Enhancer transcription detected in the nascent transcriptomic landscape of bread wheat View Full Text


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Article Info

DATE

2022-04-30

AUTHORS

Yilin Xie, Yan Chen, Zijuan Li, Jiafu Zhu, Min Liu, Yijing Zhang, Zhicheng Dong

ABSTRACT

The precise spatiotemporal gene expression is orchestrated by enhancers that lack general sequence features and thus are difficult to be computationally identified. By nascent RNA sequencing combined with epigenome profiling, we detect active transcription of enhancers from the complex bread wheat genome. We find that genes associated with transcriptional enhancers are expressed at significantly higher levels, and enhancer RNA is more precise and robust in predicting enhancer activity compared to chromatin features. We demonstrate that sub-genome-biased enhancer transcription could drive sub-genome-biased gene expression. This study highlights enhancer transcription as a hallmark in regulating gene expression in wheat. More... »

PAGES

109

References to SciGraph publications

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    http://scigraph.springernature.com/pub.10.1186/s13059-022-02675-1

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