Respective contribution of intensive care unit-acquired limb muscle and severe diaphragm weakness on weaning outcome and mortality: a post hoc ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-11-21

AUTHORS

Martin Dres, Boris Jung, Nicolas Molinari, Federico Manna, Bruno-Pierre Dubé, Gerald Chanques, Thomas Similowski, Samir Jaber, Alexandre Demoule

ABSTRACT

BackgroundIntensive care unit (ICU)-acquired weakness (ICU-AW) and ICU-acquired diaphragm dysfunction (ICU-DD) occur frequently in mechanically ventilated (MV) patients. It is unknown whether they have different risk factors and different impacts on outcome. This study was designed to (1) describe the respective risk factors associated with ICU-AW and severe ICU-DD and (2) evaluate the respective impact of ICU-AW and severe ICU-DD on outcome.MethodsPost hoc analysis of two prospective cohort studies conducted in two ICUs. In patients mechanically ventilated for at least 24 h undergoing a first spontaneous breathing trial, severe ICU-DD was defined as diaphragm twitch pressure < 7 cmH2O and ICU-AW was defined as Medical Research Council Score < 48.ResultsOne hundred sixteen patients were assessed. Factors independently associated with severe ICU-DD were age, longer duration of MV, and exposure to sufentanil, and those factors associated with ICU-AW were longer duration of MV and exposure to norepinephrine. Severe ICU-DD (OR 3.56, p = 0.008), but not ICU-AW, was independently associated with weaning failure (59%). ICU-AW (OR 4.30, p = 0.033), but not severe ICU-DD, was associated with ICU mortality. Weaning failure and mortality rate were higher in patients with both severe ICU-DD and ICU-AW (86% and 39%, respectively) than in patients with either severe ICU-DD (64% and 0%) or ICU-AW (63% and 13%).ConclusionSevere ICU-DD and ICU-AW have different risk factors and different impacts on weaning failure and mortality. The impact of the combination of ICU-DD and ICU-AW is more pronounced than their individual impact. More... »

PAGES

370

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13054-019-2650-z

DOI

http://dx.doi.org/10.1186/s13054-019-2650-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1122798205

