Association of pre-chemotherapy peripheral blood pro-inflammatory and coagulation factors with reduced relative dose intensity in women with breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Yuan Yuan, Nilesh Vora, Can-Lan Sun, Daneng Li, Enrique Soto-Perez-de-Celis, Joanne Mortimer, The-hang Luu, George Somlo, James Waisman, David Smith, Joseph Chao, Vani Katheria, Timothy Synold, Vivi Tran, Shu Mi, Abrahm Levi, Anait Arsenyan, Jennifer Choi, Laura Zavala, Susan Yost, Arti Hurria

ABSTRACT

BACKGROUND: Chemotherapy decreases the risk of relapse and mortality in early-stage breast cancer (BC), but it comes with the risk of toxicity. Chemotherapy efficacy depends on relative dose intensity (RDI), and an RDI < 85% is associated with worse overall survival. The pro-inflammatory (interleukin (IL)-6, C-reactive protein (CRP)) and coagulation factors (D-dimer) serve as biomarkers of aging. The purpose of this study is to determine if these biomarkers are associated with reduced RDI in women with stage I-III BC. METHODS: This study enrolled women with stage I-III BC. Prior to adjuvant or neoadjuvant chemotherapy, peripheral blood was collected for biomarker measurement. Dose reductions and delays were captured and utilized to calculate the RDI delivered. Univariate and multivariate analyses were performed to describe the association between pre-chemotherapy IL-6, CRP, and D-dimer levels and an RDI < 85%, controlling for relevant tumor and patient factors (age, stage, receptor status, chemotherapy regimen, and pre-chemotherapy physical function and comorbidity). RESULTS: A total of 159 patients (mean age 58 years, range 30-81, SD 11.3) with stage I-III BC were enrolled. An RDI < 85% occurred in 22.6% (N = 36) of patients and was associated with higher pre-chemotherapy IL-6 (OR 1.14, 95% CI 1.04-1.25; p = 0.006) and D-dimer (OR 2.32, 95% CI 1.27-4.24; p = 0.006) levels, increased age (p = 0.001), increased number of comorbidities (p = 0.01), and decreased physical function by the Medical Outcomes Survey Activities of Daily Living (ADL) Scale (p = 0.009) in univariate analysis. A multivariate model, including two biomarkers (IL-6 and D-dimer), age, ADL, BC stage, and chemotherapy regimen, demonstrated a significant association between the increased biomarkers and reduced RDI < 85% (OR 2.54; p = 0.04). CONCLUSIONS: Increased pre-chemotherapy biomarkers of aging (IL-6 and D-dimer) are associated with reduced RDI (<85%). Future studies are underway to validate these findings. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01030250 . Registered on 3 November 2016. More... »

PAGES

101

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13058-017-0895-5

DOI

http://dx.doi.org/10.1186/s13058-017-0895-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091370898

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28851415


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Coagulation Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "C-Reactive Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Comorbidity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrin Fibrinogen Degradation Products", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation Mediators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quality of Life", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuan", 
        "givenName": "Yuan", 
        "id": "sg:person.012547141715.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012547141715.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Long Beach Memorial Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.415304.7", 
          "name": [
            "Long Beach Memorial Medical Center, Long Beach, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vora", 
        "givenName": "Nilesh", 
        "id": "sg:person.016125200527.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016125200527.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Can-Lan", 
        "id": "sg:person.011042155707.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011042155707.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Daneng", 
        "id": "sg:person.0674034437.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674034437.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soto-Perez-de-Celis", 
        "givenName": "Enrique", 
        "id": "sg:person.0605130716.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605130716.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mortimer", 
        "givenName": "Joanne", 
        "id": "sg:person.0642024051.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642024051.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luu", 
        "givenName": "The-hang", 
        "id": "sg:person.0746550465.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746550465.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Somlo", 
        "givenName": "George", 
        "id": "sg:person.01121216740.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121216740.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Waisman", 
        "givenName": "James", 
        "id": "sg:person.01276357223.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276357223.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "David", 
        "id": "sg:person.0752060563.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752060563.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chao", 
        "givenName": "Joseph", 
        "id": "sg:person.01354323573.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354323573.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katheria", 
