Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Alexandre Mebazaa, Christopher Geven, Alexa Hollinger, Xavier Wittebole, Benjamin Glen Chousterman, Alice Blet, Etienne Gayat, Oliver Hartmann, Paul Scigalla, Joachim Struck, Andreas Bergmann, Massimo Antonelli, Albertus Beishuizen, Jean-Michel Constantin, Charles Damoisel, Nicolas Deye, Salvatore Di Somma, Thierry Dugernier, Bruno François, Stephane Gaudry, Vincent Huberlant, Jean-Baptiste Lascarrou, Gernot Marx, Emmanuelle Mercier, Haikel Oueslati, Peter Pickkers, Romain Sonneville, Matthieu Legrand, Pierre-François Laterre, AdrenOSS-1 study investigators

ABSTRACT

BACKGROUND: Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial. METHODS: AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock. RESULTS: Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p < 0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM > 70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM > 70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8). CONCLUSIONS: AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02393781 . Registered on March 19, 2015. More... »

PAGES

354

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13054-018-2243-2

DOI

http://dx.doi.org/10.1186/s13054-018-2243-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110862671

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30583748


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "Department of Anesthesiology, Burn and Critical Care Medicine, AP-HP, Saint Louis and Lariboisi\u00e8re University Hospitals, 2 rue A. Par\u00e9, 75010, Paris, France", 
            "Inserm 942, Paris, France", 
            "University Paris Diderot, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mebazaa", 
        "givenName": "Alexandre", 
        "id": "sg:person.0766273467.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766273467.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Intensive Care Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6500, Nijmegen, HB, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Geven", 
        "givenName": "Christopher", 
        "id": "sg:person.01361453546.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361453546.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Basel", 
          "id": "https://www.grid.ac/institutes/grid.410567.1", 
          "name": [
            "Department of Anesthesiology, Burn and Critical Care Medicine, AP-HP, Saint Louis and Lariboisi\u00e8re University Hospitals, 2 rue A. Par\u00e9, 75010, Paris, France", 
            "Inserm 942, Paris, France", 
            "Department of Anesthesia, Surgical Intensive Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hollinger", 
        "givenName": "Alexa", 
        "id": "sg:person.01331155435.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331155435.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cliniques Universitaires Saint-Luc", 
          "id": "https://www.grid.ac/institutes/grid.48769.34", 
          "name": [
            "Department of Critical Care Medicine, St Luc University Hospital, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wittebole", 
        "givenName": "Xavier", 
        "id": "sg:person.0742321273.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742321273.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "Department of Anesthesiology, Burn and Critical Care Medicine, AP-HP, Saint Louis and Lariboisi\u00e8re University Hospitals, 2 rue A. Par\u00e9, 75010, Paris, France", 
            "University Paris Diderot, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chousterman", 
        "givenName": "Benjamin Glen", 
        "id": "sg:person.016430760034.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016430760034.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Assistance Publique -Hopitaux De Paris", 
          "id": "https://www.grid.ac/institutes/grid.50550.35", 
          "name": [
            "Department of Anesthesiology, Burn and Critical Care Medicine, AP-HP, Saint Louis and Lariboisi\u00e8re University Hospitals, 2 rue A. Par\u00e9, 75010, Paris, France", 
            "Inserm 942, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blet", 
        "givenName": "Alice", 
        "id": "sg:person.012045331605.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012045331605.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "Department of Anesthesiology, Burn and Critical Care Medicine, AP-HP, Saint Louis and Lariboisi\u00e8re University Hospitals, 2 rue A. Par\u00e9, 75010, Paris, France", 
            "Inserm 942, Paris, France", 
            "University Paris Diderot, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gayat", 
        "givenName": "Etienne", 
        "id": "sg:person.01230310476.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230310476.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "sphingotec GmbH, Hennigsdorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hartmann", 
        "givenName": "Oliver", 
        "id": "sg:person.016015741234.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016015741234.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Adrenomed AG, Hennigsdorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scigalla", 
        "givenName": "Paul", 
        "id": "sg:person.0602755275.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602755275.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "sphingotec GmbH, Hennigsdorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Struck", 
        "givenName": "Joachim", 
        "id": "sg:person.01136323224.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136323224.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "sphingotec GmbH, Hennigsdorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bergmann", 
        "givenName": "Andreas", 
        "id": "sg:person.01014762623.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014762623.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Agostino Gemelli University Polyclinic", 
          "id": "https://www.grid.ac/institutes/grid.411075.6", 
          "name": [
            "Fondazione Policlinico Universitario A. Gemelli, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Antonelli", 
        "givenName": "Massimo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Intensive Care, Medische Spectrum Twente, Enschede, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beishuizen", 
        "givenName": "Albertus", 
        "id": "sg:person.01171362747.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171362747.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Clermont-Ferrand", 
          "id": "https://www.grid.ac/institutes/grid.411163.0", 
          "name": [
            "Department of Perioperative Medicine, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Constantin", 
        "givenName": "Jean-Michel", 
        "id": "sg:person.0721106637.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721106637.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Assistance Publique -Hopitaux De Paris", 
