Comprehensive miRNA sequence analysis reveals survival differences in diffuse large B-cell lymphoma patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Emilia L Lim, Diane L Trinh, David W Scott, Andy Chu, Martin Krzywinski, Yongjun Zhao, A Gordon Robertson, Andrew J Mungall, Jacqueline Schein, Merrill Boyle, Anja Mottok, Daisuke Ennishi, Nathalie A Johnson, Christian Steidl, Joseph M Connors, Ryan D Morin, Randy D Gascoyne, Marco A Marra

ABSTRACT

BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease, with 30% to 40% of patients failing to be cured with available primary therapy. microRNAs (miRNAs) are RNA molecules that attenuate expression of their mRNA targets. To characterize the DLBCL miRNome, we sequenced miRNAs from 92 DLBCL and 15 benign centroblast fresh frozen samples and from 140 DLBCL formalin-fixed, paraffin-embedded tissue samples for validation. RESULTS: We identify known and candidate novel miRNAs, 25 of which are associated with survival independently of cell-of-origin and International Prognostic Index scores, which are established indicators of outcome. Of these 25 miRNAs, six miRNAs are significantly associated with survival in our validation cohort. Abundant expression of miR-28-5p, miR-214-5p, miR-339-3p, and miR-5586-5p is associated with superior outcome, while abundant expression of miR-324-5p and NOVELM00203M is associated with inferior outcome. Comparison of DLBCL miRNA-seq expression profiles with those from other cancer types identifies miRNAs that were more abundant in B-cell contexts. Unsupervised clustering of miRNAs identifies two clusters of patients that have distinct differences in their outcomes. Our integrative miRNA and mRNA expression analyses reveal that miRNAs increased in abundance in DLBCL appear to regulate the expression of genes involved in metabolism, cell cycle, and protein modification. Additionally, these miRNAs, including one candidate novel miRNA, miR-10393-3p, appear to target chromatin modification genes that are frequent targets of somatic mutation in non-Hodgkin lymphomas. CONCLUSIONS: Our comprehensive sequence analysis of the DLBCL miRNome identifies candidate novel miRNAs and miRNAs associated with survival, reinforces results from previous mutational analyses, and reveals regulatory networks of significance for lymphomagenesis. More... »

PAGES

18

References to SciGraph publications

  • 2010-12. A deep investigation into the adipogenesis mechanism: Profile of microRNAs regulating adipogenesis by modulating the canonical Wnt/β-catenin signaling pathway in BMC GENOMICS
  • 2012-11. MicroRNA-29 in the adaptive immune system: setting the threshold in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2000-02. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling in NATURE
  • 2007-12. Comparison of miRNA expression patterns using total RNA extracted from matched samples of formalin-fixed paraffin-embedded (FFPE) cells and snap frozen cells in BMC BIOTECHNOLOGY
  • 2005-06. MicroRNA expression profiles classify human cancers in NATURE
  • 2010-09. OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma in NATURE
  • 2008-04. MicroRNAs accurately identify cancer tissue origin in NATURE BIOTECHNOLOGY
  • 2012-11. Systemic microRNA-34a delivery induces apoptosis and abrogates growth of diffuse large B-cell lymphoma in vivo in LEUKEMIA
  • 2013-02. Chemokine receptors in gastric MALT lymphoma: loss of CXCR4 and upregulation of CXCR7 is associated with progression to diffuse large B-cell lymphoma in MODERN PATHOLOGY
  • 2009-07. Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps in NATURE
  • 2011-01. Follicular dendritic cell-induced microRNA-mediated upregulation of PRDM1 and downregulation of BCL-6 in non-Hodgkin's B-cell lymphomas in LEUKEMIA
  • 2011-12. The different epidemiologic subtypes of Burkitt lymphoma share a homogenous micro RNA profile distinct from diffuse large B-cell lymphoma in LEUKEMIA
  • 2011-08. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma in NATURE
  • 2008-04. Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes in NATURE IMMUNOLOGY
  • 2013-10. Role of microRNAs and microRNA machinery in the pathogenesis of diffuse large B-cell lymphoma in BLOOD CANCER JOURNAL
  • 2011-10. Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2014-08. Inhibition of ZEB1 by miR-200 characterizes Helicobacter pylori-positive gastric diffuse large B-cell lymphoma with a less aggressive behavior in MODERN PATHOLOGY
  • 2006-11. MicroRNA signatures in human cancers in NATURE REVIEWS CANCER
  • 2012-03-01. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks in NATURE PROTOCOLS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13059-014-0568-y

    DOI

    http://dx.doi.org/10.1186/s13059-014-0568-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036099705

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25723320


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antibodies, Monoclonal, Murine-Derived", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Combined Chemotherapy Protocols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cluster Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclophosphamide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Doxorubicin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genomics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "High-Throughput Nucleotide Sequencing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphoma, Large B-Cell, Diffuse", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "MicroRNAs", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prednisone", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA Interference", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Messenger", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcriptome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vincristine", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "Canada\u2019s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1 L3, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lim", 
            "givenName": "Emilia L", 
            "id": "sg:person.016075170125.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016075170125.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "Canada\u2019s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1 L3, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Trinh", 
            "givenName": "Diane L", 
            "id": "sg:person.01232450166.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232450166.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "Centre for Lymphoid Cancer, Department of Experimental Therapeutics, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Scott", 
