Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Jonas Demeulemeester, Parveen Kumar, Elen K. Møller, Silje Nord, David C. Wedge, April Peterson, Randi R. Mathiesen, Renathe Fjelldal, Masoud Zamani Esteki, Koen Theunis, Elia Fernandez Gallardo, A. Jason Grundstad, Elin Borgen, Lars O. Baumbusch, Anne-Lise Børresen-Dale, Kevin P. White, Vessela N. Kristensen, Peter Van Loo, Thierry Voet, Bjørn Naume

ABSTRACT

BACKGROUND: Single-cell micro-metastases of solid tumors often occur in the bone marrow. These disseminated tumor cells (DTCs) may resist therapy and lay dormant or progress to cause overt bone and visceral metastases. The molecular nature of DTCs remains elusive, as well as when and from where in the tumor they originate. Here, we apply single-cell sequencing to identify and trace the origin of DTCs in breast cancer. RESULTS: We sequence the genomes of 63 single cells isolated from six non-metastatic breast cancer patients. By comparing the cells' DNA copy number aberration (CNA) landscapes with those of the primary tumors and lymph node metastasis, we establish that 53% of the single cells morphologically classified as tumor cells are DTCs disseminating from the observed tumor. The remaining cells represent either non-aberrant "normal" cells or "aberrant cells of unknown origin" that have CNA landscapes discordant from the tumor. Further analyses suggest that the prevalence of aberrant cells of unknown origin is age-dependent and that at least a subset is hematopoietic in origin. Evolutionary reconstruction analysis of bulk tumor and DTC genomes enables ordering of CNA events in molecular pseudo-time and traced the origin of the DTCs to either the main tumor clone, primary tumor subclones, or subclones in an axillary lymph node metastasis. CONCLUSIONS: Single-cell sequencing of bone marrow epithelial-like cells, in parallel with intra-tumor genetic heterogeneity profiling from bulk DNA, is a powerful approach to identify and study DTCs, yielding insight into metastatic processes. A heterogeneous population of CNA-positive cells is present in the bone marrow of non-metastatic breast cancer patients, only part of which are derived from the observed tumor lineages. More... »

PAGES

250

References to SciGraph publications

  • 2012-06. Detectable clonal mosaicism from birth to old age and its relationship to cancer in NATURE GENETICS
  • 2012-06. Detectable clonal mosaicism and its relationship to aging and cancer in NATURE GENETICS
  • 2014. NGS-Logistics : Federated analysis of NGS sequence variants across multiple locations in GENOME MEDICINE
  • 2013-04. Disseminated tumour cells in the bone marrow in early breast cancer: morphological categories of immunocytochemically positive cells have different impact on clinical outcome in BREAST CANCER RESEARCH AND TREATMENT
  • 2016-10. Punctuated copy number evolution and clonal stasis in triple-negative breast cancer in NATURE GENETICS
  • 2013-07. The perivascular niche regulates breast tumour dormancy in NATURE CELL BIOLOGY
  • 2009-04. Parallel progression of primary tumours and metastases in NATURE REVIEWS CANCER
  • 2009-04. The cancer genome in NATURE
  • 2014-09. Mechanisms of disseminated cancer cell dormancy: an awakening field in NATURE REVIEWS CANCER
  • 2007-11. Models, mechanisms and clinical evidence for cancer dormancy in NATURE REVIEWS CANCER
  • 2011-01. Integrative genomics viewer in NATURE BIOTECHNOLOGY
  • 2012-11. Evolution of the cancer genome in NATURE REVIEWS GENETICS
  • 2006-07. Comparison of HER2 status between primary tumor and disseminated tumor cells in␣primary breast cancer patients in BREAST CANCER RESEARCH AND TREATMENT
  • 2014-12. NGS-Logistics: federated analysis of NGS sequence variants across multiple locations in GENOME MEDICINE
  • 2013-03. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples in NATURE BIOTECHNOLOGY
  • 2011-04. Tumour evolution inferred by single-cell sequencing in NATURE
  • 2012-06. The clonal and mutational evolution spectrum of primary triple-negative breast cancers in NATURE
  • 2010-10-28. A map of human genome variation from population-scale sequencing in NATURE
  • 2012-12. Copynumber: Efficient algorithms for single- and multi-track copy number segmentation in BMC GENOMICS
  • 2014-08. Clonal evolution in breast cancer revealed by single nucleus genome sequencing in NATURE
  • 2013-09. Selection and adaptation during metastatic cancer progression in NATURE
  • 2012-08. Persistence of disseminated tumor cells after neoadjuvant treatment for locally advanced breast cancer predicts poor survival in BREAST CANCER RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13059-016-1109-7

    DOI

    http://dx.doi.org/10.1186/s13059-016-1109-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012948179

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27931250


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acid Substitution", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Axilla", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Marrow Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Copy Number Variations", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunohistochemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymph Nodes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Grading", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Staging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplastic Cells, Circulating", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sequence Analysis, DNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Single-Cell Analysis", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "KU Leuven", 
              "id": "https://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "The Francis Crick Institute, London, UK", 
                "Department of Human Genetics, KU Leuven\u2014University of Leuven, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Demeulemeester", 
            "givenName": "Jonas", 
            "id": "sg:person.01026052267.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026052267.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wellcome Sanger Institute", 
              "id": "https://www.grid.ac/institutes/grid.10306.34", 
              "name": [
                "Department of Human Genetics, KU Leuven\u2014University of Leuven, Leuven, Belgium", 
                "Single-cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kumar", 
            "givenName": "Parveen", 
            "id": "sg:person.0702220210.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702220210.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oslo University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.55325.34", 
              "name": [
                "Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway"
              ], 
              "type": "Organization"
            }, 
            "familyName": "M\u00f8ller", 
            "givenName": "Elen K.", 
            "id": "sg:person.0713273262.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713273262.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oslo University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.55325.34", 
              "name": [
                "Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nord", 
            "givenName": "Silje", 
            "id": "sg:person.01101476162.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101476162.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wellcome Sanger Institute", 
              "id": "https://www.grid.ac/institutes/grid.10306.34", 
              "name": [
                "Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wedge", 
            "givenName": "David C.", 
            "id": "sg:person.01252077430.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252077430.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Wisconsin\u2013Madison", 
              "id": "https://www.grid.ac/institutes/grid.14003.36", 