          "id": "https://www.grid.ac/institutes/grid.50550.35", 
          "name": [
            "Department of Anesthesiology, Burn and Critical Care Medicine, AP-HP, Saint Louis and Lariboisi\u00e8re University Hospitals, 2 rue A. Par\u00e9, 75010, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Damoisel", 
        "givenName": "Charles", 
        "id": "sg:person.01153177124.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153177124.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Tours", 
          "id": "https://www.grid.ac/institutes/grid.411167.4", 
          "name": [
            "Inserm 942, Paris, France", 
            "CHU de Tours, Tours, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deye", 
        "givenName": "Nicolas", 
        "id": "sg:person.015152245434.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015152245434.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Sant'Andrea", 
          "id": "https://www.grid.ac/institutes/grid.415230.1", 
          "name": [
            "Sant\u2019 Andrea Hospital, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Somma", 
        "givenName": "Salvatore", 
        "id": "sg:person.01312754161.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312754161.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Clinique St Pierre, Ottignies, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dugernier", 
        "givenName": "Thierry", 
        "id": "sg:person.012116230234.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012116230234.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Universitaire Dupuytren", 
          "id": "https://www.grid.ac/institutes/grid.412212.6", 
          "name": [
            "ICU Department, CHU Dupuytren, Limoges, France", 
            "INSERM CIC 1435/UMR 1092, Limoges, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fran\u00e7ois", 
        "givenName": "Bruno", 
        "id": "sg:person.010455154034.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010455154034.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Louis-Mourier", 
          "id": "https://www.grid.ac/institutes/grid.414205.6", 
          "name": [
            "H\u00f4pital Louis Mourier, Colombes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gaudry", 
        "givenName": "Stephane", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital de Jolimont", 
          "id": "https://www.grid.ac/institutes/grid.413908.7", 
          "name": [
            "H\u00f4pital Jolimont, Haine-St-Paul, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huberlant", 
        "givenName": "Vincent", 
        "id": "sg:person.010042135234.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010042135234.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Nantes", 
          "id": "https://www.grid.ac/institutes/grid.277151.7", 
          "name": [
            "Centre Hospitalier Universitaire de Nantes, Nantes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lascarrou", 
        "givenName": "Jean-Baptiste", 
        "id": "sg:person.01273421702.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273421702.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum Aachen", 
          "id": "https://www.grid.ac/institutes/grid.412301.5", 
          "name": [
            "Klinik f\u00fcr Operative Intensivmedizin und Intermediate Care, Universit\u00e4tsklinikum der RWTH, Aachen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marx", 
        "givenName": "Gernot", 
        "id": "sg:person.0767525156.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767525156.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Tours", 
          "id": "https://www.grid.ac/institutes/grid.411167.4", 
          "name": [
            "CHU de Tours, Tours, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mercier", 
        "givenName": "Emmanuelle", 
        "id": "sg:person.0741762205.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741762205.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Assistance Publique -Hopitaux De Paris", 
          "id": "https://www.grid.ac/institutes/grid.50550.35", 
          "name": [
            "Department of Anesthesiology, Burn and Critical Care Medicine, AP-HP, Saint Louis and Lariboisi\u00e8re University Hospitals, 2 rue A. Par\u00e9, 75010, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oueslati", 
        "givenName": "Haikel", 
        "id": "sg:person.01154433445.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154433445.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.10417.33", 
          "name": [
            "Department of Intensive Care Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6500, Nijmegen, HB, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pickkers", 
        "givenName": "Peter", 
        "id": "sg:person.012076455704.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012076455704.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Bichat-Claude-Bernard", 
          "id": "https://www.grid.ac/institutes/grid.411119.d", 
          "name": [
            "Hopital Bichat Claude-Bernard, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sonneville", 
        "givenName": "Romain", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "Department of Anesthesiology, Burn and Critical Care Medicine, AP-HP, Saint Louis and Lariboisi\u00e8re University Hospitals, 2 rue A. Par\u00e9, 75010, Paris, France", 
            "Inserm 942, Paris, France", 
            "University Paris Diderot, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Legrand", 
        "givenName": "Matthieu", 
        "id": "sg:person.0747722527.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747722527.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Critical Care Medicine, Saint Luc University Hospital, Universit\u00e9 Catholique de Louvain, Avenue Hippocrate 10, 1200, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laterre", 
        "givenName": "Pierre-Fran\u00e7ois", 
        "id": "sg:person.01103401337.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103401337.27"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "AdrenOSS-1 study investigators", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/jphp.12299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002765260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13613-016-0229-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003776082", 
          "https://doi.org/10.1186/s13613-016-0229-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13613-016-0229-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003776082", 
          "https://doi.org/10.1186/s13613-016-0229-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000036603.61868.f9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010103448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-007-0561-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023963149", 
          "https://doi.org/10.1007/s00134-007-0561-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-007-0561-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023963149", 