            "givenName": "David W", 
            "id": "sg:person.01347122425.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347122425.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "Canada\u2019s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1 L3, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chu", 
            "givenName": "Andy", 
            "id": "sg:person.0626627536.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626627536.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "Canada\u2019s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1 L3, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Krzywinski", 
            "givenName": "Martin", 
            "id": "sg:person.01116733043.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116733043.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "Canada\u2019s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1 L3, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhao", 
            "givenName": "Yongjun", 
            "id": "sg:person.013415760017.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013415760017.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "Canada\u2019s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1 L3, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Robertson", 
            "givenName": "A Gordon", 
            "id": "sg:person.01050554021.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050554021.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "Canada\u2019s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1 L3, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mungall", 
            "givenName": "Andrew J", 
            "id": "sg:person.0627357425.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627357425.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "Canada\u2019s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1 L3, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schein", 
            "givenName": "Jacqueline", 
            "id": "sg:person.01016047743.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016047743.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "Centre for Lymphoid Cancer, Department of Experimental Therapeutics, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boyle", 
            "givenName": "Merrill", 
            "id": "sg:person.01304055513.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304055513.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Centre for Lymphoid Cancer, Department of Experimental Therapeutics, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada", 
                "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mottok", 
            "givenName": "Anja", 
            "id": "sg:person.01032703763.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032703763.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "Centre for Lymphoid Cancer, Department of Experimental Therapeutics, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ennishi", 
            "givenName": "Daisuke", 
            "id": "sg:person.01322213070.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322213070.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "Centre for Lymphoid Cancer, Department of Experimental Therapeutics, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Johnson", 
            "givenName": "Nathalie A", 
            "id": "sg:person.01242370300.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242370300.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "Centre for Lymphoid Cancer, Department of Experimental Therapeutics, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Steidl", 
            "givenName": "Christian", 
            "id": "sg:person.01111177670.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111177670.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "Centre for Lymphoid Cancer, Department of Experimental Therapeutics, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Connors", 
            "givenName": "Joseph M", 
            "id": "sg:person.0677574517.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677574517.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Simon Fraser University", 
              "id": "https://www.grid.ac/institutes/grid.61971.38", 
              "name": [
                "Canada\u2019s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1 L3, Vancouver, BC, Canada", 
                "Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morin", 
            "givenName": "Ryan D", 
            "id": "sg:person.01131216113.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131216113.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Centre for Lymphoid Cancer, Department of Experimental Therapeutics, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada", 
                "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gascoyne", 
            "givenName": "Randy D", 
            "id": "sg:person.0665137436.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665137436.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Canada\u2019s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1 L3, Vancouver, BC, Canada", 
                "Department of Medical Genetics, University of British Columbia, Vancouver, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marra", 
            "givenName": "Marco A", 
            "id": "sg:person.01150455763.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150455763.02"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.1322466111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000583757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2008-10-184077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001029581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2008-10-184077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001029581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0016250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002870500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/his.12381", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003333342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-012-1124-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004050312", 
              "https://doi.org/10.1007/s00018-012-1124-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1392", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005138429", 
