Extracorporeal techniques for the treatment of critically ill patients with sepsis beyond conventional blood purification therapy: the promises and the ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Ghada Ankawi, Mauro Neri, Jingxiao Zhang, Andrea Breglia, Zaccaria Ricci, Claudio Ronco

ABSTRACT

Sepsis is one of the leading causes of morbidity and mortality worldwide. It is characterized by a dysregulated immune response to infections that results in life-threatening organ dysfunction and even death. Bacterial cell wall components (endotoxin or lipopolysaccharide), known as pathogen-associated molecular patterns (PAMPs), as well as damage-associated molecular patterns (DAMPs) released by host injured cells, are well-recognized triggers resulting in the elevation of both pro-inflammatory and anti-inflammatory cytokines. Understanding this complex pathophysiology has led to the development of therapeutic strategies aimed at restoring a balanced immune response by eliminating/deactivating these inflammatory mediators. Different extracorporeal techniques have been studied in recent years in the hope of maximizing the effect of renal replacement therapy in modulating the exaggerated host inflammatory response, including the use of high volume hemofiltration (HVHF), high cut-off (HCO) membranes, adsorption alone, and coupled plasma filtration adsorption (CPFA). These strategies are not widely utilized in practice, depending on resources and local expertise. The literature examining their use in septic patients is growing, but the evidence to support their use at this stage is considered of low level. Our aim is to provide a comprehensive overview of the technical aspects, clinical applications, and associated side effects of these techniques. More... »

PAGES

262

References to SciGraph publications

  • 2007-04. Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review in CRITICAL CARE
  • 2016-12. Nomenclature for renal replacement therapy and blood purification techniques in critically ill patients: practical applications in CRITICAL CARE
  • 2017-12. High-volume hemofiltration in adult burn patients with septic shock and acute kidney injury: a multicenter randomized controlled trial in CRITICAL CARE
  • 2005-08. Pulse high-volume haemofiltration for treatment of severe sepsis: effects on hemodynamics and survival in CRITICAL CARE
  • 2017-12. Is polymyxin B-immobilized fiber column ineffective for septic shock? A discussion on the press release for EUPHRATES trial in JOURNAL OF INTENSIVE CARE
  • 2017-09. Extracorporeal cytokine elimination as rescue therapy in refractory septic shock: a prospective single-center study in JOURNAL OF ARTIFICIAL ORGANS
  • 2012-03. Notice in KIDNEY INTERNATIONAL SUPPLEMENTS
  • 2002-01. Continuous versus intermittent renal replacement therapy: a meta-analysis in INTENSIVE CARE MEDICINE
  • 2014-02. High-volume hemofiltration for septic acute kidney injury: a systematic review and meta-analysis in CRITICAL CARE
  • 2006-01. Early isovolaemic haemofiltration in oliguric patients with septic shock in INTENSIVE CARE MEDICINE
  • 2014-02. Long-term risk of sepsis among survivors of acute kidney injury in CRITICAL CARE
  • 2016-12. Effect of hemoadsorption during cardiopulmonary bypass surgery – a blinded, randomized, controlled pilot study using a novel adsorbent in CRITICAL CARE
  • 2001-06. High-volume haemofiltration in human septic shock in INTENSIVE CARE MEDICINE
  • 2006-05. High-volume hemofiltration as salvage therapy in severe hyperdynamic septic shock in INTENSIVE CARE MEDICINE
  • 2013-09. High-volume versus standard-volume haemofiltration for septic shock patients with acute kidney injury (IVOIRE study): a multicentre randomized controlled trial in INTENSIVE CARE MEDICINE
  • 2015-12. Endotoxin Elimination in Patients with Septic Shock: An Observation Study in ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
  • 2015-06. Early use of polymyxin B hemoperfusion in patients with septic shock due to peritonitis: a multicenter randomized control trial in INTENSIVE CARE MEDICINE
  • 2017-12. Hemoadsorption by CytoSorb in septic patients: a case series in CRITICAL CARE
  • 2017-03. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 in INTENSIVE CARE MEDICINE
  • 2017-09-04. International registry on the use of the CytoSorb® adsorber in ICU patients in MEDIZINISCHE KLINIK - INTENSIVMEDIZIN UND NOTFALLMEDIZIN
  • 2006-10. Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure in KIDNEY INTERNATIONAL
  • 2003-05. Hemodynamic response to coupled plasmafiltration-adsorption in human septic shock in INTENSIVE CARE MEDICINE
  • 2016-12. Polymyxin-B hemoperfusion in septic patients: analysis of a multicenter registry in ANNALS OF INTENSIVE CARE
  • 2013-04. A multicenter randomized controlled study of an extracorporeal cytokine hemoadsorption device in septic patients in CRITICAL CARE
  • 2013-04. Continuous renal replacement therapy with the adsorbent membrane oXiris in septic patients: a clinical experience in CRITICAL CARE
  • 2003-11. Intermittent high permeability hemofiltration in septic patients with acute renal failure in INTENSIVE CARE MEDICINE
  • 2008-09. A pilot randomized study comparing high and low volume hemofiltration on vasopressor use in septic shock in INTENSIVE CARE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13054-018-2181-z

    DOI

    http://dx.doi.org/10.1186/s13054-018-2181-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107853995

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30360755


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "International Renal Research Institute of Vicenza", 
              "id": "https://www.grid.ac/institutes/grid.488957.f", 
              "name": [
                "Department of Internal Medicine and Nephrology, King Abdulaziz University, Jeddah, Saudi Arabia", 
                "International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ankawi", 
            "givenName": "Ghada", 
            "id": "sg:person.016553622337.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016553622337.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ospedale San Bortolo", 
              "id": "https://www.grid.ac/institutes/grid.416303.3", 
              "name": [