              "name": [
                "Institute for Genomics & Systems Biology and Department of Human Genetics, University of Chicago, Chicago, IL, USA", 
                "Present address: Laboratory of Genetics, University of Wisconsin, Madison, WI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peterson", 
            "givenName": "April", 
            "id": "sg:person.01075635062.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075635062.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Akershus University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411279.8", 
              "name": [
                "Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway", 
                "Department of Oncology, Division of Surgery and Cancer Medicine, Oslo University Hospital, Radiumhospitalet, Oslo, Norway", 
                "Present address: Department of Oncology, Akershus University Hospital, L\u00f8renskog, Norway"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mathiesen", 
            "givenName": "Randi R.", 
            "id": "sg:person.01232451303.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232451303.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oslo University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.55325.34", 
              "name": [
                "Department of Pathology, Oslo University Hospital, Radiumhospitalet, Oslo, Norway"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fjelldal", 
            "givenName": "Renathe", 
            "id": "sg:person.01300564503.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300564503.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "KU Leuven", 
              "id": "https://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "Department of Human Genetics, KU Leuven\u2014University of Leuven, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zamani Esteki", 
            "givenName": "Masoud", 
            "id": "sg:person.01311200335.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311200335.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "KU Leuven", 
              "id": "https://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "Department of Human Genetics, KU Leuven\u2014University of Leuven, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Theunis", 
            "givenName": "Koen", 
            "id": "sg:person.0715351523.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715351523.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "KU Leuven", 
              "id": "https://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "Department of Human Genetics, KU Leuven\u2014University of Leuven, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fernandez Gallardo", 
            "givenName": "Elia", 
            "id": "sg:person.07654502202.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07654502202.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institute for Genomics & Systems Biology and Department of Human Genetics, University of Chicago, Chicago, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grundstad", 
            "givenName": "A. Jason", 
            "id": "sg:person.0752477127.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752477127.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oslo University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.55325.34", 
              "name": [
                "Department of Pathology, Oslo University Hospital, Radiumhospitalet, Oslo, Norway"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Borgen", 
            "givenName": "Elin", 
            "id": "sg:person.01062455314.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062455314.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oslo University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.55325.34", 
              "name": [
                "Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway", 
                "Present address: Department of Pediatric Research, Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baumbusch", 
            "givenName": "Lars O.", 
            "id": "sg:person.01057611703.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057611703.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oslo University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.55325.34", 
              "name": [
                "Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway"
              ], 
              "type": "Organization"
            }, 
            "familyName": "B\u00f8rresen-Dale", 
            "givenName": "Anne-Lise", 
            "id": "sg:person.01361622203.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361622203.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institute for Genomics & Systems Biology and Department of Human Genetics, University of Chicago, Chicago, IL, USA", 
                "Tempus Labs, 60654, Chicago, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "White", 
            "givenName": "Kevin P.", 
            "id": "sg:person.01154231246.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154231246.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Akershus University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411279.8", 
              "name": [
                "Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway", 
                "Department of Clinical Molecular Biology (EpiGen), Medical Division, Akershus University Hospital, L\u00f8renskog, Norway"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kristensen", 
            "givenName": "Vessela N.", 
            "id": "sg:person.01215000714.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215000714.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "KU Leuven", 
              "id": "https://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "The Francis Crick Institute, London, UK", 
                "Department of Human Genetics, KU Leuven\u2014University of Leuven, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Van Loo", 
            "givenName": "Peter", 
            "id": "sg:person.01017630143.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017630143.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wellcome Sanger Institute", 
              "id": "https://www.grid.ac/institutes/grid.10306.34", 
              "name": [
                "Department of Human Genetics, KU Leuven\u2014University of Leuven, Leuven, Belgium", 
                "Single-cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Voet", 
            "givenName": "Thierry", 
            "id": "sg:person.01026626365.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026626365.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Oslo", 
              "id": "https://www.grid.ac/institutes/grid.5510.1", 
              "name": [
                "Department of Oncology, Division of Surgery and Cancer Medicine, Oslo University Hospital, Radiumhospitalet, Oslo, Norway", 
                "Institute of Clinical Medicine, University of Oslo, Oslo, Norway"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Naume", 
            "givenName": "Bj\u00f8rn", 
            "id": "sg:person.01071554513.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071554513.00"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nbt.2514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000477771", 
              "https://doi.org/10.1038/nbt.2514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.26444", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001176628"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/cancers6010143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004089117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004829095", 
              "https://doi.org/10.1038/nature07943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004829095", 
