Identification of novel common breast cancer risk variants at the 6q25 locus among Latinas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Joshua Hoffman, Laura Fejerman, Donglei Hu, Scott Huntsman, Min Li, Esther M. John, Gabriela Torres-Mejia, Larry Kushi, Yuan Chun Ding, Jeffrey Weitzel, Susan L. Neuhausen, Paul Lott, COLUMBUS Consortium, Magdalena Echeverry, Luis Carvajal-Carmona, Esteban Burchard, Celeste Eng, Jirong Long, Wei Zheng, Olufunmilayo Olopade, Dezheng Huo, Christopher Haiman, Elad Ziv

ABSTRACT

BACKGROUND: Breast cancer is a partially heritable trait and genome-wide association studies (GWAS) have identified over 180 common genetic variants associated with breast cancer. We have previously performed breast cancer GWAS in Latinas and identified a strongly protective single nucleotide polymorphism (SNP) at 6q25, with the protective minor allele originating from indigenous American ancestry. Here we report on fine mapping of the 6q25 locus in an expanded sample of Latinas. METHODS: We performed GWAS in 2385 cases and 6416 controls who were either US Latinas or Mexican women. We replicated the top SNPs in 2412 cases and 1620 controls of US Latina, Mexican, and Colombian women. In addition, we validated the top novel variants in studies of African, Asian and European ancestry. In each dataset we used logistic regression models to test the association between SNPs and breast cancer risk and corrected for genetic ancestry using either principal components or genetic ancestry inferred from ancestry informative markers using a model-based approach. RESULTS: We identified a novel set of SNPs at the 6q25 locus associated with genome-wide levels of significance (p = 3.3 × 10- 8 - 6.0 × 10- 9) not in linkage disequilibrium (LD) with variants previously reported at this locus. These SNPs were in high LD (r2 > 0.9) with each other, with the top SNP, rs3778609, associated with breast cancer with an odds ratio (OR) and 95% confidence interval (95% CI) of 0.76 (0.70-0.84). In a replication in women of Latin American origin, we also observed a consistent effect (OR 0.88; 95% CI 0.78-0.99; p = 0.037). We also performed a meta-analysis of these SNPs in East Asians, African ancestry and European ancestry populations and also observed a consistent effect (rs3778609, OR 0.95; 95% CI 0.91-0.97; p = 0.0017). CONCLUSION: Our study adds to evidence about the importance of the 6q25 locus for breast cancer susceptibility. Our finding also highlights the utility of performing additional searches for genetic variants for breast cancer in non-European populations. More... »

PAGES

3

References to SciGraph publications

  • 2017-11. Association analysis identifies 65 new breast cancer risk loci in NATURE
  • 2009-05. Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2 in NATURE GENETICS
  • 2014-12. Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25 in NATURE COMMUNICATIONS
  • 2009-05. A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1) in NATURE GENETICS
  • 2009-03. Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1 in NATURE GENETICS
  • 2015-07. C6ORF97-ESR1 breast cancer susceptibility locus: influence on progression and survival in breast cancer patients in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2012-11. An integrated map of genetic variation from 1,092 human genomes in NATURE
  • 2013-04. Large-scale genotyping identifies 41 new loci associated with breast cancer risk in NATURE GENETICS
  • 2015-12. Identification of two novel mammographic density loci at 6Q25.1 in BREAST CANCER RESEARCH
  • 2016-04. Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170 in NATURE GENETICS
  • 2010-06. Genome-wide association study identifies five new breast cancer susceptibility loci in NATURE GENETICS
  • 2014-12. Recurrent ESR1–CCDC170 rearrangements in an aggressive subset of oestrogen receptor-positive breast cancers in NATURE COMMUNICATIONS
  • 2012-03. Genome-wide association analysis identifies three new breast cancer susceptibility loci in NATURE GENETICS
  • 2015-10. A global reference for human genetic variation in NATURE
  • 2007-07. Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor–positive breast cancer in NATURE GENETICS
  • 2006-08. Principal components analysis corrects for stratification in genome-wide association studies in NATURE GENETICS
  • 2007-06-28. Genome-wide association study identifies novel breast cancer susceptibility loci in NATURE
  • 2007-07. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer in NATURE GENETICS
  • 1995-12. Identification of the breast cancer susceptibility gene BRCA2 in NATURE
  • 2011-12. A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer in NATURE GENETICS
  • 2011-05. A framework for variation discovery and genotyping using next-generation DNA sequencing data in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13058-018-1085-9

    DOI

    http://dx.doi.org/10.1186/s13058-018-1085-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111411765

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30642363


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    68 schema:description BACKGROUND: Breast cancer is a partially heritable trait and genome-wide association studies (GWAS) have identified over 180 common genetic variants associated with breast cancer. We have previously performed breast cancer GWAS in Latinas and identified a strongly protective single nucleotide polymorphism (SNP) at 6q25, with the protective minor allele originating from indigenous American ancestry. Here we report on fine mapping of the 6q25 locus in an expanded sample of Latinas. METHODS: We performed GWAS in 2385 cases and 6416 controls who were either US Latinas or Mexican women. We replicated the top SNPs in 2412 cases and 1620 controls of US Latina, Mexican, and Colombian women. In addition, we validated the top novel variants in studies of African, Asian and European ancestry. In each dataset we used logistic regression models to test the association between SNPs and breast cancer risk and corrected for genetic ancestry using either principal components or genetic ancestry inferred from ancestry informative markers using a model-based approach. RESULTS: We identified a novel set of SNPs at the 6q25 locus associated with genome-wide levels of significance (p = 3.3 × 10- 8 - 6.0 × 10- 9) not in linkage disequilibrium (LD) with variants previously reported at this locus. These SNPs were in high LD (r2 > 0.9) with each other, with the top SNP, rs3778609, associated with breast cancer with an odds ratio (OR) and 95% confidence interval (95% CI) of 0.76 (0.70-0.84). In a replication in women of Latin American origin, we also observed a consistent effect (OR 0.88; 95% CI 0.78-0.99; p = 0.037). We also performed a meta-analysis of these SNPs in East Asians, African ancestry and European ancestry populations and also observed a consistent effect (rs3778609, OR 0.95; 95% CI 0.91-0.97; p = 0.0017). CONCLUSION: Our study adds to evidence about the importance of the 6q25 locus for breast cancer susceptibility. Our finding also highlights the utility of performing additional searches for genetic variants for breast cancer in non-European populations.
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