          "https://doi.org/10.1007/s00134-007-0561-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2010.135996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024265629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2010.135996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024265629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep29003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026209203", 
          "https://doi.org/10.1038/srep29003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000159194.53695.7a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028307756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000159194.53695.7a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028307756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc13731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028702736", 
          "https://doi.org/10.1186/cc13731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00418-006-0174-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037560545", 
          "https://doi.org/10.1007/s00418-006-0174-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00418-006-0174-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037560545", 
          "https://doi.org/10.1007/s00418-006-0174-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000050454.01978.3b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038794529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000050454.01978.3b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038794529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-009-1610-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043635077", 
          "https://doi.org/10.1007/s00134-009-1610-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-009-1610-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043635077", 
          "https://doi.org/10.1007/s00134-009-1610-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-009-1610-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043635077", 
          "https://doi.org/10.1007/s00134-009-1610-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc3885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044042016", 
          "https://doi.org/10.1186/cc3885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1993.2241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045635247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2016.0287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045696843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2197-425x-2-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050467714", 
          "https://doi.org/10.1186/2197-425x-2-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0031-1293607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057251076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.95.5.1214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063337888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3265/nefrologia.pre2014.sep.12405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078991571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chest.2017.03.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084747468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2018.00292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101104595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1373/jalm.2017.023655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105798182"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial.\nMETHODS: AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock.\nRESULTS: Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p < 0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM > 70 pg/ml upon admission than in those with bio-ADM \u2264 70 pg/ml. In patients with bio-ADM > 70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8).\nCONCLUSIONS: AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial.\nTRIAL REGISTRATION: ClinicalTrials.gov, NCT02393781 . Registered on March 19, 2015.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13054-018-2243-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4057129", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1117766", 
        "issn": [
          "1364-8535", 
          "1466-609X"
        ], 
        "name": "Critical Care", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "name": "Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study", 
    "pagination": "354", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c0f545875848789c574974aa1af5a5a57c2e75b1722983fced342af60b458929"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30583748"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9801902"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13054-018-2243-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110862671"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13054-018-2243-2", 
      "https://app.dimensions.ai/details/publication/pub.1110862671"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000309_0000000309/records_106277_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13054-018-2243-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2243-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2243-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2243-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2243-2'


 

This table displays all metadata directly associated to this object as RDF triples.

402 TRIPLES      21 PREDICATES      50 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13054-018-2243-2 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Ne2f898db64b14cd2a90ed0830b81111c
4 schema:citation sg:pub.10.1007/s00134-007-0561-y
5 sg:pub.10.1007/s00134-009-1610-5
6 sg:pub.10.1007/s00418-006-0174-5
7 sg:pub.10.1038/srep29003
8 sg:pub.10.1186/2197-425x-2-1
9 sg:pub.10.1186/cc13731
10 sg:pub.10.1186/cc3885
11 sg:pub.10.1186/s13613-016-0229-2
12 https://doi.org/10.1001/jama.2016.0287
13 https://doi.org/10.1006/bbrc.1993.2241
14 https://doi.org/10.1016/j.chest.2017.03.035
15 https://doi.org/10.1055/s-0031-1293607
16 https://doi.org/10.1097/01.ccm.0000050454.01978.3b
17 https://doi.org/10.1097/01.ccm.0000159194.53695.7a
18 https://doi.org/10.1111/jphp.12299
19 https://doi.org/10.1136/thx.2010.135996
20 https://doi.org/10.1161/01.cir.95.5.1214
21 https://doi.org/10.1161/01.res.0000036603.61868.f9
22 https://doi.org/10.1373/jalm.2017.023655
23 https://doi.org/10.3265/nefrologia.pre2014.sep.12405
24 https://doi.org/10.3389/fimmu.2018.00292
25 schema:datePublished 2018-12
26 schema:datePublishedReg 2018-12-01
27 schema:description BACKGROUND: Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial. METHODS: AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock. RESULTS: Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p < 0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM > 70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM > 70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8). CONCLUSIONS: AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02393781 . Registered on March 19, 2015.