              "https://doi.org/10.1038/nbt1392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/10428194.2010.500046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005284461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2008.07237.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006291256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2012.134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007109450", 
              "https://doi.org/10.1038/modpathol.2012.134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-immunol-020711-075027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007124596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0602266103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007357780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1472-6750-7-36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008754233", 
              "https://doi.org/10.1186/1472-6750-7-36"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-11-320", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008813152", 
              "https://doi.org/10.1186/1471-2164-11-320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkr688", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008822585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2008.07077.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009737495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35000501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010898206", 
              "https://doi.org/10.1038/35000501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35000501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010898206", 
              "https://doi.org/10.1038/35000501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cam4.29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011194622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199309303291402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013554742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.34505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014448828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0803230105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015272111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2010-05-285320", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015769454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkt1181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016904256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2012.05.050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016964767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2011.156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017638188", 
              "https://doi.org/10.1038/leu.2011.156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2013.229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019034453", 
              "https://doi.org/10.1038/modpathol.2013.229"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10351", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019649945", 
              "https://doi.org/10.1038/nature10351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.0020363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022871535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022997022", 
              "https://doi.org/10.1038/nsmb.2115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024444585", 
              "https://doi.org/10.1038/nature09284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024444585", 
              "https://doi.org/10.1038/nature09284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03702", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024825726", 
              "https://doi.org/10.1038/nature03702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03702", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024825726", 
              "https://doi.org/10.1038/nature03702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1301689", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025463655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btr296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025650695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2010-11-321554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026558978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2012.110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028158477", 
              "https://doi.org/10.1038/leu.2012.110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2008.03.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028457353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2012.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030124536", 
              "https://doi.org/10.1038/nprot.2012.016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1582-4934.2008.00628.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030803196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-04-0713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031102903"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3324/haematol.2011.048132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031428785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1575", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033214741", 
              "https://doi.org/10.1038/ni1575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bcj.2013.49", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034268618", 
              "https://doi.org/10.1038/bcj.2013.49"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.20709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036632551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.20709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036632551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2006-08-038257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036676724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.1002884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038873835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2010.230", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039372396", 
              "https://doi.org/10.1038/leu.2010.230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btl048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039821503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.7179508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041320458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.03.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041414025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2007.07.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041591269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0703820104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042790820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0064393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042989269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043243877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043243877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044012298", 