              "https://doi.org/10.1038/nature07943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(02)09838-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005895738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9896(199808)185:4<427::aid-path127>3.0.co;2-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006166820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1009843107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007646723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0085907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007928473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-13-591", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010110271", 
              "https://doi.org/10.1186/1471-2164-13-591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010608717", 
              "https://doi.org/10.1038/nature09534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010608717", 
              "https://doi.org/10.1038/nature09534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.04.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012547698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013331797", 
              "https://doi.org/10.1038/nrg3317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.02.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014092720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014329007", 
              "https://doi.org/10.1038/ng.2271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-2515", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015515992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.17.0563", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015613811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019307928", 
              "https://doi.org/10.1038/nbt.1754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020406938", 
              "https://doi.org/10.1038/nature09807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-013-2439-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022582269", 
              "https://doi.org/10.1007/s10549-013-2439-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1415287111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023383926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr3242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024759034", 
              "https://doi.org/10.1186/bcr3242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.03.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025379962"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.02.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025548171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.22076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026540857"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10933", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027457561", 
              "https://doi.org/10.1038/nature10933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3793", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028687018", 
              "https://doi.org/10.1038/nrc3793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm200002243420801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030050346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-03-0373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030640021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030922165", 
              "https://doi.org/10.1038/nrc2256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2767", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031053152", 
              "https://doi.org/10.1038/ncb2767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.107524.110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032096953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13600", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035306231", 
              "https://doi.org/10.1038/nature13600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3641", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036124041", 
              "https://doi.org/10.1038/ng.3641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13073-014-0071-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036457346", 
              "https://doi.org/10.1186/s13073-014-0071-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13073-014-0071-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036457346", 
              "https://doi.org/10.1186/s13073-014-0071-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-03-0818", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037332991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/g3.111.001198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037455212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/g3.111.001198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037455212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp324", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038266369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.09.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039482183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1331931100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039963755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fonc.2013.00320", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042072712"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/0032472031000141283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044333286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-005-9147-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046366390", 
              "https://doi.org/10.1007/s10549-005-9147-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-005-9147-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046366390", 
              "https://doi.org/10.1007/s10549-005-9147-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.191098.115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046493374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2270", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048576872", 
              "https://doi.org/10.1038/ng.2270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12628", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048605463", 
              "https://doi.org/10.1038/nature12628"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa050434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048972336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa050434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048972336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2627", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052526028", 
              "https://doi.org/10.1038/nrc2627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2627", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052526028", 
              "https://doi.org/10.1038/nrc2627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gde.2014.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053552739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/preaccept-3696327041308731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064134533", 
              "https://doi.org/10.1186/preaccept-3696327041308731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2003.02.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064203370"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-12", 
        "datePublishedReg": "2016-12-01", 