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31752937


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Critical Illness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diaphragm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intensive Care Units", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mortality", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle Weakness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiration, Artificial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ventilator Weaning", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re Charles Foix, Intensive Care Unit and Respiratory Division (D\u00e9partement \u201cR3S\u201d), F-75013, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.50550.35", 
          "name": [
            "AP-HP, Sorbonne Universit\u00e9, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Service de Pneumologie, M\u00e9decine intensive \u2013 R\u00e9animation (D\u00e9partement \u201cR3S\u201d), F-75013, Paris, France", 
            "AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re Charles Foix, Intensive Care Unit and Respiratory Division (D\u00e9partement \u201cR3S\u201d), F-75013, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dres", 
        "givenName": "Martin", 
        "id": "sg:person.01120203457.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120203457.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Intensive Care Unit, Lapeyronie University Hospital, Montpellier, France", 
          "id": "http://www.grid.ac/institutes/grid.411572.4", 
          "name": [
            "Montpellier School of Medicine, University of Montpellier, INSERM U1046, CNRS UMR 9214, Montpellier, France", 
            "Medical Intensive Care Unit, Lapeyronie University Hospital, Montpellier, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jung", 
        "givenName": "Boris", 
        "id": "sg:person.01230435413.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230435413.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Statistics, CHU Montpellier, IMAG, CNRS, Univ Montpellier, Montpellier, France", 
          "id": "http://www.grid.ac/institutes/grid.121334.6", 
          "name": [
            "Department of Statistics, CHU Montpellier, IMAG, CNRS, Univ Montpellier, Montpellier, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Molinari", 
        "givenName": "Nicolas", 
        "id": "sg:person.01266343767.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266343767.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Statistics, CHU Montpellier, IMAG, CNRS, Univ Montpellier, Montpellier, France", 
          "id": "http://www.grid.ac/institutes/grid.121334.6", 
          "name": [
            "Department of Statistics, CHU Montpellier, IMAG, CNRS, Univ Montpellier, Montpellier, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manna", 
        "givenName": "Federico", 
        "id": "sg:person.014202751711.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014202751711.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re Charles Foix, Intensive Care Unit and Respiratory Division (D\u00e9partement \u201cR3S\u201d), F-75013, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.50550.35", 
          "name": [
            "AP-HP, Sorbonne Universit\u00e9, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Service de Pneumologie, M\u00e9decine intensive \u2013 R\u00e9animation (D\u00e9partement \u201cR3S\u201d), F-75013, Paris, France", 
            "AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re Charles Foix, Intensive Care Unit and Respiratory Division (D\u00e9partement \u201cR3S\u201d), F-75013, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dub\u00e9", 
        "givenName": "Bruno-Pierre", 
        "id": "sg:person.0637307777.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637307777.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Intensive Care and Anesthesiology Department, Saint Eloi Hospital, Montpellier, France", 
          "id": "http://www.grid.ac/institutes/grid.414352.5", 
          "name": [
            "Montpellier School of Medicine, University of Montpellier, INSERM U1046, CNRS UMR 9214, Montpellier, France", 
            "Intensive Care and Anesthesiology Department, Saint Eloi Hospital, Montpellier, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chanques", 
        "givenName": "Gerald", 
        "id": "sg:person.01202621205.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202621205.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re Charles Foix, Intensive Care Unit and Respiratory Division (D\u00e9partement \u201cR3S\u201d), F-75013, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.50550.35", 
          "name": [
            "AP-HP, Sorbonne Universit\u00e9, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Service de Pneumologie, M\u00e9decine intensive \u2013 R\u00e9animation (D\u00e9partement \u201cR3S\u201d), F-75013, Paris, France", 
            "AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re Charles Foix, Intensive Care Unit and Respiratory Division (D\u00e9partement \u201cR3S\u201d), F-75013, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Similowski", 
        "givenName": "Thomas", 
        "id": "sg:person.01235111105.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235111105.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Intensive Care and Anesthesiology Department, Saint Eloi Hospital, Montpellier, France", 
          "id": "http://www.grid.ac/institutes/grid.414352.5", 
          "name": [
            "Montpellier School of Medicine, University of Montpellier, INSERM U1046, CNRS UMR 9214, Montpellier, France", 
            "Intensive Care and Anesthesiology Department, Saint Eloi Hospital, Montpellier, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jaber", 
        "givenName": "Samir", 
