MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Yu Wei Phua, Akira Nguyen, Daniel L. Roden, Benjamin Elsworth, Niantao Deng, Iva Nikolic, Jessica Yang, Andrea Mcfarland, Roslin Russell, Warren Kaplan, Mark J. Cowley, Radhika Nair, Elena Zotenko, Sandra O’Toole, Shi-xiong Tan, David E. James, Susan J. Clark, Hosein Kouros-Mehr, Alexander Swarbrick

ABSTRACT

INTRODUCTION: The study of mammalian development has offered many insights into the molecular aetiology of cancer. We previously used analysis of mammary morphogenesis to discover a critical role for GATA-3 in mammary developmental and carcinogenesis. In recent years an important role for microRNAs (miRNAs) in a myriad of cellular processes in development and in oncogenesis has emerged. METHODS: microRNA profiling was conducted on stromal and epithelial cellular subsets microdissected from the pubertal mouse mammary gland. miR-184 was reactivated by transient or stable overexpression in breast cancer cell lines and examined using a series of in vitro (proliferation, tumour-sphere and protein synthesis) assays. Orthotopic xenografts of breast cancer cells were used to assess the effect of miR-184 on tumourigenesis as well as distant metastasis. Interactions between miR-184 and its putative targets were assessed by quantitative PCR, microarray, bioinformatics and 3' untranslated region Luciferase reporter assay. The methylation status of primary patient samples was determined by MBD-Cap sequencing. Lastly, the clinical prognostic significance of miR-184 putative targets was assessed using publicly available datasets. RESULTS: A large number of microRNA were restricted in their expression to specific tissue subsets. MicroRNA-184 (miR-184) was exclusively expressed in epithelial cells and markedly upregulated during differentiation of the proliferative, invasive cells of the pubertal terminal end bud (TEB) into ductal epithelial cells in vivo. miR-184 expression was silenced in mouse tumour models compared to non-transformed epithelium and in a majority of breast cancer cell line models. Ectopic reactivation of miR-184 inhibited the proliferation and self-renewal of triple negative breast cancer (TNBC) cell lines in vitro and delayed primary tumour formation and reduced metastatic burden in vivo. Gene expression studies uncovered multi-factorial regulation of genes in the AKT/mTORC1 pathway by miR-184. In clinical breast cancer tissues, expression of miR-184 is lost in primary TNBCs while the miR-184 promoter is methylated in a subset of lymph node metastases from TNBC patients. CONCLUSIONS: These studies elucidate a new layer of regulation in the PI3K/AKT/mTOR pathway with relevance to mammary development and tumour progression and identify miR-184 as a putative breast tumour suppressor. More... »

PAGES

83

References to SciGraph publications

  • 2012-06. The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2009-08. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers in NATURE MEDICINE
  • 2006-08. Mouse models of breast cancer metastasis in BREAST CANCER RESEARCH
  • 2010-08. Mammalian microRNAs predominantly act to decrease target mRNA levels in NATURE
  • 2007-05. Insights from transgenic mouse models of ERBB2-induced breast cancer in NATURE REVIEWS CANCER
  • 2010-03. miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis in NATURE CELL BIOLOGY
  • 2002-11. Docetaxel <i>vs</i> 5-fluorouracil plus vinorelbine in metastatic breast cancer after anthracycline therapy failure in BRITISH JOURNAL OF CANCER
  • 2008-06. Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer in ONCOGENE
  • 2008-02. Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I–III nonsmall cell lung cancer in BRITISH JOURNAL OF CANCER
  • 2010-12. MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2 in MOLECULAR CANCER
  • 2010-02. Opposing microRNA families regulate self-renewal in mouse embryonic stem cells in NATURE
  • 2008-05. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 in NATURE CELL BIOLOGY
  • 2012-08. Prognostic significance of L-type amino-acid transporter 1 expression in surgically resected pancreatic cancer in BRITISH JOURNAL OF CANCER
  • 2008-02. The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis in NATURE CELL BIOLOGY
  • 2000-02. The C3(1)/SV40 T-antigen transgenic mouse model of mammary cancer: ductal epithelial cell targeting with multistage progression to carcinoma in ONCOGENE
  • 2008-12. Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells in BREAST CANCER RESEARCH
  • 2013-05. The shaping and functional consequences of the microRNA landscape in breast cancer in NATURE
  • 2012-06. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups in NATURE
  • 2013-10. MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway in NATURE CELL BIOLOGY
  • 2012-06. The landscape of cancer genes and mutational processes in breast cancer in NATURE
  • 2002-07. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer in NATURE REVIEWS CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13058-015-0593-0

    DOI

    http://dx.doi.org/10.1186/s13058-015-0593-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024937866

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26070602


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Transformation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cluster Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epigenesis, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Silencing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, Tumor Suppressor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mammary Glands, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "MicroRNAs", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins c-akt", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA Interference", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sexual Maturation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "TOR Serine-Threonine Kinases", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Garvan Institute of Medical Research", 
              "id": "https://www.grid.ac/institutes/grid.415306.5", 
              "name": [
                "The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW, Sydney, Australia", 
                "St Vincent\u2019s Clinical School, Faculty of Medicine, Sydney, UNSW, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Phua", 
            "givenName": "Yu Wei", 
            "id": "sg:person.0625673755.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625673755.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Garvan Institute of Medical Research", 
              "id": "https://www.grid.ac/institutes/grid.415306.5", 
              "name": [
                "The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW, Sydney, Australia", 
                "St Vincent\u2019s Clinical School, Faculty of Medicine, Sydney, UNSW, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nguyen", 
            "givenName": "Akira", 
            "id": "sg:person.0737665043.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737665043.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Garvan Institute of Medical Research", 
              "id": "https://www.grid.ac/institutes/grid.415306.5", 
              "name": [
                "The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW, Sydney, Australia", 
                "St Vincent\u2019s Clinical School, Faculty of Medicine, Sydney, UNSW, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Roden", 
            "givenName": "Daniel L.", 
            "id": "sg:person.0754076316.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754076316.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Garvan Institute of Medical Research", 
              "id": "https://www.grid.ac/institutes/grid.415306.5", 
              "name": [
                "The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW, Sydney, Australia", 
                "St Vincent\u2019s Clinical School, Faculty of Medicine, Sydney, UNSW, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Elsworth", 
