Lifestyle modifications: coordinating the tRNA epitranscriptome with codon bias to adapt translation during stress responses View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Cheryl Chan, Phuong Pham, Peter C. Dedon, Thomas J. Begley

ABSTRACT

Cells adapt to stress by altering gene expression at multiple levels. Here, we propose a new mechanism regulating stress-dependent gene expression at the level of translation, with coordinated interplay between the tRNA epitranscriptome and biased codon usage in families of stress-response genes. In this model, auxiliary genetic information contained in synonymous codon usage enables regulation of codon-biased and functionally related transcripts by dynamic changes in the tRNA epitranscriptome. This model partly explains the association between synchronous stress-dependent epitranscriptomic marks and significant multi-codon usage skewing in families of translationally regulated transcripts. The model also predicts translational adaptation during viral infections. More... »

PAGES

228

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13059-018-1611-1

DOI

http://dx.doi.org/10.1186/s13059-018-1611-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110911707

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30587213


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