        "id": "sg:person.01113242353.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113242353.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de Pneumologie, M\u00e9decine Intensive et R\u00e9animation, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 Boulevard de l\u2019H\u00f4pital, 75651, Paris Cedex 13, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "AP-HP, Sorbonne Universit\u00e9, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Service de Pneumologie, M\u00e9decine intensive \u2013 R\u00e9animation (D\u00e9partement \u201cR3S\u201d), F-75013, Paris, France", 
            "AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re Charles Foix, Intensive Care Unit and Respiratory Division (D\u00e9partement \u201cR3S\u201d), F-75013, Paris, France", 
            "Service de Pneumologie, M\u00e9decine Intensive et R\u00e9animation, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 Boulevard de l\u2019H\u00f4pital, 75651, Paris Cedex 13, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Demoule", 
        "givenName": "Alexandre", 
        "id": "sg:person.0673253666.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673253666.83"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s13054-018-1992-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101629732", 
          "https://doi.org/10.1186/s13054-018-1992-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13613-018-0401-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103601685", 
          "https://doi.org/10.1186/s13613-018-0401-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-015-4125-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003806404", 
          "https://doi.org/10.1007/s00134-015-4125-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc13052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008578981", 
          "https://doi.org/10.1186/cc13052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13613-016-0179-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026819233", 
          "https://doi.org/10.1186/s13613-016-0179-8"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-11-21", 
    "datePublishedReg": "2019-11-21", 
    "description": "BackgroundIntensive care unit (ICU)-acquired weakness (ICU-AW) and ICU-acquired diaphragm dysfunction (ICU-DD) occur frequently in mechanically ventilated (MV) patients. It is unknown whether they have different risk factors and different impacts on outcome. This study was designed to (1) describe the respective risk factors associated with ICU-AW and severe ICU-DD and (2) evaluate the respective impact of ICU-AW and severe ICU-DD on outcome.MethodsPost hoc analysis of two prospective cohort studies conducted in two ICUs. In patients mechanically ventilated for at least 24\u2009h undergoing a first spontaneous breathing trial, severe ICU-DD was defined as diaphragm twitch pressure <\u20097\u00a0cmH2O and ICU-AW was defined as Medical Research Council Score\u2009<\u200948.ResultsOne hundred sixteen patients were assessed. Factors independently associated with severe ICU-DD were age, longer duration of MV, and exposure to sufentanil, and those factors associated with ICU-AW were longer duration of MV and exposure to norepinephrine. Severe ICU-DD (OR 3.56, p\u2009=\u20090.008), but not ICU-AW, was independently associated with weaning failure (59%). ICU-AW (OR 4.30, p\u2009=\u20090.033), but not severe ICU-DD, was associated with ICU mortality. Weaning failure and mortality rate were higher in patients with both severe ICU-DD and ICU-AW (86% and 39%, respectively) than in patients with either severe ICU-DD (64% and 0%) or ICU-AW (63% and 13%).ConclusionSevere ICU-DD and ICU-AW have different risk factors and different impacts on weaning failure and mortality. The impact of the combination of ICU-DD and ICU-AW is more pronounced than their individual impact.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s13054-019-2650-z", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1117766", 
        "issn": [
          "1364-8535", 
          "1466-609X"
        ], 
        "name": "Critical Care", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "keywords": [
      "ICU-AW", 
      "different risk factors", 
      "risk factors", 
      "Medical Research Council score", 
      "first spontaneous breathing trial", 
      "severe diaphragm weakness", 
      "spontaneous breathing trial", 
      "prospective cohort study", 
      "respective risk factors", 
      "longer duration", 
      "breathing trial", 
      "ICU mortality", 
      "diaphragm weakness", 
      "cohort study", 
      "diaphragm dysfunction", 
      "care unit", 
      "limb muscles", 
      "mortality rate", 
      "patients", 
      "mortality", 
      "ICU", 
      "outcomes", 
      "failure", 
      "duration", 
      "exposure", 
      "MethodsPost", 
      "factors", 
      "norepinephrine", 
      "dysfunction", 
      "cohort", 
      "trials", 
      "muscle", 
      "age", 
      "scores", 
      "study", 
      "weakness", 
      "diaphragm", 
      "impact", 
      "respective contributions", 
      "different impacts", 
      "rate", 
      "analysis", 
      "mV", 
      "respective impact", 
      "pressure", 
      "combination", 
      "individual impact", 
      "units", 
      "contribution"
    ], 
    "name": "Respective contribution of intensive care unit-acquired limb muscle and severe diaphragm weakness on weaning outcome and mortality: a post hoc analysis of two cohorts", 
    "pagination": "370", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1122798205"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13054-019-2650-z"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "31752937"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13054-019-2650-z", 
      "https://app.dimensions.ai/details/publication/pub.1122798205"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_806.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s13054-019-2650-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13054-019-2650-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13054-019-2650-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13054-019-2650-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13054-019-2650-z'