              "https://doi.org/10.1038/nrc1997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044012298", 
              "https://doi.org/10.1038/nrc1997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08170", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045137706", 
              "https://doi.org/10.1038/nature08170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08170", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045137706", 
              "https://doi.org/10.1038/nature08170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2010-05-285403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047174875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1261/rna.972008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047682260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2009.03.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048270459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-11-0224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049848067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-11-0224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049848067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.22800", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050863269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2013-11-536433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053298563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078390732", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-12", 
        "datePublishedReg": "2015-12-01", 
        "description": "BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease, with 30% to 40% of patients failing to be cured with available primary therapy. microRNAs (miRNAs) are RNA molecules that attenuate expression of their mRNA targets. To characterize the DLBCL miRNome, we sequenced miRNAs from 92 DLBCL and 15 benign centroblast fresh frozen samples and from 140 DLBCL formalin-fixed, paraffin-embedded tissue samples for validation.\nRESULTS: We identify known and candidate novel miRNAs, 25 of which are associated with survival independently of cell-of-origin and International Prognostic Index scores, which are established indicators of outcome. Of these 25 miRNAs, six miRNAs are significantly associated with survival in our validation cohort. Abundant expression of miR-28-5p, miR-214-5p, miR-339-3p, and miR-5586-5p is associated with superior outcome, while abundant expression of miR-324-5p and NOVELM00203M is associated with inferior outcome. Comparison of DLBCL miRNA-seq expression profiles with those from other cancer types identifies miRNAs that were more abundant in B-cell contexts. Unsupervised clustering of miRNAs identifies two clusters of patients that have distinct differences in their outcomes. Our integrative miRNA and mRNA expression analyses reveal that miRNAs increased in abundance in DLBCL appear to regulate the expression of genes involved in metabolism, cell cycle, and protein modification. Additionally, these miRNAs, including one candidate novel miRNA, miR-10393-3p, appear to target chromatin modification genes that are frequent targets of somatic mutation in non-Hodgkin lymphomas.\nCONCLUSIONS: Our comprehensive sequence analysis of the DLBCL miRNome identifies candidate novel miRNAs and miRNAs associated with survival, reinforces results from previous mutational analyses, and reveals regulatory networks of significance for lymphomagenesis.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s13059-014-0568-y", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5246872", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1023439", 
            "issn": [
              "1474-760X", 
              "1465-6906"
            ], 
            "name": "Genome Biology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "16"
          }
        ], 
        "name": "Comprehensive miRNA sequence analysis reveals survival differences in diffuse large B-cell lymphoma patients", 
        "pagination": "18", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "abf74bec96f5030f11f40bea8f04765cd2e86db4b05dbdc99f9cca5268d0d6d3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25723320"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100960660"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13059-014-0568-y"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1036099705"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13059-014-0568-y", 
          "https://app.dimensions.ai/details/publication/pub.1036099705"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:08", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88233_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2Fs13059-014-0568-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13059-014-0568-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13059-014-0568-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13059-014-0568-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13059-014-0568-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    474 TRIPLES      21 PREDICATES      108 URIs      39 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13059-014-0568-y schema:about N02f9845e1a1b4c0f991ce1ffbfaf9f8d
    2 N0f964fd4a49444c7ba3c517eac128624
    3 N16da5792b42e4332b60f5f7fe39701e9
    4 N25766f5fa2924dca84bf07a1b7f55249
    5 N2be16f3383e040b28ecd9f58d0c8ef33
    6 N2d4d4c3cc3c449c48fbbb9fac0c24fd5
    7 N4516139132f64a1f892be89cdb051e43
    8 N63ace517fb7f4e2f808ac647bf4e6861
    9 N7d9083e17d20440ba37d8075dcc7f4a5
    10 N899e2c9f8b5642698f93a1aa8223550c
    11 N8abdcd00b4d7424894a85d87e1b694d7
    12 N93424b9367d040deb5376cd8e662f938
    13 Nafa3fe5a3ed742ab9993bb513c314f06
    14 Nbe18fa3499004076a1afb1329d56f0e5
    15 Nc409c09ba53344eb8415550557872de8
    16 Nc4d25787e9a94e9eae1ef4465c68f005
    17 Nded3cf045f0549bca6fae4acde9612a6
    18 Nf002396148d345fbb5a875cfe47f7fb3
    19 anzsrc-for:06
    20 anzsrc-for:0601
    21 schema:author Nc4d500d9f10c4892a746ffef4e284f82
    22 schema:citation sg:pub.10.1007/s00018-012-1124-0
    23 sg:pub.10.1038/35000501
    24 sg:pub.10.1038/bcj.2013.49
    25 sg:pub.10.1038/leu.2010.230
    26 sg:pub.10.1038/leu.2011.156
    27 sg:pub.10.1038/leu.2012.110
    28 sg:pub.10.1038/modpathol.2012.134
    29 sg:pub.10.1038/modpathol.2013.229
    30 sg:pub.10.1038/nature03702
    31 sg:pub.10.1038/nature08170
    32 sg:pub.10.1038/nature09284
