Ontology type: schema:ScholarlyArticle
2019-12
AUTHORSGiovanna Brandi, Nino Stocchetti, Alberto Pagnamenta, Federica Stretti, Peter Steiger, Stephanie Klinzing
ABSTRACTBACKGROUND: Hyperventilation-induced hypocapnia (HV) reduces elevated intracranial pressure (ICP), a dangerous and potentially fatal complication of traumatic brain injury (TBI). HV decreases the arteriolar diameter of intracranial vessels, raising the risk of cerebral ischemia. The aim of this study was to characterize the effects of moderate short-term HV in patients with severe TBI by using concomitant monitoring of cerebral metabolism, brain tissue oxygen tension (PbrO2), and cerebral hemodynamics with transcranial color-coded duplex sonography (TCCD). METHODS: This prospective trial was conducted between May 2014 and May 2017 in the surgical intensive care unit (ICU) at the University Hospital of Zurich. Patients with nonpenetrating TBI older than 18 years of age with a Glasgow Coma Scale (GCS) score < 9 at presentation and with ICP monitoring, PbrO2, and/or microdialysis (MD) probes during ICU admission within 36 h after injury were included in our study. Data collection and TCCD measurements were performed at baseline (A), at the beginning of moderate HV (C), after 50 min of moderate HV (D), and after return to baseline (E). Moderate HV was defined as arterial partial pressure of carbon dioxide 4-4.7 kPa. Repeated measures analysis of variance was used to compare variables at the different time points, followed by post hoc analysis with Bonferroni adjustment as appropriate. RESULTS: Eleven patients (64% males, mean age 36 ± 14 years) with an initial median GCS score of 7 (IQR 3-8) were enrolled. During HV, ICP and mean flow velocity (CBFV) in the middle cerebral artery decreased significantly. Glucose, lactate, and pyruvate in the brain extracellular fluid did not change significantly, whereas PbrO2 showed a statistically significant reduction but remained within the normal range. CONCLUSION: Moderate short-term hyperventilation has a potent effect on the cerebral blood flow, as shown by TCCD, with a concomitant ICP reduction. Under the specific conditions of this study, this degree of hyperventilation did not induce pathological alterations of brain metabolites and oxygenation. TRIAL REGISTRATION: NCT03822026 . Registered on 30 January 2019. More... »
PAGES45
http://scigraph.springernature.com/pub.10.1186/s13054-018-2304-6
DOIhttp://dx.doi.org/10.1186/s13054-018-2304-6
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112097246
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30760295
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University Hospital of Zurich",
"id": "https://www.grid.ac/institutes/grid.412004.3",
"name": [
"Institute for Intensive Care Medicine, University Hospital of Zurich, R\u00e4mistrasse 100, 8091, Zurich, Switzerland"
],
"type": "Organization"
},
"familyName": "Brandi",
"givenName": "Giovanna",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Milan",
"id": "https://www.grid.ac/institutes/grid.4708.b",
"name": [
"Department of Physiopathology and Transplantation, Milan University and Neuro ICU Fondazione IRCCSC\u00e0 Granda Ospedale Maggiore Policlinico Milan, Milan, Italy"
],
"type": "Organization"
},
"familyName": "Stocchetti",
"givenName": "Nino",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ente Ospedaliero Cantonale",
"id": "https://www.grid.ac/institutes/grid.469433.f",
"name": [
"Unit of Clinical Epidemiology, Ente Ospedaliero Cantonale, Bellinzona, Switzerland"
],
"type": "Organization"
},
"familyName": "Pagnamenta",
"givenName": "Alberto",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Westmead Hospital",
"id": "https://www.grid.ac/institutes/grid.413252.3",
"name": [
"Institute for Intensive Care Medicine, University Hospital of Zurich, R\u00e4mistrasse 100, 8091, Zurich, Switzerland",
"Department of Intensive Care, Westmead Hospital, 2145, Westmead, NSW, Australia"
],
"type": "Organization"
},
"familyName": "Stretti",
"givenName": "Federica",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital of Zurich",
"id": "https://www.grid.ac/institutes/grid.412004.3",
"name": [
"Institute for Intensive Care Medicine, University Hospital of Zurich, R\u00e4mistrasse 100, 8091, Zurich, Switzerland"
],
"type": "Organization"
},
"familyName": "Steiger",
"givenName": "Peter",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital of Zurich",
"id": "https://www.grid.ac/institutes/grid.412004.3",
"name": [
"Institute for Intensive Care Medicine, University Hospital of Zurich, R\u00e4mistrasse 100, 8091, Zurich, Switzerland"
],
"type": "Organization"
},
"familyName": "Klinzing",
"givenName": "Stephanie",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1113/jphysiol.2012.228551",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001991936"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1378/chest.127.5.1812",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002899395"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1378/chest.127.5.1812",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002899395"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00006123-200009000-00035",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019576342"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.brainres.2008.07.048",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021413516"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00003246-200209000-00002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025049547"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00003246-200209000-00002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025049547"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.ccm.0000254066.37187.88",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031117875"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.ccm.0000254066.37187.88",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031117875"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1227/neu.0b013e3182675b42",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033641253"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.clinph.2011.08.035",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034468807"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/ccm.0b013e3181743d77",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038200060"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/ccm.0b013e3181743d77",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038200060"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00134-014-3369-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040117000",
"https://doi.org/10.1007/s00134-014-3369-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01456166",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041364402",
"https://doi.org/10.1007/bf01456166"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01456166",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041364402",