            "givenName": "Benjamin", 
            "id": "sg:person.0761204563.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761204563.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Garvan Institute of Medical Research", 
              "id": "https://www.grid.ac/institutes/grid.415306.5", 
              "name": [
                "The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW, Sydney, Australia", 
                "St Vincent\u2019s Clinical School, Faculty of Medicine, Sydney, UNSW, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deng", 
            "givenName": "Niantao", 
            "id": "sg:person.01237372011.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237372011.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Garvan Institute of Medical Research", 
              "id": "https://www.grid.ac/institutes/grid.415306.5", 
              "name": [
                "The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW, Sydney, Australia", 
                "St Vincent\u2019s Clinical School, Faculty of Medicine, Sydney, UNSW, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nikolic", 
            "givenName": "Iva", 
            "id": "sg:person.01321001716.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321001716.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Garvan Institute of Medical Research", 
              "id": "https://www.grid.ac/institutes/grid.415306.5", 
              "name": [
                "The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW, Sydney, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Jessica", 
            "id": "sg:person.0575701056.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575701056.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Garvan Institute of Medical Research", 
              "id": "https://www.grid.ac/institutes/grid.415306.5", 
              "name": [
                "The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW, Sydney, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mcfarland", 
            "givenName": "Andrea", 
            "id": "sg:person.01125744202.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125744202.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Research UK Cambridge Institute", 
              "id": "https://www.grid.ac/institutes/grid.470869.4", 
              "name": [
                "Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Russell", 
            "givenName": "Roslin", 
            "id": "sg:person.01263162406.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263162406.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Garvan Institute of Medical Research", 
              "id": "https://www.grid.ac/institutes/grid.415306.5", 
              "name": [
                "The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW, Sydney, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kaplan", 
            "givenName": "Warren", 
            "id": "sg:person.01246414054.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246414054.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Garvan Institute of Medical Research", 
              "id": "https://www.grid.ac/institutes/grid.415306.5", 
              "name": [
                "The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW, Sydney, Australia", 
                "St Vincent\u2019s Clinical School, Faculty of Medicine, Sydney, UNSW, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cowley", 
            "givenName": "Mark J.", 
            "id": "sg:person.01136642027.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136642027.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Garvan Institute of Medical Research", 
              "id": "https://www.grid.ac/institutes/grid.415306.5", 
              "name": [
                "The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW, Sydney, Australia", 
                "St Vincent\u2019s Clinical School, Faculty of Medicine, Sydney, UNSW, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nair", 
            "givenName": "Radhika", 
            "id": "sg:person.0744302671.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744302671.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Garvan Institute of Medical Research", 
              "id": "https://www.grid.ac/institutes/grid.415306.5", 
              "name": [
                "The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW, Sydney, Australia", 
                "St Vincent\u2019s Clinical School, Faculty of Medicine, Sydney, UNSW, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zotenko", 
            "givenName": "Elena", 
            "id": "sg:person.01122276475.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122276475.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Sydney", 
              "id": "https://www.grid.ac/institutes/grid.1013.3", 
              "name": [
                "The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW, Sydney, Australia", 
                "St Vincent\u2019s Clinical School, Faculty of Medicine, Sydney, UNSW, Australia", 
                "Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia", 
                "Sydney Medical School, The University of Sydney, Camperdown, NSW, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "O\u2019Toole", 
            "givenName": "Sandra", 
            "id": "sg:person.01357724675.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357724675.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Molecular and Cell Biology", 
              "id": "https://www.grid.ac/institutes/grid.418812.6", 
              "name": [
                "Metabolism in Human Diseases Unit, Institute of Molecular and Cell Biology, A*STAR, 61 Biopolis Drive, Proteos, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tan", 
            "givenName": "Shi-xiong", 
            "id": "sg:person.01174163740.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174163740.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Sydney", 
              "id": "https://www.grid.ac/institutes/grid.1013.3", 
              "name": [
                "Sydney Medical School, The University of Sydney, Camperdown, NSW, Australia", 
                "The Charles Perkins Centre, School of Molecular Bioscience, University of Sydney, Camperdown, NSW, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "James", 
            "givenName": "David E.", 
            "id": "sg:person.0627763735.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627763735.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Garvan Institute of Medical Research", 
              "id": "https://www.grid.ac/institutes/grid.415306.5", 
              "name": [
                "The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW, Sydney, Australia", 
                "St Vincent\u2019s Clinical School, Faculty of Medicine, Sydney, UNSW, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Clark", 
            "givenName": "Susan J.", 
            "id": "sg:person.014151147752.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014151147752.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Astellas Pharma (United States)", 
              "id": "https://www.grid.ac/institutes/grid.423286.9", 
              "name": [
                "Agensys, affiliate of Astellas Pharmaceuticals, 1800 Stewart St, 90403, Santa Monica, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kouros-Mehr", 
            "givenName": "Hosein", 
            "id": "sg:person.0753001570.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753001570.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Garvan Institute of Medical Research", 
              "id": "https://www.grid.ac/institutes/grid.415306.5", 
              "name": [
                "The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW, Sydney, Australia", 
                "St Vincent\u2019s Clinical School, Faculty of Medicine, Sydney, UNSW, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Swarbrick", 
            "givenName": "Alexander", 