        "givenName": "Vani", 
        "id": "sg:person.01151070774.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151070774.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Synold", 
        "givenName": "Timothy", 
        "id": "sg:person.010054353347.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010054353347.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tran", 
        "givenName": "Vivi", 
        "id": "sg:person.07470242527.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07470242527.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mi", 
        "givenName": "Shu", 
        "id": "sg:person.01114443672.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114443672.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Levi", 
        "givenName": "Abrahm", 
        "id": "sg:person.014445025501.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014445025501.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arsenyan", 
        "givenName": "Anait", 
        "id": "sg:person.012456144527.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012456144527.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Jennifer", 
        "id": "sg:person.013253525127.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013253525127.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zavala", 
        "givenName": "Laura", 
        "id": "sg:person.01117750604.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117750604.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yost", 
        "givenName": "Susan", 
        "id": "sg:person.015747502675.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015747502675.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "City Of Hope National Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.410425.6", 
          "name": [
            "City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hurria", 
        "givenName": "Arti", 
        "id": "sg:person.01340273066.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340273066.85"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.18632/oncotarget.8796", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000542577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/07357900009012191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001609224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.19.8440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001688349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.162.20.2333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005901788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-011-1949-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006286167", 
          "https://doi.org/10.1007/s10549-011-1949-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-015-3418-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007752580", 
          "https://doi.org/10.1007/s10549-015-3418-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1532-5415.1991.tb01616.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007882864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9343(99)00066-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009488098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa010957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012569804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199504063321401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012856840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jgo.2013.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013439775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/gerona/59.3.m242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018978584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20010615)91:12<2246::aid-cncr1255>3.0.co;2-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019870784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.293.9.1073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021058036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/gerona/55.11.m649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021917862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ajco.12093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023595762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199405053301801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025238022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-11-131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025745278", 
          "https://doi.org/10.1186/1471-2407-11-131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/gerona/55.12.m709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029267991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/dju057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030479541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2014.55.4261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030595690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1532-5415.2003.51454.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030862972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jgo.2016.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032799544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arr.2010.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032950437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.8939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036214341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1532-5415.1985.tb06317.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036955500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/90.16.1205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037423509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(99)00256-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038248538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.22726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038311829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-006-9254-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043713885", 