 

This table displays all metadata directly associated to this object as RDF triples.

267 TRIPLES      21 PREDICATES      95 URIs      82 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13054-019-2650-z schema:about N00bd0c909e6e4d9abb661f0bdbef797a
2 N07cecac96fda4e62b97974ce4d339375
3 N3291a713731141bba0374763d862990e
4 N3f6a847990224f888dcfa5ef9a05cb00
5 N404ba59a303a4cc3a9fd9d593bbb220f
6 N494dd1f4e9a4488c8257b58693f9f311
7 N6a9e551876ab4c0896de2b627fd3a6fa
8 N73821b27ba50486386966be12ff4e65e
9 N73ed430893c14b31937ee7c3af779fe6
10 N798dad73d8ed422f943ca45790c77023
11 N8f490cd5800c4e5399570227e6801ba1
12 Nb9be28b83ca04d4cb1ce49388e533739
13 Nc93be7014ec3496ba7c26ee017d8a536
14 Ne6e50e2ca7364962b21cfc1e37d160d3
15 Nf027ae429eb2496ca44e818aa4b96aaf
16 Nf8948bcb6428407a90d621487f37cbbf
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author N78f64a2afbf74a48ad2a48e94d84c6ff
20 schema:citation sg:pub.10.1007/s00134-015-4125-2
21 sg:pub.10.1186/cc13052
22 sg:pub.10.1186/s13054-018-1992-2
23 sg:pub.10.1186/s13613-016-0179-8
24 sg:pub.10.1186/s13613-018-0401-y
25 schema:datePublished 2019-11-21
26 schema:datePublishedReg 2019-11-21
27 schema:description BackgroundIntensive care unit (ICU)-acquired weakness (ICU-AW) and ICU-acquired diaphragm dysfunction (ICU-DD) occur frequently in mechanically ventilated (MV) patients. It is unknown whether they have different risk factors and different impacts on outcome. This study was designed to (1) describe the respective risk factors associated with ICU-AW and severe ICU-DD and (2) evaluate the respective impact of ICU-AW and severe ICU-DD on outcome.MethodsPost hoc analysis of two prospective cohort studies conducted in two ICUs. In patients mechanically ventilated for at least 24 h undergoing a first spontaneous breathing trial, severe ICU-DD was defined as diaphragm twitch pressure < 7 cmH2O and ICU-AW was defined as Medical Research Council Score < 48.ResultsOne hundred sixteen patients were assessed. Factors independently associated with severe ICU-DD were age, longer duration of MV, and exposure to sufentanil, and those factors associated with ICU-AW were longer duration of MV and exposure to norepinephrine. Severe ICU-DD (OR 3.56, p = 0.008), but not ICU-AW, was independently associated with weaning failure (59%). ICU-AW (OR 4.30, p = 0.033), but not severe ICU-DD, was associated with ICU mortality. Weaning failure and mortality rate were higher in patients with both severe ICU-DD and ICU-AW (86% and 39%, respectively) than in patients with either severe ICU-DD (64% and 0%) or ICU-AW (63% and 13%).ConclusionSevere ICU-DD and ICU-AW have different risk factors and different impacts on weaning failure and mortality. The impact of the combination of ICU-DD and ICU-AW is more pronounced than their individual impact.
28 schema:genre article
29 schema:isAccessibleForFree true
30 schema:isPartOf N1571906036f84821a156272beb6f5b1d
31 Nb35e37e635ab47e6aadb84d9645d191a
32 sg:journal.1117766
33 schema:keywords ICU
34 ICU mortality
35 ICU-AW
36 Medical Research Council score
37 MethodsPost
38 age
39 analysis
40 breathing trial
41 care unit
42 cohort
43 cohort study
44 combination
45 contribution
46 diaphragm
47 diaphragm dysfunction
48 diaphragm weakness
49 different impacts
50 different risk factors
51 duration
52 dysfunction
53 exposure
54 factors
55 failure
56 first spontaneous breathing trial
57 impact
58 individual impact
59 limb muscles
60 longer duration
61 mV
62 mortality
63 mortality rate
64 muscle
65 norepinephrine
66 outcomes
67 patients
68 pressure
69 prospective cohort study
70 rate
71 respective contributions
72 respective impact
73 respective risk factors
74 risk factors
75 scores
76 severe diaphragm weakness
77 spontaneous breathing trial
78 study
79 trials
80 units
81 weakness
82 schema:name Respective contribution of intensive care unit-acquired limb muscle and severe diaphragm weakness on weaning outcome and mortality: a post hoc analysis of two cohorts
83 schema:pagination 370
84 schema:productId N593826bc26b0494487d62ec0cd6ce062
85 Nb346d5aee2f04db2b60697c829e45fd8
86 Ne8d58cd28b504e2f9a89e45fcaaad9c2
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1122798205
88 https://doi.org/10.1186/s13054-019-2650-z
89 schema:sdDatePublished 2022-10-01T06:45
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N32e65ebebc9c4eba9ae450e55b87d341
92 schema:url https://doi.org/10.1186/s13054-019-2650-z
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N00bd0c909e6e4d9abb661f0bdbef797a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Ventilator Weaning
98 rdf:type schema:DefinedTerm
99 N07cecac96fda4e62b97974ce4d339375 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Humans