            "id": "sg:person.01115722222.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115722222.51"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.bjc.6600645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000892697", 
              "https://doi.org/10.1038/sj.bjc.6600645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6600645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000892697", 
              "https://doi.org/10.1038/sj.bjc.6600645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0010854", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001510381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.2011.02151.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001641436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.24831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002203934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1248505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005395432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1522907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005513074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203280", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005683287", 
              "https://doi.org/10.1038/sj.onc.1203280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203280", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005683287", 
              "https://doi.org/10.1038/sj.onc.1203280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr1530", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008378724", 
              "https://doi.org/10.1186/bcr1530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.03.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008596750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-9-83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008806285", 
              "https://doi.org/10.1186/1476-4598-9-83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biocel.2010.09.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009073137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09267", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009165330", 
              "https://doi.org/10.1038/nature09267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09267", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009165330", 
              "https://doi.org/10.1038/nature09267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1750-3639.2009.00328.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010355557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1750-3639.2009.00328.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010355557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2008.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011647077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0064434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012389336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1872909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013848860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jclinpath-2012-200826", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013866566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc839", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014023118", 
              "https://doi.org/10.1038/nrc839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc839", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014023118", 
              "https://doi.org/10.1038/nrc839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2006.09.3849", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014603619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10983", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014607335", 
              "https://doi.org/10.1038/nature10983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-11-1821", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015403031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1091903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016003758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2009.06.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017534005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2008.03.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018526747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.03.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019285947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.20138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020626779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020751102", 
              "https://doi.org/10.1038/ncb2024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020751102", 
              "https://doi.org/10.1038/ncb2024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-0325", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020851898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.193.6.727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021607618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.03.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022080500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022446492", 
              "https://doi.org/10.1038/nature08725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022446492", 
              "https://doi.org/10.1038/nature08725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db07-0175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022968665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2008.01.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024085818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1184404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024436325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1018862108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026124870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0803992105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026192445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1227/01.neu.0000316018.51292.19", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026343406"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027957670", 
              "https://doi.org/10.1038/nature12108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1827.2008.02319.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028514312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028707295", 
              "https://doi.org/10.1038/nsmb.2296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-1449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029719280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.21227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032265548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2008.10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032322087", 
              "https://doi.org/10.1038/onc.2008.10"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2827", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033672593", 
              "https://doi.org/10.1038/ncb2827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034041413", 
              "https://doi.org/10.1038/nature11017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.2008.00969.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034553455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr2204", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034649250", 
              "https://doi.org/10.1186/bcr2204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604235", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034990628", 
              "https://doi.org/10.1038/sj.bjc.6604235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2010.02.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035347603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2012.310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035982517", 