        "description": "BACKGROUND: Single-cell micro-metastases of solid tumors often occur in the bone marrow. These disseminated tumor cells (DTCs) may resist therapy and lay dormant or progress to cause overt bone and visceral metastases. The molecular nature of DTCs remains elusive, as well as when and from where in the tumor they originate. Here, we apply single-cell sequencing to identify and trace the origin of DTCs in breast cancer.\nRESULTS: We sequence the genomes of 63 single cells isolated from six non-metastatic breast cancer patients. By comparing the cells' DNA copy number aberration (CNA) landscapes with those of the primary tumors and lymph node metastasis, we establish that 53% of the single cells morphologically classified as tumor cells are DTCs disseminating from the observed tumor. The remaining cells represent either non-aberrant \"normal\" cells or \"aberrant cells of unknown origin\" that have CNA landscapes discordant from the tumor. Further analyses suggest that the prevalence of aberrant cells of unknown origin is age-dependent and that at least a subset is hematopoietic in origin. Evolutionary reconstruction analysis of bulk tumor and DTC genomes enables ordering of CNA events in molecular pseudo-time and traced the origin of the DTCs to either the main tumor clone, primary tumor subclones, or subclones in an axillary lymph node metastasis.\nCONCLUSIONS: Single-cell sequencing of bone marrow epithelial-like cells, in parallel with intra-tumor genetic heterogeneity profiling from bulk DNA, is a powerful approach to identify and study DTCs, yielding insight into metastatic processes. A heterogeneous population of CNA-positive cells is present in the bone marrow of non-metastatic breast cancer patients, only part of which are derived from the observed tumor lineages.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s13059-016-1109-7", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3635170", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6798148", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5494085", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1023439", 
            "issn": [
              "1474-760X", 
              "1465-6906"
            ], 
            "name": "Genome Biology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "17"
          }
        ], 
        "name": "Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing", 
        "pagination": "250", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "3dafbaa1135301d9e02c4ecb87424e6165617136e68fdf203900bc6f526347e7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27931250"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100960660"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13059-016-1109-7"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1012948179"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13059-016-1109-7", 
          "https://app.dimensions.ai/details/publication/pub.1012948179"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:42", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70061_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1186%2Fs13059-016-1109-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13059-016-1109-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13059-016-1109-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13059-016-1109-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13059-016-1109-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    490 TRIPLES      21 PREDICATES      99 URIs      41 LITERALS      29 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13059-016-1109-7 schema:about N0085a42370fa4fed9a6ce8b34584a15c
    2 N0b52d18c81104014860062a1fec3e738
    3 N1fd6ac7ba6684cdb8c2e74e147fcfa3e
    4 N32342de3742244bea955b21648b40e59
    5 N42e225f9ea6e44d694c802eed278f980
    6 N4bffcfa91f9a45b0b181f23471efbe59
    7 N57a12f74df464685a36c9a73a1a94f95
    8 N57ccc53d6e844e10b41eff4b00247f7f
    9 N5b88510f2f5b4f229c8f335b4f799ece
    10 N64eb23b70f644fa7a48a172711ed7951
    11 N6c76b30b014b4639b630ab7796d421ca
    12 N76bce8a6ac2d4b40a9daa14c10bd2c11
    13 N8d8089dd19444b63b83fc8bf4d50aacc
    14 N9a7d66e6ed844d388cb82a58afe5efac
    15 Na800ee1fe3ba4389b1e5a5fc71bce96b
    16 Nab58183384eb4257aea8cb9e83ea9862
    17 Nae94984a8aee47a082498a2c77678c04
    18 Nb1b08dd9ee5740c9bca1bb9085a6fedc
    19 Nc90090d7d1c64f00b633ececffbdf667
    20 Ndcd7f274b44d4e1f924d760253ea7d19
    21 anzsrc-for:11
    22 anzsrc-for:1112
    23 schema:author N610fb2fbca344cab967f3b4e500ec2fc
    24 schema:citation sg:pub.10.1007/s10549-005-9147-y
    25 sg:pub.10.1007/s10549-013-2439-8
    26 sg:pub.10.1038/nature07943
    27 sg:pub.10.1038/nature09534
    28 sg:pub.10.1038/nature09807
    29 sg:pub.10.1038/nature10933
    30 sg:pub.10.1038/nature12628
    31 sg:pub.10.1038/nature13600
    32 sg:pub.10.1038/nbt.1754
    33 sg:pub.10.1038/nbt.2514
    34 sg:pub.10.1038/ncb2767
    35 sg:pub.10.1038/ng.2270
    36 sg:pub.10.1038/ng.2271
    37 sg:pub.10.1038/ng.3641
    38 sg:pub.10.1038/nrc2256
    39 sg:pub.10.1038/nrc2627
    40 sg:pub.10.1038/nrc3793
    41 sg:pub.10.1038/nrg3317
    42 sg:pub.10.1186/1471-2164-13-591
    43 sg:pub.10.1186/bcr3242
    44 sg:pub.10.1186/preaccept-3696327041308731
    45 sg:pub.10.1186/s13073-014-0071-9
    46 https://doi.org/10.1002/(sici)1096-9896(199808)185:4<427::aid-path127>3.0.co;2-7
    47 https://doi.org/10.1002/cncr.22076
    48 https://doi.org/10.1002/ijc.26444
    49 https://doi.org/10.1016/j.cell.2011.09.024
    50 https://doi.org/10.1016/j.cell.2012.02.025
    51 https://doi.org/10.1016/j.cell.2012.02.028
    52 https://doi.org/10.1016/j.cell.2012.04.023
    53 https://doi.org/10.1016/j.cell.2013.03.021
    54 https://doi.org/10.1016/j.gde.2014.12.001
    55 https://doi.org/10.1016/s0140-6736(02)09838-0
    56 https://doi.org/10.1056/nejm200002243420801
    57 https://doi.org/10.1056/nejmoa050434
    58 https://doi.org/10.1073/pnas.1009843107
    59 https://doi.org/10.1073/pnas.1331931100
    60 https://doi.org/10.1073/pnas.1415287111
    61 https://doi.org/10.1080/0032472031000141283
    62 https://doi.org/10.1093/bioinformatics/btp324
    63 https://doi.org/10.1101/gr.107524.110
    64 https://doi.org/10.1101/gr.191098.115
    65 https://doi.org/10.1158/1078-0432.ccr-03-0373
    66 https://doi.org/10.1158/1078-0432.ccr-03-0818
    67 https://doi.org/10.1158/1078-0432.ccr-10-2515
    68 https://doi.org/10.1200/jco.2003.02.009
    69 https://doi.org/10.1200/jco.2008.17.0563
    70 https://doi.org/10.1371/journal.pone.0085907
    71 https://doi.org/10.1534/g3.111.001198
    72 https://doi.org/10.3389/fonc.2013.00320
    73 https://doi.org/10.3390/cancers6010143
    74 schema:datePublished 2016-12
    75 schema:datePublishedReg 2016-12-01
    76 schema:description BACKGROUND: Single-cell micro-metastases of solid tumors often occur in the bone marrow. These disseminated tumor cells (DTCs) may resist therapy and lay dormant or progress to cause overt bone and visceral metastases. The molecular nature of DTCs remains elusive, as well as when and from where in the tumor they originate. Here, we apply single-cell sequencing to identify and trace the origin of DTCs in breast cancer. RESULTS: We sequence the genomes of 63 single cells isolated from six non-metastatic breast cancer patients. By comparing the cells' DNA copy number aberration (CNA) landscapes with those of the primary tumors and lymph node metastasis, we establish that 53% of the single cells morphologically classified as tumor cells are DTCs disseminating from the observed tumor. The remaining cells represent either non-aberrant "normal" cells or "aberrant cells of unknown origin" that have CNA landscapes discordant from the tumor. Further analyses suggest that the prevalence of aberrant cells of unknown origin is age-dependent and that at least a subset is hematopoietic in origin. Evolutionary reconstruction analysis of bulk tumor and DTC genomes enables ordering of CNA events in molecular pseudo-time and traced the origin of the DTCs to either the main tumor clone, primary tumor subclones, or subclones in an axillary lymph node metastasis. CONCLUSIONS: Single-cell sequencing of bone marrow epithelial-like cells, in parallel with intra-tumor genetic heterogeneity profiling from bulk DNA, is a powerful approach to identify and study DTCs, yielding insight into metastatic processes. A heterogeneous population of CNA-positive cells is present in the bone marrow of non-metastatic breast cancer patients, only part of which are derived from the observed tumor lineages.