    33 sg:pub.10.1038/nature10351
    34 sg:pub.10.1038/nbt1392
    35 sg:pub.10.1038/ni1575
    36 sg:pub.10.1038/nprot.2012.016
    37 sg:pub.10.1038/nrc1997
    38 sg:pub.10.1038/nsmb.2115
    39 sg:pub.10.1186/1471-2164-11-320
    40 sg:pub.10.1186/1472-6750-7-36
    41 https://app.dimensions.ai/details/publication/pub.1078390732
    42 https://doi.org/10.1002/art.34505
    43 https://doi.org/10.1002/cam4.29
    44 https://doi.org/10.1002/gcc.20709
    45 https://doi.org/10.1002/ijc.22800
    46 https://doi.org/10.1002/path.2736
    47 https://doi.org/10.1016/j.cell.2010.03.009
    48 https://doi.org/10.1016/j.febslet.2012.05.050
    49 https://doi.org/10.1016/j.immuni.2007.07.009
    50 https://doi.org/10.1016/j.immuni.2008.03.015
    51 https://doi.org/10.1016/j.immuni.2009.03.017
    52 https://doi.org/10.1056/nejm199309303291402
    53 https://doi.org/10.1056/nejmoa1301689
    54 https://doi.org/10.1073/pnas.0602266103
    55 https://doi.org/10.1073/pnas.0703820104
    56 https://doi.org/10.1073/pnas.0803230105
    57 https://doi.org/10.1073/pnas.1322466111
    58 https://doi.org/10.1093/bioinformatics/btl048
    59 https://doi.org/10.1093/bioinformatics/btr296
    60 https://doi.org/10.1093/nar/gkr688
    61 https://doi.org/10.1093/nar/gkt1181
    62 https://doi.org/10.1101/gr.7179508
    63 https://doi.org/10.1111/his.12381
    64 https://doi.org/10.1111/j.1365-2141.2008.07077.x
    65 https://doi.org/10.1111/j.1365-2141.2008.07237.x
    66 https://doi.org/10.1111/j.1582-4934.2008.00628.x
    67 https://doi.org/10.1146/annurev-immunol-020711-075027
    68 https://doi.org/10.1158/1078-0432.ccr-04-0713
    69 https://doi.org/10.1158/1078-0432.ccr-11-0224
    70 https://doi.org/10.1182/blood-2006-08-038257
    71 https://doi.org/10.1182/blood-2008-10-184077
    72 https://doi.org/10.1182/blood-2010-05-285320
    73 https://doi.org/10.1182/blood-2010-05-285403
    74 https://doi.org/10.1182/blood-2010-11-321554
    75 https://doi.org/10.1182/blood-2013-11-536433
    76 https://doi.org/10.1261/rna.972008
    77 https://doi.org/10.1371/journal.pbio.0020363
    78 https://doi.org/10.1371/journal.pone.0016250
    79 https://doi.org/10.1371/journal.pone.0064393
    80 https://doi.org/10.1371/journal.ppat.1002884
    81 https://doi.org/10.3109/10428194.2010.500046
    82 https://doi.org/10.3324/haematol.2011.048132
    83 schema:datePublished 2015-12
    84 schema:datePublishedReg 2015-12-01
    85 schema:description BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease, with 30% to 40% of patients failing to be cured with available primary therapy. microRNAs (miRNAs) are RNA molecules that attenuate expression of their mRNA targets. To characterize the DLBCL miRNome, we sequenced miRNAs from 92 DLBCL and 15 benign centroblast fresh frozen samples and from 140 DLBCL formalin-fixed, paraffin-embedded tissue samples for validation. RESULTS: We identify known and candidate novel miRNAs, 25 of which are associated with survival independently of cell-of-origin and International Prognostic Index scores, which are established indicators of outcome. Of these 25 miRNAs, six miRNAs are significantly associated with survival in our validation cohort. Abundant expression of miR-28-5p, miR-214-5p, miR-339-3p, and miR-5586-5p is associated with superior outcome, while abundant expression of miR-324-5p and NOVELM00203M is associated with inferior outcome. Comparison of DLBCL miRNA-seq expression profiles with those from other cancer types identifies miRNAs that were more abundant in B-cell contexts. Unsupervised clustering of miRNAs identifies two clusters of patients that have distinct differences in their outcomes. Our integrative miRNA and mRNA expression analyses reveal that miRNAs increased in abundance in DLBCL appear to regulate the expression of genes involved in metabolism, cell cycle, and protein modification. Additionally, these miRNAs, including one candidate novel miRNA, miR-10393-3p, appear to target chromatin modification genes that are frequent targets of somatic mutation in non-Hodgkin lymphomas. CONCLUSIONS: Our comprehensive sequence analysis of the DLBCL miRNome identifies candidate novel miRNAs and miRNAs associated with survival, reinforces results from previous mutational analyses, and reveals regulatory networks of significance for lymphomagenesis.
    86 schema:genre research_article
    87 schema:inLanguage en
    88 schema:isAccessibleForFree true
    89 schema:isPartOf N6651b6be177b4967b4ce7591d21e2241
    90 N9fc06d81a7db47949ef7d8192bdd3cd6
    91 sg:journal.1023439
    92 schema:name Comprehensive miRNA sequence analysis reveals survival differences in diffuse large B-cell lymphoma patients
    93 schema:pagination 18
    94 schema:productId N0a2bb8b6411a4f9b979514919956efa2
    95 N37f08240477c4ecc8af33c1c77a1e037
    96 N4903c009e81648a986bfa3a95d6790dc
    97 Naa5d94a6b108450bb8efec21e2397f1f
    98 Nc65f7deea97445ab9e0838aa00b348fb
    99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036099705
    100 https://doi.org/10.1186/s13059-014-0568-y
    101 schema:sdDatePublished 2019-04-11T13:08
    102 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    103 schema:sdPublisher Nef430ad23a6f4fc9bc7da5c9f148dc5e
    104 schema:url http://link.springer.com/10.1186%2Fs13059-014-0568-y
    105 sgo:license sg:explorer/license/
    106 sgo:sdDataset articles
    107 rdf:type schema:ScholarlyArticle
    108 N02f9845e1a1b4c0f991ce1ffbfaf9f8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Humans
    110 rdf:type schema:DefinedTerm
    111 N0a2bb8b6411a4f9b979514919956efa2 schema:name nlm_unique_id
    112 schema:value 100960660
    113 rdf:type schema:PropertyValue
    114 N0f964fd4a49444c7ba3c517eac128624 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Prognosis
    116 rdf:type schema:DefinedTerm
    117 N1254c26605964e1d9e59fc18f3358008 rdf:first sg:person.0627357425.48
    118 rdf:rest Nbf34e8ee32714401b3265c1bf808ecb6
    119 N16da5792b42e4332b60f5f7fe39701e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name RNA Interference
    121 rdf:type schema:DefinedTerm
    122 N21cc8df253164d2c836084adb2b5fd05 rdf:first sg:person.013415760017.30
    123 rdf:rest Na8bd45ab532248ecb1bd9198d5555588
    124 N25766f5fa2924dca84bf07a1b7f55249 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Gene Expression Regulation, Neoplastic
    126 rdf:type schema:DefinedTerm
    127 N2be16f3383e040b28ecd9f58d0c8ef33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Doxorubicin
    129 rdf:type schema:DefinedTerm
    130 N2d4d4c3cc3c449c48fbbb9fac0c24fd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Lymphoma, Large B-Cell, Diffuse
