Prevention of thrombotic risk in hospitalized patients with COVID-19 and hemostasis monitoring View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-06-19

AUTHORS

Sophie Susen, Charles Ambroise Tacquard, Alexandre Godon, Alexandre Mansour, Delphine Garrigue, Philippe Nguyen, Anne Godier, Sophie Testa, Jerrold H. Levy, Pierre Albaladejo, Yves Gruel, P. Albaladejo, N. Blais, F. Bonhomme, A. Borel-Derlon, A. Cohen, J.-P. Collet, E. de Maistre, P. Fontana, D. Garrigue Huet, A. Godier, Y. Gruel, A. Godon, B. Ickx, S. Laporte, D. Lasne, J. Llau, G. Le Gal, T. Lecompte, S. Lessire, J. H. Levy, D. Longrois, S. Madi-Jebara, A. Mansour, M. Mazighi, P. Mismetti, P. E. Morange, S. Motte, F. Mullier, N. Nathan, P. Nguyen, G. Pernod, N. Rosencher, S. Roullet, P. M. Roy, S. Schlumberger, P. Sié, A. Steib, S. Susen, C. A. Tacquard, S. Testa, A. Vincentelli, P. Zufferey, A. Borel-Derlon, E. Boissier, B. Dumont, E. de Maistre, Y. Gruel, C. James, D. Lasne, T. Lecompte, P. E. Morange, P. Nguyen, V. Siguret, S. Susen

ABSTRACT

COVID-19 is an infection induced by the SARS-CoV-2 coronavirus, and severe forms can lead to acute respiratory distress syndrome (ARDS) requiring intensive care unit (ICU) management. Severe forms are associated with coagulation changes, mainly characterized by an increase in D-dimer and fibrinogen levels, with a higher risk of thrombosis, particularly pulmonary embolism. The impact of obesity in severe COVID-19 has also been highlighted.In this context, standard doses of low molecular weight heparin (LMWH) may be inadequate in ICU patients, with obesity, major inflammation, and hypercoagulability. We therefore urgently developed proposals on the prevention of thromboembolism and monitoring of hemostasis in hospitalized patients with COVID-19.Four levels of thromboembolic risk were defined according to the severity of COVID-19 reflected by oxygen requirement and treatment, the body mass index, and other risk factors. Monitoring of hemostasis (including fibrinogen and D-dimer levels) every 48 h is proposed. Standard doses of LMWH (e.g., enoxaparin 4000 IU/24 h SC) are proposed in case of intermediate thrombotic risk (BMI < 30 kg/m2, no other risk factors and no ARDS). In all obese patients (high thrombotic risk), adjusted prophylaxis with intermediate doses of LMWH (e.g., enoxaparin 4000 IU/12 h SC or 6000 IU/12 h SC if weight > 120 kg), or unfractionated heparin (UFH) if renal insufficiency (200 IU/kg/24 h, IV), is proposed. The thrombotic risk was defined as very high in obese patients with ARDS and added risk factors for thromboembolism, and also in case of extracorporeal membrane oxygenation (ECMO), unexplained catheter thrombosis, dialysis filter thrombosis, or marked inflammatory syndrome and/or hypercoagulability (e.g., fibrinogen > 8 g/l and/or D-dimers > 3 μg/ml). In ICU patients, it is sometimes difficult to confirm a diagnosis of thrombosis, and curative anticoagulant treatment may also be discussed on a probabilistic basis. In all these situations, therapeutic doses of LMWH, or UFH in case of renal insufficiency with monitoring of anti-Xa activity, are proposed.In conclusion, intensification of heparin treatment should be considered in the context of COVID-19 on the basis of clinical and biological criteria of severity, especially in severely ill ventilated patients, for whom the diagnosis of pulmonary embolism cannot be easily confirmed. More... »

PAGES

364

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13054-020-03000-7

DOI

http://dx.doi.org/10.1186/s13054-020-03000-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1128622084

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32560658


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "COVID-19", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronavirus Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemostasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hospitalization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Monitoring, Physiologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pandemics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pneumonia, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thrombosis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Hemostasis and Transfusion, CHU Lille, Lille, France", 
          "id": "http://www.grid.ac/institutes/grid.410463.4", 
          "name": [
            "Department of Hematology and Transfusion, Lille University Hospital, Lille, France", 
            "Department of Hemostasis and Transfusion, CHU Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Susen", 
        "givenName": "Sophie", 
        "id": "sg:person.01124537322.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124537322.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anesthesia and Intensive Care, Strasbourg University Hospital, Strasbourg, France", 
          "id": "http://www.grid.ac/institutes/grid.412220.7", 
          "name": [
            "Department of Anesthesia and Intensive Care, Strasbourg University Hospital, Strasbourg, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tacquard", 
        "givenName": "Charles Ambroise", 
        "id": "sg:person.0746414510.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746414510.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anesthesiology and Critical Care, Grenoble Alpes University Hospital, La Tronche, France", 
          "id": "http://www.grid.ac/institutes/grid.410529.b", 
          "name": [
            "Department of Anesthesiology and Critical Care, Grenoble Alpes University Hospital, La Tronche, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Godon", 
        "givenName": "Alexandre", 
        "id": "sg:person.013744635717.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013744635717.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anesthesiology and Critical Care Medicine, Rennes University Hospital, Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.411154.4", 
          "name": [
            "Department of Anesthesiology and Critical Care Medicine, Rennes University Hospital, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mansour", 
        "givenName": "Alexandre", 
        "id": "sg:person.015553145733.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015553145733.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Transfusion, Lille University Hospital, Lille, France", 
          "id": "http://www.grid.ac/institutes/grid.410463.4", 
          "name": [
            "Department of Hematology and Transfusion, Lille University Hospital, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garrigue", 
        "givenName": "Delphine", 
        "id": "sg:person.01004633606.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004633606.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology Laboratory, Reims University Hospital, Reims, France", 
          "id": "http://www.grid.ac/institutes/grid.139510.f", 
          "name": [
            "Department of Hematology Laboratory, Reims University Hospital, Reims, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nguyen", 
        "givenName": "Philippe", 
        "id": "sg:person.01203524373.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203524373.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anesthesia and Intensive Care, HEGP-AP-HP, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.50550.35", 