    77 schema:genre research_article
    78 schema:inLanguage en
    79 schema:isAccessibleForFree true
    80 schema:isPartOf N44669f2cd1b44b998b1c2a2eb5abd170
    81 Na59da694dd7c4f0aaf1535f17bfdc43e
    82 sg:journal.1023439
    83 schema:name Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing
    84 schema:pagination 250
    85 schema:productId N7176705863b14a9cb4f5f87b5b2bd45c
    86 N83267750635648019480c4e17873cea3
    87 N8e50f5aeab6548548696f6756dabf0e6
    88 N94cc88e469134867aebe4e9df1324d48
    89 Ne4df2d86e2ac4d81bec4b21401729a23
    90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012948179
    91 https://doi.org/10.1186/s13059-016-1109-7
    92 schema:sdDatePublished 2019-04-11T12:42
    93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    94 schema:sdPublisher N57c8ae57ceb349db80343bfdcceedd40
    95 schema:url https://link.springer.com/10.1186%2Fs13059-016-1109-7
    96 sgo:license sg:explorer/license/
    97 sgo:sdDataset articles
    98 rdf:type schema:ScholarlyArticle
    99 N0085a42370fa4fed9a6ce8b34584a15c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Sequence Analysis, DNA
    101 rdf:type schema:DefinedTerm
    102 N0b52d18c81104014860062a1fec3e738 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Neoplastic Cells, Circulating
    104 rdf:type schema:DefinedTerm
    105 N0f20458162d44c01a1ede5e587dd7bb5 rdf:first sg:person.07654502202.28
    106 rdf:rest N8e18ad3ae2bb45a681586bf462aa62a3
    107 N0f8a19a8e53f4bab8eb25f912ce535dd rdf:first sg:person.01252077430.47
    108 rdf:rest N7196496847234bccb33161ec6292258c
    109 N1db63155c0c04f00b371a4ed77be115d rdf:first sg:person.0702220210.53
    110 rdf:rest N74fa061e913e4825add8524136386aa1
    111 N1fd6ac7ba6684cdb8c2e74e147fcfa3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Single-Cell Analysis
    113 rdf:type schema:DefinedTerm
    114 N2533d4acdead4bf9ac38a262049da920 schema:name Institute for Genomics & Systems Biology and Department of Human Genetics, University of Chicago, Chicago, IL, USA
    115 Tempus Labs, 60654, Chicago, IL, USA
    116 rdf:type schema:Organization
    117 N32342de3742244bea955b21648b40e59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Biomarkers, Tumor
    119 rdf:type schema:DefinedTerm
    120 N42e225f9ea6e44d694c802eed278f980 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Neoplasm Metastasis
    122 rdf:type schema:DefinedTerm
    123 N44669f2cd1b44b998b1c2a2eb5abd170 schema:issueNumber 1
    124 rdf:type schema:PublicationIssue
    125 N4bffcfa91f9a45b0b181f23471efbe59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Humans
    127 rdf:type schema:DefinedTerm
    128 N4cf2be0eaf234481bcccaabfd4facda1 rdf:first sg:person.01215000714.10
    129 rdf:rest Nd15f03dd81c344589625d493cd462b05
    130 N57a12f74df464685a36c9a73a1a94f95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Aged, 80 and over
    132 rdf:type schema:DefinedTerm
    133 N57c8ae57ceb349db80343bfdcceedd40 schema:name Springer Nature - SN SciGraph project
    134 rdf:type schema:Organization
    135 N57ccc53d6e844e10b41eff4b00247f7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Aged
    137 rdf:type schema:DefinedTerm
    138 N5b88510f2f5b4f229c8f335b4f799ece schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name DNA Copy Number Variations
    140 rdf:type schema:DefinedTerm
    141 N610fb2fbca344cab967f3b4e500ec2fc rdf:first sg:person.01026052267.93
    142 rdf:rest N1db63155c0c04f00b371a4ed77be115d
    143 N64eb23b70f644fa7a48a172711ed7951 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Middle Aged
    145 rdf:type schema:DefinedTerm
    146 N6c76b30b014b4639b630ab7796d421ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Mutation
    148 rdf:type schema:DefinedTerm
    149 N6d3d1f85719c4b8ea0dd931f38d54b34 rdf:first sg:person.01062455314.30
    150 rdf:rest Nfd36802e02ef41a6a290bf9bdeee06fc
    151 N7176705863b14a9cb4f5f87b5b2bd45c schema:name pubmed_id
    152 schema:value 27931250
    153 rdf:type schema:PropertyValue
    154 N7196496847234bccb33161ec6292258c rdf:first sg:person.01075635062.50
    155 rdf:rest Nfd2eb6a89f2644a5b6f2950c4d1404e6
    156 N74fa061e913e4825add8524136386aa1 rdf:first sg:person.0713273262.02
    157 rdf:rest Nc97325af1f6145b4b309eb4d5163fb47
    158 N76bce8a6ac2d4b40a9daa14c10bd2c11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Bone Marrow Cells
