Domain atrophy creates rare cases of functional partial protein domains View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Ananth Prakash, Alex Bateman

ABSTRACT

BACKGROUND: Protein domains display a range of structural diversity, with numerous additions and deletions of secondary structural elements between related domains. We have observed a small number of cases of surprising large-scale deletions of core elements of structural domains. We propose a new concept called domain atrophy, where protein domains lose a significant number of core structural elements. RESULTS: Here, we implement a new pipeline to systematically identify new cases of domain atrophy across all known protein sequences. The output of this pipeline was carefully checked by hand, which filtered out partial domain instances that were unlikely to represent true domain atrophy due to misannotations or un-annotated sequence fragments. We identify 75 cases of domain atrophy, of which eight cases are found in a three-dimensional protein structure and 67 cases have been inferred based on mapping to a known homologous structure. Domains with structural variations include ancient folds such as the TIM-barrel and Rossmann folds. Most of these domains are observed to show structural loss that does not affect their functional sites. CONCLUSION: Our analysis has significantly increased the known cases of domain atrophy. We discuss specific instances of domain atrophy and see that there has often been a compensatory mechanism that helps to maintain the stability of the partial domain. Our study indicates that although domain atrophy is an extremely rare phenomenon, protein domains under certain circumstances can tolerate extreme mutations giving rise to partial, but functional, domains. More... »

PAGES

88

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13059-015-0655-8

DOI

http://dx.doi.org/10.1186/s13059-015-0655-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039042950

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25924720


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacterial Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Burkholderia cenocepacia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cryptococcus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Escherichia coli", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evolution, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Bacterial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lactobacillus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Luciferases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidoreductases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Photobacterium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phylogeny", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Tertiary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyrococcus furiosus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Staphylococcus aureus", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "European Bioinformatics Institute", 
          "id": "https://www.grid.ac/institutes/grid.225360.0", 
          "name": [
            "European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, CB10 1SD, Cambridgeshire, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Prakash", 
        "givenName": "Ananth", 
        "id": "sg:person.0654527715.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654527715.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "European Bioinformatics Institute", 
          "id": "https://www.grid.ac/institutes/grid.225360.0", 
          "name": [
            "European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, CB10 1SD, Cambridgeshire, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bateman", 
        "givenName": "Alex", 
        "id": "sg:person.01253551753.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253551753.58"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/pro.5560031103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000071038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jsbi.2001.4335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000207821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6807-10-24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000712244", 
          "https://doi.org/10.1186/1472-6807-10-24"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-9525(03)00023-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000767736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m603593200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003609791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2010.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004261370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2010.08.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004284409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.73.011303.074134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005186109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.73.011303.074134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005186109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0700800104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005491807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.1995.0289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008024301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcc.20084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008225564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1981.tb05644.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009089095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.219683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009607340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444995009796", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010058393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkt1223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010707975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkr367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012248325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-4658.2006.05220.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015287964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.071324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016186126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkm1054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017285110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2010-11-7-r74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017528733", 
          "https://doi.org/10.1186/gb-2010-11-7-r74"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2011-12-1-r4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018763863", 
          "https://doi.org/10.1186/gb-2011-12-1-r4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2008.30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020907431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002530100704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021301331", 
          "https://doi.org/10.1007/s002530100704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijbiomac.2014.04.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021852059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-15-75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023869045", 
          "https://doi.org/10.1186/1471-2105-15-75"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-15-75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023869045", 
          "https://doi.org/10.1186/1471-2105-15-75"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep00040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024700298", 
          "https://doi.org/10.1038/srep00040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0004981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026203333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026999760", 
          "https://doi.org/10.1038/nature04084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026999760", 
          "https://doi.org/10.1038/nature04084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.22482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029582046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.22482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029582046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-015-0656-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031310486", 
          "https://doi.org/10.1186/s13059-015-0656-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-015-0656-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031310486", 
          "https://doi.org/10.1186/s13059-015-0656-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2008.04.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031995600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(02)00805-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033248017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.1977804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034009905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pcbi.1003452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035127954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2011.02.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035755962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-6-108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037048502", 
          "https://doi.org/10.1186/1471-2105-6-108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.05.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041285763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(96)00641-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041319802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0969-2126(96)00033-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041984099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1980.tb04726.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042555294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molbev/mst010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045545793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1439-7633(20020703)3:7<604::aid-cbic604>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046037733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1119456109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046702350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444911023821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047165781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20021968", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047483824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20021968", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047483824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047907914", 
          "https://doi.org/10.1038/nature02505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047907914", 
          "https://doi.org/10.1038/nature02505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2836(92)91008-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051531610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gene.2007.02.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052163345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00253-005-1904-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052469692", 
          "https://doi.org/10.1007/s00253-005-1904-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00390a004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055173418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi049384m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055199718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi049384m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055199718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi800696y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055208619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi800696y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055208619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/cmb.2008.03tt", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059245755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.289.5484.1546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062570834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078661660", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1993.tb05824.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082829500"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: Protein domains display a range of structural diversity, with numerous additions and deletions of secondary structural elements between related domains. We have observed a small number of cases of surprising large-scale deletions of core elements of structural domains. We propose a new concept called domain atrophy, where protein domains lose a significant number of core structural elements.\nRESULTS: Here, we implement a new pipeline to systematically identify new cases of domain atrophy across all known protein sequences. The output of this pipeline was carefully checked by hand, which filtered out partial domain instances that were unlikely to represent true domain atrophy due to misannotations or un-annotated sequence fragments. We identify 75 cases of domain atrophy, of which eight cases are found in a three-dimensional protein structure and 67 cases have been inferred based on mapping to a known homologous structure. Domains with structural variations include ancient folds such as the TIM-barrel and Rossmann folds. Most of these domains are observed to show structural loss that does not affect their functional sites.\nCONCLUSION: Our analysis has significantly increased the known cases of domain atrophy. We discuss specific instances of domain atrophy and see that there has often been a compensatory mechanism that helps to maintain the stability of the partial domain. Our study indicates that although domain atrophy is an extremely rare phenomenon, protein domains under certain circumstances can tolerate extreme mutations giving rise to partial, but functional, domains.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13059-015-0655-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1023439", 
        "issn": [
          "1474-760X", 
          "1465-6906"
        ], 
        "name": "Genome Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Domain atrophy creates rare cases of functional partial protein domains", 
    "pagination": "88", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b9faed49255181b952ede9509c1e14ca97530131b01b66e606c1cac706fd91b0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25924720"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100960660"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13059-015-0655-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039042950"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13059-015-0655-8", 
      "https://app.dimensions.ai/details/publication/pub.1039042950"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88253_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs13059-015-0655-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13059-015-0655-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13059-015-0655-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13059-015-0655-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13059-015-0655-8'