28 schema:genre research_article
29 schema:inLanguage en
30 schema:isAccessibleForFree true
31 schema:isPartOf N6402f85c4ee24aae8d7463d6af3fac76
32 Nef0b99a102cf4040bf07843dda0ca4a5
33 sg:journal.1117766
34 schema:name Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study
35 schema:pagination 354
36 schema:productId N0fc47598a2f645f6a8d04e7b474d67ad
37 N21290aed8d414162b795ad5b5d49ef8f
38 N26f7b072499d415e94440cefc61dd639
39 N2da77386cb8f4f328c3ebd9c5f7ec833
40 N8ae44c4603cc4be382bbe96b57e7a645
41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110862671
42 https://doi.org/10.1186/s13054-018-2243-2
43 schema:sdDatePublished 2019-04-11T08:31
44 schema:sdLicense https://scigraph.springernature.com/explorer/license/
45 schema:sdPublisher N27668b112d954a62b9954e1263b5fa50
46 schema:url https://link.springer.com/10.1186%2Fs13054-018-2243-2
47 sgo:license sg:explorer/license/
48 sgo:sdDataset articles
49 rdf:type schema:ScholarlyArticle
50 N001bbd9540b643aa914ebb37b406a4d1 schema:name sphingotec GmbH, Hennigsdorf, Germany
51 rdf:type schema:Organization
52 N01d7404ee9204b9ab3faece483c8c582 rdf:first sg:person.0741762205.37
53 rdf:rest N5433d58c805e4510a355e50630625f76
54 N069e369a89b442a89181cccfaf865d7a rdf:first sg:person.0767525156.52
55 rdf:rest N01d7404ee9204b9ab3faece483c8c582
56 N0fc47598a2f645f6a8d04e7b474d67ad schema:name dimensions_id
57 schema:value pub.1110862671
58 rdf:type schema:PropertyValue
59 N1f8b9e36830a4ffaad2730f6a1d586f8 schema:name sphingotec GmbH, Hennigsdorf, Germany
60 rdf:type schema:Organization
61 N21290aed8d414162b795ad5b5d49ef8f schema:name doi
62 schema:value 10.1186/s13054-018-2243-2
63 rdf:type schema:PropertyValue
64 N21604914c6a841eeac39acaa8860cb80 schema:name sphingotec GmbH, Hennigsdorf, Germany
65 rdf:type schema:Organization
66 N239103fc4999403eb1535dcc9e8aea83 schema:name Department of Critical Care Medicine, Saint Luc University Hospital, Université Catholique de Louvain, Avenue Hippocrate 10, 1200, Brussels, Belgium
67 rdf:type schema:Organization
68 N26f7b072499d415e94440cefc61dd639 schema:name pubmed_id
69 schema:value 30583748
70 rdf:type schema:PropertyValue
71 N27668b112d954a62b9954e1263b5fa50 schema:name Springer Nature - SN SciGraph project
72 rdf:type schema:Organization
73 N2da77386cb8f4f328c3ebd9c5f7ec833 schema:name nlm_unique_id
74 schema:value 9801902
75 rdf:type schema:PropertyValue
76 N2ffeda77725d4d09ba8fda4934853257 rdf:first N432b9ee66d1c4dd3baa1c888a0f9881a
77 rdf:rest Ne76668128c1d455f921a561fa231e353
78 N35ed3d16848b45b1855c099579d2da4a rdf:first sg:person.01136323224.23
79 rdf:rest N622dbdd596254f299b2bcf4109cc4058
80 N397c801a269a483f988256e450054d4b schema:name Adrenomed AG, Hennigsdorf, Germany
81 rdf:type schema:Organization
82 N3de66a18f3d9459fb0a30e722544f607 rdf:first sg:person.0742321273.31
83 rdf:rest Nc3c40c41660c4828b3776cfb3e43bc1a
84 N3ee1ec792c7049879cca05dc4eee83d5 rdf:first sg:person.0602755275.22
85 rdf:rest N35ed3d16848b45b1855c099579d2da4a
86 N41fc48d819404137827a5af724ffd8d2 rdf:first Nf525f78272c94affaac6359413c23a67
87 rdf:rest Ned6cbfe9cc33440cb5f14b021e8cd159
88 N432b9ee66d1c4dd3baa1c888a0f9881a schema:affiliation https://www.grid.ac/institutes/grid.411119.d
89 schema:familyName Sonneville
90 schema:givenName Romain
91 rdf:type schema:Person
92 N5095c77bdd7446749f7d6b80a085ec94 schema:familyName AdrenOSS-1 study investigators
93 rdf:type schema:Person
94 N5377134fa18242a5b4e22dbe9640584b rdf:first sg:person.012045331605.21
95 rdf:rest Ne1f4e193a8484b81b0b477938b5b5db6
96 N5433d58c805e4510a355e50630625f76 rdf:first sg:person.01154433445.12
97 rdf:rest N926bed2e347c4794841680d2ad65ef07
98 N54ab6983baaa4debba3e1075128990b1 rdf:first sg:person.01273421702.14
99 rdf:rest N069e369a89b442a89181cccfaf865d7a
100 N59c07f2acf844063a3dae11081d896ed rdf:first sg:person.012116230234.47
101 rdf:rest Nacd51d7a6ce9481a90d7e169e2e83e6f
102 N5b137701882449d184756b8326e9242d schema:affiliation https://www.grid.ac/institutes/grid.411075.6
103 schema:familyName Antonelli
104 schema:givenName Massimo
105 rdf:type schema:Person
106 N622dbdd596254f299b2bcf4109cc4058 rdf:first sg:person.01014762623.23
107 rdf:rest Na00d6b6462354a9eb7194bce23a16d1c