    160 rdf:type schema:DefinedTerm
    161 N7f242eb30979427c919130f087808d63 rdf:first sg:person.01361622203.97
    162 rdf:rest Neb3d47edd2c246f4a8e8a6357431d6b1
    163 N83267750635648019480c4e17873cea3 schema:name doi
    164 schema:value 10.1186/s13059-016-1109-7
    165 rdf:type schema:PropertyValue
    166 N8d8089dd19444b63b83fc8bf4d50aacc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Immunohistochemistry
    168 rdf:type schema:DefinedTerm
    169 N8e18ad3ae2bb45a681586bf462aa62a3 rdf:first sg:person.0752477127.73
    170 rdf:rest N6d3d1f85719c4b8ea0dd931f38d54b34
    171 N8e50f5aeab6548548696f6756dabf0e6 schema:name nlm_unique_id
    172 schema:value 100960660
    173 rdf:type schema:PropertyValue
    174 N9492bd040a2e4fdfa02cdac7a92d5c80 rdf:first sg:person.01311200335.49
    175 rdf:rest Nb069a256fe484eddaa854b462dfb4f17
    176 N94cc88e469134867aebe4e9df1324d48 schema:name dimensions_id
    177 schema:value pub.1012948179
    178 rdf:type schema:PropertyValue
    179 N9a7d66e6ed844d388cb82a58afe5efac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Neoplasm Grading
    181 rdf:type schema:DefinedTerm
    182 Na2cb27cc4aee49a596f71b81ef07b575 rdf:first sg:person.01300564503.78
    183 rdf:rest N9492bd040a2e4fdfa02cdac7a92d5c80
    184 Na59da694dd7c4f0aaf1535f17bfdc43e schema:volumeNumber 17
    185 rdf:type schema:PublicationVolume
    186 Na800ee1fe3ba4389b1e5a5fc71bce96b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Amino Acid Substitution
    188 rdf:type schema:DefinedTerm
    189 Na803cd329f144b25879609abd677ca4e rdf:first sg:person.01026626365.10
    190 rdf:rest Ndf62f01645db4bef985ba051aab3baca
    191 Nab58183384eb4257aea8cb9e83ea9862 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Lymph Nodes
    193 rdf:type schema:DefinedTerm
    194 Nae94984a8aee47a082498a2c77678c04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Breast Neoplasms
    196 rdf:type schema:DefinedTerm
    197 Nb069a256fe484eddaa854b462dfb4f17 rdf:first sg:person.0715351523.85
    198 rdf:rest N0f20458162d44c01a1ede5e587dd7bb5
    199 Nb1b08dd9ee5740c9bca1bb9085a6fedc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Axilla
    201 rdf:type schema:DefinedTerm
    202 Nbc275743adce4ebfa20d55b8a78f8ad2 schema:name Institute for Genomics & Systems Biology and Department of Human Genetics, University of Chicago, Chicago, IL, USA
    203 rdf:type schema:Organization
    204 Nc90090d7d1c64f00b633ececffbdf667 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Neoplasm Staging
    206 rdf:type schema:DefinedTerm
    207 Nc97325af1f6145b4b309eb4d5163fb47 rdf:first sg:person.01101476162.97
    208 rdf:rest N0f8a19a8e53f4bab8eb25f912ce535dd
    209 Nd15f03dd81c344589625d493cd462b05 rdf:first sg:person.01017630143.46
    210 rdf:rest Na803cd329f144b25879609abd677ca4e
    211 Ndcd7f274b44d4e1f924d760253ea7d19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Adult
    213 rdf:type schema:DefinedTerm
    214 Ndf62f01645db4bef985ba051aab3baca rdf:first sg:person.01071554513.00
    215 rdf:rest rdf:nil
    216 Ne4df2d86e2ac4d81bec4b21401729a23 schema:name readcube_id
    217 schema:value 3dafbaa1135301d9e02c4ecb87424e6165617136e68fdf203900bc6f526347e7
    218 rdf:type schema:PropertyValue
    219 Neb3d47edd2c246f4a8e8a6357431d6b1 rdf:first sg:person.01154231246.74
    220 rdf:rest N4cf2be0eaf234481bcccaabfd4facda1
    221 Nfd2eb6a89f2644a5b6f2950c4d1404e6 rdf:first sg:person.01232451303.86
    222 rdf:rest Na2cb27cc4aee49a596f71b81ef07b575
    223 Nfd36802e02ef41a6a290bf9bdeee06fc rdf:first sg:person.01057611703.28
    224 rdf:rest N7f242eb30979427c919130f087808d63
    225 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    226 schema:name Medical and Health Sciences
    227 rdf:type schema:DefinedTerm
    228 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    229 schema:name Oncology and Carcinogenesis
    230 rdf:type schema:DefinedTerm
    231 sg:grant.3635170 http://pending.schema.org/fundedItem sg:pub.10.1186/s13059-016-1109-7
    232 rdf:type schema:MonetaryGrant
    233 sg:grant.5494085 http://pending.schema.org/fundedItem sg:pub.10.1186/s13059-016-1109-7
    234 rdf:type schema:MonetaryGrant
    235 sg:grant.6798148 http://pending.schema.org/fundedItem sg:pub.10.1186/s13059-016-1109-7
    236 rdf:type schema:MonetaryGrant
    237 sg:journal.1023439 schema:issn 1465-6906