 

This table displays all metadata directly associated to this object as RDF triples.

326 TRIPLES      21 PREDICATES      103 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13059-015-0655-8 schema:about N15da8b24231746f9bfa933b027516c96
2 N1ca3fb7e0f134b1ca40b0beab1d60002
3 N54f006d6f3f44ebca87f431c7e336675
4 N58a8259bd5da497b94cb23b154602141
5 N61274a76e84d4e049a59bd1c3bf717ce
6 N6d20724dad1f430085a6055a206588aa
7 N71d25721534a46d9a36406e282efc2dc
8 N90a7fa0b4c414a8d92ead0283ec3dcfb
9 N9ea671231cc945cebe23bdde9d943353
10 Na00031a638a445b0927f3cbceabcaca5
11 Na042654c8336407a865257e0cc6a8ad1
12 Na073d5a6cb084d4ea52020c8d00ddc14
13 Na78f9eacaec048a7bd0c06cbd48fba0d
14 Nb20cd7e5163e4a899320de32cc131272
15 Nc643f2fbb2cd4cb0b0f4893b05b3a125
16 Ncc0b76c1f53946678e07fb991c52be7c
17 Neb42b08b3ee04592abae99646a78a179
18 Neef8520cd99944b590758f0b43e2d136
19 anzsrc-for:06
20 anzsrc-for:0601
21 schema:author N1819218b28c84b0bb8fafa604d87b82a
22 schema:citation sg:pub.10.1007/s00253-005-1904-7
23 sg:pub.10.1007/s002530100704
24 sg:pub.10.1038/nature02505
25 sg:pub.10.1038/nature04084
26 sg:pub.10.1038/srep00040
27 sg:pub.10.1186/1471-2105-15-75
28 sg:pub.10.1186/1471-2105-6-108
29 sg:pub.10.1186/1472-6807-10-24
30 sg:pub.10.1186/gb-2010-11-7-r74
31 sg:pub.10.1186/gb-2011-12-1-r4
32 sg:pub.10.1186/s13059-015-0656-7
33 https://app.dimensions.ai/details/publication/pub.1078661660
34 https://doi.org/10.1002/1439-7633(20020703)3:7<604::aid-cbic604>3.0.co;2-x
35 https://doi.org/10.1002/j.1460-2075.1993.tb05824.x
36 https://doi.org/10.1002/jcc.20084
37 https://doi.org/10.1002/pro.5560031103
38 https://doi.org/10.1002/prot.22482
39 https://doi.org/10.1006/jmbi.1995.0289
40 https://doi.org/10.1006/jsbi.2001.4335
41 https://doi.org/10.1016/0014-5793(96)00641-2
42 https://doi.org/10.1016/0022-2836(92)91008-d
43 https://doi.org/10.1016/j.bbrc.2010.11.010
44 https://doi.org/10.1016/j.cell.2007.05.018
45 https://doi.org/10.1016/j.gene.2007.02.045
46 https://doi.org/10.1016/j.ijbiomac.2014.04.048
47 https://doi.org/10.1016/j.jmb.2011.02.053
48 https://doi.org/10.1016/j.str.2008.04.017
49 https://doi.org/10.1016/j.str.2010.08.017
50 https://doi.org/10.1016/s0022-2836(02)00805-7
51 https://doi.org/10.1016/s0168-9525(03)00023-4
52 https://doi.org/10.1016/s0969-2126(96)00033-0
53 https://doi.org/10.1021/bi00390a004
54 https://doi.org/10.1021/bi049384m
55 https://doi.org/10.1021/bi800696y
56 https://doi.org/10.1038/emboj.2008.30
57 https://doi.org/10.1042/bj20021968
58 https://doi.org/10.1073/pnas.0700800104
59 https://doi.org/10.1073/pnas.1119456109
60 https://doi.org/10.1074/jbc.m109.071324
61 https://doi.org/10.1074/jbc.m111.219683
62 https://doi.org/10.1074/jbc.m603593200
63 https://doi.org/10.1089/cmb.2008.03tt
64 https://doi.org/10.1093/molbev/mst010
65 https://doi.org/10.1093/nar/gkm1054
66 https://doi.org/10.1093/nar/gkr367
67 https://doi.org/10.1093/nar/gkt1223
68 https://doi.org/10.1101/gr.1977804
69 https://doi.org/10.1107/s0907444911023821
70 https://doi.org/10.1107/s0907444995009796
71 https://doi.org/10.1111/j.1432-1033.1980.tb04726.x
72 https://doi.org/10.1111/j.1432-1033.1981.tb05644.x
73 https://doi.org/10.1111/j.1742-4658.2006.05220.x
74 https://doi.org/10.1126/science.289.5484.1546
75 https://doi.org/10.1146/annurev.biochem.73.011303.074134
76 https://doi.org/10.1371/journal.pcbi.1003452
77 https://doi.org/10.1371/journal.pone.0004981
78 schema:datePublished 2015-12
79 schema:datePublishedReg 2015-12-01
80 schema:description BACKGROUND: Protein domains display a range of structural diversity, with numerous additions and deletions of secondary structural elements between related domains. We have observed a small number of cases of surprising large-scale deletions of core elements of structural domains. We propose a new concept called domain atrophy, where protein domains lose a significant number of core structural elements. RESULTS: Here, we implement a new pipeline to systematically identify new cases of domain atrophy across all known protein sequences. The output of this pipeline was carefully checked by hand, which filtered out partial domain instances that were unlikely to represent true domain atrophy due to misannotations or un-annotated sequence fragments. We identify 75 cases of domain atrophy, of which eight cases are found in a three-dimensional protein structure and 67 cases have been inferred based on mapping to a known homologous structure. Domains with structural variations include ancient folds such as the TIM-barrel and Rossmann folds. Most of these domains are observed to show structural loss that does not affect their functional sites. CONCLUSION: Our analysis has significantly increased the known cases of domain atrophy. We discuss specific instances of domain atrophy and see that there has often been a compensatory mechanism that helps to maintain the stability of the partial domain. Our study indicates that although domain atrophy is an extremely rare phenomenon, protein domains under certain circumstances can tolerate extreme mutations giving rise to partial, but functional, domains.