              "https://doi.org/10.1038/bjc.2012.310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddm018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036027686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-0533", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036272016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.09.048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036510501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-1853", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036987348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2011.593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037071104"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci45014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037799511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.24.8.3112-3124.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038588630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0015224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039710694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2006.10.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040586971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1974211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040920403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1681", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040922017", 
              "https://doi.org/10.1038/ncb1681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-3667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041483621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.13.1748", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042281410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2007.06.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042435091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044471342", 
              "https://doi.org/10.1038/nrc2127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.79.23.7346", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045022965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045151043", 
              "https://doi.org/10.1038/nm.2000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045151043", 
              "https://doi.org/10.1038/nm.2000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2008.01.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045432090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/stem.1068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046164770"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2008-09-181156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046471960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2008-09-181156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046471960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-10-3253", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046978138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1722", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047429448", 
              "https://doi.org/10.1038/ncb1722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db12-0451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048151699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1096502", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049080424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2008.04.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051991611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-1486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052416169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.13-247247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052455235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078308545", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081952800", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-12", 
        "datePublishedReg": "2015-12-01", 
        "description": "INTRODUCTION: The study of mammalian development has offered many insights into the molecular aetiology of cancer. We previously used analysis of mammary morphogenesis to discover a critical role for GATA-3 in mammary developmental and carcinogenesis. In recent years an important role for microRNAs (miRNAs) in a myriad of cellular processes in development and in oncogenesis has emerged.\nMETHODS: microRNA profiling was conducted on stromal and epithelial cellular subsets microdissected from the pubertal mouse mammary gland. miR-184 was reactivated by transient or stable overexpression in breast cancer cell lines and examined using a series of in vitro (proliferation, tumour-sphere and protein synthesis) assays. Orthotopic xenografts of breast cancer cells were used to assess the effect of miR-184 on tumourigenesis as well as distant metastasis. Interactions between miR-184 and its putative targets were assessed by quantitative PCR, microarray, bioinformatics and 3' untranslated region Luciferase reporter assay. The methylation status of primary patient samples was determined by MBD-Cap sequencing. Lastly, the clinical prognostic significance of miR-184 putative targets was assessed using publicly available datasets.\nRESULTS: A large number of microRNA were restricted in their expression to specific tissue subsets. MicroRNA-184 (miR-184) was exclusively expressed in epithelial cells and markedly upregulated during differentiation of the proliferative, invasive cells of the pubertal terminal end bud (TEB) into ductal epithelial cells in vivo. miR-184 expression was silenced in mouse tumour models compared to non-transformed epithelium and in a majority of breast cancer cell line models. Ectopic reactivation of miR-184 inhibited the proliferation and self-renewal of triple negative breast cancer (TNBC) cell lines in vitro and delayed primary tumour formation and reduced metastatic burden in vivo. Gene expression studies uncovered multi-factorial regulation of genes in the AKT/mTORC1 pathway by miR-184. In clinical breast cancer tissues, expression of miR-184 is lost in primary TNBCs while the miR-184 promoter is methylated in a subset of lymph node metastases from TNBC patients.\nCONCLUSIONS: These studies elucidate a new layer of regulation in the PI3K/AKT/mTOR pathway with relevance to mammary development and tumour progression and identify miR-184 as a putative breast tumour suppressor.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s13058-015-0593-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2762393", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1022375", 
            "issn": [
              "1465-5411", 
              "1465-542X"
            ], 
            "name": "Breast Cancer Research", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "17"
          }
        ], 
        "name": "MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene", 
        "pagination": "83", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "76cddcfe5dde061835134c8539c47d100fa87c83761378890f5d83f98f5bb4fb"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26070602"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100927353"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13058-015-0593-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1024937866"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13058-015-0593-0", 
          "https://app.dimensions.ai/details/publication/pub.1024937866"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:20", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78972_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2Fs13058-015-0593-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13058-015-0593-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13058-015-0593-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13058-015-0593-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13058-015-0593-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    561 TRIPLES      21 PREDICATES      131 URIs      43 LITERALS      31 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13058-015-0593-0 schema:about N2f371211371e4946aad632f561ea4d37
    2 N3a4ff4dfa051454f920d8b6580048974
    3 N42926558aedd4836b1a2c042501033be
    4 N4460147a91fa4237b8631cdfb706e23e
    5 N448028cbbc5b4e8dba6a20aa77f52e5e
    6 N4b2cb61867064c75a4f32c15157d56fa
    7 N4eab9953d4db448fb6f4b9c89627e0e6
    8 N5c4cf897e102488f8ea83058a62d319c