    238 1474-760X
    239 schema:name Genome Biology
    240 rdf:type schema:Periodical
    241 sg:person.01017630143.46 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
    242 schema:familyName Van Loo
    243 schema:givenName Peter
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017630143.46
    245 rdf:type schema:Person
    246 sg:person.01026052267.93 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
    247 schema:familyName Demeulemeester
    248 schema:givenName Jonas
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026052267.93
    250 rdf:type schema:Person
    251 sg:person.01026626365.10 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
    252 schema:familyName Voet
    253 schema:givenName Thierry
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026626365.10
    255 rdf:type schema:Person
    256 sg:person.01057611703.28 schema:affiliation https://www.grid.ac/institutes/grid.55325.34
    257 schema:familyName Baumbusch
    258 schema:givenName Lars O.
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057611703.28
    260 rdf:type schema:Person
    261 sg:person.01062455314.30 schema:affiliation https://www.grid.ac/institutes/grid.55325.34
    262 schema:familyName Borgen
    263 schema:givenName Elin
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062455314.30
    265 rdf:type schema:Person
    266 sg:person.01071554513.00 schema:affiliation https://www.grid.ac/institutes/grid.5510.1
    267 schema:familyName Naume
    268 schema:givenName Bjørn
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071554513.00
    270 rdf:type schema:Person
    271 sg:person.01075635062.50 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
    272 schema:familyName Peterson
    273 schema:givenName April
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075635062.50
    275 rdf:type schema:Person
    276 sg:person.01101476162.97 schema:affiliation https://www.grid.ac/institutes/grid.55325.34
    277 schema:familyName Nord
    278 schema:givenName Silje
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101476162.97
    280 rdf:type schema:Person
    281 sg:person.01154231246.74 schema:affiliation N2533d4acdead4bf9ac38a262049da920
    282 schema:familyName White
    283 schema:givenName Kevin P.
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154231246.74
    285 rdf:type schema:Person
    286 sg:person.01215000714.10 schema:affiliation https://www.grid.ac/institutes/grid.411279.8
    287 schema:familyName Kristensen
    288 schema:givenName Vessela N.
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215000714.10
    290 rdf:type schema:Person
    291 sg:person.01232451303.86 schema:affiliation https://www.grid.ac/institutes/grid.411279.8
    292 schema:familyName Mathiesen
    293 schema:givenName Randi R.
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232451303.86
    295 rdf:type schema:Person
    296 sg:person.01252077430.47 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
    297 schema:familyName Wedge
    298 schema:givenName David C.
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252077430.47
    300 rdf:type schema:Person
    301 sg:person.01300564503.78 schema:affiliation https://www.grid.ac/institutes/grid.55325.34
    302 schema:familyName Fjelldal
    303 schema:givenName Renathe
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300564503.78
    305 rdf:type schema:Person
    306 sg:person.01311200335.49 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
    307 schema:familyName Zamani Esteki
    308 schema:givenName Masoud
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311200335.49
    310 rdf:type schema:Person
    311 sg:person.01361622203.97 schema:affiliation https://www.grid.ac/institutes/grid.55325.34
    312 schema:familyName Børresen-Dale
    313 schema:givenName Anne-Lise
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361622203.97
    315 rdf:type schema:Person
    316 sg:person.0702220210.53 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
    317 schema:familyName Kumar
    318 schema:givenName Parveen
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702220210.53
    320 rdf:type schema:Person
    321 sg:person.0713273262.02 schema:affiliation https://www.grid.ac/institutes/grid.55325.34
    322 schema:familyName Møller
    323 schema:givenName Elen K.