                "International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy", 
                "Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Neri", 
            "givenName": "Mauro", 
            "id": "sg:person.0622176750.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622176750.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Affiliated Hospital of Jilin University", 
              "id": "https://www.grid.ac/institutes/grid.452829.0", 
              "name": [
                "International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy", 
                "Department of Emergency and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Jingxiao", 
            "id": "sg:person.011731125464.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011731125464.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Trieste", 
              "id": "https://www.grid.ac/institutes/grid.5133.4", 
              "name": [
                "International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy", 
                "Department of Internal Medicine, University of Trieste, Trieste, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Breglia", 
            "givenName": "Andrea", 
            "id": "sg:person.01151625550.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151625550.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Bambino Ges\u00f9 Children's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.414125.7", 
              "name": [
                "Department of Cardiology and Cardiac Surgery, Paediatric Cardiac Intensive Care Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ricci", 
            "givenName": "Zaccaria", 
            "id": "sg:person.014376075700.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014376075700.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ospedale San Bortolo", 
              "id": "https://www.grid.ac/institutes/grid.416303.3", 
              "name": [
                "International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy", 
                "Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ronco", 
            "givenName": "Claudio", 
            "id": "sg:person.01125357131.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125357131.76"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1159/000446978", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000609636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-017-4683-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003731534", 
              "https://doi.org/10.1007/s00134-017-4683-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-017-4683-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003731534", 
              "https://doi.org/10.1007/s00134-017-4683-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.ajkd.2003.11.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004341883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/kisup.2012.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004822134", 
              "https://doi.org/10.1038/kisup.2012.1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0902413", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006934186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-016-1270-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007759151", 
              "https://doi.org/10.1186/s13054-016-1270-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm198908033210503", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008087393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000444474", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008434310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e318241e553", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008851386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e318241e553", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008851386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ki.5001705", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008879150", 
              "https://doi.org/10.1038/sj.ki.5001705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000229147.50592.f9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009377518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000229147.50592.f9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009377518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-015-3751-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011041720", 
              "https://doi.org/10.1007/s00134-015-3751-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-015-3751-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011041720", 
              "https://doi.org/10.1007/s00134-015-3751-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000330323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011404943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001340100963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011872292", 
              "https://doi.org/10.1007/s001340100963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ndt/gfr486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012268439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000360268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012627437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mat.0000000000000009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013105318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mat.0000000000000009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013105318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1744-9987.2012.01083.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014060552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000063108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015205757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5812/numonthly.11904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019186567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00005-015-0348-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019200164", 
              "https://doi.org/10.1007/s00005-015-0348-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00005-015-0348-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019200164", 
