Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSGarry Taverny, Thomas Lescot, Emmanuel Pardo, Frederique Thonon, Manar Maarouf, Corinne Alberti
ABSTRACTBACKGROUND: No evidence exists to date on which to base the selection of outcome measures for assessing nutritional interventions in critically ill patients. We conducted a systematic literature review to describe the outcomes used in recent randomised controlled trials (RCTs) assessing nutritional interventions in critically ill patients. Our objective was to set the foundation for the development of a core set of outcome measures for use in future RCTs. METHODS: We searched the PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases for RCTs of nutritional interventions in critically ill patients aged 18 years or older, published and/or registered between January 2000 and August 2018. Outcomes were divided into six categories (mortality, length of stay, duration of organ dysfunction, complications, functional outcomes, and others) and analysed according to the study characteristics and publication year. RESULTS: Of the 885 references retrieved, 170 were included in the review. Of these, 136 (80%) defined a primary outcome, 114 (67%) defined secondary outcomes (two per study on average), and 34 (20%) did not specify whether outcomes were primary or secondary. We identified 24 different outcomes in all, of which 19 were primary. Complications were the most widely used primary outcome (65/136, 48%). Mortality was the primary outcome in 17/136 (13%) studies, with six different timepoints. The main secondary outcomes were length of stay (90/114, 79%), mortality (82/114, 72%), and duration of organ dysfunction (75/114, 65%). CONCLUSIONS: This systematic review highlights the heterogeneity of outcomes used in recent randomized controlled trials evaluating nutritional interventions in critically ill patients. The results of our systematic review may have implications for designing future RCTs of nutritional interventions in the ICU. More... »
PAGES12
http://scigraph.springernature.com/pub.10.1186/s13054-018-2303-7
DOIhttp://dx.doi.org/10.1186/s13054-018-2303-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1111400393
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30642377
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Assistance Publique -Hopitaux De Paris",
"id": "https://www.grid.ac/institutes/grid.50550.35",
"name": [
"Paris Diderot University, Sorbonne Paris-Cit\u00e9, INSERM U1123, Paris, France",
"Unit of Clinical Epidemiology, Assistance Publique-H\u00f4pitaux de Paris, CHU Robert Debr\u00e9, Paris, France"
],
"type": "Organization"
},
"familyName": "Taverny",
"givenName": "Garry",
"id": "sg:person.01227627515.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227627515.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Sorbonne University",
"id": "https://www.grid.ac/institutes/grid.462844.8",
"name": [
"Department of Anesthesiology and Critical Care Medicine, Saint-Antoine Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France",
"Sorbonne Universit\u00e9, UPMC Univ Paris 06, Paris, France"
],
"type": "Organization"
},
"familyName": "Lescot",
"givenName": "Thomas",
"id": "sg:person.01156715673.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156715673.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital Saint-Antoine",
"id": "https://www.grid.ac/institutes/grid.412370.3",
"name": [
"Department of Anesthesiology and Critical Care Medicine, Saint-Antoine Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"
],
"type": "Organization"
},
"familyName": "Pardo",
"givenName": "Emmanuel",
"id": "sg:person.012774551344.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012774551344.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Paris Diderot University",
"id": "https://www.grid.ac/institutes/grid.7452.4",
"name": [
"EA 7334 REMES (Recherche Clinique ville h\u00f4pital, M\u00e9thodologies et Soci\u00e9t\u00e9s), Paris Diderot University, Paris, France"
],
"type": "Organization"
},
"familyName": "Thonon",
"givenName": "Frederique",
"id": "sg:person.01104726774.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104726774.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital Saint-Antoine",
"id": "https://www.grid.ac/institutes/grid.412370.3",
"name": [
"Department of Anesthesiology and Critical Care Medicine, Saint-Antoine Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"
],
"type": "Organization"
},
"familyName": "Maarouf",
"givenName": "Manar",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Assistance Publique -Hopitaux De Paris",
"id": "https://www.grid.ac/institutes/grid.50550.35",
"name": [
"Paris Diderot University, Sorbonne Paris-Cit\u00e9, INSERM U1123, Paris, France",
"Unit of Clinical Epidemiology, Assistance Publique-H\u00f4pitaux de Paris, CHU Robert Debr\u00e9, Paris, France"
],
"type": "Organization"
},
"familyName": "Alberti",
"givenName": "Corinne",
"id": "sg:person.01132547050.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132547050.16"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1186/s13054-014-0701-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000552537",
"https://doi.org/10.1186/s13054-014-0701-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13054-014-0701-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000552537",
