Non-AUG translation initiation in mammals View Full Text


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Article Info

DATE

2022-05-09

AUTHORS

Dmitry E. Andreev, Gary Loughran, Alla D. Fedorova, Maria S. Mikhaylova, Ivan N. Shatsky, Pavel V. Baranov

ABSTRACT

Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality within the same RNA. This plurality is often due to the failure of some scanning ribosomes to recognize potential start codons leading to initiation downstream—a process termed leaky scanning. Codons other than AUG (non-AUG) are particularly leaky due to their inefficiency. Here we discuss our current understanding of non-AUG initiation. We argue for a near-ubiquitous role of non-AUG initiation in shaping the dynamic composition of mammalian proteomes. More... »

PAGES

111

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13059-022-02674-2

    DOI

    http://dx.doi.org/10.1186/s13059-022-02674-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1147723623

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35534899


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