              "https://doi.org/10.1007/s00005-015-0348-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.mat.0000104846.27116.ea", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019594238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.mat.0000104846.27116.ea", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019594238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.shk.0000159930.87737.8a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021359181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.shk.0000159930.87737.8a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021359181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2016.0289", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021634419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000291646.34815.bb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022726476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000291646.34815.bb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022726476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-006-0118-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023167412", 
              "https://doi.org/10.1007/s00134-006-0118-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-006-0118-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023167412", 
              "https://doi.org/10.1007/s00134-006-0118-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jramc-2015-000552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023623557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jramc-2015-000552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023623557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-005-2815-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024752504", 
              "https://doi.org/10.1007/s00134-005-2815-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-005-2815-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024752504", 
              "https://doi.org/10.1007/s00134-005-2815-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-013-2967-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025156351", 
              "https://doi.org/10.1007/s00134-013-2967-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc13184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026090143", 
              "https://doi.org/10.1186/cc13184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-016-1456-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026410571", 
              "https://doi.org/10.1186/s13054-016-1456-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-016-1456-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026410571", 
              "https://doi.org/10.1186/s13054-016-1456-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-001-1159-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027104848", 
              "https://doi.org/10.1007/s00134-001-1159-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.ajkd.2007.05.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028460511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2009.856", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028798191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ndt/gfg615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028974790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13613-016-0178-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029705405", 
              "https://doi.org/10.1186/s13613-016-0178-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13613-016-0178-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029705405", 
              "https://doi.org/10.1186/s13613-016-0178-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-003-1724-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032206321", 
              "https://doi.org/10.1007/s00134-003-1724-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000231988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032254571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmjopen-2013-003536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034546730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000369155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035277378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000078788", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036384014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0000000000000150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036630370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0000000000000150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036630370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00003246-200011000-00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037671147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00003246-200011000-00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037671147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.colsurfb.2011.09.046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039291294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000072024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039386951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0040911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040713218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc13708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043853206", 
              "https://doi.org/10.1186/cc13708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1213/00000539-199309000-00032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045416171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e31828cf412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045670827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e31828cf412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045670827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2016.0287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045696843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0802639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047549700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc3529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048609297", 
