RnBeads 2.0: comprehensive analysis of DNA methylation data View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-03-14

AUTHORS

Fabian Müller, Michael Scherer, Yassen Assenov, Pavlo Lutsik, Jörn Walter, Thomas Lengauer, Christoph Bock

ABSTRACT

DNA methylation is a widely investigated epigenetic mark with important roles in development and disease. High-throughput assays enable genome-scale DNA methylation analysis in large numbers of samples. Here, we describe a new version of our RnBeads software - an R/Bioconductor package that implements start-to-finish analysis workflows for Infinium microarrays and various types of bisulfite sequencing. RnBeads 2.0 (https://rnbeads.org/) provides additional data types and analysis methods, new functionality for interpreting DNA methylation differences, improved usability with a novel graphical user interface, and better use of computational resources. We demonstrate RnBeads 2.0 in four re-runnable use cases focusing on cell differentiation and cancer. More... »

PAGES

55

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    URI

    http://scigraph.springernature.com/pub.10.1186/s13059-019-1664-9

    DOI

    http://dx.doi.org/10.1186/s13059-019-1664-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112761203

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30871603


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