          "https://doi.org/10.1007/s10549-006-9254-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-006-9254-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043713885", 
          "https://doi.org/10.1007/s10549-006-9254-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(99)00259-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048861207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1532-5415.1999.tb01583.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050767834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2014.55.1432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051524590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/gerona/glv007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059623010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/geronj/36.4.428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059626882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.09.081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074474855", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.3.600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074583464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.7.1412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074611329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075211382", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6004/jnccn.2009.0009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077842290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6004/jnccn.2009.0009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077842290"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: Chemotherapy decreases the risk of relapse and mortality in early-stage breast cancer (BC), but it comes with the risk of toxicity. Chemotherapy efficacy depends on relative dose intensity (RDI), and an RDI\u2009<\u200985% is associated with worse overall survival. The pro-inflammatory (interleukin (IL)-6, C-reactive protein (CRP)) and coagulation factors (D-dimer) serve as biomarkers of aging. The purpose of this study is to determine if these biomarkers are associated with reduced RDI in women with stage I-III BC.\nMETHODS: This study enrolled women with stage I-III BC. Prior to adjuvant or neoadjuvant chemotherapy, peripheral blood was collected for biomarker measurement. Dose reductions and delays were captured and utilized to calculate the RDI delivered. Univariate and multivariate analyses were performed to describe the association between pre-chemotherapy IL-6, CRP, and D-dimer levels and an RDI\u2009<\u200985%, controlling for relevant tumor and patient factors (age, stage, receptor status, chemotherapy regimen, and pre-chemotherapy physical function and comorbidity).\nRESULTS: A total of 159 patients (mean age 58\u00a0years, range 30-81, SD 11.3) with stage I-III BC were enrolled. An RDI\u2009<\u200985% occurred in 22.6% (N\u2009=\u200936) of patients and was associated with higher pre-chemotherapy IL-6 (OR 1.14, 95% CI 1.04-1.25; p\u2009=\u20090.006) and D-dimer (OR 2.32, 95% CI 1.27-4.24; p\u2009=\u20090.006) levels, increased age (p\u2009=\u20090.001), increased number of comorbidities (p\u2009=\u20090.01), and decreased physical function by the Medical Outcomes Survey Activities of Daily Living (ADL) Scale (p\u2009=\u20090.009) in univariate analysis. A multivariate model, including two biomarkers (IL-6 and D-dimer), age, ADL, BC stage, and chemotherapy regimen, demonstrated a significant association between the increased biomarkers and reduced RDI\u2009<\u200985% (OR 2.54; p\u2009=\u20090.04).\nCONCLUSIONS: Increased pre-chemotherapy biomarkers of aging (IL-6 and D-dimer) are associated with reduced RDI (<85%). Future studies are underway to validate these findings.\nTRIAL REGISTRATION: ClinicalTrials.gov, NCT01030250 . Registered on 3 November 2016.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13058-017-0895-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438845", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4243704", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2416423", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1022375", 
        "issn": [
          "1465-5411", 
          "1465-542X"
        ], 
        "name": "Breast Cancer Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Association of pre-chemotherapy peripheral blood pro-inflammatory and coagulation factors with reduced relative dose intensity in women with breast cancer", 
    "pagination": "101", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "819ff93514131bc16cdb4d253258059e4126895e59fc26524d10418fe45a36ba"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28851415"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100927353"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13058-017-0895-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1091370898"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13058-017-0895-5", 