          "name": [
            "Department of Anesthesia and Intensive Care, HEGP-AP-HP, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Godier", 
        "givenName": "Anne", 
        "id": "sg:person.0756207247.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756207247.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "AO Istituti Ospitalieri, Cremona, Italy", 
          "id": "http://www.grid.ac/institutes/grid.419450.d", 
          "name": [
            "AO Istituti Ospitalieri, Cremona, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Testa", 
        "givenName": "Sophie", 
        "id": "sg:person.0615061225.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615061225.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital, Durham, NC USA", 
          "id": "http://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Hospital, Durham, NC USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Levy", 
        "givenName": "Jerrold H.", 
        "id": "sg:person.01273437327.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273437327.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anesthesiology and Critical Care, Grenoble Alpes University Hospital, La Tronche, France", 
          "id": "http://www.grid.ac/institutes/grid.410529.b", 
          "name": [
            "Department of Anesthesiology and Critical Care, Grenoble Alpes University Hospital, La Tronche, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Albaladejo", 
        "givenName": "Pierre", 
        "id": "sg:person.0651366611.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651366611.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology-Hemostasis, Tours University Hospital, CHRU Tours, Tours, France", 
          "id": "http://www.grid.ac/institutes/grid.411167.4", 
          "name": [
            "Department of Hematology-Hemostasis, Tours University Hospital, CHRU Tours, Tours, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gruel", 
        "givenName": "Yves", 
        "id": "sg:person.01004442736.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004442736.15"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Albaladejo", 
        "givenName": "P.", 
        "type": "Person"
      }, 
      {
        "familyName": "Blais", 
        "givenName": "N.", 
        "type": "Person"
      }, 
      {
        "familyName": "Bonhomme", 
        "givenName": "F.", 
        "type": "Person"
      }, 
      {
        "familyName": "Borel-Derlon", 
        "givenName": "A.", 
        "type": "Person"
      }, 
      {
        "familyName": "Cohen", 
        "givenName": "A.", 
        "type": "Person"
      }, 
      {
        "familyName": "Collet", 
        "givenName": "J.-P.", 
        "type": "Person"
      }, 
      {
        "familyName": "de Maistre", 
        "givenName": "E.", 
        "type": "Person"
      }, 
      {
        "familyName": "Fontana", 
        "givenName": "P.", 
        "type": "Person"
      }, 
      {
        "familyName": "Huet", 
        "givenName": "D. Garrigue", 
        "id": "sg:person.016544012140.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016544012140.32"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Godier", 
        "givenName": "A.", 
        "type": "Person"
      }, 
      {
        "familyName": "Gruel", 
        "givenName": "Y.", 
        "type": "Person"
      }, 
      {
        "familyName": "Godon", 
        "givenName": "A.", 
        "type": "Person"
      }, 
      {
        "familyName": "Ickx", 
        "givenName": "B.", 
        "type": "Person"
      }, 
      {
        "familyName": "Laporte", 
        "givenName": "S.", 
        "type": "Person"
      }, 
      {
        "familyName": "Lasne", 
        "givenName": "D.", 
        "type": "Person"
      }, 
      {
        "familyName": "Llau", 
        "givenName": "J.", 
        "type": "Person"
      }, 
      {
        "familyName": "Le Gal", 
        "givenName": "G.", 
        "type": "Person"
      }, 
      {
        "familyName": "Lecompte", 
        "givenName": "T.", 
        "type": "Person"
      }, 
      {
        "familyName": "Lessire", 
        "givenName": "S.", 
        "type": "Person"
      }, 
      {
        "familyName": "Levy", 
        "givenName": "J. H.", 
        "type": "Person"
      }, 
      {
        "familyName": "Longrois", 
        "givenName": "D.", 
        "type": "Person"
      }, 
      {
        "familyName": "Madi-Jebara", 
        "givenName": "S.", 
        "type": "Person"
      }, 
      {
        "familyName": "Mansour", 
        "givenName": "A.", 
        "type": "Person"
      }, 
      {
        "familyName": "Mazighi", 
        "givenName": "M.", 
        "type": "Person"
      }, 
      {
        "familyName": "Mismetti", 
        "givenName": "P.", 
        "type": "Person"
      }, 
      {
        "familyName": "Morange", 
        "givenName": "P. E.", 
        "type": "Person"
      }, 
      {
        "familyName": "Motte", 
        "givenName": "S.", 
        "type": "Person"
      }, 
      {
        "familyName": "Mullier", 
        "givenName": "F.", 
        "type": "Person"
      }, 
      {
        "familyName": "Nathan", 
        "givenName": "N.", 
        "type": "Person"
      }, 
      {
        "familyName": "Nguyen", 
        "givenName": "P.", 
        "type": "Person"
      }, 
      {
        "familyName": "Pernod", 
        "givenName": "G.", 
        "type": "Person"
      }, 
      {
        "familyName": "Rosencher", 
        "givenName": "N.", 
        "type": "Person"
      }, 
      {
        "familyName": "Roullet", 
        "givenName": "S.", 
        "type": "Person"
      }, 
      {
        "familyName": "Roy", 
        "givenName": "P. M.", 
        "type": "Person"
      }, 
      {
        "familyName": "Schlumberger", 
        "givenName": "S.", 
        "type": "Person"
      }, 
      {
        "familyName": "Si\u00e9", 
        "givenName": "P.", 
        "type": "Person"
      }, 
      {
        "familyName": "Steib", 
        "givenName": "A.", 
        "type": "Person"
      }, 
      {
        "familyName": "Susen", 
        "givenName": "S.", 
        "type": "Person"
      }, 
      {
        "familyName": "Tacquard", 
        "givenName": "C. A.", 
        "type": "Person"
      }, 
      {
        "familyName": "Testa", 
        "givenName": "S.", 
        "type": "Person"
      }, 
      {
        "familyName": "Vincentelli", 
        "givenName": "A.", 
        "type": "Person"
      }, 
      {
        "familyName": "Zufferey", 
        "givenName": "P.", 
        "type": "Person"
      }, 
      {
        "familyName": "Borel-Derlon", 
        "givenName": "A.", 
        "type": "Person"
      }, 
      {
        "familyName": "Boissier", 
        "givenName": "E.", 
        "type": "Person"
      }, 
      {
        "familyName": "Dumont", 
        "givenName": "B.", 
        "type": "Person"
      }, 
      {
        "familyName": "de Maistre", 
        "givenName": "E.", 
        "type": "Person"
      }, 
      {
        "familyName": "Gruel", 
        "givenName": "Y.", 
        "type": "Person"
      }, 
      {
        "familyName": "James", 
        "givenName": "C.", 
        "type": "Person"
      }, 
      {
        "familyName": "Lasne", 
        "givenName": "D.", 
        "type": "Person"
