Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Eleni van Schooneveld, Hans Wildiers, Ignace Vergote, Peter B Vermeulen, Luc Y Dirix, Steven J Van Laere

ABSTRACT

MicroRNAs (miRNAs) are an emerging class of gene expression modulators with relevant roles in several biological processes, including cell differentiation, development, apoptosis, and regulation of the cell cycle. Deregulation of those tiny RNA molecules has been described frequently as a major determinant for the initiation and progression of diseases, including cancer. Not only miRNAs but also the enzymes responsible for miRNA processing could be deregulated in cancer. In this review, we address the role of miRNAs in the pathogenesis of breast cancer, since there are oncogenic, tumor-suppressive, and metastatic-influencing miRNAs. Additionally, the different detection platforms and normalization strategies for miRNAs will be discussed. The major part of this review, however, will focus on the capability of miRNAs to act as diagnostic, predictive, or prognostic biomarkers. We will give an overview of their potential to correlate with response to or benefit from a given treatment and we will consider their ability to give information on prognosis in breast cancer. We will focus on miRNAs validated by more than one study or verified in independent cohorts or where results rely on preclinical as well as clinical evidence. As such, we will discuss their potential use in the personalized management of breast cancer. More... »

PAGES

21

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13058-015-0526-y

    DOI

    http://dx.doi.org/10.1186/s13058-015-0526-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015273431

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25849621


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