101 rdf:type schema:DefinedTerm
102 N1571906036f84821a156272beb6f5b1d schema:volumeNumber 23
103 rdf:type schema:PublicationVolume
104 N3291a713731141bba0374763d862990e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Critical Illness
106 rdf:type schema:DefinedTerm
107 N32e65ebebc9c4eba9ae450e55b87d341 schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 N3cb986d3a5154edaa508f9a91a26267a rdf:first sg:person.01202621205.57
110 rdf:rest Nb5ed0411aaa747d8ae859f688a0e2f8f
111 N3f6a847990224f888dcfa5ef9a05cb00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Severity of Illness Index
113 rdf:type schema:DefinedTerm
114 N404ba59a303a4cc3a9fd9d593bbb220f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Male
116 rdf:type schema:DefinedTerm
117 N48bb62b7a3f9415aaa2afad0e3f36e0b rdf:first sg:person.01266343767.08
118 rdf:rest N5cb3a94b268f4511bcdbd25b93d21e3b
119 N494dd1f4e9a4488c8257b58693f9f311 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Diaphragm
121 rdf:type schema:DefinedTerm
122 N593826bc26b0494487d62ec0cd6ce062 schema:name dimensions_id
123 schema:value pub.1122798205
124 rdf:type schema:PropertyValue
125 N5cb3a94b268f4511bcdbd25b93d21e3b rdf:first sg:person.014202751711.43
126 rdf:rest N8c51da3c3f314698b49ee8652de07be0
127 N6a9e551876ab4c0896de2b627fd3a6fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Middle Aged
129 rdf:type schema:DefinedTerm
130 N73821b27ba50486386966be12ff4e65e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Respiration, Artificial
132 rdf:type schema:DefinedTerm
133 N73ed430893c14b31937ee7c3af779fe6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cohort Studies
135 rdf:type schema:DefinedTerm
136 N78f64a2afbf74a48ad2a48e94d84c6ff rdf:first sg:person.01120203457.34
137 rdf:rest Nca4c97c822e2424e843dc4fe65257673
138 N798dad73d8ed422f943ca45790c77023 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Intensive Care Units
140 rdf:type schema:DefinedTerm
141 N8c51da3c3f314698b49ee8652de07be0 rdf:first sg:person.0637307777.78
142 rdf:rest N3cb986d3a5154edaa508f9a91a26267a
143 N8f490cd5800c4e5399570227e6801ba1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Female
145 rdf:type schema:DefinedTerm
146 Na51fed4017a04981877ea6e09f14f8d0 rdf:first sg:person.01113242353.35
147 rdf:rest Nadabe15494a344e5b0d426ba2011e954
148 Nadabe15494a344e5b0d426ba2011e954 rdf:first sg:person.0673253666.83
149 rdf:rest rdf:nil
150 Nb346d5aee2f04db2b60697c829e45fd8 schema:name doi
151 schema:value 10.1186/s13054-019-2650-z
152 rdf:type schema:PropertyValue
153 Nb35e37e635ab47e6aadb84d9645d191a schema:issueNumber 1
154 rdf:type schema:PublicationIssue
155 Nb5ed0411aaa747d8ae859f688a0e2f8f rdf:first sg:person.01235111105.45
156 rdf:rest Na51fed4017a04981877ea6e09f14f8d0
157 Nb9be28b83ca04d4cb1ce49388e533739 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Aged
159 rdf:type schema:DefinedTerm
160 Nc93be7014ec3496ba7c26ee017d8a536 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Adult
162 rdf:type schema:DefinedTerm
163 Nca4c97c822e2424e843dc4fe65257673 rdf:first sg:person.01230435413.18
164 rdf:rest N48bb62b7a3f9415aaa2afad0e3f36e0b
165 Ne6e50e2ca7364962b21cfc1e37d160d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Prospective Studies
167 rdf:type schema:DefinedTerm
168 Ne8d58cd28b504e2f9a89e45fcaaad9c2 schema:name pubmed_id
169 schema:value 31752937
170 rdf:type schema:PropertyValue
171 Nf027ae429eb2496ca44e818aa4b96aaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Muscle Weakness
173 rdf:type schema:DefinedTerm
174 Nf8948bcb6428407a90d621487f37cbbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Mortality
176 rdf:type schema:DefinedTerm
177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
178 schema:name Medical and Health Sciences
179 rdf:type schema:DefinedTerm
180 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
181 schema:name Clinical Sciences
182 rdf:type schema:DefinedTerm
183 sg:journal.1117766 schema:issn 1364-8535
184 1466-609X
185 schema:name Critical Care
186 schema:publisher Springer Nature
187 rdf:type schema:Periodical
188 sg:person.01113242353.35 schema:affiliation grid-institutes:grid.414352.5
189 schema:familyName Jaber
190 schema:givenName Samir
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113242353.35
192 rdf:type schema:Person
193 sg:person.01120203457.34 schema:affiliation grid-institutes:grid.50550.35
194 schema:familyName Dres
195 schema:givenName Martin
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120203457.34
197 rdf:type schema:Person
198 sg:person.01202621205.57 schema:affiliation grid-institutes:grid.414352.5
199 schema:familyName Chanques
200 schema:givenName Gerald