      "https://app.dimensions.ai/details/publication/pub.1091370898"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000552.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186/s13058-017-0895-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13058-017-0895-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13058-017-0895-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13058-017-0895-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13058-017-0895-5'


 

This table displays all metadata directly associated to this object as RDF triples.

422 TRIPLES      21 PREDICATES      90 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13058-017-0895-5 schema:about N0c38eed3134f4ec7ba68f3b4779bb6e9
2 N1c2f7b6fbe604d19b5417b70caa2891a
3 N395ab906229241789065f119daa0cc66
4 N48b22c47ad7f42b29d6c50596ba43c55
5 N49b4fa9c5ea14e419c66ad6911ad4ee2
6 N5db5dde3b676459897464b6abbc8962a
7 N629601dbbcae4dfeb8bf69f3100409ee
8 N6976b1273c5d48628bca26907d530022
9 N7408399a97d047399f8064eef208b988
10 N7ae9ef7340a248fc8e44951e3f13fb83
11 N8645b7751473492f9132a5eb0bd779da
12 Nb11d0b8201fe488ea62bdc913e73a77e
13 Nbca020287de646bf9e34265640413680
14 Nc152c2b79a35425f915c455f61ce9319
15 Nc3bf9dc535af45ebb09d179942dd98f4
16 Nd1416d6399b64c45bb2ea3c9544b338b
17 Nd70d3cb4ab5d4e59bc0da8fbfbeadffc
18 Ne069fbee4a434f8d8410d3817987a1dc
19 Ne25b3a02d1b1467d830c1d1d7c64cea8
20 anzsrc-for:11
21 anzsrc-for:1112
22 schema:author N602c24324b064a24979fe2c60dccc5e2
23 schema:citation sg:pub.10.1007/s10549-006-9254-4
24 sg:pub.10.1007/s10549-011-1949-5
25 sg:pub.10.1007/s10549-015-3418-z
26 sg:pub.10.1186/1471-2407-11-131
27 https://app.dimensions.ai/details/publication/pub.1074474855
28 https://app.dimensions.ai/details/publication/pub.1075211382
29 https://doi.org/10.1001/archinte.162.20.2333
30 https://doi.org/10.1001/jama.293.9.1073
31 https://doi.org/10.1002/1097-0142(20010615)91:12<2246::aid-cncr1255>3.0.co;2-4
32 https://doi.org/10.1002/cncr.22726
33 https://doi.org/10.1016/j.arr.2010.11.002
34 https://doi.org/10.1016/j.jgo.2013.09.001
35 https://doi.org/10.1016/j.jgo.2016.09.004
36 https://doi.org/10.1016/s0002-9343(99)00066-2
37 https://doi.org/10.1016/s0959-8049(99)00256-7
38 https://doi.org/10.1016/s0959-8049(99)00259-2
39 https://doi.org/10.1046/j.1532-5415.2003.51454.x
40 https://doi.org/10.1056/nejm199405053301801
41 https://doi.org/10.1056/nejm199504063321401
42 https://doi.org/10.1056/nejmoa010957
43 https://doi.org/10.1093/gerona/55.11.m649
44 https://doi.org/10.1093/gerona/55.12.m709
45 https://doi.org/10.1093/gerona/59.3.m242
46 https://doi.org/10.1093/gerona/glv007
47 https://doi.org/10.1093/geronj/36.4.428
48 https://doi.org/10.1093/jnci/90.16.1205
49 https://doi.org/10.1093/jnci/dju057
50 https://doi.org/10.1111/ajco.12093
51 https://doi.org/10.1111/j.1532-5415.1985.tb06317.x
52 https://doi.org/10.1111/j.1532-5415.1991.tb01616.x
53 https://doi.org/10.1111/j.1532-5415.1999.tb01583.x
54 https://doi.org/10.1200/jco.2000.18.3.600
55 https://doi.org/10.1200/jco.2000.18.7.1412
56 https://doi.org/10.1200/jco.2003.05.002
57 https://doi.org/10.1200/jco.2003.09.081
58 https://doi.org/10.1200/jco.2008.19.8440
59 https://doi.org/10.1200/jco.2014.55.1432
60 https://doi.org/10.1200/jco.2014.55.4261
61 https://doi.org/10.18632/oncotarget.8796
62 https://doi.org/10.18632/oncotarget.8939
63 https://doi.org/10.3109/07357900009012191
64 https://doi.org/10.6004/jnccn.2009.0009
65 schema:datePublished 2017-12
66 schema:datePublishedReg 2017-12-01
67 schema:description BACKGROUND: Chemotherapy decreases the risk of relapse and mortality in early-stage breast cancer (BC), but it comes with the risk of toxicity. Chemotherapy efficacy depends on relative dose intensity (RDI), and an RDI < 85% is associated with worse overall survival. The pro-inflammatory (interleukin (IL)-6, C-reactive protein (CRP)) and coagulation factors (D-dimer) serve as biomarkers of aging. The purpose of this study is to determine if these biomarkers are associated with reduced RDI in women with stage I-III BC. METHODS: This study enrolled women with stage I-III BC. Prior to adjuvant or neoadjuvant chemotherapy, peripheral blood was collected for biomarker measurement. Dose reductions and delays were captured and utilized to calculate the RDI delivered. Univariate and multivariate analyses were performed to describe the association between pre-chemotherapy IL-6, CRP, and D-dimer levels and an RDI < 85%, controlling for relevant tumor and patient factors (age, stage, receptor status, chemotherapy regimen, and pre-chemotherapy physical function and comorbidity). RESULTS: A total of 159 patients (mean age 58 years, range 30-81, SD 11.3) with stage I-III BC were enrolled. An RDI < 85% occurred in 22.6% (N = 36) of patients and was associated with higher pre-chemotherapy IL-6 (OR 1.14, 95% CI 1.04-1.25; p = 0.006) and D-dimer (OR 2.32, 95% CI 1.27-4.24; p = 0.006) levels, increased age (p = 0.001), increased number of comorbidities (p = 0.01), and decreased physical function by the Medical Outcomes Survey Activities of Daily Living (ADL) Scale (p = 0.009) in univariate analysis. A multivariate model, including two biomarkers (IL-6 and D-dimer), age, ADL, BC stage, and chemotherapy regimen, demonstrated a significant association between the increased biomarkers and reduced RDI < 85% (OR 2.54; p = 0.04). CONCLUSIONS: Increased pre-chemotherapy biomarkers of aging (IL-6 and D-dimer) are associated with reduced RDI (<85%). Future studies are underway to validate these findings. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01030250 . Registered on 3 November 2016.
