Timing somatic events in the evolution of cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Clemency Jolly, Peter Van Loo

ABSTRACT

Cancer arises through the accumulation of somatic mutations over time. An understanding of the sequence of events during this process should allow both earlier diagnosis and better prediction of cancer progression. However, the pathways of tumor evolution have not yet been comprehensively characterized. With the advent of whole genome sequencing, it is now possible to infer the evolutionary history of single tumors from the snapshot of their genome taken at diagnosis, giving new insights into the biology of tumorigenesis. More... »

PAGES

95

References to SciGraph publications

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  • Journal

    TITLE

    Genome Biology

    ISSUE

    1

    VOLUME

    19

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13059-018-1476-3

    DOI

    http://dx.doi.org/10.1186/s13059-018-1476-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105809031

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30041675


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