              "https://doi.org/10.1186/cc3529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1744-9987.2010.00825.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049178164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1744-9987.2010.00825.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049178164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc5780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049942593", 
              "https://doi.org/10.1186/cc5780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc5780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049942593", 
              "https://doi.org/10.1186/cc5780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-008-1127-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050859583", 
              "https://doi.org/10.1007/s00134-008-1127-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-008-1127-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050859583", 
              "https://doi.org/10.1007/s00134-008-1127-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc12001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051366832", 
              "https://doi.org/10.1186/cc12001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-003-2003-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052391678", 
              "https://doi.org/10.1007/s00134-003-2003-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.12659/msm.896819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064589213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.12809/hkmj133910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064675452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074358486", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/039139881003300801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078224807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/039139881003300801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078224807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078400049", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078820765", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079183915", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/sur.2016.168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079393035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/14651858.cd008075.pub3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083398300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc12000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083682477", 
              "https://doi.org/10.1186/cc12000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0172039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083844359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-017-1662-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084252003", 
              "https://doi.org/10.1186/s13054-017-1662-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-017-1662-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084252003", 
              "https://doi.org/10.1186/s13054-017-1662-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10047-017-0967-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085886329", 
              "https://doi.org/10.1007/s10047-017-0967-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10047-017-0967-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085886329", 
              "https://doi.org/10.1007/s10047-017-0967-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40560-017-0236-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090335829", 
              "https://doi.org/10.1186/s40560-017-0236-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40560-017-0236-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090335829", 
              "https://doi.org/10.1186/s40560-017-0236-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00063-017-0342-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091477313", 
              "https://doi.org/10.1007/s00063-017-0342-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0187015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092450706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-017-1878-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092985769", 
              "https://doi.org/10.1186/s13054-017-1878-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0191676", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100650159"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "Sepsis is one of the leading causes of morbidity and mortality worldwide. It is characterized by a dysregulated immune response to infections that results in life-threatening organ dysfunction and even death. Bacterial cell wall components (endotoxin or lipopolysaccharide), known as pathogen-associated molecular patterns (PAMPs), as well as damage-associated molecular patterns (DAMPs) released by host injured cells, are well-recognized triggers resulting in the elevation of both pro-inflammatory and anti-inflammatory cytokines. Understanding this complex pathophysiology has led to the development of therapeutic strategies aimed at restoring a balanced immune response by eliminating/deactivating these inflammatory mediators. Different extracorporeal techniques have been studied in recent years in the hope of maximizing the effect of renal replacement therapy in modulating the exaggerated host inflammatory response, including the use of high volume hemofiltration (HVHF), high cut-off (HCO) membranes, adsorption alone, and coupled plasma filtration adsorption (CPFA). These strategies are not widely utilized in practice, depending on resources and local expertise. The literature examining their use in septic patients is growing, but the evidence to support their use at this stage is considered of low level. Our aim is to provide a comprehensive overview of the technical aspects, clinical applications, and associated side effects of these techniques.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s13054-018-2181-z", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1117766", 
            "issn": [
              "1364-8535", 
              "1466-609X"
            ], 
            "name": "Critical Care", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "22"
          }
        ], 
        "name": "Extracorporeal techniques for the treatment of critically ill patients with sepsis beyond conventional blood purification therapy: the promises and the pitfalls", 