      }, 
      {
        "familyName": "Lecompte", 
        "givenName": "T.", 
        "type": "Person"
      }, 
      {
        "familyName": "Morange", 
        "givenName": "P. E.", 
        "type": "Person"
      }, 
      {
        "familyName": "Nguyen", 
        "givenName": "P.", 
        "type": "Person"
      }, 
      {
        "familyName": "Siguret", 
        "givenName": "V.", 
        "type": "Person"
      }, 
      {
        "familyName": "Susen", 
        "givenName": "S.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11239-020-02105-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1126110034", 
          "https://doi.org/10.1007/s11239-020-02105-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-020-06062-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1127350891", 
          "https://doi.org/10.1007/s00134-020-06062-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-020-2726-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1124199777", 
          "https://doi.org/10.1186/s13054-020-2726-9"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-06-19", 
    "datePublishedReg": "2020-06-19", 
    "description": "COVID-19 is an infection induced by the SARS-CoV-2 coronavirus, and severe forms can lead to acute respiratory distress syndrome (ARDS) requiring intensive care unit (ICU) management. Severe forms are associated with coagulation changes, mainly characterized by an increase in D-dimer and fibrinogen levels, with a higher risk of thrombosis, particularly pulmonary embolism. The impact of obesity in severe COVID-19 has also been highlighted.In this context, standard doses of low molecular weight heparin (LMWH) may be inadequate in ICU patients, with obesity, major inflammation, and hypercoagulability. We therefore urgently developed proposals on the prevention of thromboembolism and monitoring of hemostasis in hospitalized patients with COVID-19.Four levels of thromboembolic risk were defined according to the severity of COVID-19 reflected by oxygen requirement and treatment, the body mass index, and other risk factors. Monitoring of hemostasis (including fibrinogen and D-dimer levels) every 48\u2009h is proposed. Standard doses of LMWH (e.g., enoxaparin 4000\u2009IU/24\u2009h SC) are proposed in case of intermediate thrombotic risk (BMI\u2009<\u200930\u2009kg/m2, no other risk factors and no ARDS). In all obese patients (high thrombotic risk), adjusted prophylaxis with intermediate doses of LMWH (e.g., enoxaparin 4000\u2009IU/12\u2009h SC or 6000\u2009IU/12\u2009h SC if weight\u2009>\u2009120\u2009kg), or unfractionated heparin (UFH) if renal insufficiency (200\u2009IU/kg/24\u2009h, IV), is proposed. The thrombotic risk was defined as very high in obese patients with ARDS and added risk factors for thromboembolism, and also in case of extracorporeal membrane oxygenation (ECMO), unexplained catheter thrombosis, dialysis filter thrombosis, or marked inflammatory syndrome and/or hypercoagulability (e.g., fibrinogen >\u20098\u2009g/l and/or D-dimers >\u20093\u2009\u03bcg/ml). In ICU patients, it is sometimes difficult to confirm a diagnosis of thrombosis, and curative anticoagulant treatment may also be discussed on a probabilistic basis. In all these situations, therapeutic doses of LMWH, or UFH in case of renal insufficiency with monitoring of anti-Xa activity, are proposed.In conclusion, intensification of heparin treatment should be considered in the context of COVID-19 on the basis of clinical and biological criteria of severity, especially in severely ill ventilated patients, for whom the diagnosis of pulmonary embolism cannot be easily confirmed.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s13054-020-03000-7", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1117766", 
        "issn": [
          "1364-8535", 
          "1466-609X"
        ], 
        "name": "Critical Care", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "24"
      }
    ], 
    "keywords": [
      "low molecular weight heparin", 
      "acute respiratory distress syndrome", 
      "monitoring of hemostasis", 
      "extracorporeal membrane oxygenation", 
      "thrombotic risk", 
      "renal insufficiency", 
      "pulmonary embolism", 
      "obese patients", 
      "standard doses", 
      "ICU patients", 
      "hospitalized patients", 
      "COVID-19", 
      "risk factors", 
      "severe form", 
      "intensive care unit management", 
      "curative anticoagulant treatment", 
      "impact of obesity", 
      "severe COVID-19", 
      "prevention of thromboembolism", 
      "respiratory distress syndrome", 
      "ill ventilated patients", 
      "anti-Xa activity", 
      "body mass index", 
      "molecular weight heparin", 
      "diagnosis of thrombosis", 
      "SARS-CoV-2 coronavirus", 
      "hemostasis monitoring", 
      "catheter thrombosis", 
      "thromboembolic risk", 
      "inflammatory syndrome", 
      "anticoagulant treatment", 
      "distress syndrome", 
      "filter thrombosis", 
      "coagulation changes", 
      "membrane oxygenation", 
      "weight heparin", 
      "mass index", 
      "ventilated patients", 
      "heparin treatment", 
      "therapeutic doses", 
      "fibrinogen levels", 
      "high risk", 
      "patients", 
      "thrombosis", 
      "major inflammation", 
      "intermediate doses", 
      "doses", 
      "oxygen requirement", 
      "unit management", 
      "thromboembolism", 
      "hypercoagulability", 
      "embolism", 
      "obesity", 
      "risk", 
      "syndrome", 
      "insufficiency", 
      "hemostasis", 
      "treatment", 
      "diagnosis", 
      "prevention", 
      "severity", 
      "heparin", 
      "prophylaxis", 
      "UFH", 
      "inflammation", 
      "infection", 
      "cases", 
      "oxygenation", 
      "biological criteria", 
      "coronavirus", 
      "levels", 
      "factors", 
      "monitoring", 
      "conclusion", 
      "index", 
      "management", 
      "activity", 
      "criteria", 
      "increase", 
      "changes", 
      "basis", 
      "form", 
      "impact", 
      "context", 
      "situation", 
      "dimer", 
      "intensification", 
      "requirements", 
      "proposal", 
      "probabilistic basis", 
      "care unit (ICU) management", 
      "intermediate thrombotic risk", 
      "unexplained catheter thrombosis", 
      "dialysis filter thrombosis"
    ], 
    "name": "Prevention of thrombotic risk in hospitalized patients with COVID-19 and hemostasis monitoring", 
    "pagination": "364", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1128622084"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13054-020-03000-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "32560658"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13054-020-03000-7", 
      "https://app.dimensions.ai/details/publication/pub.1128622084"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_843.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s13054-020-03000-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13054-020-03000-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13054-020-03000-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13054-020-03000-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13054-020-03000-7'


 

This table displays all metadata directly associated to this object as RDF triples.

