Comparison of two strategies for initiating renal replacement therapy in the intensive care unit: study protocol for a randomized controlled ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Stéphane Gaudry, David Hajage, Fréderique Schortgen, Laurent Martin-Lefevre, Florence Tubach, Bertrand Pons, Eric Boulet, Alexandre Boyer, Nicolas Lerolle, Guillaume Chevrel, Dorothée Carpentier, Alexandre Lautrette, Anne Bretagnol, Julien Mayaux, Marina Thirion, Philippe Markowicz, Guillemette Thomas, Jean Dellamonica, Jack Richecoeur, Michael Darmon, Nicolas de Prost, Hodane Yonis, Bruno Megarbane, Yann Loubières, Clarisse Blayau, Julien Maizel, Benjamin Zuber, Saad Nseir, Naïke Bigé, Isabelle Hoffmann, Jean-Damien Ricard, Didier Dreyfuss

ABSTRACT

BACKGROUND: There is currently no validated strategy for the timing of renal replacement therapy (RRT) for acute kidney injury (AKI) in the intensive care unit (ICU) when short-term life-threatening metabolic abnormalities are absent. No adequately powered prospective randomized study has addressed this issue to date. As a result, significant practice heterogeneity exists and may expose patients to either unnecessary hazardous procedures or undue delay in RRT. METHODS/DESIGN: This is a multicenter, prospective, randomized, open-label parallel-group clinical trial that compares the effect of two RRT initiation strategies on overall survival of critically ill patients receiving intravenous catecholamines or invasive mechanical ventilation and presenting with AKI classification stage 3 (KDIGO 2012). In the 'early' strategy, RRT is initiated immediately. In the 'delayed' strategy, clinical and metabolic conditions are closely monitored and RRT is initiated only when one or more events (severity criteria) occur, including: oliguria or anuria for more than 72 hours after randomization, serum urea concentration >40 mmol/l, serum potassium concentration >6 mmol/l, serum potassium concentration >5.5 mmol/l persisting despite medical treatment, arterial blood pH <7.15 in a context of pure metabolic acidosis (PaCO2 < 35 mmHg) or in a context of mixed acidosis with a PaCO2 ≥ 50 mmHg without possibility of increasing alveolar ventilation, acute pulmonary edema due to fluid overload despite diuretic therapy leading to severe hypoxemia requiring oxygen flow rate >5 l/min to maintain SpO2 > 95% or FiO2 > 50% under invasive or noninvasive mechanical ventilation. The primary outcome measure is overall survival, measured from randomization (D0) until death, regardless of the cause. The minimum follow-up duration for each patient will be 60 days. Two interim analyses are planned, blinded to group allocation. It is expected that there will be 620 subjects in all. DISCUSSION: The AKIKI study will be one of the very few large randomized controlled trials evaluating mortality according to the timing of RRT in critically ill patients with AKI classification stage 3 (KDIGO 2012). Results should help clinicians decide when to initiate RRT. TRIAL REGISTRATION: ClinicalTrials.gov NCT01932190. More... »

PAGES

170

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13063-015-0718-x

DOI

http://dx.doi.org/10.1186/s13063-015-0718-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030061328

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25902813


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