Glucocorticoid receptor and nuclear factor kappa-b affect three-dimensional chromatin organization View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Tatyana Kuznetsova, Shuang-Yin Wang, Nagesha A. Rao, Amit Mandoli, Joost H. A. Martens, Nils Rother, Aafke Aartse, Laszlo Groh, Eva M. Janssen-Megens, Guoliang Li, Yijun Ruan, Colin Logie, Hendrik G. Stunnenberg

ABSTRACT

BACKGROUND: The impact of signal-dependent transcription factors, such as glucocorticoid receptor and nuclear factor kappa-b, on the three-dimensional organization of chromatin remains a topic of discussion. The possible scenarios range from remodeling of higher order chromatin architecture by activated transcription factors to recruitment of activated transcription factors to pre-established long-range interactions. RESULTS: Using circular chromosome conformation capture coupled with next generation sequencing and high-resolution chromatin interaction analysis by paired-end tag sequencing of P300, we observed agonist-induced changes in long-range chromatin interactions, and uncovered interconnected enhancer-enhancer hubs spanning up to one megabase. The vast majority of activated glucocorticoid receptor and nuclear factor kappa-b appeared to join pre-existing P300 enhancer hubs without affecting the chromatin conformation. In contrast, binding of the activated transcription factors to loci with their consensus response elements led to the increased formation of an active epigenetic state of enhancers and a significant increase in long-range interactions within pre-existing enhancer networks. De novo enhancers or ligand-responsive enhancer hubs preferentially interacted with ligand-induced genes. CONCLUSIONS: We demonstrate that, at a subset of genomic loci, ligand-mediated induction leads to active enhancer formation and an increase in long-range interactions, facilitating efficient regulation of target genes. Therefore, our data suggest an active role of signal-dependent transcription factors in chromatin and long-range interaction remodeling. More... »

PAGES

264

References to SciGraph publications

  • 2012-04-11. Topological domains in mammalian genomes identified by analysis of chromatin interactions in NATURE
  • 2008-11. Model-based Analysis of ChIP-Seq (MACS) in GENOME BIOLOGY
  • 1996-09. Role of CBP/P300 in nuclear receptor signalling in NATURE
  • 2009-01. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources in NATURE PROTOCOLS
  • 2009-11. An oestrogen-receptor-α-bound human chromatin interactome in NATURE
  • 2009-02. ChIP-seq accurately predicts tissue-specific activity of enhancers in NATURE
  • 2012-10. Robust 4C-seq data analysis to screen for regulatory DNA interactions in NATURE METHODS
  • 2009-05. Histone modifications at human enhancers reflect global cell-type-specific gene expression in NATURE
  • 2014-11. Topologically associating domains are stable units of replication-timing regulation in NATURE
  • 2013-10-23. Topology of mammalian developmental enhancers and their regulatory landscapes in NATURE
  • 2015-02. Chromatin architecture reorganization during stem cell differentiation in NATURE
  • 2011-03. Chromatin accessibility pre-determines glucocorticoid receptor binding patterns in NATURE GENETICS
  • 2006-11. Genome-wide analysis of estrogen receptor binding sites in NATURE GENETICS
  • 2012-09. An integrated encyclopedia of DNA elements in the human genome in NATURE
  • 2008-12. ReplicationDomain: a visualization tool and comparative database for genome-wide replication timing data in BMC BIOINFORMATICS
  • 2013-11. A high-resolution map of the three-dimensional chromatin interactome in human cells in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13059-015-0832-9

    DOI

    http://dx.doi.org/10.1186/s13059-015-0832-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007453046

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26619937


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