dedicated only to ACS patients, will offer important information on the optimal prasugrel dose in the Asian population by comparing a 10-mg versus a 5-mg maintenance dose beyond 1 month after PCI, as well as giving important insight into the polymer issue by comparing BP-BES versus biostable-polymer PtCr-EES.Method/DesignHarmonizing Optimal Strategy for Treatment of coronary artery diseases – comparison of REDUCtion of prasugrEl dose or POLYmer TECHnology in ACS patients (HOST-REDUCE-POLYTECH-ACS) trial is a multicenter, randomized and open-label clinical study with a 2 × 2 factorial design, according to the type of stent (PtCr-EES versus BP-BES) and prasugrel maintenance dose (5 mg versus 10 mg), to demonstrate non-inferiority of PtCr-EES relative to BP-BES or the reduced prasugrel dose relative to conventional dose in an Asian all-comers PCI population presenting with ACS. Approximately 3400 patients will undergo prospective, random assignment separately to either stent or prasugrel arm (1:1 ratio, respectively). When the patients have contraindications to prasugrel, they are categorized into an antiplatelet observation group after stent-randomization. The primary endpoint is the patient-oriented composite outcome, which is a composite of all-cause mortality, any myocardial infarction (MI), any repeat revascularization in the stent arm at 12 months after index PCI. In the prasugrel arm, primary endpoint is any major adverse cardiovascular event, which is a composite of all-cause mortality, any MI, any stent thrombosis (Academic Research Consortium (ARC)-defined), any repeat revascularization, stroke, or bleeding (BARC class ≥ 2).DiscussionThe HOST-REDUCE-POLYTECH-ACS RCT is the first study exploring the optimal maintenance dose of prasugrel beyond 1 month after PCI for ACS in Asian all-comers. In addition, this is the largest study dedicated only to ACS patients to evaluate the polymer issue in the situation of ACS by directly comparing biostable-polymer PtCr-EES versus BP-BES.Trial registrationClinicalTrials.gov (ID: NCT02193971, 13 July 2014). More... »
PAGES409
http://scigraph.springernature.com/pub.10.1186/s13063-015-0925-5
DOIhttp://dx.doi.org/10.1186/s13063-015-0925-5
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1046144609
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26374625
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Cardiorespiratory Medicine and Haematology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Absorbable Implants",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Acute Coronary Syndrome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Asians",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cause of Death",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Clinical Protocols",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug-Eluting Stents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Everolimus",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hemorrhage",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Myocardial Infarction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Percutaneous Coronary Intervention",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Platelet Aggregation Inhibitors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polymers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prasugrel Hydrochloride",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prosthesis Design",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Republic of Korea",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Research Design",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Risk Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Stroke",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Time Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.412484.f",
"name": [
"Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Joo Myung",
"id": "sg:person.01243434760.90",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243434760.90"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.412484.f",
"name": [
"Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Jung",
"givenName": "Ji-Hyun",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.412484.f",
"name": [
"Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Park",
"givenName": "Kyung Woo",
"id": "sg:person.0755760133.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755760133.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea",
"id": "http://www.grid.ac/institutes/grid.412830.c",
"name": [
"Division of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea"
],
"type": "Organization"
},
"familyName": "Shin",
"givenName": "Eun-Seok",
"id": "sg:person.0712020725.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712020725.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiovascular Medicine, Regional Cardiocerebrovascular Center, Wonkwang University Hospital, Iksan, Korea",
"id": "http://www.grid.ac/institutes/grid.413112.4",
"name": [
"Department of Cardiovascular Medicine, Regional Cardiocerebrovascular Center, Wonkwang University Hospital, Iksan, Korea"
