Understanding p53 tumour suppressor network View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-08-06

AUTHORS

Emanuele Panatta, Carlotta Zampieri, Gerry Melino, Ivano Amelio

ABSTRACT

The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulation of several cellular functions, including cell cycle progression and cell death in response to genotoxic stress. In the recent years additional p53-mediated tumour suppression mechanisms have been described, questioning the contribution of its canonical pathway for tumour suppression. These include regulation of alternative cell death modalities (i.e. ferroptosis), cell metabolism and the emerging role in RNA stability. Here we briefly summarize our knowledge on p53 "canonical DNA damage response" and discuss the most relevant recent findings describing potential mechanistic explanation of p53-mediated tumour suppression. More... »

PAGES

14

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    URI

    http://scigraph.springernature.com/pub.10.1186/s13062-021-00298-3

    DOI

    http://dx.doi.org/10.1186/s13062-021-00298-3

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34362419


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