575 TRIPLES      22 PREDICATES      133 URIs      122 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13054-020-03000-7 schema:about N10324cc8fe2548bc83c4cf80317ff425
2 N13cd28a17a6a41ec90327a74b3b98c85
3 N35d4f69017e842c1badb90bfdf6602ed
4 N37e2026873d44e81882496cd29ca7b6c
5 N999be0c09b014b5b8358a967ea88df4a
6 N9f05f0b90cd440049c3f3bb0d429d762
7 Na2591a0be6b142949a5fc448397c6233
8 Nb2c3c251e70643778ac0e7af9bd41587
9 Nd282952582404e5086ead6abd36b8740
10 Neb7f1cee860440cc973705735dd544ea
11 anzsrc-for:11
12 anzsrc-for:1103
13 schema:author N3adb1ee198c1401abe7e21f735a12511
14 schema:citation sg:pub.10.1007/s00134-020-06062-x
15 sg:pub.10.1007/s11239-020-02105-8
16 sg:pub.10.1186/s13054-020-2726-9
17 schema:datePublished 2020-06-19
18 schema:datePublishedReg 2020-06-19
19 schema:description COVID-19 is an infection induced by the SARS-CoV-2 coronavirus, and severe forms can lead to acute respiratory distress syndrome (ARDS) requiring intensive care unit (ICU) management. Severe forms are associated with coagulation changes, mainly characterized by an increase in D-dimer and fibrinogen levels, with a higher risk of thrombosis, particularly pulmonary embolism. The impact of obesity in severe COVID-19 has also been highlighted.In this context, standard doses of low molecular weight heparin (LMWH) may be inadequate in ICU patients, with obesity, major inflammation, and hypercoagulability. We therefore urgently developed proposals on the prevention of thromboembolism and monitoring of hemostasis in hospitalized patients with COVID-19.Four levels of thromboembolic risk were defined according to the severity of COVID-19 reflected by oxygen requirement and treatment, the body mass index, and other risk factors. Monitoring of hemostasis (including fibrinogen and D-dimer levels) every 48 h is proposed. Standard doses of LMWH (e.g., enoxaparin 4000 IU/24 h SC) are proposed in case of intermediate thrombotic risk (BMI &lt; 30 kg/m<sup>2</sup>, no other risk factors and no ARDS). In all obese patients (high thrombotic risk), adjusted prophylaxis with intermediate doses of LMWH (e.g., enoxaparin 4000 IU/12 h SC or 6000 IU/12 h SC if weight &gt; 120 kg), or unfractionated heparin (UFH) if renal insufficiency (200 IU/kg/24 h, IV), is proposed. The thrombotic risk was defined as very high in obese patients with ARDS and added risk factors for thromboembolism, and also in case of extracorporeal membrane oxygenation (ECMO), unexplained catheter thrombosis, dialysis filter thrombosis, or marked inflammatory syndrome and/or hypercoagulability (e.g., fibrinogen &gt; 8 g/l and/or D-dimers &gt; 3 μg/ml). In ICU patients, it is sometimes difficult to confirm a diagnosis of thrombosis, and curative anticoagulant treatment may also be discussed on a probabilistic basis. In all these situations, therapeutic doses of LMWH, or UFH in case of renal insufficiency with monitoring of anti-Xa activity, are proposed.In conclusion, intensification of heparin treatment should be considered in the context of COVID-19 on the basis of clinical and biological criteria of severity, especially in severely ill ventilated patients, for whom the diagnosis of pulmonary embolism cannot be easily confirmed.
20 schema:genre article
21 schema:inLanguage en
22 schema:isAccessibleForFree true
23 schema:isPartOf N2a521f2a4b3148e1a0f80ea69b4eb452
24 Nca6c746edc7e43feb7de5c406ca0660e
25 sg:journal.1117766
26 schema:keywords COVID-19
27 ICU patients
28 SARS-CoV-2 coronavirus
29 UFH
30 activity
31 acute respiratory distress syndrome
32 anti-Xa activity
33 anticoagulant treatment
34 basis
35 biological criteria
36 body mass index
37 care unit (ICU) management
38 cases
39 catheter thrombosis
40 changes
41 coagulation changes
42 conclusion
43 context
44 coronavirus
45 criteria
46 curative anticoagulant treatment
47 diagnosis
48 diagnosis of thrombosis
49 dialysis filter thrombosis
50 dimer
51 distress syndrome
52 doses
53 embolism
54 extracorporeal membrane oxygenation
55 factors
56 fibrinogen levels
57 filter thrombosis
58 form
59 hemostasis
60 hemostasis monitoring
61 heparin
62 heparin treatment
63 high risk
64 hospitalized patients
65 hypercoagulability
66 ill ventilated patients
67 impact
68 impact of obesity
69 increase
70 index
71 infection
72 inflammation
73 inflammatory syndrome
74 insufficiency
75 intensification
76 intensive care unit management
77 intermediate doses
78 intermediate thrombotic risk
79 levels
80 low molecular weight heparin
81 major inflammation
82 management
83 mass index
84 membrane oxygenation
85 molecular weight heparin
86 monitoring
87 monitoring of hemostasis
88 obese patients
89 obesity
90 oxygen requirement
91 oxygenation
92 patients
93 prevention
94 prevention of thromboembolism
95 probabilistic basis
96 prophylaxis
97 proposal
98 pulmonary embolism
99 renal insufficiency
100 requirements
101 respiratory distress syndrome
102 risk
103 risk factors
104 severe COVID-19
105 severe form
106 severity
107 situation
108 standard doses
109 syndrome
110 therapeutic doses
111 thromboembolic risk
112 thromboembolism
113 thrombosis
114 thrombotic risk
115 treatment
116 unexplained catheter thrombosis
117 unit management
118 ventilated patients
119 weight heparin
120 schema:name Prevention of thrombotic risk in hospitalized patients with COVID-19 and hemostasis monitoring
121 schema:pagination 364
122 schema:productId N233808f31b464204b1ff09ef684916d3
123 N7d843da761b84d5494fd64c31a7ec430
124 Nb62f025ffdbe4824a5928a2f019ca443
125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1128622084
126 https://doi.org/10.1186/s13054-020-03000-7
127 schema:sdDatePublished 2022-01-01T18:52
128 schema:sdLicense https://scigraph.springernature.com/explorer/license/
129 schema:sdPublisher N9f26049b26284e9cb659eb2d58bc75af
130 schema:url https://doi.org/10.1186/s13054-020-03000-7
131 sgo:license sg:explorer/license/
132 sgo:sdDataset articles
133 rdf:type schema:ScholarlyArticle
134 N001c1a512920487ba84ebe7ac071fb43 rdf:first Ne6d7f07cf5174c4382b9e22cf86a2f38
135 rdf:rest N61c87476f109482ba29adc734d507c51
136 N01e600f0010b4744a3e114ce980e29d6 rdf:first N036ca3f95ddb474b99dd98d486c6bcbe
137 rdf:rest N62096163debc4956acebed0b04ee6c01
138 N036ca3f95ddb474b99dd98d486c6bcbe schema:familyName Susen
139 schema:givenName S.
140 rdf:type schema:Person
141 N0545c48472614bc5b7cc1ed9abe34e6f schema:familyName Motte
142 schema:givenName S.
143 rdf:type schema:Person
144 N05643a55c6d84ff0a7a4610e04545c29 rdf:first N2e268a935e8a4c4ea5ed5cccf7a6b938
145 rdf:rest N290c52ae20b8436381f808aa47181f53
146 N0e7b89e23a4448c1beb9ba59a268dad0 schema:familyName Boissier
147 schema:givenName E.
148 rdf:type schema:Person
149 N0f2b76253210482d9403dc251a1ab58a schema:familyName Sié
150 schema:givenName P.
151 rdf:type schema:Person
152 N10324cc8fe2548bc83c4cf80317ff425 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Risk
154 rdf:type schema:DefinedTerm
155 N115fe76550c14f9b9dc83cff8b588018 rdf:first N7e7b66878e9e41fdbb347ce872593352
156 rdf:rest Nde9828ed402a49a7a8b8e097abde73c7
157 N13cd28a17a6a41ec90327a74b3b98c85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Coronavirus Infections
159 rdf:type schema:DefinedTerm
160 N14cf1d12b3f44607b6dde7620990c7c3 rdf:first Ne88b4068d67b43489522e0920db616f4
161 rdf:rest N8de604600cb14d68bcbd79e10fe2f0bc
162 N15da0a47befc4013b4bb5d23ac6c655d schema:familyName Laporte
163 schema:givenName S.