        "pagination": "262", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d1d0a7616c6db69d1837ce349d3ffd070c8a3ee45b6f6c93b5bcbc80178601a6"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30360755"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9801902"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13054-018-2181-z"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1107853995"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13054-018-2181-z", 
          "https://app.dimensions.ai/details/publication/pub.1107853995"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T22:43", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000575.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1186%2Fs13054-018-2181-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2181-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2181-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2181-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2181-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    368 TRIPLES      21 PREDICATES      104 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13054-018-2181-z schema:about anzsrc-for:11
    2 anzsrc-for:1107
    3 schema:author Ndc434a7e54134535a8c6264780394b74
    4 schema:citation sg:pub.10.1007/s00005-015-0348-8
    5 sg:pub.10.1007/s00063-017-0342-5
    6 sg:pub.10.1007/s00134-001-1159-4
    7 sg:pub.10.1007/s00134-003-1724-0
    8 sg:pub.10.1007/s00134-003-2003-9
    9 sg:pub.10.1007/s00134-005-2815-x
    10 sg:pub.10.1007/s00134-006-0118-5
    11 sg:pub.10.1007/s00134-008-1127-3
    12 sg:pub.10.1007/s00134-013-2967-z
    13 sg:pub.10.1007/s00134-015-3751-z
    14 sg:pub.10.1007/s00134-017-4683-6
    15 sg:pub.10.1007/s001340100963
    16 sg:pub.10.1007/s10047-017-0967-4
    17 sg:pub.10.1038/kisup.2012.1
    18 sg:pub.10.1038/sj.ki.5001705
    19 sg:pub.10.1186/cc12000
    20 sg:pub.10.1186/cc12001
    21 sg:pub.10.1186/cc13184
    22 sg:pub.10.1186/cc13708
    23 sg:pub.10.1186/cc3529
    24 sg:pub.10.1186/cc5780
    25 sg:pub.10.1186/s13054-016-1270-0
    26 sg:pub.10.1186/s13054-016-1456-5
    27 sg:pub.10.1186/s13054-017-1662-9
    28 sg:pub.10.1186/s13054-017-1878-8
    29 sg:pub.10.1186/s13613-016-0178-9
    30 sg:pub.10.1186/s40560-017-0236-x
    31 https://app.dimensions.ai/details/publication/pub.1074358486
    32 https://app.dimensions.ai/details/publication/pub.1078400049
    33 https://app.dimensions.ai/details/publication/pub.1078820765
    34 https://app.dimensions.ai/details/publication/pub.1079183915
    35 https://doi.org/10.1001/jama.2009.856
    36 https://doi.org/10.1001/jama.2016.0287
    37 https://doi.org/10.1001/jama.2016.0289
    38 https://doi.org/10.1002/14651858.cd008075.pub3
    39 https://doi.org/10.1016/j.colsurfb.2011.09.046
    40 https://doi.org/10.1053/j.ajkd.2003.11.006
    41 https://doi.org/10.1053/j.ajkd.2007.05.003
    42 https://doi.org/10.1056/nejm198908033210503
    43 https://doi.org/10.1056/nejmoa0802639
    44 https://doi.org/10.1056/nejmoa0902413
    45 https://doi.org/10.1089/sur.2016.168
    46 https://doi.org/10.1093/ndt/gfg615
    47 https://doi.org/10.1093/ndt/gfr486
    48 https://doi.org/10.1097/00003246-200011000-00001
    49 https://doi.org/10.1097/01.ccm.0000229147.50592.f9
    50 https://doi.org/10.1097/01.ccm.0000291646.34815.bb
    51 https://doi.org/10.1097/01.mat.0000104846.27116.ea
    52 https://doi.org/10.1097/01.shk.0000159930.87737.8a
    53 https://doi.org/10.1097/ccm.0000000000000150
    54 https://doi.org/10.1097/ccm.0b013e318241e553
    55 https://doi.org/10.1097/ccm.0b013e31828cf412
    56 https://doi.org/10.1097/mat.0000000000000009
    57 https://doi.org/10.1111/j.1744-9987.2010.00825.x
    58 https://doi.org/10.1111/j.1744-9987.2012.01083.x
    59 https://doi.org/10.1136/bmjopen-2013-003536
    60 https://doi.org/10.1136/jramc-2015-000552
    61 https://doi.org/10.1159/000063108
    62 https://doi.org/10.1159/000072024
    63 https://doi.org/10.1159/000078788
    64 https://doi.org/10.1159/000231988
    65 https://doi.org/10.1159/000330323
    66 https://doi.org/10.1159/000360268
    67 https://doi.org/10.1159/000369155
    68 https://doi.org/10.1159/000444474
    69 https://doi.org/10.1159/000446978
    70 https://doi.org/10.1177/039139881003300801
    71 https://doi.org/10.1213/00000539-199309000-00032
    72 https://doi.org/10.12659/msm.896819
    73 https://doi.org/10.12809/hkmj133910
    74 https://doi.org/10.1371/journal.pone.0040911
    75 https://doi.org/10.1371/journal.pone.0172039
    76 https://doi.org/10.1371/journal.pone.0187015
    77 https://doi.org/10.1371/journal.pone.0191676
    78 https://doi.org/10.5812/numonthly.11904
    79 schema:datePublished 2018-12
    80 schema:datePublishedReg 2018-12-01
    81 schema:description Sepsis is one of the leading causes of morbidity and mortality worldwide. It is characterized by a dysregulated immune response to infections that results in life-threatening organ dysfunction and even death. Bacterial cell wall components (endotoxin or lipopolysaccharide), known as pathogen-associated molecular patterns (PAMPs), as well as damage-associated molecular patterns (DAMPs) released by host injured cells, are well-recognized triggers resulting in the elevation of both pro-inflammatory and anti-inflammatory cytokines. Understanding this complex pathophysiology has led to the development of therapeutic strategies aimed at restoring a balanced immune response by eliminating/deactivating these inflammatory mediators. Different extracorporeal techniques have been studied in recent years in the hope of maximizing the effect of renal replacement therapy in modulating the exaggerated host inflammatory response, including the use of high volume hemofiltration (HVHF), high cut-off (HCO) membranes, adsorption alone, and coupled plasma filtration adsorption (CPFA). These strategies are not widely utilized in practice, depending on resources and local expertise. The literature examining their use in septic patients is growing, but the evidence to support their use at this stage is considered of low level. Our aim is to provide a comprehensive overview of the technical aspects, clinical applications, and associated side effects of these techniques.