108 N6402f85c4ee24aae8d7463d6af3fac76 schema:volumeNumber 22
109 rdf:type schema:PublicationVolume
110 N6c17e1dcc2e34523a2886cb2c13e4e9b schema:name Department of Intensive Care, Medische Spectrum Twente, Enschede, The Netherlands
111 rdf:type schema:Organization
112 N757679fc738c4ef8b26909f7b5dd25f2 rdf:first sg:person.01103401337.27
113 rdf:rest Nbedf80a842af4a1c94b42e666be756f5
114 N7fada73cd1f34da1acb77ff56cc2b1ad rdf:first sg:person.016015741234.95
115 rdf:rest N3ee1ec792c7049879cca05dc4eee83d5
116 N8ae44c4603cc4be382bbe96b57e7a645 schema:name readcube_id
117 schema:value c0f545875848789c574974aa1af5a5a57c2e75b1722983fced342af60b458929
118 rdf:type schema:PropertyValue
119 N9064721e013244318253d45e415ef9ae rdf:first sg:person.01171362747.56
120 rdf:rest Na19adf70769b4300bbeb4b3188a1e74d
121 N926bed2e347c4794841680d2ad65ef07 rdf:first sg:person.012076455704.56
122 rdf:rest N2ffeda77725d4d09ba8fda4934853257
123 Na00d6b6462354a9eb7194bce23a16d1c rdf:first N5b137701882449d184756b8326e9242d
124 rdf:rest N9064721e013244318253d45e415ef9ae
125 Na19adf70769b4300bbeb4b3188a1e74d rdf:first sg:person.0721106637.40
126 rdf:rest Nb7c72697edbd42a09f7f3eb68f5b6e1a
127 Nacd51d7a6ce9481a90d7e169e2e83e6f rdf:first sg:person.010455154034.28
128 rdf:rest N41fc48d819404137827a5af724ffd8d2
129 Nb7c72697edbd42a09f7f3eb68f5b6e1a rdf:first sg:person.01153177124.01
130 rdf:rest Nc274e5f0052f4c6b86addd9ffbd5b72c
131 Nbedf80a842af4a1c94b42e666be756f5 rdf:first N5095c77bdd7446749f7d6b80a085ec94
132 rdf:rest rdf:nil
133 Nc057e63b229b4b76bd4bce0c2bb72876 schema:name Clinique St Pierre, Ottignies, Belgium
134 rdf:type schema:Organization
135 Nc274e5f0052f4c6b86addd9ffbd5b72c rdf:first sg:person.015152245434.30
136 rdf:rest Nd5e0ed6d83b4419292d4d1cb0f419230
137 Nc3c40c41660c4828b3776cfb3e43bc1a rdf:first sg:person.016430760034.35
138 rdf:rest N5377134fa18242a5b4e22dbe9640584b
139 Nd5e0ed6d83b4419292d4d1cb0f419230 rdf:first sg:person.01312754161.28
140 rdf:rest N59c07f2acf844063a3dae11081d896ed
141 Ne1f4e193a8484b81b0b477938b5b5db6 rdf:first sg:person.01230310476.53
142 rdf:rest N7fada73cd1f34da1acb77ff56cc2b1ad
143 Ne2f898db64b14cd2a90ed0830b81111c rdf:first sg:person.0766273467.81
144 rdf:rest Nee00d81db35c455481fb65057645fb56
145 Ne76668128c1d455f921a561fa231e353 rdf:first sg:person.0747722527.06
146 rdf:rest N757679fc738c4ef8b26909f7b5dd25f2
147 Ned6cbfe9cc33440cb5f14b021e8cd159 rdf:first sg:person.010042135234.93
148 rdf:rest N54ab6983baaa4debba3e1075128990b1
149 Nee00d81db35c455481fb65057645fb56 rdf:first sg:person.01361453546.33
150 rdf:rest Needb479df5b24f69a9392d493c369229
151 Needb479df5b24f69a9392d493c369229 rdf:first sg:person.01331155435.83
152 rdf:rest N3de66a18f3d9459fb0a30e722544f607
153 Nef0b99a102cf4040bf07843dda0ca4a5 schema:issueNumber 1
154 rdf:type schema:PublicationIssue
155 Nf525f78272c94affaac6359413c23a67 schema:affiliation https://www.grid.ac/institutes/grid.414205.6
156 schema:familyName Gaudry
157 schema:givenName Stephane
158 rdf:type schema:Person
159 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
160 schema:name Medical and Health Sciences
161 rdf:type schema:DefinedTerm
162 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
163 schema:name Clinical Sciences
164 rdf:type schema:DefinedTerm
165 sg:grant.4057129 http://pending.schema.org/fundedItem sg:pub.10.1186/s13054-018-2243-2
166 rdf:type schema:MonetaryGrant
167 sg:journal.1117766 schema:issn 1364-8535
168 1466-609X
169 schema:name Critical Care
170 rdf:type schema:Periodical
171 sg:person.010042135234.93 schema:affiliation https://www.grid.ac/institutes/grid.413908.7
172 schema:familyName Huberlant
173 schema:givenName Vincent
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010042135234.93
175 rdf:type schema:Person
176 sg:person.01014762623.23 schema:affiliation N1f8b9e36830a4ffaad2730f6a1d586f8
177 schema:familyName Bergmann
178 schema:givenName Andreas
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014762623.23
180 rdf:type schema:Person
181 sg:person.010455154034.28 schema:affiliation https://www.grid.ac/institutes/grid.412212.6
182 schema:familyName François
183 schema:givenName Bruno
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010455154034.28
185 rdf:type schema:Person