"https://doi.org/10.1007/bf01456166"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1227/neu.0b013e318243fc59",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044551933"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/pbc.21430",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046231227"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/2015.7.jns15809",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071081914"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/2015.7.jns15809",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071081914"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/2015.7.jns15809",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071081914"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/2015.7.jns15809",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071081914"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/2015.7.jns15809",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071081914"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/2015.7.jns15809",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071081914"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1984.61.2.0241",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071093659"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1984.61.2.0241",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071093659"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1984.61.2.0241",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071093659"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1988.69.6.0923",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071095229"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1988.69.6.0923",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071095229"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1988.69.6.0923",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071095229"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1991.75.5.0685",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071096283"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1991.75.5.0685",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071096283"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1991.75.5.0685",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071096283"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1991.75.5.0731",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071096289"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1991.75.5.0731",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071096289"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1991.75.5.0731",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071096289"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.2000.92.1.0007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071099418"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.2000.92.1.0007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071099418"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.2000.92.1.0007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071099418"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.2002.96.1.0103",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071100196"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.2002.96.1.0103",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071100196"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.2002.96.1.0103",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071100196"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078946453",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3389/fneur.2017.00250",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090739017"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/neu.2016.4472",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090830343"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/neu.2016.4472",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090830343"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1088/1361-6579/aac76b",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1104167564"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1088/1361-6579/aac76b",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1104167564"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1088/1361-6579/aac76b",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1104167564"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1088/1361-6579/aac76b",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1104167564"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1088/1361-6579/aae469",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1107234668"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1088/1361-6579/aae469",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1107234668"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcu.22645",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1107328007"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcu.22645",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1107328007"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "BACKGROUND: Hyperventilation-induced hypocapnia (HV) reduces elevated intracranial pressure (ICP), a dangerous and potentially fatal complication of traumatic brain injury (TBI). HV decreases the arteriolar diameter of intracranial vessels, raising the risk of cerebral ischemia. The aim of this study was to characterize the effects of moderate short-term HV in patients with severe TBI by using concomitant monitoring of cerebral metabolism, brain tissue oxygen tension (PbrO2), and cerebral hemodynamics with transcranial color-coded duplex sonography (TCCD).\nMETHODS: This prospective trial was conducted between May 2014 and May 2017 in the surgical intensive care unit (ICU) at the University Hospital of Zurich. Patients with nonpenetrating TBI older than 18 years of age with a Glasgow Coma Scale (GCS) score\u2009<\u20099 at presentation and with ICP monitoring, PbrO2, and/or microdialysis (MD) probes during ICU admission within 36\u2009h after injury were included in our study. Data collection and TCCD measurements were performed at baseline (A), at the beginning of moderate HV (C), after 50\u2009min of moderate HV (D), and after return to baseline (E). Moderate HV was defined as arterial partial pressure of carbon dioxide 4-4.7\u2009kPa. Repeated measures analysis of variance was used to compare variables at the different time points, followed by post hoc analysis with Bonferroni adjustment as appropriate.\nRESULTS: Eleven patients (64% males, mean age 36\u2009\u00b1\u200914\u2009years) with an initial median GCS score of 7 (IQR 3-8) were enrolled. During HV, ICP and mean flow velocity (CBFV) in the middle cerebral artery decreased significantly. Glucose, lactate, and pyruvate in the brain extracellular fluid did not change significantly, whereas PbrO2 showed a statistically significant reduction but remained within the normal range.\nCONCLUSION: Moderate short-term hyperventilation has a potent effect on the cerebral blood flow, as shown by TCCD, with a concomitant ICP reduction. Under the specific conditions of this study, this degree of hyperventilation did not induce pathological alterations of brain metabolites and oxygenation.\nTRIAL REGISTRATION: NCT03822026 . Registered on 30 January 2019.",
"genre": "research_article",
"id": "sg:pub.10.1186/s13054-018-2304-6",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1117766",
"issn": [
"1364-8535",
"1466-609X"
],
"name": "Critical Care",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "23"
}
],
"name": "Cerebral metabolism is not affected by moderate hyperventilation in patients with traumatic brain injury",
"pagination": "45",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"92848339188aa98e2f5e0619f430d1d442cfed28f7aa2b98e30f653f09ff0cd5"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30760295"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9801902"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s13054-018-2304-6"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112097246"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s13054-018-2304-6",
"https://app.dimensions.ai/details/publication/pub.1112097246"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T09:55",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89801_00000004.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1186%2Fs13054-018-2304-6"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2304-6'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2304-6'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2304-6'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2304-6'
This table displays all metadata directly associated to this object as RDF triples.
187 TRIPLES
21 PREDICATES
55 URIs
21 LITERALS
9 BLANK NODES