    82 schema:genre research_article
    83 schema:inLanguage en
    84 schema:isAccessibleForFree true
    85 schema:isPartOf N338962dbf467462680fb79f0003bf735
    86 Nb9d4fff16e7a4445a1abe491ea0082b8
    87 sg:journal.1117766
    88 schema:name Extracorporeal techniques for the treatment of critically ill patients with sepsis beyond conventional blood purification therapy: the promises and the pitfalls
    89 schema:pagination 262
    90 schema:productId N314cc202408d4536808b8f4f93ab97af
    91 N6794ea166e3a4b41936986e984b7befe
    92 N72d079e7a203426583b817c5928551cd
    93 N980c755d3d604a94a0c5d02b70b0fabb
    94 Ne3d1372e85064989b74b47176a0c7066
    95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107853995
    96 https://doi.org/10.1186/s13054-018-2181-z
    97 schema:sdDatePublished 2019-04-10T22:43
    98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    99 schema:sdPublisher Nc1fc5f937b8b4217804ec0019ac5234f
    100 schema:url https://link.springer.com/10.1186%2Fs13054-018-2181-z
    101 sgo:license sg:explorer/license/
    102 sgo:sdDataset articles
    103 rdf:type schema:ScholarlyArticle
    104 N261ec1714cc643fa826244999f5f6857 rdf:first sg:person.01151625550.19
    105 rdf:rest Nf76a3933951e42a2ba0459498f59fce1
    106 N2ac2e59476344a8387cc40d0f7eb896d rdf:first sg:person.011731125464.65
    107 rdf:rest N261ec1714cc643fa826244999f5f6857
    108 N2d2c91cec2aa4f5f84d6f335e904a6c9 rdf:first sg:person.0622176750.83
    109 rdf:rest N2ac2e59476344a8387cc40d0f7eb896d
    110 N314cc202408d4536808b8f4f93ab97af schema:name readcube_id
    111 schema:value d1d0a7616c6db69d1837ce349d3ffd070c8a3ee45b6f6c93b5bcbc80178601a6
    112 rdf:type schema:PropertyValue
    113 N338962dbf467462680fb79f0003bf735 schema:issueNumber 1
    114 rdf:type schema:PublicationIssue
    115 N3988e249d07c414d9505cda5d5348020 rdf:first sg:person.01125357131.76
    116 rdf:rest rdf:nil
    117 N6794ea166e3a4b41936986e984b7befe schema:name dimensions_id
    118 schema:value pub.1107853995
    119 rdf:type schema:PropertyValue
    120 N72d079e7a203426583b817c5928551cd schema:name doi
    121 schema:value 10.1186/s13054-018-2181-z
    122 rdf:type schema:PropertyValue
    123 N980c755d3d604a94a0c5d02b70b0fabb schema:name nlm_unique_id
    124 schema:value 9801902
    125 rdf:type schema:PropertyValue
    126 Nb9d4fff16e7a4445a1abe491ea0082b8 schema:volumeNumber 22
    127 rdf:type schema:PublicationVolume
    128 Nc1fc5f937b8b4217804ec0019ac5234f schema:name Springer Nature - SN SciGraph project
    129 rdf:type schema:Organization
    130 Ndc434a7e54134535a8c6264780394b74 rdf:first sg:person.016553622337.53
    131 rdf:rest N2d2c91cec2aa4f5f84d6f335e904a6c9
    132 Ne3d1372e85064989b74b47176a0c7066 schema:name pubmed_id
    133 schema:value 30360755
    134 rdf:type schema:PropertyValue
    135 Nf76a3933951e42a2ba0459498f59fce1 rdf:first sg:person.014376075700.05
    136 rdf:rest N3988e249d07c414d9505cda5d5348020
    137 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    138 schema:name Medical and Health Sciences
    139 rdf:type schema:DefinedTerm
    140 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    141 schema:name Immunology
    142 rdf:type schema:DefinedTerm
    143 sg:journal.1117766 schema:issn 1364-8535
    144 1466-609X
    145 schema:name Critical Care
    146 rdf:type schema:Periodical
    147 sg:person.01125357131.76 schema:affiliation https://www.grid.ac/institutes/grid.416303.3
    148 schema:familyName Ronco
    149 schema:givenName Claudio
    150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125357131.76
    151 rdf:type schema:Person
    152 sg:person.01151625550.19 schema:affiliation https://www.grid.ac/institutes/grid.5133.4
    153 schema:familyName Breglia
    154 schema:givenName Andrea
    155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151625550.19
    156 rdf:type schema:Person
    157 sg:person.011731125464.65 schema:affiliation https://www.grid.ac/institutes/grid.452829.0
    158 schema:familyName Zhang
    159 schema:givenName Jingxiao
    160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011731125464.65
    161 rdf:type schema:Person
    162 sg:person.014376075700.05 schema:affiliation https://www.grid.ac/institutes/grid.414125.7
    163 schema:familyName Ricci
    164 schema:givenName Zaccaria
    165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014376075700.05
    166 rdf:type schema:Person
    167 sg:person.016553622337.53 schema:affiliation https://www.grid.ac/institutes/grid.488957.f
    168 schema:familyName Ankawi
    169 schema:givenName Ghada
    170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016553622337.53
    171 rdf:type schema:Person
    172 sg:person.0622176750.83 schema:affiliation https://www.grid.ac/institutes/grid.416303.3
    173 schema:familyName Neri
    174 schema:givenName Mauro
    175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622176750.83
    176 rdf:type schema:Person
    177 sg:pub.10.1007/s00005-015-0348-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019200164
    178 https://doi.org/10.1007/s00005-015-0348-8
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1007/s00063-017-0342-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091477313
    181 https://doi.org/10.1007/s00063-017-0342-5
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1007/s00134-001-1159-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027104848
    184 https://doi.org/10.1007/s00134-001-1159-4
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1007/s00134-003-1724-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032206321
    187 https://doi.org/10.1007/s00134-003-1724-0
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1007/s00134-003-2003-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052391678
    190 https://doi.org/10.1007/s00134-003-2003-9
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1007/s00134-005-2815-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024752504