    9 N5fe82d2c1d984df2a4212bfc3b2b36e9
    10 N6545b21a850541d595956b1fbbeda194
    11 N7bacf9bd892649ff86f19e76817ad594
    12 N843e26b8e7d3400383cc084eb5f77908
    13 N8e590fcf9fa34b54b67f663c49dd6c20
    14 Nb5e8d921ea0a4147b78b316367f96963
    15 Nb70a80dec7c2482c902c7b3f4bb1b4df
    16 Nb7ed7b704c6646b493783b5d1d28f46d
    17 Nbdd10c43deae4fac8d5856e000dfcdb6
    18 Nc2827fb5bce34110b0670d937ed3048a
    19 Ndc619da86c2f412082a3183288912fad
    20 Ne04ce37f2dd84183b32968f252bd486b
    21 Ne475fa988b7f4c178fb2c4de21f426a1
    22 Nfa053189ad674e40a9a0bb169f9d7dec
    23 anzsrc-for:11
    24 anzsrc-for:1112
    25 schema:author N7c924bf288de4028af4c3e51d009acfa
    26 schema:citation sg:pub.10.1038/bjc.2012.310
    27 sg:pub.10.1038/nature08725
    28 sg:pub.10.1038/nature09267
    29 sg:pub.10.1038/nature10983
    30 sg:pub.10.1038/nature11017
    31 sg:pub.10.1038/nature12108
    32 sg:pub.10.1038/ncb1681
    33 sg:pub.10.1038/ncb1722
    34 sg:pub.10.1038/ncb2024
    35 sg:pub.10.1038/ncb2827
    36 sg:pub.10.1038/nm.2000
    37 sg:pub.10.1038/nrc2127
    38 sg:pub.10.1038/nrc839
    39 sg:pub.10.1038/nsmb.2296
    40 sg:pub.10.1038/onc.2008.10
    41 sg:pub.10.1038/sj.bjc.6600645
    42 sg:pub.10.1038/sj.bjc.6604235
    43 sg:pub.10.1038/sj.onc.1203280
    44 sg:pub.10.1186/1476-4598-9-83
    45 sg:pub.10.1186/bcr1530
    46 sg:pub.10.1186/bcr2204
    47 https://app.dimensions.ai/details/publication/pub.1078308545
    48 https://app.dimensions.ai/details/publication/pub.1081952800
    49 https://doi.org/10.1001/jama.2011.593
    50 https://doi.org/10.1002/cncr.21227
    51 https://doi.org/10.1002/ijc.24831
    52 https://doi.org/10.1002/stem.1068
    53 https://doi.org/10.1016/j.biocel.2010.09.018
    54 https://doi.org/10.1016/j.ccr.2006.10.008
    55 https://doi.org/10.1016/j.ccr.2008.01.011
    56 https://doi.org/10.1016/j.ccr.2008.04.018
    57 https://doi.org/10.1016/j.cell.2006.09.048
    58 https://doi.org/10.1016/j.cell.2007.03.030
    59 https://doi.org/10.1016/j.cell.2009.03.047
    60 https://doi.org/10.1016/j.cell.2012.03.017
    61 https://doi.org/10.1016/j.devcel.2008.03.003
    62 https://doi.org/10.1016/j.devcel.2008.03.012
    63 https://doi.org/10.1016/j.devcel.2009.06.008
    64 https://doi.org/10.1016/j.molcel.2007.06.017
    65 https://doi.org/10.1016/j.stem.2008.01.016
    66 https://doi.org/10.1016/j.stem.2010.02.017
    67 https://doi.org/10.1073/pnas.0506580102
    68 https://doi.org/10.1073/pnas.0803992105
    69 https://doi.org/10.1073/pnas.1018862108
    70 https://doi.org/10.1073/pnas.79.23.7346
    71 https://doi.org/10.1084/jem.193.6.727
    72 https://doi.org/10.1093/hmg/ddm018
    73 https://doi.org/10.1096/fj.13-247247
    74 https://doi.org/10.1101/gad.1184404
    75 https://doi.org/10.1101/gad.1248505
    76 https://doi.org/10.1101/gad.1522907
    77 https://doi.org/10.1101/gad.1872909
    78 https://doi.org/10.1101/gad.1974211
    79 https://doi.org/10.1111/j.1349-7006.2008.00969.x
    80 https://doi.org/10.1111/j.1349-7006.2011.02151.x
    81 https://doi.org/10.1111/j.1440-1827.2008.02319.x
    82 https://doi.org/10.1111/j.1750-3639.2009.00328.x
    83 https://doi.org/10.1126/science.1091903
    84 https://doi.org/10.1126/science.1096502
    85 https://doi.org/10.1128/mcb.24.8.3112-3124.2004
    86 https://doi.org/10.1136/jclinpath-2012-200826
    87 https://doi.org/10.1158/0008-5472.can-04-1449
    88 https://doi.org/10.1158/0008-5472.can-04-1853
    89 https://doi.org/10.1158/0008-5472.can-06-3667
    90 https://doi.org/10.1158/0008-5472.can-07-0533
    91 https://doi.org/10.1158/0008-5472.can-07-1486
    92 https://doi.org/10.1158/0008-5472.can-08-0325
    93 https://doi.org/10.1158/0008-5472.can-10-3253
    94 https://doi.org/10.1158/0008-5472.can-11-1821
    95 https://doi.org/10.1172/jci45014
    96 https://doi.org/10.1182/blood-2008-09-181156
    97 https://doi.org/10.1200/jco.2006.09.3849
    98 https://doi.org/10.1200/jco.2007.13.1748
    99 https://doi.org/10.1227/01.neu.0000316018.51292.19
    100 https://doi.org/10.1371/journal.pone.0010854
    101 https://doi.org/10.1371/journal.pone.0015224
    102 https://doi.org/10.1371/journal.pone.0064434
    103 https://doi.org/10.2337/db07-0175
    104 https://doi.org/10.2337/db12-0451
    105 https://doi.org/10.3322/caac.20138
    106 schema:datePublished 2015-12
    107 schema:datePublishedReg 2015-12-01
    108 schema:description INTRODUCTION: The study of mammalian development has offered many insights into the molecular aetiology of cancer. We previously used analysis of mammary morphogenesis to discover a critical role for GATA-3 in mammary developmental and carcinogenesis. In recent years an important role for microRNAs (miRNAs) in a myriad of cellular processes in development and in oncogenesis has emerged. METHODS: microRNA profiling was conducted on stromal and epithelial cellular subsets microdissected from the pubertal mouse mammary gland. miR-184 was reactivated by transient or stable overexpression in breast cancer cell lines and examined using a series of in vitro (proliferation, tumour-sphere and protein synthesis) assays. Orthotopic xenografts of breast cancer cells were used to assess the effect of miR-184 on tumourigenesis as well as distant metastasis. Interactions between miR-184 and its putative targets were assessed by quantitative PCR, microarray, bioinformatics and 3' untranslated region Luciferase reporter assay. The methylation status of primary patient samples was determined by MBD-Cap sequencing. Lastly, the clinical prognostic significance of miR-184 putative targets was assessed using publicly available datasets. RESULTS: A large number of microRNA were restricted in their expression to specific tissue subsets. MicroRNA-184 (miR-184) was exclusively expressed in epithelial cells and markedly upregulated during differentiation of the proliferative, invasive cells of the pubertal terminal end bud (TEB) into ductal epithelial cells in vivo. miR-184 expression was silenced in mouse tumour models compared to non-transformed epithelium and in a majority of breast cancer cell line models. Ectopic reactivation of miR-184 inhibited the proliferation and self-renewal of triple negative breast cancer (TNBC) cell lines in vitro and delayed primary tumour formation and reduced metastatic burden in vivo. Gene expression studies uncovered multi-factorial regulation of genes in the AKT/mTORC1 pathway by miR-184. In clinical breast cancer tissues, expression of miR-184 is lost in primary TNBCs while the miR-184 promoter is methylated in a subset of lymph node metastases from TNBC patients. CONCLUSIONS: These studies elucidate a new layer of regulation in the PI3K/AKT/mTOR pathway with relevance to mammary development and tumour progression and identify miR-184 as a putative breast tumour suppressor.
    109 schema:genre research_article
    110 schema:inLanguage en
    111 schema:isAccessibleForFree true
    112 schema:isPartOf N10f80eab7af74f2e9253b13087cc33c1
    113 Ndc06b04e4dfc43809fe242ecae6ef7fe
    114 sg:journal.1022375
    115 schema:name MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene
    116 schema:pagination 83
    117 schema:productId N9da704795e034837b198219e25765bdc
    118 Nb548d0ce76ff4ebaa28743c0179adcfc
    119 Nc31bad1fcda6482a9fe86d85b4603a12
    120 Nc908351590df4bfd91ba7d0fc0d206c4
    121 Nebfde5e4755b46c0b897c34f917bd404
    122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024937866
    123 https://doi.org/10.1186/s13058-015-0593-0
    124 schema:sdDatePublished 2019-04-11T13:20
    125 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    126 schema:sdPublisher Nf9c5a2a4fa5d4516bda1bd78002b0d28
    127 schema:url http://link.springer.com/10.1186%2Fs13058-015-0593-0
    128 sgo:license sg:explorer/license/
    129 sgo:sdDataset articles
    130 rdf:type schema:ScholarlyArticle
    131 N0886cfff12b846cf814d2a706d6c7814 rdf:first sg:person.0754076316.70
    132 rdf:rest N646155f57aa04d46924c59be6d132896
    133 N10f80eab7af74f2e9253b13087cc33c1 schema:volumeNumber 17
    134 rdf:type schema:PublicationVolume