164 rdf:type schema:Person
165 N1787b5f5b81c4426bebf6492f2b6d8a2 rdf:first Nb495f72f14ac43d9a29508316c2cb2e4
166 rdf:rest N743e63ac61c34dd691b2a657b8d31b01
167 N18325d570e034b3cbff18ff805ed58b3 schema:familyName Tacquard
168 schema:givenName C. A.
169 rdf:type schema:Person
170 N19843cf897c1412d91dac912c0daa445 schema:familyName Vincentelli
171 schema:givenName A.
172 rdf:type schema:Person
173 N1d45dd578bb84c6f9fd97c6b806573fa rdf:first Nc598375192484ad58f6afc3e320cdf99
174 rdf:rest Nde387b40e03b47c59de373e220964fa1
175 N1e3488771e5c4801a04af77f6769bc74 rdf:first N899d77a2805a43aa87b70931cc8cd370
176 rdf:rest N115fe76550c14f9b9dc83cff8b588018
177 N1f69942f7d804181844d028d9db453d9 schema:familyName Dumont
178 schema:givenName B.
179 rdf:type schema:Person
180 N20277715ec7a4eaf9efc74ec3b6f6181 schema:familyName Collet
181 schema:givenName J.-P.
182 rdf:type schema:Person
183 N233808f31b464204b1ff09ef684916d3 schema:name dimensions_id
184 schema:value pub.1128622084
185 rdf:type schema:PropertyValue
186 N290c52ae20b8436381f808aa47181f53 rdf:first Nb416f4ea3293453fb87ba316fdeabc3e
187 rdf:rest Nc9830d5b76934abfb3fbaa26399fa0ff
188 N2a521f2a4b3148e1a0f80ea69b4eb452 schema:volumeNumber 24
189 rdf:type schema:PublicationVolume
190 N2e268a935e8a4c4ea5ed5cccf7a6b938 schema:familyName Levy
191 schema:givenName J. H.
192 rdf:type schema:Person
193 N3298261c66eb49cf92238d7fafd671c5 schema:familyName Cohen
194 schema:givenName A.
195 rdf:type schema:Person
196 N35d4f69017e842c1badb90bfdf6602ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name COVID-19
198 rdf:type schema:DefinedTerm
199 N36feb2c29a6545f0b8ae693ccb91a9e6 schema:familyName Le Gal
200 schema:givenName G.
201 rdf:type schema:Person
202 N37e2026873d44e81882496cd29ca7b6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Humans
204 rdf:type schema:DefinedTerm
205 N3adb1ee198c1401abe7e21f735a12511 rdf:first sg:person.01124537322.21
206 rdf:rest N4dfb82625db2494fbbfbb27bfe6e1921
207 N42bbdedbb15446e08d1834167d6ef0a0 rdf:first Ne460937f762e4948996fa41cc6d95145
208 rdf:rest Nffbca96a8c46469ba47474adc41f97fd
209 N42f68283f85840879900253da2fd13a7 schema:familyName Nathan
210 schema:givenName N.
211 rdf:type schema:Person
212 N437a376195904cc7ae99f0283d9af592 rdf:first N5b27532a3ecf48fdb958cf6f793b9b1e
213 rdf:rest Nc6a67349e0834387b6f2474c100f4e45
214 N438c45f76b15494ab053b5502f67b8cd schema:familyName Mullier
215 schema:givenName F.
216 rdf:type schema:Person
217 N4c9cd0ce9f8d49449ae926a646107b12 schema:familyName Bonhomme
218 schema:givenName F.
219 rdf:type schema:Person
220 N4dfb82625db2494fbbfbb27bfe6e1921 rdf:first sg:person.0746414510.48
221 rdf:rest Ndb81288a80fd4d3da88674031df9e588
222 N5149caaf6e2a4952af679b76e73d134d schema:familyName Gruel
223 schema:givenName Y.
224 rdf:type schema:Person
225 N54d922d962194ba28bf591c049ed64bf schema:familyName Testa
226 schema:givenName S.
227 rdf:type schema:Person
228 N555a295cd1b4436baecd847f3e49e982 rdf:first sg:person.01203524373.09
229 rdf:rest N5cfe9b78c19e4ca983c7577134b1daaf
230 N56f2267c3fe244cbbb147e73e037db4f schema:familyName Borel-Derlon
231 schema:givenName A.
232 rdf:type schema:Person
233 N5b27532a3ecf48fdb958cf6f793b9b1e schema:familyName Roullet
234 schema:givenName S.
235 rdf:type schema:Person
236 N5cfe9b78c19e4ca983c7577134b1daaf rdf:first sg:person.0756207247.23
237 rdf:rest N9ff56ba2a73a49e2a75800a5825d2105
238 N5d2854e8008e447e9214991ad1de2a61 rdf:first N0f2b76253210482d9403dc251a1ab58a
239 rdf:rest Ndc4ad637e9ea4484999f3736045279c6
240 N5fcac5d60a1f42b99db2bb325eaa0e39 rdf:first N0e7b89e23a4448c1beb9ba59a268dad0
241 rdf:rest Nd6efc4cd98f946b9b0c43a564316279d
242 N61c87476f109482ba29adc734d507c51 rdf:first Ndee140134f984e378496ccce92be4ca9
243 rdf:rest N1e3488771e5c4801a04af77f6769bc74
244 N62096163debc4956acebed0b04ee6c01 rdf:first N18325d570e034b3cbff18ff805ed58b3
245 rdf:rest N7a5980564d394a3d9ca233870e4e9a4d
246 N62f9dc268db0479490fa88273461ef59 schema:familyName Rosencher
247 schema:givenName N.
248 rdf:type schema:Person
249 N636a234d01d4469da76367ddc50ef3df rdf:first sg:person.016544012140.32
250 rdf:rest Ndc016a2dd9e54fb6866128a69f9ea355
251 N6541af8fc63544b999ec7e1cf03113bd rdf:first N842c7d5f66834294b525ea346ed7d3a8
252 rdf:rest Nc93aec288e584eaca0eab4cd3c4bfe8d
253 N6ab7537698e1466487cf11a1eb77e274 schema:familyName Mansour
254 schema:givenName A.
255 rdf:type schema:Person
256 N6b042a1e999c4b4eac799ca3772cd9d8 schema:familyName Fontana
257 schema:givenName P.
258 rdf:type schema:Person
259 N6c2fe315989841729e0251e79dbe09e0 schema:familyName Zufferey
260 schema:givenName P.
261 rdf:type schema:Person
262 N6fee14093b4342199c8e27445765b07a schema:familyName Roy
263 schema:givenName P. M.