186 sg:person.01103401337.27 schema:affiliation N239103fc4999403eb1535dcc9e8aea83
187 schema:familyName Laterre
188 schema:givenName Pierre-François
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103401337.27
190 rdf:type schema:Person
191 sg:person.01136323224.23 schema:affiliation N001bbd9540b643aa914ebb37b406a4d1
192 schema:familyName Struck
193 schema:givenName Joachim
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136323224.23
195 rdf:type schema:Person
196 sg:person.01153177124.01 schema:affiliation https://www.grid.ac/institutes/grid.50550.35
197 schema:familyName Damoisel
198 schema:givenName Charles
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153177124.01
200 rdf:type schema:Person
201 sg:person.01154433445.12 schema:affiliation https://www.grid.ac/institutes/grid.50550.35
202 schema:familyName Oueslati
203 schema:givenName Haikel
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154433445.12
205 rdf:type schema:Person
206 sg:person.01171362747.56 schema:affiliation N6c17e1dcc2e34523a2886cb2c13e4e9b
207 schema:familyName Beishuizen
208 schema:givenName Albertus
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171362747.56
210 rdf:type schema:Person
211 sg:person.012045331605.21 schema:affiliation https://www.grid.ac/institutes/grid.50550.35
212 schema:familyName Blet
213 schema:givenName Alice
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012045331605.21
215 rdf:type schema:Person
216 sg:person.012076455704.56 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
217 schema:familyName Pickkers
218 schema:givenName Peter
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012076455704.56
220 rdf:type schema:Person
221 sg:person.012116230234.47 schema:affiliation Nc057e63b229b4b76bd4bce0c2bb72876
222 schema:familyName Dugernier
223 schema:givenName Thierry
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012116230234.47
225 rdf:type schema:Person
226 sg:person.01230310476.53 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
227 schema:familyName Gayat
228 schema:givenName Etienne
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230310476.53
230 rdf:type schema:Person
231 sg:person.01273421702.14 schema:affiliation https://www.grid.ac/institutes/grid.277151.7
232 schema:familyName Lascarrou
233 schema:givenName Jean-Baptiste
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273421702.14
235 rdf:type schema:Person
236 sg:person.01312754161.28 schema:affiliation https://www.grid.ac/institutes/grid.415230.1
237 schema:familyName Di Somma
238 schema:givenName Salvatore
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312754161.28
240 rdf:type schema:Person
241 sg:person.01331155435.83 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
242 schema:familyName Hollinger
243 schema:givenName Alexa
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331155435.83
245 rdf:type schema:Person
246 sg:person.01361453546.33 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
247 schema:familyName Geven
248 schema:givenName Christopher
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361453546.33
250 rdf:type schema:Person
251 sg:person.015152245434.30 schema:affiliation https://www.grid.ac/institutes/grid.411167.4
252 schema:familyName Deye
253 schema:givenName Nicolas
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015152245434.30
255 rdf:type schema:Person
256 sg:person.016015741234.95 schema:affiliation N21604914c6a841eeac39acaa8860cb80
257 schema:familyName Hartmann
258 schema:givenName Oliver
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016015741234.95
260 rdf:type schema:Person
261 sg:person.016430760034.35 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
262 schema:familyName Chousterman
263 schema:givenName Benjamin Glen
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016430760034.35
265 rdf:type schema:Person
266 sg:person.0602755275.22 schema:affiliation N397c801a269a483f988256e450054d4b
267 schema:familyName Scigalla
268 schema:givenName Paul
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602755275.22
270 rdf:type schema:Person
271 sg:person.0721106637.40 schema:affiliation https://www.grid.ac/institutes/grid.411163.0
272 schema:familyName Constantin