"https://doi.org/10.1186/s13054-014-0701-z"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/9780470712184.ch8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002462072"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(12)61351-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002948681"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.2013.5124",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003506088"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1164/rccm.201411-2011st",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006868116"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3945/ajcn.110.005074",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007744910"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.clnu.2005.03.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008506594"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.clnu.2005.03.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008506594"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.physio.2012.01.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009503847"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/ccm.0b013e3181ffdd2f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009554117"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/ccm.0b013e3181ffdd2f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009554117"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2522/ptj.20110412",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013166300"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa022450",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014588036"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1409860",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016731320"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/09638288809164103",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017708270"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1745-6215-13-132",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024507815",
"https://doi.org/10.1186/1745-6215-13-132"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1102662",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035985351"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pmed.1000097",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037575666"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/cc13720",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047256925",
"https://doi.org/10.1186/cc13720"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00134-011-2146-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047968881",
"https://doi.org/10.1007/s00134-011-2146-z"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.ccm.0000168253.91200.83",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050860787"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.ccm.0000168253.91200.83",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050860787"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.ccm.0000168253.91200.83",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050860787"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/ccm.0000000000001949",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053023923"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/ccm.0000000000001949",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053023923"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079788487",
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13613-017-0243-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084252529",
"https://doi.org/10.1186/s13613-017-0243-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13613-017-0243-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084252529",
"https://doi.org/10.1186/s13613-017-0243-z"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "BACKGROUND: No evidence exists to date on which to base the selection of outcome measures for assessing nutritional interventions in critically ill patients. We conducted a systematic literature review to describe the outcomes used in recent randomised controlled trials (RCTs) assessing nutritional interventions in critically ill patients. Our objective was to set the foundation for the development of a core set of outcome measures for use in future RCTs.\nMETHODS: We searched the PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases for RCTs of nutritional interventions in critically ill patients aged 18\u2009years or older, published and/or registered between January 2000 and August 2018. Outcomes were divided into six categories (mortality, length of stay, duration of organ dysfunction, complications, functional outcomes, and others) and analysed according to the study characteristics and publication year.\nRESULTS: Of the 885 references retrieved, 170 were included in the review. Of these, 136 (80%) defined a primary outcome, 114 (67%) defined secondary outcomes (two per study on average), and 34 (20%) did not specify whether outcomes were primary or secondary. We identified 24 different outcomes in all, of which 19 were primary. Complications were the most widely used primary outcome (65/136, 48%). Mortality was the primary outcome in 17/136 (13%) studies, with six different timepoints. The main secondary outcomes were length of stay (90/114, 79%), mortality (82/114, 72%), and duration of organ dysfunction (75/114, 65%).\nCONCLUSIONS: This systematic review highlights the heterogeneity of outcomes used in recent randomized controlled trials evaluating nutritional interventions in critically ill patients. The results of our systematic review may have implications for designing future RCTs of nutritional interventions in the ICU.",
"genre": "research_article",
"id": "sg:pub.10.1186/s13054-018-2303-7",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1117766",
"issn": [
"1364-8535",
"1466-609X"
],
"name": "Critical Care",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "23"
}
],
"name": "Outcomes used in randomised controlled trials of nutrition in the critically ill: a systematic review",
"pagination": "12",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"0e58dd157cebc1bff55ea818159701407c05f5ba8df2136808150fe502d02f43"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30642377"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9801902"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s13054-018-2303-7"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1111400393"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s13054-018-2303-7",
"https://app.dimensions.ai/details/publication/pub.1111400393"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T08:41",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000320_0000000320/records_101403_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1186%2Fs13054-018-2303-7"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2303-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2303-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2303-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2303-7'
This table displays all metadata directly associated to this object as RDF triples.
184 TRIPLES
21 PREDICATES
51 URIs
21 LITERALS
9 BLANK NODES