Genome analysis of a major urban malaria vector mosquito, Anopheles stephensi View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-09-23

AUTHORS

Xiaofang Jiang, Ashley Peery, A Brantley Hall, Atashi Sharma, Xiao-Guang Chen, Robert M Waterhouse, Aleksey Komissarov, Michelle M Riehle, Yogesh Shouche, Maria V Sharakhova, Dan Lawson, Nazzy Pakpour, Peter Arensburger, Victoria L M Davidson, Karin Eiglmeier, Scott Emrich, Phillip George, Ryan C Kennedy, Shrinivasrao P Mane, Gareth Maslen, Chioma Oringanje, Yumin Qi, Robert Settlage, Marta Tojo, Jose M C Tubio, Maria F Unger, Bo Wang, Kenneth D Vernick, Jose M C Ribeiro, Anthony A James, Kristin Michel, Michael A Riehle, Shirley Luckhart, Igor V Sharakhov, Zhijian Tu

ABSTRACT

BackgroundAnopheles stephensi is the key vector of malaria throughout the Indian subcontinent and Middle East and an emerging model for molecular and genetic studies of mosquito-parasite interactions. The type form of the species is responsible for the majority of urban malaria transmission across its range.ResultsHere, we report the genome sequence and annotation of the Indian strain of the type form of An. stephensi. The 221 Mb genome assembly represents more than 92% of the entire genome and was produced using a combination of 454, Illumina, and PacBio sequencing. Physical mapping assigned 62% of the genome onto chromosomes, enabling chromosome-based analysis. Comparisons between An. stephensi and An. gambiae reveal that the rate of gene order reshuffling on the X chromosome was three times higher than that on the autosomes. An. stephensi has more heterochromatin in pericentric regions but less repetitive DNA in chromosome arms than An. gambiae. We also identify a number of Y-chromosome contigs and BACs. Interspersed repeats constitute 7.1% of the assembled genome while LTR retrotransposons alone comprise more than 49% of the Y contigs. RNA-seq analyses provide new insights into mosquito innate immunity, development, and sexual dimorphism.ConclusionsThe genome analysis described in this manuscript provides a resource and platform for fundamental and translational research into a major urban malaria vector. Chromosome-based investigations provide unique perspectives on Anopheles chromosome evolution. RNA-seq analysis and studies of immunity genes offer new insights into mosquito biology and mosquito-parasite interactions. More... »

PAGES

459

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  • Journal

    TITLE

    Genome Biology

    ISSUE

    9

    VOLUME

    15

    Author Affiliations

  • Department of Biochemistry, Virginia Tech, Blacksburg, VA, USA
  • Department of Entomology, Virginia Tech, Blacksburg, VA, USA
  • Department of Pathogen Biology, Southern Medical University, Guangdong, Guangzhou, China
  • The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, USA
  • Institute of Cytology Russian Academy of Sciences, St. Petersburg, Russia
  • Department of Microbiology, University of Minnesota, Minneapolis, MN, USA
  • National Center for Cell Science, Pune University Campus, Pune, Ganeshkhind, India
  • European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, CB10 1SD, Cambridge, Hinxton, UK
  • Department of Medical Microbiology and Immunology, University of California, Davis, CA, USA
  • Biological Sciences Department, California State Polytechnic University, Pomona, CA, USA
  • Division of Biology, Kansas State University, Manhattan, KS, USA
  • CNRS Unit of Hosts, Vectors and Pathogens (URA3012), Paris, France
  • Department of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN, USA
  • Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA
  • Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, USA
  • Department of Entomology, University of Arizona, Tucson, AZ, USA
  • Department of Physiology, School of Medicine - CIMUS, Instituto de Investigaciones Sanitarias, University of Santiago de Compostela, Santiago de Compostela, Spain
  • Wellcome Trust Sanger Institute, Cambridgeshire, Hinxton, UK
  • Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA
  • Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, MD, USA
  • Departments of Microbiology & Molecular Genetics and Molecular Biology & Biochemistry, University of California, Irvine, CA, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13059-014-0459-2

    DOI

    http://dx.doi.org/10.1186/s13059-014-0459-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047844702

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25244985


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