273 schema:givenName Jean-Michel
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721106637.40
275 rdf:type schema:Person
276 sg:person.0741762205.37 schema:affiliation https://www.grid.ac/institutes/grid.411167.4
277 schema:familyName Mercier
278 schema:givenName Emmanuelle
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741762205.37
280 rdf:type schema:Person
281 sg:person.0742321273.31 schema:affiliation https://www.grid.ac/institutes/grid.48769.34
282 schema:familyName Wittebole
283 schema:givenName Xavier
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742321273.31
285 rdf:type schema:Person
286 sg:person.0747722527.06 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
287 schema:familyName Legrand
288 schema:givenName Matthieu
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747722527.06
290 rdf:type schema:Person
291 sg:person.0766273467.81 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
292 schema:familyName Mebazaa
293 schema:givenName Alexandre
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766273467.81
295 rdf:type schema:Person
296 sg:person.0767525156.52 schema:affiliation https://www.grid.ac/institutes/grid.412301.5
297 schema:familyName Marx
298 schema:givenName Gernot
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767525156.52
300 rdf:type schema:Person
301 sg:pub.10.1007/s00134-007-0561-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1023963149
302 https://doi.org/10.1007/s00134-007-0561-y
303 rdf:type schema:CreativeWork
304 sg:pub.10.1007/s00134-009-1610-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043635077
305 https://doi.org/10.1007/s00134-009-1610-5
306 rdf:type schema:CreativeWork
307 sg:pub.10.1007/s00418-006-0174-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037560545
308 https://doi.org/10.1007/s00418-006-0174-5
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/srep29003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026209203
311 https://doi.org/10.1038/srep29003
312 rdf:type schema:CreativeWork
313 sg:pub.10.1186/2197-425x-2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050467714
314 https://doi.org/10.1186/2197-425x-2-1
315 rdf:type schema:CreativeWork
316 sg:pub.10.1186/cc13731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028702736
317 https://doi.org/10.1186/cc13731
318 rdf:type schema:CreativeWork
319 sg:pub.10.1186/cc3885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044042016
320 https://doi.org/10.1186/cc3885
321 rdf:type schema:CreativeWork
322 sg:pub.10.1186/s13613-016-0229-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003776082
323 https://doi.org/10.1186/s13613-016-0229-2
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1001/jama.2016.0287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045696843
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1006/bbrc.1993.2241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045635247
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/j.chest.2017.03.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084747468
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1055/s-0031-1293607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057251076
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1097/01.ccm.0000050454.01978.3b schema:sameAs https://app.dimensions.ai/details/publication/pub.1038794529
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1097/01.ccm.0000159194.53695.7a schema:sameAs https://app.dimensions.ai/details/publication/pub.1028307756
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1111/jphp.12299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002765260
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1136/thx.2010.135996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024265629
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1161/01.cir.95.5.1214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063337888
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1161/01.res.0000036603.61868.f9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010103448
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1373/jalm.2017.023655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105798182