    132 rdf:type schema:DefinedTerm
    133 N307cae32a91940d9bd454070a37979cb rdf:first sg:person.01347122425.52
    134 rdf:rest Na5bcdd2d0b48432999eddf372a9de34a
    135 N37f08240477c4ecc8af33c1c77a1e037 schema:name dimensions_id
    136 schema:value pub.1036099705
    137 rdf:type schema:PropertyValue
    138 N4516139132f64a1f892be89cdb051e43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Antineoplastic Combined Chemotherapy Protocols
    140 rdf:type schema:DefinedTerm
    141 N4903c009e81648a986bfa3a95d6790dc schema:name pubmed_id
    142 schema:value 25723320
    143 rdf:type schema:PropertyValue
    144 N55661e3e285747fcba0090b8a0ec374b rdf:first sg:person.01150455763.02
    145 rdf:rest rdf:nil
    146 N595b2b0d605a4b94ac8fa584c3d379e5 rdf:first sg:person.01242370300.29
    147 rdf:rest N958c345620764170aa3a3badd3f68179
    148 N63ace517fb7f4e2f808ac647bf4e6861 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Gene Expression Profiling
    150 rdf:type schema:DefinedTerm
    151 N6651b6be177b4967b4ce7591d21e2241 schema:volumeNumber 16
    152 rdf:type schema:PublicationVolume
    153 N69988f7cb40f46bebe98750a64f8e614 rdf:first sg:person.01322213070.14
    154 rdf:rest N595b2b0d605a4b94ac8fa584c3d379e5
    155 N6a1124a96d4e40dfb12f9913759d0c08 rdf:first sg:person.01232450166.46
    156 rdf:rest N307cae32a91940d9bd454070a37979cb
    157 N7d9083e17d20440ba37d8075dcc7f4a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Transcriptome
    159 rdf:type schema:DefinedTerm
    160 N8296b35d2a2d4829ba3a4af170d63e64 rdf:first sg:person.01304055513.78
    161 rdf:rest Ne78cf286aa314353ba5b80a350c0c819
    162 N899e2c9f8b5642698f93a1aa8223550c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name MicroRNAs
    164 rdf:type schema:DefinedTerm
    165 N8abdcd00b4d7424894a85d87e1b694d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Antibodies, Monoclonal, Murine-Derived
    167 rdf:type schema:DefinedTerm
    168 N93424b9367d040deb5376cd8e662f938 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name High-Throughput Nucleotide Sequencing
    170 rdf:type schema:DefinedTerm
    171 N958c345620764170aa3a3badd3f68179 rdf:first sg:person.01111177670.12
    172 rdf:rest Nb6edb90d46ae42d0b0fbe1ceaa20dbed
    173 N9fc06d81a7db47949ef7d8192bdd3cd6 schema:issueNumber 1
    174 rdf:type schema:PublicationIssue
    175 Na5bcdd2d0b48432999eddf372a9de34a rdf:first sg:person.0626627536.77
    176 rdf:rest Nc60e8f2a95444457bca779a18ea567fe
    177 Na8bd45ab532248ecb1bd9198d5555588 rdf:first sg:person.01050554021.92
    178 rdf:rest N1254c26605964e1d9e59fc18f3358008
    179 Naa5d94a6b108450bb8efec21e2397f1f schema:name doi
    180 schema:value 10.1186/s13059-014-0568-y
    181 rdf:type schema:PropertyValue
    182 Nafa3fe5a3ed742ab9993bb513c314f06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Cluster Analysis
    184 rdf:type schema:DefinedTerm
    185 Nb6edb90d46ae42d0b0fbe1ceaa20dbed rdf:first sg:person.0677574517.97
    186 rdf:rest Nd0ea4983999f4245b81c437bddd66d72
    187 Nbe18fa3499004076a1afb1329d56f0e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Cyclophosphamide
    189 rdf:type schema:DefinedTerm
    190 Nbf34e8ee32714401b3265c1bf808ecb6 rdf:first sg:person.01016047743.23
    191 rdf:rest N8296b35d2a2d4829ba3a4af170d63e64
    192 Nc409c09ba53344eb8415550557872de8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Prednisone
    194 rdf:type schema:DefinedTerm
    195 Nc4d25787e9a94e9eae1ef4465c68f005 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Vincristine
    197 rdf:type schema:DefinedTerm
    198 Nc4d500d9f10c4892a746ffef4e284f82 rdf:first sg:person.016075170125.28
    199 rdf:rest N6a1124a96d4e40dfb12f9913759d0c08
    200 Nc60e8f2a95444457bca779a18ea567fe rdf:first sg:person.01116733043.02
    201 rdf:rest N21cc8df253164d2c836084adb2b5fd05
    202 Nc65f7deea97445ab9e0838aa00b348fb schema:name readcube_id
    203 schema:value abf74bec96f5030f11f40bea8f04765cd2e86db4b05dbdc99f9cca5268d0d6d3
    204 rdf:type schema:PropertyValue
    205 Nd0ea4983999f4245b81c437bddd66d72 rdf:first sg:person.01131216113.19
    206 rdf:rest Nfc28253bfaa04cb58dff32e85c938861
    207 Nded3cf045f0549bca6fae4acde9612a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Genomics
    209 rdf:type schema:DefinedTerm
    210 Ne78cf286aa314353ba5b80a350c0c819 rdf:first sg:person.01032703763.30
    211 rdf:rest N69988f7cb40f46bebe98750a64f8e614
    212 Nef430ad23a6f4fc9bc7da5c9f148dc5e schema:name Springer Nature - SN SciGraph project
    213 rdf:type schema:Organization
    214 Nf002396148d345fbb5a875cfe47f7fb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name RNA, Messenger
    216 rdf:type schema:DefinedTerm
    217 Nfc28253bfaa04cb58dff32e85c938861 rdf:first sg:person.0665137436.55
    218 rdf:rest N55661e3e285747fcba0090b8a0ec374b
    219 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    220 schema:name Biological Sciences
    221 rdf:type schema:DefinedTerm
    222 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    223 schema:name Biochemistry and Cell Biology
    224 rdf:type schema:DefinedTerm
    225 sg:grant.5246872 http://pending.schema.org/fundedItem sg:pub.10.1186/s13059-014-0568-y
    226 rdf:type schema:MonetaryGrant
    227 sg:journal.1023439 schema:issn 1465-6906
    228 1474-760X
    229 schema:name Genome Biology
    230 rdf:type schema:Periodical
    231 sg:person.01016047743.23 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    232 schema:familyName Schein
    233 schema:givenName Jacqueline
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016047743.23
    235 rdf:type schema:Person
    236 sg:person.01032703763.30 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    237 schema:familyName Mottok
    238 schema:givenName Anja
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032703763.30
    240 rdf:type schema:Person
    241 sg:person.01050554021.92 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    242 schema:familyName Robertson
    243 schema:givenName A Gordon
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050554021.92
    245 rdf:type schema:Person
    246 sg:person.01111177670.12 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    247 schema:familyName Steidl
    248 schema:givenName Christian
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111177670.12
    250 rdf:type schema:Person
    251 sg:person.01116733043.02 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    252 schema:familyName Krzywinski
    253 schema:givenName Martin
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116733043.02
    255 rdf:type schema:Person
    256 sg:person.01131216113.19 schema:affiliation https://www.grid.ac/institutes/grid.61971.38