68 schema:genre research_article
69 schema:inLanguage en
70 schema:isAccessibleForFree true
71 schema:isPartOf N7c5b1619e8214dc593bc5ba8d4c66c0b
72 N88c9921372ad4e56a92941e6c94c99d2
73 sg:journal.1022375
74 schema:name Association of pre-chemotherapy peripheral blood pro-inflammatory and coagulation factors with reduced relative dose intensity in women with breast cancer
75 schema:pagination 101
76 schema:productId N5dfa651f53914653915a93c0dfe57777
77 N882625439f41444a83a843a7b9f914c0
78 N8d516ba2795f4f95a6e1e47f93f1f85c
79 Nae13b026890f49f5a2a854203e83ab70
80 Nfaf69a0d9f9c4b6785e86cd3a132cdee
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091370898
82 https://doi.org/10.1186/s13058-017-0895-5
83 schema:sdDatePublished 2019-04-10T15:58
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher N92bc391887574f4b85d79c6449d79c91
86 schema:url http://link.springer.com/10.1186/s13058-017-0895-5
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N0c38eed3134f4ec7ba68f3b4779bb6e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Aged, 80 and over
92 rdf:type schema:DefinedTerm
93 N0d7ea007d3ab401bae6ccb9b22dd2c22 rdf:first sg:person.016125200527.64
94 rdf:rest N3e0fb50baec5424589bfb543b5c76696
95 N1c2f7b6fbe604d19b5417b70caa2891a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Biomarkers
97 rdf:type schema:DefinedTerm
98 N299bf5335fec466599fbabac2199c9bd rdf:first sg:person.014445025501.15
99 rdf:rest N4f9aa6ed92994e78bcd7b1e4e1b66b5e
100 N338c66e46f784f3d82128d3ce1a8b9b4 rdf:first sg:person.0642024051.23
101 rdf:rest N95e62922d0d34f1fa95d93969484b990
102 N395ab906229241789065f119daa0cc66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Comorbidity
104 rdf:type schema:DefinedTerm
105 N3c322dedac424af2ba99e5c0b2da5033 rdf:first sg:person.01117750604.88
106 rdf:rest N850e36089d45405fb15e7d3a3902b877
107 N3e0fb50baec5424589bfb543b5c76696 rdf:first sg:person.011042155707.25
108 rdf:rest N795328365b1a4ba29c74cacd89a00a96
109 N40c66560596a44828335eaf8a9f3414b rdf:first sg:person.01340273066.85
110 rdf:rest rdf:nil
111 N41a21270a6694811a9e5b0a5af154fd6 rdf:first sg:person.01354323573.20
112 rdf:rest N7afa693bd5dd44cda79117ba1ad57d6b
113 N48b22c47ad7f42b29d6c50596ba43c55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Quality of Life
115 rdf:type schema:DefinedTerm
116 N49b4fa9c5ea14e419c66ad6911ad4ee2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Adult
118 rdf:type schema:DefinedTerm
119 N4f9aa6ed92994e78bcd7b1e4e1b66b5e rdf:first sg:person.012456144527.29
120 rdf:rest Nbf56fb5df1e44447a232c9ff696a4351
121 N52ef1bbbc1ad454dab6d99951bf5ad05 rdf:first sg:person.01114443672.54
122 rdf:rest N299bf5335fec466599fbabac2199c9bd
123 N5c3e0c5dbb1f43f4b5a68158cf456fa2 rdf:first sg:person.07470242527.23
124 rdf:rest N52ef1bbbc1ad454dab6d99951bf5ad05
125 N5db5dde3b676459897464b6abbc8962a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Inflammation Mediators
127 rdf:type schema:DefinedTerm
128 N5dfa651f53914653915a93c0dfe57777 schema:name nlm_unique_id
129 schema:value 100927353
130 rdf:type schema:PropertyValue
131 N602c24324b064a24979fe2c60dccc5e2 rdf:first sg:person.012547141715.18
132 rdf:rest N0d7ea007d3ab401bae6ccb9b22dd2c22
133 N629601dbbcae4dfeb8bf69f3100409ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Fibrin Fibrinogen Degradation Products
135 rdf:type schema:DefinedTerm
136 N6976b1273c5d48628bca26907d530022 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Interleukin-6
138 rdf:type schema:DefinedTerm
139 N7408399a97d047399f8064eef208b988 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name C-Reactive Protein
141 rdf:type schema:DefinedTerm
142 N74bb57ad343b4ef9afbf96238187526d rdf:first sg:person.01121216740.00
143 rdf:rest Nf1866a32469d4821bf3e38f38f073a0f
144 N795328365b1a4ba29c74cacd89a00a96 rdf:first sg:person.0674034437.31
145 rdf:rest Nd1b97c4da06448ef98f26e5bd10de0e8
146 N7ae9ef7340a248fc8e44951e3f13fb83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Antineoplastic Combined Chemotherapy Protocols
148 rdf:type schema:DefinedTerm
149 N7afa693bd5dd44cda79117ba1ad57d6b rdf:first sg:person.01151070774.06
150 rdf:rest Nd396d900a7b64c9f8b640012a48ecc25
151 N7c5b1619e8214dc593bc5ba8d4c66c0b schema:issueNumber 1
152 rdf:type schema:PublicationIssue
153 N850e36089d45405fb15e7d3a3902b877 rdf:first sg:person.015747502675.02
154 rdf:rest N40c66560596a44828335eaf8a9f3414b
155 N8645b7751473492f9132a5eb0bd779da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Female
157 rdf:type schema:DefinedTerm
158 N882625439f41444a83a843a7b9f914c0 schema:name pubmed_id
159 schema:value 28851415
160 rdf:type schema:PropertyValue
161 N88c9921372ad4e56a92941e6c94c99d2 schema:volumeNumber 19
162 rdf:type schema:PublicationVolume
163 N8d516ba2795f4f95a6e1e47f93f1f85c schema:name dimensions_id