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713273262.02
    325 rdf:type schema:Person
    326 sg:person.0715351523.85 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
    327 schema:familyName Theunis
    328 schema:givenName Koen
    329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715351523.85
    330 rdf:type schema:Person
    331 sg:person.0752477127.73 schema:affiliation Nbc275743adce4ebfa20d55b8a78f8ad2
    332 schema:familyName Grundstad
    333 schema:givenName A. Jason
    334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752477127.73
    335 rdf:type schema:Person
    336 sg:person.07654502202.28 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
    337 schema:familyName Fernandez Gallardo
    338 schema:givenName Elia
    339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07654502202.28
    340 rdf:type schema:Person
    341 sg:pub.10.1007/s10549-005-9147-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1046366390
    342 https://doi.org/10.1007/s10549-005-9147-y
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1007/s10549-013-2439-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022582269
    345 https://doi.org/10.1007/s10549-013-2439-8
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1038/nature07943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004829095
    348 https://doi.org/10.1038/nature07943
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1038/nature09534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010608717
    351 https://doi.org/10.1038/nature09534
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1038/nature09807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020406938
    354 https://doi.org/10.1038/nature09807
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/nature10933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027457561
    357 https://doi.org/10.1038/nature10933
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1038/nature12628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048605463
    360 https://doi.org/10.1038/nature12628
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/nature13600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035306231
    363 https://doi.org/10.1038/nature13600
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1038/nbt.1754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019307928
    366 https://doi.org/10.1038/nbt.1754
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/nbt.2514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000477771
    369 https://doi.org/10.1038/nbt.2514
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1038/ncb2767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031053152
    372 https://doi.org/10.1038/ncb2767
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1038/ng.2270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048576872
    375 https://doi.org/10.1038/ng.2270
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1038/ng.2271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014329007
    378 https://doi.org/10.1038/ng.2271
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1038/ng.3641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036124041
    381 https://doi.org/10.1038/ng.3641
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1038/nrc2256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030922165
    384 https://doi.org/10.1038/nrc2256
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1038/nrc2627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052526028
    387 https://doi.org/10.1038/nrc2627
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1038/nrc3793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028687018
    390 https://doi.org/10.1038/nrc3793
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1038/nrg3317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013331797
    393 https://doi.org/10.1038/nrg3317
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1186/1471-2164-13-591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010110271
    396 https://doi.org/10.1186/1471-2164-13-591
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1186/bcr3242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024759034
    399 https://doi.org/10.1186/bcr3242
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1186/preaccept-3696327041308731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064134533
    402 https://doi.org/10.1186/preaccept-3696327041308731
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1186/s13073-014-0071-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036457346
    405 https://doi.org/10.1186/s13073-014-0071-9
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1002/(sici)1096-9896(199808)185:4<427::aid-path127>3.0.co;2-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006166820
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1002/cncr.22076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026540857
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1002/ijc.26444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001176628
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1016/j.cell.2011.09.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039482183
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1016/j.cell.2012.02.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025548171
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1016/j.cell.2012.02.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014092720
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1016/j.cell.2012.04.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012547698
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1016/j.cell.2013.03.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025379962
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1016/j.gde.2014.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053552739
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1016/s0140-6736(02)09838-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005895738
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1056/nejm200002243420801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030050346
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1056/nejmoa050434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048972336
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1073/pnas.1009843107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007646723
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1073/pnas.1331931100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039963755
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1073/pnas.1415287111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023383926
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1080/0032472031000141283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044333286
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1093/bioinformatics/btp324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038266369
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1101/gr.107524.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032096953
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1101/gr.191098.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046493374
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1158/1078-0432.ccr-03-0373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030640021
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1158/1078-0432.ccr-03-0818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037332991
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1158/1078-0432.ccr-10-2515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015515992
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1200/jco.2003.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203370
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1200/jco.2008.17.0563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015613811
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1371/journal.pone.0085907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007928473
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1534/g3.111.001198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037455212
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.3389/fonc.2013.00320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042072712
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.3390/cancers6010143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004089117
    462 rdf:type schema:CreativeWork
    463 https://www.grid.ac/institutes/grid.10306.34 schema:alternateName Wellcome Sanger Institute
    464 schema:name Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK
    465 Department of Human Genetics, KU Leuven—University of Leuven, Leuven, Belgium
    466 Single-cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, UK
    467 rdf:type schema:Organization
    468 https://www.grid.ac/institutes/grid.14003.36 schema:alternateName University of Wisconsin–Madison
    469 schema:name Institute for Genomics & Systems Biology and Department of Human Genetics, University of Chicago, Chicago, IL, USA
    470 Present address: Laboratory of Genetics, University of Wisconsin, Madison, WI, USA
    471 rdf:type schema:Organization
    472 https://www.grid.ac/institutes/grid.411279.8 schema:alternateName Akershus University Hospital
    473 schema:name Department of Clinical Molecular Biology (EpiGen), Medical Division, Akershus University Hospital, Lørenskog, Norway
    474 Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
    475 Department of Oncology, Division of Surgery and Cancer Medicine, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
    476 Present address: Department of Oncology, Akershus University Hospital, Lørenskog, Norway
    477 rdf:type schema:Organization
    478 https://www.grid.ac/institutes/grid.5510.1 schema:alternateName University of Oslo
    479 schema:name Department of Oncology, Division of Surgery and Cancer Medicine, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
    480 Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    481 rdf:type schema:Organization
    482 https://www.grid.ac/institutes/grid.55325.34 schema:alternateName Oslo University Hospital
    483 schema:name Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
    484 Department of Pathology, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
    485 Present address: Department of Pediatric Research, Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    486 rdf:type schema:Organization
    487 https://www.grid.ac/institutes/grid.5596.f schema:alternateName KU Leuven
    488 schema:name Department of Human Genetics, KU Leuven—University of Leuven, Leuven, Belgium
    489 The Francis Crick Institute, London, UK
    490 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...