    257 schema:familyName Morin
    258 schema:givenName Ryan D
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131216113.19
    260 rdf:type schema:Person
    261 sg:person.01150455763.02 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    262 schema:familyName Marra
    263 schema:givenName Marco A
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150455763.02
    265 rdf:type schema:Person
    266 sg:person.01232450166.46 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    267 schema:familyName Trinh
    268 schema:givenName Diane L
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232450166.46
    270 rdf:type schema:Person
    271 sg:person.01242370300.29 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    272 schema:familyName Johnson
    273 schema:givenName Nathalie A
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242370300.29
    275 rdf:type schema:Person
    276 sg:person.01304055513.78 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    277 schema:familyName Boyle
    278 schema:givenName Merrill
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304055513.78
    280 rdf:type schema:Person
    281 sg:person.01322213070.14 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    282 schema:familyName Ennishi
    283 schema:givenName Daisuke
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322213070.14
    285 rdf:type schema:Person
    286 sg:person.013415760017.30 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    287 schema:familyName Zhao
    288 schema:givenName Yongjun
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013415760017.30
    290 rdf:type schema:Person
    291 sg:person.01347122425.52 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    292 schema:familyName Scott
    293 schema:givenName David W
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347122425.52
    295 rdf:type schema:Person
    296 sg:person.016075170125.28 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    297 schema:familyName Lim
    298 schema:givenName Emilia L
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016075170125.28
    300 rdf:type schema:Person
    301 sg:person.0626627536.77 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    302 schema:familyName Chu
    303 schema:givenName Andy
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626627536.77
    305 rdf:type schema:Person
    306 sg:person.0627357425.48 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    307 schema:familyName Mungall
    308 schema:givenName Andrew J
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627357425.48
    310 rdf:type schema:Person
    311 sg:person.0665137436.55 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    312 schema:familyName Gascoyne
    313 schema:givenName Randy D
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665137436.55
    315 rdf:type schema:Person
    316 sg:person.0677574517.97 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    317 schema:familyName Connors
    318 schema:givenName Joseph M
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677574517.97
    320 rdf:type schema:Person
    321 sg:pub.10.1007/s00018-012-1124-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004050312
    322 https://doi.org/10.1007/s00018-012-1124-0
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/35000501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010898206
    325 https://doi.org/10.1038/35000501
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/bcj.2013.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034268618
    328 https://doi.org/10.1038/bcj.2013.49
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/leu.2010.230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039372396
    331 https://doi.org/10.1038/leu.2010.230
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/leu.2011.156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017638188
    334 https://doi.org/10.1038/leu.2011.156
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/leu.2012.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028158477
    337 https://doi.org/10.1038/leu.2012.110
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/modpathol.2012.134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007109450
    340 https://doi.org/10.1038/modpathol.2012.134
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/modpathol.2013.229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019034453
    343 https://doi.org/10.1038/modpathol.2013.229
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/nature03702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024825726
    346 https://doi.org/10.1038/nature03702
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/nature08170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045137706
    349 https://doi.org/10.1038/nature08170
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/nature09284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024444585
    352 https://doi.org/10.1038/nature09284
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/nature10351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019649945
    355 https://doi.org/10.1038/nature10351
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/nbt1392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005138429
    358 https://doi.org/10.1038/nbt1392
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/ni1575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033214741
    361 https://doi.org/10.1038/ni1575
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/nprot.2012.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030124536
    364 https://doi.org/10.1038/nprot.2012.016
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/nrc1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044012298
    367 https://doi.org/10.1038/nrc1997
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1038/nsmb.2115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022997022
    370 https://doi.org/10.1038/nsmb.2115
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1186/1471-2164-11-320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008813152
    373 https://doi.org/10.1186/1471-2164-11-320
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1186/1472-6750-7-36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008754233
    376 https://doi.org/10.1186/1472-6750-7-36
    377 rdf:type schema:CreativeWork
    378 https://app.dimensions.ai/details/publication/pub.1078390732 schema:CreativeWork
    379 https://doi.org/10.1002/art.34505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014448828
