Designing nutrition-based interventional trials for the future: addressing the known knowns View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12

AUTHORS

Danielle E. Bear, Zudin A. Puthucheary

ABSTRACT

The consistent decline in critical illness mortality has a significant effect on trial design, whereby either an improbable effect sizes or large number of patients are required.The signal-to-noise ratio is of particular interest for the critically ill. When considering the potential signal, interventions need to match outcomes in regard to biological plausibility. Provision of nutrition is a complex decision with many underappreciated aspects of noise. However, a fundamental interaction is often not accounted for time.Working as a community to evolve trial design will be our challenge for nutrition interventions in the critically ill for the future. More... »

PAGES

53

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13054-019-2345-5

DOI

http://dx.doi.org/10.1186/s13054-019-2345-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112223470

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30782189


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