    193 https://doi.org/10.1007/s00134-005-2815-x
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1007/s00134-006-0118-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023167412
    196 https://doi.org/10.1007/s00134-006-0118-5
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1007/s00134-008-1127-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050859583
    199 https://doi.org/10.1007/s00134-008-1127-3
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1007/s00134-013-2967-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1025156351
    202 https://doi.org/10.1007/s00134-013-2967-z
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1007/s00134-015-3751-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1011041720
    205 https://doi.org/10.1007/s00134-015-3751-z
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1007/s00134-017-4683-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003731534
    208 https://doi.org/10.1007/s00134-017-4683-6
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1007/s001340100963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011872292
    211 https://doi.org/10.1007/s001340100963
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1007/s10047-017-0967-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085886329
    214 https://doi.org/10.1007/s10047-017-0967-4
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/kisup.2012.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004822134
    217 https://doi.org/10.1038/kisup.2012.1
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/sj.ki.5001705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008879150
    220 https://doi.org/10.1038/sj.ki.5001705
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1186/cc12000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083682477
    223 https://doi.org/10.1186/cc12000
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1186/cc12001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051366832
    226 https://doi.org/10.1186/cc12001
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1186/cc13184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026090143
    229 https://doi.org/10.1186/cc13184
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1186/cc13708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043853206
    232 https://doi.org/10.1186/cc13708
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1186/cc3529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048609297
    235 https://doi.org/10.1186/cc3529
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1186/cc5780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049942593
    238 https://doi.org/10.1186/cc5780
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1186/s13054-016-1270-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007759151
    241 https://doi.org/10.1186/s13054-016-1270-0
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1186/s13054-016-1456-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026410571
    244 https://doi.org/10.1186/s13054-016-1456-5
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1186/s13054-017-1662-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084252003
    247 https://doi.org/10.1186/s13054-017-1662-9
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1186/s13054-017-1878-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092985769
    250 https://doi.org/10.1186/s13054-017-1878-8
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1186/s13613-016-0178-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029705405
    253 https://doi.org/10.1186/s13613-016-0178-9
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1186/s40560-017-0236-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1090335829
    256 https://doi.org/10.1186/s40560-017-0236-x
    257 rdf:type schema:CreativeWork
    258 https://app.dimensions.ai/details/publication/pub.1074358486 schema:CreativeWork
    259 https://app.dimensions.ai/details/publication/pub.1078400049 schema:CreativeWork
    260 https://app.dimensions.ai/details/publication/pub.1078820765 schema:CreativeWork
    261 https://app.dimensions.ai/details/publication/pub.1079183915 schema:CreativeWork
    262 https://doi.org/10.1001/jama.2009.856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028798191
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1001/jama.2016.0287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045696843
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1001/jama.2016.0289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021634419
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1002/14651858.cd008075.pub3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083398300
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/j.colsurfb.2011.09.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039291294
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1053/j.ajkd.2003.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004341883
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1053/j.ajkd.2007.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028460511
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1056/nejm198908033210503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008087393
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1056/nejmoa0802639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047549700
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1056/nejmoa0902413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006934186
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1089/sur.2016.168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079393035
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1093/ndt/gfg615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028974790
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1093/ndt/gfr486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012268439