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1002/cam4.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011194622
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1002/gcc.20709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036632551
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1002/ijc.22800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050863269
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1002/path.2736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043243877
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1016/j.cell.2010.03.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041414025
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1016/j.febslet.2012.05.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016964767
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1016/j.immuni.2007.07.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041591269
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1016/j.immuni.2008.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028457353
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1016/j.immuni.2009.03.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048270459
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1056/nejm199309303291402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013554742
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1056/nejmoa1301689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025463655
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1073/pnas.0602266103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007357780
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1073/pnas.0703820104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042790820
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1073/pnas.0803230105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015272111
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1073/pnas.1322466111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000583757
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1093/bioinformatics/btl048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039821503
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1093/bioinformatics/btr296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025650695
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1093/nar/gkr688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008822585
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1093/nar/gkt1181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016904256
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1101/gr.7179508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041320458
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1111/his.12381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003333342
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1111/j.1365-2141.2008.07077.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009737495
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1111/j.1365-2141.2008.07237.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006291256
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1111/j.1582-4934.2008.00628.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030803196
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1146/annurev-immunol-020711-075027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007124596
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1158/1078-0432.ccr-04-0713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031102903
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1158/1078-0432.ccr-11-0224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049848067
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1182/blood-2006-08-038257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036676724
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1182/blood-2008-10-184077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001029581
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1182/blood-2010-05-285320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015769454
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1182/blood-2010-05-285403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047174875
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1182/blood-2010-11-321554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026558978
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1182/blood-2013-11-536433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053298563
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1261/rna.972008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047682260
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1371/journal.pbio.0020363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022871535
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1371/journal.pone.0016250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002870500
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1371/journal.pone.0064393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042989269
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1371/journal.ppat.1002884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038873835
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.3109/10428194.2010.500046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005284461
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.3324/haematol.2011.048132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031428785
    460 rdf:type schema:CreativeWork
    461 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
    462 schema:name Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1 L3, Vancouver, BC, Canada
    463 Centre for Lymphoid Cancer, Department of Experimental Therapeutics, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada
    464 Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    465 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    466 rdf:type schema:Organization
    467 https://www.grid.ac/institutes/grid.248762.d schema:alternateName BC Cancer Agency
    468 schema:name Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1 L3, Vancouver, BC, Canada
    469 Centre for Lymphoid Cancer, Department of Experimental Therapeutics, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada
    470 rdf:type schema:Organization
    471 https://www.grid.ac/institutes/grid.61971.38 schema:alternateName Simon Fraser University
    472 schema:name Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Avenue, V5Z 1 L3, Vancouver, BC, Canada
    473 Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
    474 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...