81 schema:genre research_article
82 schema:inLanguage en
83 schema:isAccessibleForFree true
84 schema:isPartOf N17adc05a4ea24617ab4d137b266fca17
85 Nd42d9c1ecac44b988db1c2d66f5ba613
86 sg:journal.1023439
87 schema:name Domain atrophy creates rare cases of functional partial protein domains
88 schema:pagination 88
89 schema:productId N143d4ae6a6aa4e86b3e11d0da4adb891
90 N6501ce4989914ac8beee4cff469f877d
91 N78b4a76a6c21415d938365ea7087841a
92 N9e3df234f4044696981ffcdbfefc51cd
93 Ndeb487987d964ea18fbda196197a821b
94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039042950
95 https://doi.org/10.1186/s13059-015-0655-8
96 schema:sdDatePublished 2019-04-11T13:11
97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
98 schema:sdPublisher N6bb737665d864641bb9b865c5e6bf4ad
99 schema:url http://link.springer.com/10.1186%2Fs13059-015-0655-8
100 sgo:license sg:explorer/license/
101 sgo:sdDataset articles
102 rdf:type schema:ScholarlyArticle
103 N143d4ae6a6aa4e86b3e11d0da4adb891 schema:name pubmed_id
104 schema:value 25924720
105 rdf:type schema:PropertyValue
106 N15da8b24231746f9bfa933b027516c96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Models, Molecular
108 rdf:type schema:DefinedTerm
109 N17adc05a4ea24617ab4d137b266fca17 schema:issueNumber 1
110 rdf:type schema:PublicationIssue
111 N1819218b28c84b0bb8fafa604d87b82a rdf:first sg:person.0654527715.82
112 rdf:rest N87b1c854dcd648e9876ad217402b3e48
113 N1ca3fb7e0f134b1ca40b0beab1d60002 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Photobacterium
115 rdf:type schema:DefinedTerm
116 N54f006d6f3f44ebca87f431c7e336675 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Humans
118 rdf:type schema:DefinedTerm
119 N58a8259bd5da497b94cb23b154602141 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Staphylococcus aureus
121 rdf:type schema:DefinedTerm
122 N61274a76e84d4e049a59bd1c3bf717ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Carrier Proteins
124 rdf:type schema:DefinedTerm
125 N6501ce4989914ac8beee4cff469f877d schema:name readcube_id
126 schema:value b9faed49255181b952ede9509c1e14ca97530131b01b66e606c1cac706fd91b0
127 rdf:type schema:PropertyValue
128 N6bb737665d864641bb9b865c5e6bf4ad schema:name Springer Nature - SN SciGraph project
129 rdf:type schema:Organization
130 N6d20724dad1f430085a6055a206588aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Phylogeny
132 rdf:type schema:DefinedTerm
133 N71d25721534a46d9a36406e282efc2dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Luciferases
135 rdf:type schema:DefinedTerm
136 N78b4a76a6c21415d938365ea7087841a schema:name dimensions_id
137 schema:value pub.1039042950
138 rdf:type schema:PropertyValue
139 N87b1c854dcd648e9876ad217402b3e48 rdf:first sg:person.01253551753.58
140 rdf:rest rdf:nil
141 N90a7fa0b4c414a8d92ead0283ec3dcfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Escherichia coli
143 rdf:type schema:DefinedTerm
144 N9e3df234f4044696981ffcdbfefc51cd schema:name nlm_unique_id
145 schema:value 100960660
146 rdf:type schema:PropertyValue
147 N9ea671231cc945cebe23bdde9d943353 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Oxidoreductases
149 rdf:type schema:DefinedTerm
150 Na00031a638a445b0927f3cbceabcaca5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Cryptococcus
152 rdf:type schema:DefinedTerm
153 Na042654c8336407a865257e0cc6a8ad1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Evolution, Molecular
155 rdf:type schema:DefinedTerm
156 Na073d5a6cb084d4ea52020c8d00ddc14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Gene Deletion
158 rdf:type schema:DefinedTerm
159 Na78f9eacaec048a7bd0c06cbd48fba0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Genes, Bacterial
161 rdf:type schema:DefinedTerm
162 Nb20cd7e5163e4a899320de32cc131272 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Pyrococcus furiosus
164 rdf:type schema:DefinedTerm
165 Nc643f2fbb2cd4cb0b0f4893b05b3a125 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Protein Structure, Tertiary
167 rdf:type schema:DefinedTerm
168 Ncc0b76c1f53946678e07fb991c52be7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Bacterial Proteins
170 rdf:type schema:DefinedTerm
171 Nd42d9c1ecac44b988db1c2d66f5ba613 schema:volumeNumber 16
172 rdf:type schema:PublicationVolume
173 Ndeb487987d964ea18fbda196197a821b schema:name doi
174 schema:value 10.1186/s13059-015-0655-8