    135 N21c004dbecdc4880ac42b9e0cb061af4 rdf:first sg:person.0753001570.96
    136 rdf:rest N4749d591f0db49c89d0763b63ce71b20
    137 N2f371211371e4946aad632f561ea4d37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Mammary Glands, Animal
    139 rdf:type schema:DefinedTerm
    140 N3a4ff4dfa051454f920d8b6580048974 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Proto-Oncogene Proteins c-akt
    142 rdf:type schema:DefinedTerm
    143 N42926558aedd4836b1a2c042501033be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Genes, Tumor Suppressor
    145 rdf:type schema:DefinedTerm
    146 N4460147a91fa4237b8631cdfb706e23e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Epigenesis, Genetic
    148 rdf:type schema:DefinedTerm
    149 N448028cbbc5b4e8dba6a20aa77f52e5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Mice
    151 rdf:type schema:DefinedTerm
    152 N4749d591f0db49c89d0763b63ce71b20 rdf:first sg:person.01115722222.51
    153 rdf:rest rdf:nil
    154 N4a3b3a6662cb4d59847920e895a22eb2 rdf:first sg:person.0627763735.00
    155 rdf:rest Nb2832eb51b9e4a2f9708ea7c35233bed
    156 N4b2cb61867064c75a4f32c15157d56fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Cell Proliferation
    158 rdf:type schema:DefinedTerm
    159 N4eab9953d4db448fb6f4b9c89627e0e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name RNA Interference
    161 rdf:type schema:DefinedTerm
    162 N5c4cf897e102488f8ea83058a62d319c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Humans
    164 rdf:type schema:DefinedTerm
    165 N5fe82d2c1d984df2a4212bfc3b2b36e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Gene Silencing
    167 rdf:type schema:DefinedTerm
    168 N646155f57aa04d46924c59be6d132896 rdf:first sg:person.0761204563.29
    169 rdf:rest Ndbde2f000d8e43258a37f21b456af4a9
    170 N6545b21a850541d595956b1fbbeda194 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Gene Expression Profiling
    172 rdf:type schema:DefinedTerm
    173 N71c649b6810d45439f7669f28b02c8d0 rdf:first sg:person.0575701056.59
    174 rdf:rest Nc028fe0fb075467184980224308e5960
    175 N73c75bf2a3364b028d52442d26ef79f2 rdf:first sg:person.01122276475.53
    176 rdf:rest Naa6debaaa8dd402fb4a1403477e8f7a8
    177 N799fa1bc0566468c8ecdf8d448919e98 rdf:first sg:person.01246414054.79
    178 rdf:rest Nbb956fb024444843bd5788ce3851e6c0
    179 N7bacf9bd892649ff86f19e76817ad594 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Prognosis
    181 rdf:type schema:DefinedTerm
    182 N7c924bf288de4028af4c3e51d009acfa rdf:first sg:person.0625673755.06
    183 rdf:rest N7ca63623555242a4a13e0c780d119398
    184 N7ca63623555242a4a13e0c780d119398 rdf:first sg:person.0737665043.06
    185 rdf:rest N0886cfff12b846cf814d2a706d6c7814
    186 N843e26b8e7d3400383cc084eb5f77908 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Female
    188 rdf:type schema:DefinedTerm
    189 N88a6e1afb9654f09b28e97212eb9776f rdf:first sg:person.01174163740.86
    190 rdf:rest N4a3b3a6662cb4d59847920e895a22eb2
    191 N8e590fcf9fa34b54b67f663c49dd6c20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Neoplasm Metastasis
    193 rdf:type schema:DefinedTerm
    194 N9805e2f30c864b7e9090c32dc6d4d3bb rdf:first sg:person.0744302671.13
    195 rdf:rest N73c75bf2a3364b028d52442d26ef79f2
    196 N9da704795e034837b198219e25765bdc schema:name readcube_id
    197 schema:value 76cddcfe5dde061835134c8539c47d100fa87c83761378890f5d83f98f5bb4fb
    198 rdf:type schema:PropertyValue
    199 Na842e47f1135481ca49d2e846fcaac77 rdf:first sg:person.01321001716.13
    200 rdf:rest N71c649b6810d45439f7669f28b02c8d0
    201 Naa6debaaa8dd402fb4a1403477e8f7a8 rdf:first sg:person.01357724675.15
    202 rdf:rest N88a6e1afb9654f09b28e97212eb9776f
    203 Nb2832eb51b9e4a2f9708ea7c35233bed rdf:first sg:person.014151147752.43
    204 rdf:rest N21c004dbecdc4880ac42b9e0cb061af4
    205 Nb548d0ce76ff4ebaa28743c0179adcfc schema:name doi
    206 schema:value 10.1186/s13058-015-0593-0
    207 rdf:type schema:PropertyValue
    208 Nb5e8d921ea0a4147b78b316367f96963 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Animals
    210 rdf:type schema:DefinedTerm
    211 Nb70a80dec7c2482c902c7b3f4bb1b4df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Breast Neoplasms
    213 rdf:type schema:DefinedTerm
    214 Nb7ed7b704c6646b493783b5d1d28f46d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Cell Line, Tumor
    216 rdf:type schema:DefinedTerm
    217 Nbb956fb024444843bd5788ce3851e6c0 rdf:first sg:person.01136642027.79
    218 rdf:rest N9805e2f30c864b7e9090c32dc6d4d3bb
    219 Nbbfd494132154bf19c68a1eebc1ac12a rdf:first sg:person.01263162406.13
    220 rdf:rest N799fa1bc0566468c8ecdf8d448919e98
    221 Nbdd10c43deae4fac8d5856e000dfcdb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    222 schema:name Sexual Maturation
    223 rdf:type schema:DefinedTerm
    224 Nc028fe0fb075467184980224308e5960 rdf:first sg:person.01125744202.36
    225 rdf:rest Nbbfd494132154bf19c68a1eebc1ac12a
    226 Nc2827fb5bce34110b0670d937ed3048a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    227 schema:name MicroRNAs
    228 rdf:type schema:DefinedTerm
    229 Nc31bad1fcda6482a9fe86d85b4603a12 schema:name dimensions_id
    230 schema:value pub.1024937866
    231 rdf:type schema:PropertyValue
    232 Nc908351590df4bfd91ba7d0fc0d206c4 schema:name pubmed_id
    233 schema:value 26070602
    234 rdf:type schema:PropertyValue
    235 Ndbde2f000d8e43258a37f21b456af4a9 rdf:first sg:person.01237372011.56
    236 rdf:rest Na842e47f1135481ca49d2e846fcaac77
    237 Ndc06b04e4dfc43809fe242ecae6ef7fe schema:issueNumber 1
    238 rdf:type schema:PublicationIssue
    239 Ndc619da86c2f412082a3183288912fad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    240 schema:name Cluster Analysis
    241 rdf:type schema:DefinedTerm
    242 Ne04ce37f2dd84183b32968f252bd486b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    243 schema:name TOR Serine-Threonine Kinases
    244 rdf:type schema:DefinedTerm
    245 Ne475fa988b7f4c178fb2c4de21f426a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    246 schema:name Cell Transformation, Neoplastic
    247 rdf:type schema:DefinedTerm
    248 Nebfde5e4755b46c0b897c34f917bd404 schema:name nlm_unique_id
    249 schema:value 100927353
    250 rdf:type schema:PropertyValue
    251 Nf9c5a2a4fa5d4516bda1bd78002b0d28 schema:name Springer Nature - SN SciGraph project
    252 rdf:type schema:Organization
    253 Nfa053189ad674e40a9a0bb169f9d7dec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    254 schema:name Gene Expression Regulation, Neoplastic
    255 rdf:type schema:DefinedTerm
    256 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    257 schema:name Medical and Health Sciences
    258 rdf:type schema:DefinedTerm
    259 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    260 schema:name Oncology and Carcinogenesis
    261 rdf:type schema:DefinedTerm
    262 sg:grant.2762393 http://pending.schema.org/fundedItem sg:pub.10.1186/s13058-015-0593-0
    263 rdf:type schema:MonetaryGrant
    264 sg:journal.1022375 schema:issn 1465-5411
    265 1465-542X
    266 schema:name Breast Cancer Research
    267 rdf:type schema:Periodical
    268 sg:person.01115722222.51 schema:affiliation https://www.grid.ac/institutes/grid.415306.5
    269 schema:familyName Swarbrick
    270 schema:givenName Alexander
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115722222.51
    272 rdf:type schema:Person
    273 sg:person.01122276475.53 schema:affiliation https://www.grid.ac/institutes/grid.415306.5
    274 schema:familyName Zotenko
    275 schema:givenName Elena
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122276475.53
    277 rdf:type schema:Person
    278 sg:person.01125744202.36 schema:affiliation https://www.grid.ac/institutes/grid.415306.5
    279 schema:familyName Mcfarland
    280 schema:givenName Andrea
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125744202.36
    282 rdf:type schema:Person
    283 sg:person.01136642027.79 schema:affiliation https://www.grid.ac/institutes/grid.415306.5
    284 schema:familyName Cowley
    285 schema:givenName Mark J.