],
"type": "Organization"
},
"familyName": "Oh",
"givenName": "Seok Kyu",
"id": "sg:person.01020022220.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020022220.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Chungbuk National University, Cheongju, Republic of Korea",
"id": "http://www.grid.ac/institutes/grid.254229.a",
"name": [
"Chungbuk National University, Cheongju, Republic of Korea"
],
"type": "Organization"
},
"familyName": "Bae",
"givenName": "Jang-Whan",
"id": "sg:person.0770120366.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770120366.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Internal Medicine and Cardiovascular Center, Presbyterian Medical Center, Jeonju, Republic of Korea",
"id": "http://www.grid.ac/institutes/grid.415170.6",
"name": [
"Department of Internal Medicine and Cardiovascular Center, Presbyterian Medical Center, Jeonju, Republic of Korea"
],
"type": "Organization"
},
"familyName": "Rhew",
"givenName": "Jay Young",
"id": "sg:person.01155120154.27",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155120154.27"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cardiology Division, Kangnam Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.464606.6",
"name": [
"Cardiology Division, Kangnam Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Namho",
"id": "sg:person.0641537221.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641537221.72"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cardiovascular Center, St. Paul\u2019s Hospital, The Catholic University of Korea, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.411947.e",
"name": [
"Cardiovascular Center, St. Paul\u2019s Hospital, The Catholic University of Korea, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Dong-Bin",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiology, Yeungnam University Medical Center, Daegu, Korea",
"id": "http://www.grid.ac/institutes/grid.413040.2",
"name": [
"Division of Cardiology, Yeungnam University Medical Center, Daegu, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Ung",
"id": "sg:person.01215314244.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215314244.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.412484.f",
"name": [
"Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Han",
"givenName": "Jung-Kyu",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.412484.f",
"name": [
"Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Sang Eun",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.412484.f",
"name": [
"Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Yang",
"givenName": "Han-Mo",
"id": "sg:person.01101257615.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101257615.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.412484.f",
"name": [
"Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Kang",
"givenName": "Hyun-Jae",
"id": "sg:person.01254550333.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254550333.69"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.412484.f",
"name": [
"Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Koo",
"givenName": "Bon-Kwon",
"id": "sg:person.01031167354.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031167354.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cardiovascular Center, Seoul National University, Boramae Medical Center, Seoul, Korea",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Cardiovascular Center, Seoul National University, Boramae Medical Center, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Sanghyun",
"id": "sg:person.0720751404.96",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720751404.96"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University College of Medicine, Daegu, Korea",
"id": "http://www.grid.ac/institutes/grid.412091.f",
"name": [
"Division of Cardiology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University College of Medicine, Daegu, Korea"
],
"type": "Organization"
},
"familyName": "Cho",
"givenName": "Yun Kyeong",
"id": "sg:person.01270650574.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270650574.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Soon Chun Hyang University Hospital Cheonan, Cheonan, Korea",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Cardiology, Soon Chun Hyang University Hospital Cheonan, Cheonan, Korea"
],
"type": "Organization"
},
"familyName": "Shin",
"givenName": "Won-Yong",
"id": "sg:person.01025234565.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025234565.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiology, Department of Internal Medicine, College of Medicine, Hanyang University Medical Center, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.411986.3",
"name": [
"Division of Cardiology, Department of Internal Medicine, College of Medicine, Hanyang University Medical Center, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Lim",
"givenName": "Young-Hyo",