175 rdf:type schema:PropertyValue
176 Neb42b08b3ee04592abae99646a78a179 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Lactobacillus
178 rdf:type schema:DefinedTerm
179 Neef8520cd99944b590758f0b43e2d136 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Burkholderia cenocepacia
181 rdf:type schema:DefinedTerm
182 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
183 schema:name Biological Sciences
184 rdf:type schema:DefinedTerm
185 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
186 schema:name Biochemistry and Cell Biology
187 rdf:type schema:DefinedTerm
188 sg:journal.1023439 schema:issn 1465-6906
189 1474-760X
190 schema:name Genome Biology
191 rdf:type schema:Periodical
192 sg:person.01253551753.58 schema:affiliation https://www.grid.ac/institutes/grid.225360.0
193 schema:familyName Bateman
194 schema:givenName Alex
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253551753.58
196 rdf:type schema:Person
197 sg:person.0654527715.82 schema:affiliation https://www.grid.ac/institutes/grid.225360.0
198 schema:familyName Prakash
199 schema:givenName Ananth
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654527715.82
201 rdf:type schema:Person
202 sg:pub.10.1007/s00253-005-1904-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052469692
203 https://doi.org/10.1007/s00253-005-1904-7
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/s002530100704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021301331
206 https://doi.org/10.1007/s002530100704
207 rdf:type schema:CreativeWork
208 sg:pub.10.1038/nature02505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047907914
209 https://doi.org/10.1038/nature02505
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/nature04084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026999760
212 https://doi.org/10.1038/nature04084
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/srep00040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024700298
215 https://doi.org/10.1038/srep00040
216 rdf:type schema:CreativeWork
217 sg:pub.10.1186/1471-2105-15-75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023869045
218 https://doi.org/10.1186/1471-2105-15-75
219 rdf:type schema:CreativeWork
220 sg:pub.10.1186/1471-2105-6-108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037048502
221 https://doi.org/10.1186/1471-2105-6-108
222 rdf:type schema:CreativeWork
223 sg:pub.10.1186/1472-6807-10-24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000712244
224 https://doi.org/10.1186/1472-6807-10-24
225 rdf:type schema:CreativeWork
226 sg:pub.10.1186/gb-2010-11-7-r74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017528733
227 https://doi.org/10.1186/gb-2010-11-7-r74
228 rdf:type schema:CreativeWork
229 sg:pub.10.1186/gb-2011-12-1-r4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018763863
230 https://doi.org/10.1186/gb-2011-12-1-r4
231 rdf:type schema:CreativeWork
232 sg:pub.10.1186/s13059-015-0656-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031310486
233 https://doi.org/10.1186/s13059-015-0656-7
234 rdf:type schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1078661660 schema:CreativeWork
236 https://doi.org/10.1002/1439-7633(20020703)3:7<604::aid-cbic604>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046037733
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1002/j.1460-2075.1993.tb05824.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082829500
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1002/jcc.20084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008225564
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1002/pro.5560031103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000071038
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1002/prot.22482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029582046
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1006/jmbi.1995.0289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008024301
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1006/jsbi.2001.4335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000207821
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/0014-5793(96)00641-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041319802
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/0022-2836(92)91008-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1051531610
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.bbrc.2010.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004261370
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.cell.2007.05.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041285763
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.gene.2007.02.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052163345