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136642027.79
    287 rdf:type schema:Person
    288 sg:person.01174163740.86 schema:affiliation https://www.grid.ac/institutes/grid.418812.6
    289 schema:familyName Tan
    290 schema:givenName Shi-xiong
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174163740.86
    292 rdf:type schema:Person
    293 sg:person.01237372011.56 schema:affiliation https://www.grid.ac/institutes/grid.415306.5
    294 schema:familyName Deng
    295 schema:givenName Niantao
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237372011.56
    297 rdf:type schema:Person
    298 sg:person.01246414054.79 schema:affiliation https://www.grid.ac/institutes/grid.415306.5
    299 schema:familyName Kaplan
    300 schema:givenName Warren
    301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246414054.79
    302 rdf:type schema:Person
    303 sg:person.01263162406.13 schema:affiliation https://www.grid.ac/institutes/grid.470869.4
    304 schema:familyName Russell
    305 schema:givenName Roslin
    306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263162406.13
    307 rdf:type schema:Person
    308 sg:person.01321001716.13 schema:affiliation https://www.grid.ac/institutes/grid.415306.5
    309 schema:familyName Nikolic
    310 schema:givenName Iva
    311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321001716.13
    312 rdf:type schema:Person
    313 sg:person.01357724675.15 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
    314 schema:familyName O’Toole
    315 schema:givenName Sandra
    316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357724675.15
    317 rdf:type schema:Person
    318 sg:person.014151147752.43 schema:affiliation https://www.grid.ac/institutes/grid.415306.5
    319 schema:familyName Clark
    320 schema:givenName Susan J.
    321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014151147752.43
    322 rdf:type schema:Person
    323 sg:person.0575701056.59 schema:affiliation https://www.grid.ac/institutes/grid.415306.5
    324 schema:familyName Yang
    325 schema:givenName Jessica
    326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575701056.59
    327 rdf:type schema:Person
    328 sg:person.0625673755.06 schema:affiliation https://www.grid.ac/institutes/grid.415306.5
    329 schema:familyName Phua
    330 schema:givenName Yu Wei
    331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625673755.06
    332 rdf:type schema:Person
    333 sg:person.0627763735.00 schema:affiliation https://www.grid.ac/institutes/grid.1013.3
    334 schema:familyName James
    335 schema:givenName David E.
    336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627763735.00
    337 rdf:type schema:Person
    338 sg:person.0737665043.06 schema:affiliation https://www.grid.ac/institutes/grid.415306.5
    339 schema:familyName Nguyen
    340 schema:givenName Akira
    341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737665043.06
    342 rdf:type schema:Person
    343 sg:person.0744302671.13 schema:affiliation https://www.grid.ac/institutes/grid.415306.5
    344 schema:familyName Nair
    345 schema:givenName Radhika
    346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744302671.13
    347 rdf:type schema:Person
    348 sg:person.0753001570.96 schema:affiliation https://www.grid.ac/institutes/grid.423286.9
    349 schema:familyName Kouros-Mehr
    350 schema:givenName Hosein
    351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753001570.96
    352 rdf:type schema:Person
    353 sg:person.0754076316.70 schema:affiliation https://www.grid.ac/institutes/grid.415306.5
    354 schema:familyName Roden
    355 schema:givenName Daniel L.
    356 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754076316.70
    357 rdf:type schema:Person
    358 sg:person.0761204563.29 schema:affiliation https://www.grid.ac/institutes/grid.415306.5
    359 schema:familyName Elsworth
    360 schema:givenName Benjamin
    361 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761204563.29
    362 rdf:type schema:Person
    363 sg:pub.10.1038/bjc.2012.310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035982517
    364 https://doi.org/10.1038/bjc.2012.310
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/nature08725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022446492
    367 https://doi.org/10.1038/nature08725
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1038/nature09267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009165330
    370 https://doi.org/10.1038/nature09267
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1038/nature10983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014607335
    373 https://doi.org/10.1038/nature10983
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1038/nature11017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034041413
    376 https://doi.org/10.1038/nature11017
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.1038/nature12108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027957670
    379 https://doi.org/10.1038/nature12108
    380 rdf:type schema:CreativeWork
    381 sg:pub.10.1038/ncb1681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040922017
    382 https://doi.org/10.1038/ncb1681
    383 rdf:type schema:CreativeWork
    384 sg:pub.10.1038/ncb1722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047429448
    385 https://doi.org/10.1038/ncb1722
    386 rdf:type schema:CreativeWork
    387 sg:pub.10.1038/ncb2024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020751102
    388 https://doi.org/10.1038/ncb2024
    389 rdf:type schema:CreativeWork
    390 sg:pub.10.1038/ncb2827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033672593
    391 https://doi.org/10.1038/ncb2827
    392 rdf:type schema:CreativeWork
    393 sg:pub.10.1038/nm.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045151043
    394 https://doi.org/10.1038/nm.2000
    395 rdf:type schema:CreativeWork
    396 sg:pub.10.1038/nrc2127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044471342
    397 https://doi.org/10.1038/nrc2127
    398 rdf:type schema:CreativeWork
    399 sg:pub.10.1038/nrc839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014023118
    400 https://doi.org/10.1038/nrc839
    401 rdf:type schema:CreativeWork
    402 sg:pub.10.1038/nsmb.2296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028707295
    403 https://doi.org/10.1038/nsmb.2296
    404 rdf:type schema:CreativeWork
    405 sg:pub.10.1038/onc.2008.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032322087
    406 https://doi.org/10.1038/onc.2008.10
    407 rdf:type schema:CreativeWork
    408 sg:pub.10.1038/sj.bjc.6600645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000892697
    409 https://doi.org/10.1038/sj.bjc.6600645
    410 rdf:type schema:CreativeWork
    411 sg:pub.10.1038/sj.bjc.6604235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034990628
    412 https://doi.org/10.1038/sj.bjc.6604235
    413 rdf:type schema:CreativeWork
    414 sg:pub.10.1038/sj.onc.1203280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005683287
    415 https://doi.org/10.1038/sj.onc.1203280
    416 rdf:type schema:CreativeWork
    417 sg:pub.10.1186/1476-4598-9-83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008806285
    418 https://doi.org/10.1186/1476-4598-9-83
    419 rdf:type schema:CreativeWork
    420 sg:pub.10.1186/bcr1530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008378724
    421 https://doi.org/10.1186/bcr1530
    422 rdf:type schema:CreativeWork
    423 sg:pub.10.1186/bcr2204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034649250
    424 https://doi.org/10.1186/bcr2204
    425 rdf:type schema:CreativeWork
    426 https://app.dimensions.ai/details/publication/pub.1078308545 schema:CreativeWork
    427 https://app.dimensions.ai/details/publication/pub.1081952800 schema:CreativeWork
    428 https://doi.org/10.1001/jama.2011.593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037071104
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1002/cncr.21227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032265548
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1002/ijc.24831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002203934
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1002/stem.1068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046164770
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1016/j.biocel.2010.09.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009073137
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1016/j.ccr.2006.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040586971