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202621205.57
202 rdf:type schema:Person
203 sg:person.01230435413.18 schema:affiliation grid-institutes:grid.411572.4
204 schema:familyName Jung
205 schema:givenName Boris
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230435413.18
207 rdf:type schema:Person
208 sg:person.01235111105.45 schema:affiliation grid-institutes:grid.50550.35
209 schema:familyName Similowski
210 schema:givenName Thomas
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235111105.45
212 rdf:type schema:Person
213 sg:person.01266343767.08 schema:affiliation grid-institutes:grid.121334.6
214 schema:familyName Molinari
215 schema:givenName Nicolas
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266343767.08
217 rdf:type schema:Person
218 sg:person.014202751711.43 schema:affiliation grid-institutes:grid.121334.6
219 schema:familyName Manna
220 schema:givenName Federico
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014202751711.43
222 rdf:type schema:Person
223 sg:person.0637307777.78 schema:affiliation grid-institutes:grid.50550.35
224 schema:familyName Dubé
225 schema:givenName Bruno-Pierre
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637307777.78
227 rdf:type schema:Person
228 sg:person.0673253666.83 schema:affiliation grid-institutes:grid.411439.a
229 schema:familyName Demoule
230 schema:givenName Alexandre
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673253666.83
232 rdf:type schema:Person
233 sg:pub.10.1007/s00134-015-4125-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003806404
234 https://doi.org/10.1007/s00134-015-4125-2
235 rdf:type schema:CreativeWork
236 sg:pub.10.1186/cc13052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008578981
237 https://doi.org/10.1186/cc13052
238 rdf:type schema:CreativeWork
239 sg:pub.10.1186/s13054-018-1992-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101629732
240 https://doi.org/10.1186/s13054-018-1992-2
241 rdf:type schema:CreativeWork
242 sg:pub.10.1186/s13613-016-0179-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026819233
243 https://doi.org/10.1186/s13613-016-0179-8
244 rdf:type schema:CreativeWork
245 sg:pub.10.1186/s13613-018-0401-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1103601685
246 https://doi.org/10.1186/s13613-018-0401-y
247 rdf:type schema:CreativeWork
248 grid-institutes:grid.121334.6 schema:alternateName Department of Statistics, CHU Montpellier, IMAG, CNRS, Univ Montpellier, Montpellier, France
249 schema:name Department of Statistics, CHU Montpellier, IMAG, CNRS, Univ Montpellier, Montpellier, France
250 rdf:type schema:Organization
251 grid-institutes:grid.411439.a schema:alternateName Service de Pneumologie, Médecine Intensive et Réanimation, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l’Hôpital, 75651, Paris Cedex 13, France
252 schema:name AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Intensive Care Unit and Respiratory Division (Département “R3S”), F-75013, Paris, France
253 AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, Service de Pneumologie, Médecine intensive – Réanimation (Département “R3S”), F-75013, Paris, France
254 Service de Pneumologie, Médecine Intensive et Réanimation, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l’Hôpital, 75651, Paris Cedex 13, France
255 rdf:type schema:Organization
256 grid-institutes:grid.411572.4 schema:alternateName Medical Intensive Care Unit, Lapeyronie University Hospital, Montpellier, France
257 schema:name Medical Intensive Care Unit, Lapeyronie University Hospital, Montpellier, France
258 Montpellier School of Medicine, University of Montpellier, INSERM U1046, CNRS UMR 9214, Montpellier, France
259 rdf:type schema:Organization
260 grid-institutes:grid.414352.5 schema:alternateName Intensive Care and Anesthesiology Department, Saint Eloi Hospital, Montpellier, France
261 schema:name Intensive Care and Anesthesiology Department, Saint Eloi Hospital, Montpellier, France
262 Montpellier School of Medicine, University of Montpellier, INSERM U1046, CNRS UMR 9214, Montpellier, France
263 rdf:type schema:Organization
264 grid-institutes:grid.50550.35 schema:alternateName AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Intensive Care Unit and Respiratory Division (Département “R3S”), F-75013, Paris, France
265 schema:name AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Intensive Care Unit and Respiratory Division (Département “R3S”), F-75013, Paris, France
266 AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, Service de Pneumologie, Médecine intensive – Réanimation (Département “R3S”), F-75013, Paris, France
267 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...