264 rdf:type schema:Person
265 N711a6734410f4223a0c56b8d071a2e66 rdf:first sg:person.015553145733.45
266 rdf:rest N7e757ae1e832401eab93c48fddb9d6a4
267 N73a5dc7adba04f1cac637747762a4667 rdf:first N97830b3084a44102bcc03cff0bae41ea
268 rdf:rest N8647db8a7a204167b47ca12dd497bdc0
269 N743e63ac61c34dd691b2a657b8d31b01 rdf:first Na6ac5271fc494191844b817c7b3fc052
270 rdf:rest Nfcdfaf41bb1c4b24ac4c8bc50e8a8c7a
271 N758487d73e9f446d9bfc8fef2484754d rdf:first sg:person.01273437327.74
272 rdf:rest Ncc6d1db354b24ee082c3d9b8a97f9f09
273 N77c70064a3c64b269cf0bbfae94b4769 rdf:first N9ad9a41a6d2343638c8e259cfc34102e
274 rdf:rest N42bbdedbb15446e08d1834167d6ef0a0
275 N77e8c1fff8394f0b9493185522867012 schema:familyName Mazighi
276 schema:givenName M.
277 rdf:type schema:Person
278 N79d99203880c44e3b896b4857dd15f4b rdf:first N6ab7537698e1466487cf11a1eb77e274
279 rdf:rest Ndfc98b9aa1624973820ae8398df536a3
280 N7a5980564d394a3d9ca233870e4e9a4d rdf:first N54d922d962194ba28bf591c049ed64bf
281 rdf:rest Na40cd7ff654b4de698d6b5fcc049db48
282 N7d843da761b84d5494fd64c31a7ec430 schema:name doi
283 schema:value 10.1186/s13054-020-03000-7
284 rdf:type schema:PropertyValue
285 N7dd3f89643984711bf64a0c5e44ee586 schema:familyName Mismetti
286 schema:givenName P.
287 rdf:type schema:Person
288 N7e757ae1e832401eab93c48fddb9d6a4 rdf:first sg:person.01004633606.40
289 rdf:rest N555a295cd1b4436baecd847f3e49e982
290 N7e7b66878e9e41fdbb347ce872593352 schema:familyName Lecompte
291 schema:givenName T.
292 rdf:type schema:Person
293 N842c7d5f66834294b525ea346ed7d3a8 schema:familyName de Maistre
294 schema:givenName E.
295 rdf:type schema:Person
296 N8647db8a7a204167b47ca12dd497bdc0 rdf:first N3298261c66eb49cf92238d7fafd671c5
297 rdf:rest Nb79d476514324e7a9db4847a2b6d4287
298 N873251f440964ac69cbdc2f16b77dc8c rdf:first N42f68283f85840879900253da2fd13a7
299 rdf:rest N1787b5f5b81c4426bebf6492f2b6d8a2
300 N8940258f596246ab99f970bd5fa7a58c rdf:first Neafd818cdb834c9781afb12d70e696fa
301 rdf:rest Nc0227e4f9b034e468de015343e9dcda7
302 N899d77a2805a43aa87b70931cc8cd370 schema:familyName Lasne
303 schema:givenName D.
304 rdf:type schema:Person
305 N8a713af47cdc4cfcbd031f1b1029ace6 rdf:first N9bb3dab261dc4ea2b353c66314b03f41
306 rdf:rest N05643a55c6d84ff0a7a4610e04545c29
307 N8de604600cb14d68bcbd79e10fe2f0bc rdf:first Nee187d338f57498c9210e1ddcb9aef01
308 rdf:rest rdf:nil
309 N9063a69d1ff0439a9313bcec17284722 schema:familyName Steib
310 schema:givenName A.
311 rdf:type schema:Person
312 N9370eb6d9beb4dd783dbb1c1170ceeb6 rdf:first Nfa633bd034304c18b89fab22d55b02aa
313 rdf:rest Ne28b941687b54ce995d3b2dab2623d89
314 N96c7b73094dc4ecf89afcc5244e26a3a rdf:first N15da0a47befc4013b4bb5d23ac6c655d
315 rdf:rest N77c70064a3c64b269cf0bbfae94b4769
316 N97830b3084a44102bcc03cff0bae41ea schema:familyName Borel-Derlon
317 schema:givenName A.
318 rdf:type schema:Person
319 N999be0c09b014b5b8358a967ea88df4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
320 schema:name Monitoring, Physiologic
321 rdf:type schema:DefinedTerm
322 N9ad9a41a6d2343638c8e259cfc34102e schema:familyName Lasne
323 schema:givenName D.
324 rdf:type schema:Person
325 N9bb3dab261dc4ea2b353c66314b03f41 schema:familyName Lessire
326 schema:givenName S.
327 rdf:type schema:Person
328 N9c7e9167500f4fb1bfd3f6f707b4ab1b schema:familyName Blais
329 schema:givenName N.
330 rdf:type schema:Person
331 N9f05f0b90cd440049c3f3bb0d429d762 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
332 schema:name Pneumonia, Viral
333 rdf:type schema:DefinedTerm
334 N9f26049b26284e9cb659eb2d58bc75af schema:name Springer Nature - SN SciGraph project
335 rdf:type schema:Organization
336 N9ff56ba2a73a49e2a75800a5825d2105 rdf:first sg:person.0615061225.45
337 rdf:rest N758487d73e9f446d9bfc8fef2484754d
338 Na2591a0be6b142949a5fc448397c6233 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
339 schema:name Pandemics
340 rdf:type schema:DefinedTerm
341 Na3b9ebb1ca12474081f1e6049a624864 rdf:first N4c9cd0ce9f8d49449ae926a646107b12
342 rdf:rest N73a5dc7adba04f1cac637747762a4667
343 Na40cd7ff654b4de698d6b5fcc049db48 rdf:first N19843cf897c1412d91dac912c0daa445
344 rdf:rest Nb930ea9d870940b4a08bca49f945657b
345 Na6ac5271fc494191844b817c7b3fc052 schema:familyName Pernod
346 schema:givenName G.
347 rdf:type schema:Person
348 Na74793e6afaa4b2a830958c7f5728432 rdf:first sg:person.01004442736.15
349 rdf:rest N1d45dd578bb84c6f9fd97c6b806573fa
350 Naa8c28930bb24965b10a25b29ddc7a93 schema:familyName Lecompte
351 schema:givenName T.
352 rdf:type schema:Person
353 Naf856e4a41fc41e599fb281b0ba7a91b rdf:first N56f2267c3fe244cbbb147e73e037db4f
354 rdf:rest N5fcac5d60a1f42b99db2bb325eaa0e39
355 Nb0cfb574c47a4dfb8998f19f355cd235 rdf:first N438c45f76b15494ab053b5502f67b8cd
356 rdf:rest N873251f440964ac69cbdc2f16b77dc8c
357 Nb1c9cd9ea0e44960ba3b7fe3d696b708 schema:familyName Nguyen
358 schema:givenName P.