"id": "sg:person.0770335234.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770335234.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Korea University Guro Hospital, Seoul, Republic of Korea",
"id": "http://www.grid.ac/institutes/grid.411134.2",
"name": [
"Korea University Guro Hospital, Seoul, Republic of Korea"
],
"type": "Organization"
},
"familyName": "Rha",
"givenName": "Seung-Woon",
"id": "sg:person.01167206253.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167206253.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Seoul Medical Center, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.415520.7",
"name": [
"Department of Cardiology, Seoul Medical Center, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Seok-Yeon",
"id": "sg:person.01235154754.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235154754.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Inje University Ilsan Paik Hospital, Goyang, Republic of Korea",
"id": "http://www.grid.ac/institutes/grid.411633.2",
"name": [
"Inje University Ilsan Paik Hospital, Goyang, Republic of Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Sung Yun",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Dong-A University Hospital, Busan, Korea",
"id": "http://www.grid.ac/institutes/grid.412048.b",
"name": [
"Department of Cardiology, Dong-A University Hospital, Busan, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Young-Dae",
"id": "sg:person.01102560303.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102560303.56"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Seoul National University Bundang Hospital, Seongnam, Republic of Korea",
"id": "http://www.grid.ac/institutes/grid.412480.b",
"name": [
"Seoul National University Bundang Hospital, Seongnam, Republic of Korea"
],
"type": "Organization"
},
"familyName": "Chae",
"givenName": "In-Ho",
"id": "sg:person.0750274114.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750274114.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Pusan National University Hospital, Busan, South Korea",
"id": "http://www.grid.ac/institutes/grid.412588.2",
"name": [
"Department of Cardiology, Pusan National University Hospital, Busan, South Korea"
],
"type": "Organization"
},
"familyName": "Cha",
"givenName": "Kwang Soo",
"id": "sg:person.01016102700.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016102700.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.412484.f",
"name": [
"Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongro-gu, 110-744, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Hyo-Soo",
"id": "sg:person.010705376560.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010705376560.19"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1186/1745-6215-13-29",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003289835",
"https://doi.org/10.1186/1745-6215-13-29"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00228-009-0737-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017322702",
"https://doi.org/10.1007/s00228-009-0737-1"
],
"type": "CreativeWork"
}
],
"datePublished": "2015-09-15",
"datePublishedReg": "2015-09-15",
"description": "BackgroundAntiplatelet treatment is an important component in optimizing the clinical outcomes after percutaneous coronary intervention (PCI) especially in patients with acute coronary syndrome (ACS). Prasugrel, which is a new P2Y12 inhibitor, has been confirmed as efficacious in a large trial in Western countries, and a similar trial is also to be launched in Asian countries. Although a 60-mg loading dose of prasugrel followed by 10\u00a0mg per day should be acceptable, there have been no data regarding the optimal dose in Asian patients. Furthermore, serum levels of prasugrel and the rates of platelet inhibition are known to be higher in Asians than Caucasians with the same dose of the drug.Polymer, a key component of drug-eluting stents (DES), has been suggested as the cause of inflammation leading to late complications, and has driven many companies to develop biodegradable-polymer DES. Currently, there are limited data regarding the head-to-head comparison between BP-BES and the biostable polymer CoCr-EES or the newest platinum-chromium everolimus-eluting stent (PtCr-EES). Furthermore, the polymer issue may be more important in ACS where there is ruptured thrombotic plaque where polymer-induced inflammation may affect the local milieu of the stented artery.Therefore, the present study dedicated only to ACS patients, will offer important information on the optimal prasugrel dose in the Asian population by comparing a 10-mg versus a 5-mg maintenance dose beyond 1\u00a0month after PCI, as well as giving important insight into the polymer issue by comparing BP-BES versus biostable-polymer PtCr-EES.Method/DesignHarmonizing Optimal Strategy for Treatment of coronary artery diseases \u2013 comparison of REDUCtion of prasugrEl dose or POLYmer TECHnology in ACS patients (HOST-REDUCE-POLYTECH-ACS) trial is a multicenter, randomized and open-label clinical study with a 2\u2009\u00d7\u20092 factorial design, according to the type of stent (PtCr-EES versus BP-BES) and prasugrel maintenance