164 schema:value pub.1091370898
165 rdf:type schema:PropertyValue
166 N92bc391887574f4b85d79c6449d79c91 schema:name Springer Nature - SN SciGraph project
167 rdf:type schema:Organization
168 N95e62922d0d34f1fa95d93969484b990 rdf:first sg:person.0746550465.00
169 rdf:rest N74bb57ad343b4ef9afbf96238187526d
170 Nae13b026890f49f5a2a854203e83ab70 schema:name doi
171 schema:value 10.1186/s13058-017-0895-5
172 rdf:type schema:PropertyValue
173 Nb11d0b8201fe488ea62bdc913e73a77e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Treatment Outcome
175 rdf:type schema:DefinedTerm
176 Nbca020287de646bf9e34265640413680 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Aged
178 rdf:type schema:DefinedTerm
179 Nbf56fb5df1e44447a232c9ff696a4351 rdf:first sg:person.013253525127.19
180 rdf:rest N3c322dedac424af2ba99e5c0b2da5033
181 Nc152c2b79a35425f915c455f61ce9319 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Breast Neoplasms
183 rdf:type schema:DefinedTerm
184 Nc3bf9dc535af45ebb09d179942dd98f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Middle Aged
186 rdf:type schema:DefinedTerm
187 Nd1416d6399b64c45bb2ea3c9544b338b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Neoplasm Staging
189 rdf:type schema:DefinedTerm
190 Nd1b97c4da06448ef98f26e5bd10de0e8 rdf:first sg:person.0605130716.85
191 rdf:rest N338c66e46f784f3d82128d3ce1a8b9b4
192 Nd396d900a7b64c9f8b640012a48ecc25 rdf:first sg:person.010054353347.22
193 rdf:rest N5c3e0c5dbb1f43f4b5a68158cf456fa2
194 Nd70d3cb4ab5d4e59bc0da8fbfbeadffc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Humans
196 rdf:type schema:DefinedTerm
197 Ne069fbee4a434f8d8410d3817987a1dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Antineoplastic Agents
199 rdf:type schema:DefinedTerm
200 Ne25b3a02d1b1467d830c1d1d7c64cea8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Blood Coagulation Factors
202 rdf:type schema:DefinedTerm
203 Nf1866a32469d4821bf3e38f38f073a0f rdf:first sg:person.01276357223.69
204 rdf:rest Nfbdede369df74348bd4381f2c6663b79
205 Nfaf69a0d9f9c4b6785e86cd3a132cdee schema:name readcube_id
206 schema:value 819ff93514131bc16cdb4d253258059e4126895e59fc26524d10418fe45a36ba
207 rdf:type schema:PropertyValue
208 Nfbdede369df74348bd4381f2c6663b79 rdf:first sg:person.0752060563.20
209 rdf:rest N41a21270a6694811a9e5b0a5af154fd6
210 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
211 schema:name Medical and Health Sciences
212 rdf:type schema:DefinedTerm
213 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
214 schema:name Oncology and Carcinogenesis
215 rdf:type schema:DefinedTerm
216 sg:grant.2416423 http://pending.schema.org/fundedItem sg:pub.10.1186/s13058-017-0895-5
217 rdf:type schema:MonetaryGrant
218 sg:grant.2438845 http://pending.schema.org/fundedItem sg:pub.10.1186/s13058-017-0895-5
219 rdf:type schema:MonetaryGrant
220 sg:grant.4243704 http://pending.schema.org/fundedItem sg:pub.10.1186/s13058-017-0895-5
221 rdf:type schema:MonetaryGrant
222 sg:journal.1022375 schema:issn 1465-5411
223 1465-542X
224 schema:name Breast Cancer Research
225 rdf:type schema:Periodical
226 sg:person.010054353347.22 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
227 schema:familyName Synold
228 schema:givenName Timothy
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010054353347.22
230 rdf:type schema:Person
231 sg:person.011042155707.25 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
232 schema:familyName Sun
233 schema:givenName Can-Lan
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011042155707.25
235 rdf:type schema:Person
236 sg:person.01114443672.54 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
237 schema:familyName Mi
238 schema:givenName Shu
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114443672.54
240 rdf:type schema:Person
241 sg:person.01117750604.88 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
242 schema:familyName Zavala
243 schema:givenName Laura
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117750604.88
245 rdf:type schema:Person
246 sg:person.01121216740.00 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
247 schema:familyName Somlo
248 schema:givenName George
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121216740.00
250 rdf:type schema:Person
251 sg:person.01151070774.06 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
252 schema:familyName Katheria
253 schema:givenName Vani
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151070774.06
255 rdf:type schema:Person
256 sg:person.012456144527.29 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
257 schema:familyName Arsenyan
258 schema:givenName Anait
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012456144527.29
260 rdf:type schema:Person
261 sg:person.012547141715.18 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