359 rdf:type schema:Person
360 Nb2c3c251e70643778ac0e7af9bd41587 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
361 schema:name Hospitalization
362 rdf:type schema:DefinedTerm
363 Nb416f4ea3293453fb87ba316fdeabc3e schema:familyName Longrois
364 schema:givenName D.
365 rdf:type schema:Person
366 Nb495f72f14ac43d9a29508316c2cb2e4 schema:familyName Nguyen
367 schema:givenName P.
368 rdf:type schema:Person
369 Nb5b419c71f5c40d3b62173f9961dc75f rdf:first Nb1c9cd9ea0e44960ba3b7fe3d696b708
370 rdf:rest N14cf1d12b3f44607b6dde7620990c7c3
371 Nb62f025ffdbe4824a5928a2f019ca443 schema:name pubmed_id
372 schema:value 32560658
373 rdf:type schema:PropertyValue
374 Nb79d476514324e7a9db4847a2b6d4287 rdf:first N20277715ec7a4eaf9efc74ec3b6f6181
375 rdf:rest N6541af8fc63544b999ec7e1cf03113bd
376 Nb930ea9d870940b4a08bca49f945657b rdf:first N6c2fe315989841729e0251e79dbe09e0
377 rdf:rest Naf856e4a41fc41e599fb281b0ba7a91b
378 Nbdf8b99c6a154f0897e183a3d688ba89 rdf:first N7dd3f89643984711bf64a0c5e44ee586
379 rdf:rest N9370eb6d9beb4dd783dbb1c1170ceeb6
380 Nc0227e4f9b034e468de015343e9dcda7 rdf:first Ncf0266a46cdd4b6db46c350bb154e8c2
381 rdf:rest N96c7b73094dc4ecf89afcc5244e26a3a
382 Nc54cc89ef895401bb05c379bc4ee316d schema:familyName Godier
383 schema:givenName A.
384 rdf:type schema:Person
385 Nc598375192484ad58f6afc3e320cdf99 schema:familyName Albaladejo
386 schema:givenName P.
387 rdf:type schema:Person
388 Nc6a67349e0834387b6f2474c100f4e45 rdf:first N6fee14093b4342199c8e27445765b07a
389 rdf:rest Nd288d225d60d4a2ea155f6e6bf9c6f2c
390 Nc71599bb636745c591b91ad2eb467d9b rdf:first Ne0d3d756dbd041c2ab62e7b17bca246a
391 rdf:rest N001c1a512920487ba84ebe7ac071fb43
392 Nc93aec288e584eaca0eab4cd3c4bfe8d rdf:first N6b042a1e999c4b4eac799ca3772cd9d8
393 rdf:rest N636a234d01d4469da76367ddc50ef3df
394 Nc9830d5b76934abfb3fbaa26399fa0ff rdf:first Nee77aa0697d4442984ff1684dd2831c0
395 rdf:rest N79d99203880c44e3b896b4857dd15f4b
396 Nca6c746edc7e43feb7de5c406ca0660e schema:issueNumber 1
397 rdf:type schema:PublicationIssue
398 Ncc6d1db354b24ee082c3d9b8a97f9f09 rdf:first sg:person.0651366611.28
399 rdf:rest Na74793e6afaa4b2a830958c7f5728432
400 Ncf0266a46cdd4b6db46c350bb154e8c2 schema:familyName Ickx
401 schema:givenName B.
402 rdf:type schema:Person
403 Nd282952582404e5086ead6abd36b8740 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
404 schema:name Thrombosis
405 rdf:type schema:DefinedTerm
406 Nd288d225d60d4a2ea155f6e6bf9c6f2c rdf:first Ne8691227e98f48588be242bc9b25dbea
407 rdf:rest N5d2854e8008e447e9214991ad1de2a61
408 Nd6efc4cd98f946b9b0c43a564316279d rdf:first N1f69942f7d804181844d028d9db453d9
409 rdf:rest Nc71599bb636745c591b91ad2eb467d9b
410 Ndb81288a80fd4d3da88674031df9e588 rdf:first sg:person.013744635717.76
411 rdf:rest N711a6734410f4223a0c56b8d071a2e66
412 Ndc016a2dd9e54fb6866128a69f9ea355 rdf:first Nc54cc89ef895401bb05c379bc4ee316d
413 rdf:rest Nebf5d64bf7fe4e4385da5300917f9b11
414 Ndc4ad637e9ea4484999f3736045279c6 rdf:first N9063a69d1ff0439a9313bcec17284722
415 rdf:rest N01e600f0010b4744a3e114ce980e29d6
416 Nde387b40e03b47c59de373e220964fa1 rdf:first N9c7e9167500f4fb1bfd3f6f707b4ab1b
417 rdf:rest Na3b9ebb1ca12474081f1e6049a624864
418 Nde9828ed402a49a7a8b8e097abde73c7 rdf:first Nfb281fac6b0b4b53b516eaeb42091819
419 rdf:rest Nb5b419c71f5c40d3b62173f9961dc75f
420 Ndee140134f984e378496ccce92be4ca9 schema:familyName James
421 schema:givenName C.
422 rdf:type schema:Person
423 Ndfc98b9aa1624973820ae8398df536a3 rdf:first N77e8c1fff8394f0b9493185522867012
424 rdf:rest Nbdf8b99c6a154f0897e183a3d688ba89
425 Ne0d3d756dbd041c2ab62e7b17bca246a schema:familyName de Maistre
426 schema:givenName E.
427 rdf:type schema:Person
428 Ne28b941687b54ce995d3b2dab2623d89 rdf:first N0545c48472614bc5b7cc1ed9abe34e6f
429 rdf:rest Nb0cfb574c47a4dfb8998f19f355cd235
430 Ne460937f762e4948996fa41cc6d95145 schema:familyName Llau
431 schema:givenName J.
432 rdf:type schema:Person
433 Ne6d7f07cf5174c4382b9e22cf86a2f38 schema:familyName Gruel
434 schema:givenName Y.
435 rdf:type schema:Person
436 Ne8691227e98f48588be242bc9b25dbea schema:familyName Schlumberger
437 schema:givenName S.
438 rdf:type schema:Person
439 Ne88b4068d67b43489522e0920db616f4 schema:familyName Siguret
440 schema:givenName V.
441 rdf:type schema:Person
442 Neafd818cdb834c9781afb12d70e696fa schema:familyName Godon
443 schema:givenName A.
444 rdf:type schema:Person
445 Neb7f1cee860440cc973705735dd544ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
446 schema:name Hemostasis
447 rdf:type schema:DefinedTerm
448 Nebf5d64bf7fe4e4385da5300917f9b11 rdf:first N5149caaf6e2a4952af679b76e73d134d
449 rdf:rest N8940258f596246ab99f970bd5fa7a58c
450 Nee187d338f57498c9210e1ddcb9aef01 schema:familyName Susen
451 schema:givenName S.
452 rdf:type schema:Person
453 Nee77aa0697d4442984ff1684dd2831c0 schema:familyName Madi-Jebara
454 schema:givenName S.