dose (5\u00a0mg versus 10\u00a0mg), to demonstrate non-inferiority of PtCr-EES relative to BP-BES or the reduced prasugrel dose relative to conventional dose in an Asian all-comers PCI population presenting with ACS. Approximately 3400 patients will undergo prospective, random assignment separately to either stent or prasugrel arm (1:1 ratio, respectively). When the patients have contraindications to prasugrel, they are categorized into an antiplatelet observation group after stent-randomization. The primary endpoint is the patient-oriented composite outcome, which is a composite of all-cause mortality, any myocardial infarction (MI), any repeat revascularization in the stent arm at 12 months after index PCI. In the prasugrel arm, primary endpoint is any major adverse cardiovascular event, which is a composite of all-cause mortality, any MI, any stent thrombosis (Academic Research Consortium (ARC)-defined), any repeat revascularization, stroke, or bleeding (BARC class \u2265 2).DiscussionThe HOST-REDUCE-POLYTECH-ACS RCT is the first study exploring the optimal maintenance dose of prasugrel beyond 1\u00a0month after PCI for ACS in Asian all-comers. In addition, this is the largest study dedicated only to ACS patients to evaluate the polymer issue in the situation of ACS by directly comparing biostable-polymer PtCr-EES versus BP-BES.Trial registrationClinicalTrials.gov (ID: NCT02193971, 13 July 2014).",
"genre": "article",
"id": "sg:pub.10.1186/s13063-015-0925-5",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1297400",
"issn": [
"1468-6708",
"1745-6215"
],
"name": "Trials",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "16"
}
],
"keywords": [
"acute coronary syndrome",
"percutaneous coronary intervention",
"drug-eluting stents",
"prasugrel dose",
"BP-BES",
"ACS patients",
"maintenance dose",
"myocardial infarction",
"prasugrel arm",
"primary endpoint",
"cause mortality",
"repeat revascularization",
"coronary artery",
"PtCr-EES",
"open-label clinical study",
"patient-oriented composite outcome",
"index percutaneous coronary intervention",
"major adverse cardiovascular events",
"biodegradable polymer drug-eluting stents",
"new P2Y12 inhibitors",
"prasugrel maintenance dose",
"comers PCI population",
"adverse cardiovascular events",
"cause of inflammation",
"optimal maintenance dose",
"stent arm",
"coronary syndrome",
"P2Y12 inhibitors",
"cardiovascular events",
"coronary intervention",
"late complications",
"PCI population",
"composite outcome",
"loading dose",
"serum levels",
"platelet inhibition",
"clinical outcomes",
"observation group",
"large trials",
"Asian patients",
"stent thrombosis",
"conventional dose",
"thrombotic plaques",
"clinical studies",
"same dose",
"CoCr-EES",
"patient trials",
"optimal dose",
"patients",
"prasugrel",
"head comparison",
"larger study",
"dose",
"artery",
"stented artery",
"Asian populations",
"trials",
"similar trials",
"revascularization",
"months",
"inflammation",
"mortality",
"treatment",
"Western countries",
"local milieu",
"endpoint",
"present study",
"outcomes",
"random assignment",
"first study",
"arm",
"multicenter",
"contraindications",
"complications",
"infarction",
"thrombosis",
"RCTs",
"syndrome",
"population",
"stroke",
"plaques",
"stents",
"study",
"Caucasians",
"drugs",
"intervention",
"inhibitors",
"inhibition",
"Asian countries",
"cause",
"days",
"reduction",
"Asians",
"important information",
"group",
"optimal strategy",
"important component",
"head",
"milieu",
"relatives",
"levels",
"data",
"key component",
"important insights",
"strategies",
"protocol",
"rate",
"countries",
"events",
"comers",
"factorial design",
"addition",
"components",
"types",
"comparison",
"issues",
"information",
"insights",
"situation",
"design",
"technology",
"assignment",
"polymer technology",
"companies",
"composites",
"polymers"
],
"name": "Harmonizing Optimal Strategy for Treatment of coronary artery diseases \u2013 comparison of REDUCtion of prasugrEl dose or POLYmer TECHnology in ACS patients (HOST-REDUCE-POLYTECH-ACS RCT): study protocol for a randomized controlled trial",
"pagination": "409",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1046144609"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s13063-015-0925-5"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"26374625"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s13063-015-0925-5",
"https://app.dimensions.ai/details/publication/pub.1046144609"
],
"sdDataset": "articles",
"sdDatePublished": "2022-06-01T22:14",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_684.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1186/s13063-015-0925-5"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13063-015-0925-5'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13063-015-0925-5'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13063-015-0925-5'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13063-015-0925-5'
This table displays all metadata directly associated to this object as RDF triples.
504 TRIPLES
22 PREDICATES
176 URIs
166 LITERALS
29 BLANK NODES