262 schema:familyName Yuan
263 schema:givenName Yuan
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012547141715.18
265 rdf:type schema:Person
266 sg:person.01276357223.69 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
267 schema:familyName Waisman
268 schema:givenName James
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276357223.69
270 rdf:type schema:Person
271 sg:person.013253525127.19 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
272 schema:familyName Choi
273 schema:givenName Jennifer
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013253525127.19
275 rdf:type schema:Person
276 sg:person.01340273066.85 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
277 schema:familyName Hurria
278 schema:givenName Arti
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340273066.85
280 rdf:type schema:Person
281 sg:person.01354323573.20 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
282 schema:familyName Chao
283 schema:givenName Joseph
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354323573.20
285 rdf:type schema:Person
286 sg:person.014445025501.15 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
287 schema:familyName Levi
288 schema:givenName Abrahm
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014445025501.15
290 rdf:type schema:Person
291 sg:person.015747502675.02 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
292 schema:familyName Yost
293 schema:givenName Susan
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015747502675.02
295 rdf:type schema:Person
296 sg:person.016125200527.64 schema:affiliation https://www.grid.ac/institutes/grid.415304.7
297 schema:familyName Vora
298 schema:givenName Nilesh
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016125200527.64
300 rdf:type schema:Person
301 sg:person.0605130716.85 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
302 schema:familyName Soto-Perez-de-Celis
303 schema:givenName Enrique
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605130716.85
305 rdf:type schema:Person
306 sg:person.0642024051.23 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
307 schema:familyName Mortimer
308 schema:givenName Joanne
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642024051.23
310 rdf:type schema:Person
311 sg:person.0674034437.31 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
312 schema:familyName Li
313 schema:givenName Daneng
314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674034437.31
315 rdf:type schema:Person
316 sg:person.0746550465.00 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
317 schema:familyName Luu
318 schema:givenName The-hang
319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746550465.00
320 rdf:type schema:Person
321 sg:person.07470242527.23 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
322 schema:familyName Tran
323 schema:givenName Vivi
324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07470242527.23
325 rdf:type schema:Person
326 sg:person.0752060563.20 schema:affiliation https://www.grid.ac/institutes/grid.410425.6
327 schema:familyName Smith
328 schema:givenName David
329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752060563.20
330 rdf:type schema:Person
331 sg:pub.10.1007/s10549-006-9254-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043713885
332 https://doi.org/10.1007/s10549-006-9254-4
333 rdf:type schema:CreativeWork
334 sg:pub.10.1007/s10549-011-1949-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006286167
335 https://doi.org/10.1007/s10549-011-1949-5
336 rdf:type schema:CreativeWork
337 sg:pub.10.1007/s10549-015-3418-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1007752580
338 https://doi.org/10.1007/s10549-015-3418-z
339 rdf:type schema:CreativeWork
340 sg:pub.10.1186/1471-2407-11-131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025745278
341 https://doi.org/10.1186/1471-2407-11-131
342 rdf:type schema:CreativeWork
343 https://app.dimensions.ai/details/publication/pub.1074474855 schema:CreativeWork
344 https://app.dimensions.ai/details/publication/pub.1075211382 schema:CreativeWork
345 https://doi.org/10.1001/archinte.162.20.2333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005901788
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1001/jama.293.9.1073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021058036
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1002/1097-0142(20010615)91:12<2246::aid-cncr1255>3.0.co;2-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019870784
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1002/cncr.22726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038311829
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1016/j.arr.2010.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032950437