346 rdf:type schema:CreativeWork
347 https://doi.org/10.3265/nefrologia.pre2014.sep.12405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078991571
348 rdf:type schema:CreativeWork
349 https://doi.org/10.3389/fimmu.2018.00292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101104595
350 rdf:type schema:CreativeWork
351 https://www.grid.ac/institutes/grid.10417.33 schema:alternateName Radboud University Nijmegen Medical Centre
352 schema:name Department of Intensive Care Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6500, Nijmegen, HB, The Netherlands
353 rdf:type schema:Organization
354 https://www.grid.ac/institutes/grid.277151.7 schema:alternateName Centre Hospitalier Universitaire de Nantes
355 schema:name Centre Hospitalier Universitaire de Nantes, Nantes, France
356 rdf:type schema:Organization
357 https://www.grid.ac/institutes/grid.410567.1 schema:alternateName University Hospital of Basel
358 schema:name Department of Anesthesia, Surgical Intensive Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel, Basel, Switzerland
359 Department of Anesthesiology, Burn and Critical Care Medicine, AP-HP, Saint Louis and Lariboisière University Hospitals, 2 rue A. Paré, 75010, Paris, France
360 Inserm 942, Paris, France
361 rdf:type schema:Organization
362 https://www.grid.ac/institutes/grid.411075.6 schema:alternateName Agostino Gemelli University Polyclinic
363 schema:name Fondazione Policlinico Universitario A. Gemelli, Rome, Italy
364 rdf:type schema:Organization
365 https://www.grid.ac/institutes/grid.411119.d schema:alternateName Hôpital Bichat-Claude-Bernard
366 schema:name Hopital Bichat Claude-Bernard, Paris, France
367 rdf:type schema:Organization
368 https://www.grid.ac/institutes/grid.411163.0 schema:alternateName Centre Hospitalier Universitaire de Clermont-Ferrand
369 schema:name Department of Perioperative Medicine, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France
370 rdf:type schema:Organization
371 https://www.grid.ac/institutes/grid.411167.4 schema:alternateName Centre Hospitalier Universitaire de Tours
372 schema:name CHU de Tours, Tours, France
373 Inserm 942, Paris, France
374 rdf:type schema:Organization
375 https://www.grid.ac/institutes/grid.412212.6 schema:alternateName Hôpital Universitaire Dupuytren
376 schema:name ICU Department, CHU Dupuytren, Limoges, France
377 INSERM CIC 1435/UMR 1092, Limoges, France
378 rdf:type schema:Organization
379 https://www.grid.ac/institutes/grid.412301.5 schema:alternateName Universitätsklinikum Aachen
380 schema:name Klinik für Operative Intensivmedizin und Intermediate Care, Universitätsklinikum der RWTH, Aachen, Germany
381 rdf:type schema:Organization
382 https://www.grid.ac/institutes/grid.413908.7 schema:alternateName Hôpital de Jolimont
383 schema:name Hôpital Jolimont, Haine-St-Paul, Belgium
384 rdf:type schema:Organization
385 https://www.grid.ac/institutes/grid.414205.6 schema:alternateName Hôpital Louis-Mourier
386 schema:name Hôpital Louis Mourier, Colombes, France
387 rdf:type schema:Organization
388 https://www.grid.ac/institutes/grid.415230.1 schema:alternateName Azienda Ospedaliera Sant'Andrea
389 schema:name Sant’ Andrea Hospital, Rome, Italy
390 rdf:type schema:Organization
391 https://www.grid.ac/institutes/grid.48769.34 schema:alternateName Cliniques Universitaires Saint-Luc
392 schema:name Department of Critical Care Medicine, St Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium
393 rdf:type schema:Organization
394 https://www.grid.ac/institutes/grid.50550.35 schema:alternateName Assistance Publique -Hopitaux De Paris
395 schema:name Department of Anesthesiology, Burn and Critical Care Medicine, AP-HP, Saint Louis and Lariboisière University Hospitals, 2 rue A. Paré, 75010, Paris, France
396 Inserm 942, Paris, France
397 rdf:type schema:Organization
398 https://www.grid.ac/institutes/grid.7452.4 schema:alternateName Paris Diderot University
399 schema:name Department of Anesthesiology, Burn and Critical Care Medicine, AP-HP, Saint Louis and Lariboisière University Hospitals, 2 rue A. Paré, 75010, Paris, France
400 Inserm 942, Paris, France
401 University Paris Diderot, Paris, France
402 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...