455 rdf:type schema:Person
456 Nef679889cca0481892e7785eabafe85e rdf:first Naa8c28930bb24965b10a25b29ddc7a93
457 rdf:rest N8a713af47cdc4cfcbd031f1b1029ace6
458 Nfa633bd034304c18b89fab22d55b02aa schema:familyName Morange
459 schema:givenName P. E.
460 rdf:type schema:Person
461 Nfb281fac6b0b4b53b516eaeb42091819 schema:familyName Morange
462 schema:givenName P. E.
463 rdf:type schema:Person
464 Nfcdfaf41bb1c4b24ac4c8bc50e8a8c7a rdf:first N62f9dc268db0479490fa88273461ef59
465 rdf:rest N437a376195904cc7ae99f0283d9af592
466 Nffbca96a8c46469ba47474adc41f97fd rdf:first N36feb2c29a6545f0b8ae693ccb91a9e6
467 rdf:rest Nef679889cca0481892e7785eabafe85e
468 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
469 schema:name Medical and Health Sciences
470 rdf:type schema:DefinedTerm
471 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
472 schema:name Clinical Sciences
473 rdf:type schema:DefinedTerm
474 sg:journal.1117766 schema:issn 1364-8535
475 1466-609X
476 schema:name Critical Care
477 schema:publisher Springer Nature
478 rdf:type schema:Periodical
479 sg:person.01004442736.15 schema:affiliation grid-institutes:grid.411167.4
480 schema:familyName Gruel
481 schema:givenName Yves
482 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004442736.15
483 rdf:type schema:Person
484 sg:person.01004633606.40 schema:affiliation grid-institutes:grid.410463.4
485 schema:familyName Garrigue
486 schema:givenName Delphine
487 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004633606.40
488 rdf:type schema:Person
489 sg:person.01124537322.21 schema:affiliation grid-institutes:grid.410463.4
490 schema:familyName Susen
491 schema:givenName Sophie
492 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124537322.21
493 rdf:type schema:Person
494 sg:person.01203524373.09 schema:affiliation grid-institutes:grid.139510.f
495 schema:familyName Nguyen
496 schema:givenName Philippe
497 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203524373.09
498 rdf:type schema:Person
499 sg:person.01273437327.74 schema:affiliation grid-institutes:grid.189509.c
500 schema:familyName Levy
501 schema:givenName Jerrold H.
502 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273437327.74
503 rdf:type schema:Person
504 sg:person.013744635717.76 schema:affiliation grid-institutes:grid.410529.b
505 schema:familyName Godon
506 schema:givenName Alexandre
507 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013744635717.76
508 rdf:type schema:Person
509 sg:person.015553145733.45 schema:affiliation grid-institutes:grid.411154.4
510 schema:familyName Mansour
511 schema:givenName Alexandre
512 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015553145733.45
513 rdf:type schema:Person
514 sg:person.016544012140.32 schema:familyName Huet
515 schema:givenName D. Garrigue
516 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016544012140.32
517 rdf:type schema:Person
518 sg:person.0615061225.45 schema:affiliation grid-institutes:grid.419450.d
519 schema:familyName Testa
520 schema:givenName Sophie
521 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615061225.45
522 rdf:type schema:Person
523 sg:person.0651366611.28 schema:affiliation grid-institutes:grid.410529.b
524 schema:familyName Albaladejo
525 schema:givenName Pierre
526 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651366611.28
527 rdf:type schema:Person
528 sg:person.0746414510.48 schema:affiliation grid-institutes:grid.412220.7
529 schema:familyName Tacquard
530 schema:givenName Charles Ambroise
531 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746414510.48
532 rdf:type schema:Person
533 sg:person.0756207247.23 schema:affiliation grid-institutes:grid.50550.35
534 schema:familyName Godier
535 schema:givenName Anne
536 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756207247.23
537 rdf:type schema:Person
538 sg:pub.10.1007/s00134-020-06062-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1127350891
539 https://doi.org/10.1007/s00134-020-06062-x
540 rdf:type schema:CreativeWork
541 sg:pub.10.1007/s11239-020-02105-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1126110034
542 https://doi.org/10.1007/s11239-020-02105-8
543 rdf:type schema:CreativeWork
544 sg:pub.10.1186/s13054-020-2726-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1124199777
545 https://doi.org/10.1186/s13054-020-2726-9
546 rdf:type schema:CreativeWork
547 grid-institutes:grid.139510.f schema:alternateName Department of Hematology Laboratory, Reims University Hospital, Reims, France
548 schema:name Department of Hematology Laboratory, Reims University Hospital, Reims, France
549 rdf:type schema:Organization
550 grid-institutes:grid.189509.c schema:alternateName Duke University Hospital, Durham, NC USA
551 schema:name Duke University Hospital, Durham, NC USA
552 rdf:type schema:Organization
553 grid-institutes:grid.410463.4 schema:alternateName Department of Hematology and Transfusion, Lille University Hospital, Lille, France
554 Department of Hemostasis and Transfusion, CHU Lille, Lille, France
555 schema:name Department of Hematology and Transfusion, Lille University Hospital, Lille, France
556 Department of Hemostasis and Transfusion, CHU Lille, Lille, France
557 rdf:type schema:Organization
558 grid-institutes:grid.410529.b schema:alternateName Department of Anesthesiology and Critical Care, Grenoble Alpes University Hospital, La Tronche, France
559 schema:name Department of Anesthesiology and Critical Care, Grenoble Alpes University Hospital, La Tronche, France
560 rdf:type schema:Organization
561 grid-institutes:grid.411154.4 schema:alternateName Department of Anesthesiology and Critical Care Medicine, Rennes University Hospital, Rennes, France
562 schema:name Department of Anesthesiology and Critical Care Medicine, Rennes University Hospital, Rennes, France
563 rdf:type schema:Organization
564 grid-institutes:grid.411167.4 schema:alternateName Department of Hematology-Hemostasis, Tours University Hospital, CHRU Tours, Tours, France
565 schema:name Department of Hematology-Hemostasis, Tours University Hospital, CHRU Tours, Tours, France
566 rdf:type schema:Organization
567 grid-institutes:grid.412220.7 schema:alternateName Department of Anesthesia and Intensive Care, Strasbourg University Hospital, Strasbourg, France
568 schema:name Department of Anesthesia and Intensive Care, Strasbourg University Hospital, Strasbourg, France
569 rdf:type schema:Organization
570 grid-institutes:grid.419450.d schema:alternateName AO Istituti Ospitalieri, Cremona, Italy
571 schema:name AO Istituti Ospitalieri, Cremona, Italy
572 rdf:type schema:Organization
573 grid-institutes:grid.50550.35 schema:alternateName Department of Anesthesia and Intensive Care, HEGP-AP-HP, Paris, France
574 schema:name Department of Anesthesia and Intensive Care, HEGP-AP-HP, Paris, France
575 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...