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1016/j.jgo.2013.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013439775
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1016/j.jgo.2016.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032799544
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1016/s0002-9343(99)00066-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009488098
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1016/s0959-8049(99)00256-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038248538
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1016/s0959-8049(99)00259-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048861207
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1046/j.1532-5415.2003.51454.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030862972
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1056/nejm199405053301801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025238022
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1056/nejm199504063321401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012856840
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1056/nejmoa010957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012569804
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1093/gerona/55.11.m649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021917862
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1093/gerona/55.12.m709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029267991
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1093/gerona/59.3.m242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018978584
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1093/gerona/glv007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059623010
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1093/geronj/36.4.428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059626882
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1093/jnci/90.16.1205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037423509
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1093/jnci/dju057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030479541
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1111/ajco.12093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023595762
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1111/j.1532-5415.1985.tb06317.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036955500
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1111/j.1532-5415.1991.tb01616.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007882864
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1111/j.1532-5415.1999.tb01583.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050767834
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1200/jco.2000.18.3.600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074583464
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1200/jco.2000.18.7.1412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074611329
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1200/jco.2003.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203579
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1200/jco.2003.09.081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203847
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1200/jco.2008.19.8440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001688349
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1200/jco.2014.55.1432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051524590
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1200/jco.2014.55.4261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030595690
408 rdf:type schema:CreativeWork
409 https://doi.org/10.18632/oncotarget.8796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000542577
410 rdf:type schema:CreativeWork
411 https://doi.org/10.18632/oncotarget.8939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036214341
412 rdf:type schema:CreativeWork
413 https://doi.org/10.3109/07357900009012191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001609224
414 rdf:type schema:CreativeWork
415 https://doi.org/10.6004/jnccn.2009.0009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077842290
416 rdf:type schema:CreativeWork
417 https://www.grid.ac/institutes/grid.410425.6 schema:alternateName City Of Hope National Medical Center
418 schema:name City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA, USA
419 rdf:type schema:Organization
420 https://www.grid.ac/institutes/grid.415304.7 schema:alternateName Long Beach Memorial Medical Center
421 schema:name Long Beach Memorial Medical Center, Long Beach, CA, USA
422 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...