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.ijbiomac.2014.04.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021852059
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.jmb.2011.02.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035755962
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.str.2008.04.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031995600
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.str.2010.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004284409
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/s0022-2836(02)00805-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033248017
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/s0168-9525(03)00023-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000767736
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s0969-2126(96)00033-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041984099
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1021/bi00390a004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055173418
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1021/bi049384m schema:sameAs https://app.dimensions.ai/details/publication/pub.1055199718
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1021/bi800696y schema:sameAs https://app.dimensions.ai/details/publication/pub.1055208619
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1038/emboj.2008.30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020907431
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1042/bj20021968 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047483824
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1073/pnas.0700800104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005491807
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1073/pnas.1119456109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046702350
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1074/jbc.m109.071324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016186126
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1074/jbc.m111.219683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009607340
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1074/jbc.m603593200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003609791
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1089/cmb.2008.03tt schema:sameAs https://app.dimensions.ai/details/publication/pub.1059245755
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1093/molbev/mst010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045545793
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1093/nar/gkm1054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017285110
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1093/nar/gkr367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012248325
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1093/nar/gkt1223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010707975
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1101/gr.1977804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034009905
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1107/s0907444911023821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047165781
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1107/s0907444995009796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010058393
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1111/j.1432-1033.1980.tb04726.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042555294
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1111/j.1432-1033.1981.tb05644.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009089095
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1111/j.1742-4658.2006.05220.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015287964
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1126/science.289.5484.1546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062570834
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1146/annurev.biochem.73.011303.074134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005186109
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1371/journal.pcbi.1003452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035127954
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1371/journal.pone.0004981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026203333
323 rdf:type schema:CreativeWork
324 https://www.grid.ac/institutes/grid.225360.0 schema:alternateName European Bioinformatics Institute
325 schema:name European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, CB10 1SD, Cambridgeshire, UK
326 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...