Redressing the interactions between stem cells and immune system in tissue regeneration View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-10-20

AUTHORS

Jiankai Fang, Chao Feng, Wangwang Chen, Pengbo Hou, Zhanhong Liu, Muqiu Zuo, Yuyi Han, Chenchang Xu, Gerry Melino, Alexei Verkhratsky, Ying Wang, Changshun Shao, Yufang Shi

ABSTRACT

Skeletal muscle has an extraordinary regenerative capacity reflecting the rapid activation and effective differentiation of muscle stem cells (MuSCs). In the course of muscle regeneration, MuSCs are reprogrammed by immune cells. In turn, MuSCs confer immune cells anti-inflammatory properties to resolve inflammation and facilitate tissue repair. Indeed, MuSCs can exert therapeutic effects on various degenerative and inflammatory disorders based on their immunoregulatory ability, including effects primed by interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α). At the molecular level, the tryptophan metabolites, kynurenine or kynurenic acid, produced by indoleamine 2,3-dioxygenase (IDO), augment the expression of TNF-stimulated gene 6 (TSG6) through the activation of the aryl hydrocarbon receptor (AHR). In addition, insulin growth factor 2 (IGF2) produced by MuSCs can endow maturing macrophages oxidative phosphorylation (OXPHOS)-dependent anti-inflammatory functions. Herein, we summarize the current understanding of the immunomodulatory characteristics of MuSCs and the issues related to their potential applications in pathological conditions, including COVID-19. More... »

PAGES

18

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  • Journal

    TITLE

    Biology Direct

    ISSUE

    1

    VOLUME

    16

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13062-021-00306-6

    DOI

    http://dx.doi.org/10.1186/s13062-021-00306-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1141982448

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34670590


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