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1016/j.ccr.2008.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045432090
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1016/j.ccr.2008.04.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051991611
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1016/j.cell.2006.09.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036510501
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1016/j.cell.2007.03.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019285947
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1016/j.cell.2009.03.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008596750
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1016/j.cell.2012.03.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022080500
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1016/j.devcel.2008.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011647077
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1016/j.devcel.2008.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018526747
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1016/j.devcel.2009.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017534005
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1016/j.molcel.2007.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042435091
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1016/j.stem.2008.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024085818
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1016/j.stem.2010.02.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035347603
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1073/pnas.0803992105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026192445
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1073/pnas.1018862108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026124870
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1073/pnas.79.23.7346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045022965
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1084/jem.193.6.727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021607618
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1093/hmg/ddm018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036027686
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1096/fj.13-247247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052455235
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1101/gad.1184404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024436325
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1101/gad.1248505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005395432
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1101/gad.1522907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005513074
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1101/gad.1872909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013848860
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1101/gad.1974211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040920403
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1111/j.1349-7006.2008.00969.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034553455
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1111/j.1349-7006.2011.02151.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001641436
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1111/j.1440-1827.2008.02319.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028514312
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1111/j.1750-3639.2009.00328.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010355557
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1126/science.1091903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016003758
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1126/science.1096502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049080424
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1128/mcb.24.8.3112-3124.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038588630
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1136/jclinpath-2012-200826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013866566
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1158/0008-5472.can-04-1449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029719280
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1158/0008-5472.can-04-1853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036987348
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1158/0008-5472.can-06-3667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041483621
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.1158/0008-5472.can-07-0533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036272016
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.1158/0008-5472.can-07-1486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052416169
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.1158/0008-5472.can-08-0325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020851898
    515 rdf:type schema:CreativeWork
    516 https://doi.org/10.1158/0008-5472.can-10-3253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046978138
    517 rdf:type schema:CreativeWork
    518 https://doi.org/10.1158/0008-5472.can-11-1821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015403031
    519 rdf:type schema:CreativeWork
    520 https://doi.org/10.1172/jci45014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037799511
    521 rdf:type schema:CreativeWork
    522 https://doi.org/10.1182/blood-2008-09-181156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046471960
    523 rdf:type schema:CreativeWork
    524 https://doi.org/10.1200/jco.2006.09.3849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014603619
    525 rdf:type schema:CreativeWork
    526 https://doi.org/10.1200/jco.2007.13.1748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042281410
    527 rdf:type schema:CreativeWork
    528 https://doi.org/10.1227/01.neu.0000316018.51292.19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026343406
    529 rdf:type schema:CreativeWork
    530 https://doi.org/10.1371/journal.pone.0010854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001510381
    531 rdf:type schema:CreativeWork
    532 https://doi.org/10.1371/journal.pone.0015224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039710694
    533 rdf:type schema:CreativeWork
    534 https://doi.org/10.1371/journal.pone.0064434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012389336
    535 rdf:type schema:CreativeWork
    536 https://doi.org/10.2337/db07-0175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022968665
    537 rdf:type schema:CreativeWork
    538 https://doi.org/10.2337/db12-0451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048151699
    539 rdf:type schema:CreativeWork
    540 https://doi.org/10.3322/caac.20138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020626779
    541 rdf:type schema:CreativeWork
    542 https://www.grid.ac/institutes/grid.1013.3 schema:alternateName University of Sydney
    543 schema:name Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    544 St Vincent’s Clinical School, Faculty of Medicine, Sydney, UNSW, Australia
    545 Sydney Medical School, The University of Sydney, Camperdown, NSW, Australia
    546 The Charles Perkins Centre, School of Molecular Bioscience, University of Sydney, Camperdown, NSW, Australia
    547 The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW, Sydney, Australia
    548 rdf:type schema:Organization
    549 https://www.grid.ac/institutes/grid.415306.5 schema:alternateName Garvan Institute of Medical Research
    550 schema:name St Vincent’s Clinical School, Faculty of Medicine, Sydney, UNSW, Australia
    551 The Kinghorn Cancer Centre & Cancer Research Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW, Sydney, Australia
    552 rdf:type schema:Organization
    553 https://www.grid.ac/institutes/grid.418812.6 schema:alternateName Institute of Molecular and Cell Biology
    554 schema:name Metabolism in Human Diseases Unit, Institute of Molecular and Cell Biology, A*STAR, 61 Biopolis Drive, Proteos, Singapore
    555 rdf:type schema:Organization
    556 https://www.grid.ac/institutes/grid.423286.9 schema:alternateName Astellas Pharma (United States)
    557 schema:name Agensys, affiliate of Astellas Pharmaceuticals, 1800 Stewart St, 90403, Santa Monica, CA, USA
    558 rdf:type schema:Organization
    559 https://www.grid.ac/institutes/grid.470869.4 schema:alternateName Cancer Research UK Cambridge Institute
    560 schema:name Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, UK
    561 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...