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1097/00003246-200011000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037671147
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1097/01.ccm.0000229147.50592.f9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009377518
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1097/01.ccm.0000291646.34815.bb schema:sameAs https://app.dimensions.ai/details/publication/pub.1022726476
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1097/01.mat.0000104846.27116.ea schema:sameAs https://app.dimensions.ai/details/publication/pub.1019594238
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1097/01.shk.0000159930.87737.8a schema:sameAs https://app.dimensions.ai/details/publication/pub.1021359181
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1097/ccm.0000000000000150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036630370
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1097/ccm.0b013e318241e553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008851386
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1097/ccm.0b013e31828cf412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045670827
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1097/mat.0000000000000009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013105318
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1111/j.1744-9987.2010.00825.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049178164
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1111/j.1744-9987.2012.01083.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014060552
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1136/bmjopen-2013-003536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034546730
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1136/jramc-2015-000552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023623557
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1159/000063108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015205757
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1159/000072024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039386951
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1159/000078788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036384014
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1159/000231988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032254571
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1159/000330323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011404943
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1159/000360268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012627437
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1159/000369155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035277378
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1159/000444474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008434310
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1159/000446978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000609636
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1177/039139881003300801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078224807
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1213/00000539-199309000-00032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045416171
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.12659/msm.896819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064589213
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.12809/hkmj133910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064675452
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1371/journal.pone.0040911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040713218
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1371/journal.pone.0172039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083844359
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1371/journal.pone.0187015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092450706
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1371/journal.pone.0191676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100650159
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.5812/numonthly.11904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019186567
    349 rdf:type schema:CreativeWork
    350 https://www.grid.ac/institutes/grid.414125.7 schema:alternateName Bambino Gesù Children's Hospital
    351 schema:name Department of Cardiology and Cardiac Surgery, Paediatric Cardiac Intensive Care Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
    352 rdf:type schema:Organization
    353 https://www.grid.ac/institutes/grid.416303.3 schema:alternateName Ospedale San Bortolo
    354 schema:name Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy
    355 International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy
    356 rdf:type schema:Organization
    357 https://www.grid.ac/institutes/grid.452829.0 schema:alternateName Second Affiliated Hospital of Jilin University
    358 schema:name Department of Emergency and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, China
    359 International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy
    360 rdf:type schema:Organization
    361 https://www.grid.ac/institutes/grid.488957.f schema:alternateName International Renal Research Institute of Vicenza
    362 schema:name Department of Internal Medicine and Nephrology, King Abdulaziz University, Jeddah, Saudi Arabia
    363 International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy
    364 rdf:type schema:Organization
    365 https://www.grid.ac/institutes/grid.5133.4 schema:alternateName University of Trieste
    366 schema:name Department of Internal Medicine, University of Trieste, Trieste, Italy
    367 International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy
    368 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...