High-flow nasal cannula oxygen therapy decreases postextubation neuroventilatory drive and work of breathing in patients with chronic obstructive pulmonary disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Rosa Di mussi, Savino Spadaro, Tania Stripoli, Carlo Alberto Volta, Paolo Trerotoli, Paola Pierucci, Francesco Staffieri, Francesco Bruno, Luigi Camporota, Salvatore Grasso

ABSTRACT

BACKGROUND: The physiological effects of high-flow nasal cannula O2 therapy (HFNC) have been evaluated mainly in patients with hypoxemic respiratory failure. In this study, we compared the effects of HFNC and conventional low-flow O2 therapy on the neuroventilatory drive and work of breathing postextubation in patients with a background of chronic obstructive pulmonary disease (COPD) who had received mechanical ventilation for hypercapnic respiratory failure. METHODS: This was a single center, unblinded, cross-over study on 14 postextubation COPD patients who were recovering from an episode of acute hypercapnic respiratory failure of various etiologies. After extubation, each patient received two 1-h periods of HFNC (HFNC1 and HFNC2) alternated with 1 h of conventional low-flow O2 therapy via a face mask. The inspiratory fraction of oxygen was titrated to achieve an arterial O2 saturation target of 88-92%. Gas exchange, breathing pattern, neuroventilatory drive (electrical diaphragmatic activity (EAdi)) and work of breathing (inspiratory trans-diaphragmatic pressure-time product per minute (PTPDI/min)) were recorded. RESULTS: EAdi peak increased from a mean (±SD) of 15.4 ± 6.4 to 23.6 ± 10.5 μV switching from HFNC1 to conventional O2, and then returned to 15.2 ± 6.4 μV during HFNC2 (conventional O2: p < 0.05 versus HFNC1 and HFNC2). Similarly, the PTPDI/min increased from 135 ± 60 to 211 ± 70 cmH2O/s/min, and then decreased again during HFNC2 to 132 ± 56 (conventional O2: p < 0.05 versus HFNC1 and HFNC2). CONCLUSIONS: In patients with COPD, the application of HFNC postextubation significantly decreased the neuroventilatory drive and work of breathing compared with conventional O2 therapy. More... »

PAGES

180

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13054-018-2107-9

DOI

http://dx.doi.org/10.1186/s13054-018-2107-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105969953

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30071876


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Bari Aldo Moro", 
          "id": "https://www.grid.ac/institutes/grid.7644.1", 
          "name": [
            "Dipartimento dell\u2019Emergenza e Trapianti d\u2019Organo (DETO), Sezione di Anestesiologia e Rianimazione, Ospedale Policlinico, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare 11, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di mussi", 
        "givenName": "Rosa", 
        "id": "sg:person.0720267603.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720267603.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ferrara", 
          "id": "https://www.grid.ac/institutes/grid.8484.0", 
          "name": [
            "Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Sezione di Anestesiologia e Terapia Intensiva Universitaria, Universit\u00e0 degli studi di Ferrara, Ferrara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spadaro", 
        "givenName": "Savino", 
        "id": "sg:person.0707071472.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707071472.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bari Aldo Moro", 
          "id": "https://www.grid.ac/institutes/grid.7644.1", 
          "name": [
            "Dipartimento dell\u2019Emergenza e Trapianti d\u2019Organo (DETO), Sezione di Anestesiologia e Rianimazione, Ospedale Policlinico, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare 11, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stripoli", 
        "givenName": "Tania", 
        "id": "sg:person.01133041663.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133041663.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ferrara", 
          "id": "https://www.grid.ac/institutes/grid.8484.0", 
          "name": [
            "Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Sezione di Anestesiologia e Terapia Intensiva Universitaria, Universit\u00e0 degli studi di Ferrara, Ferrara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Volta", 
        "givenName": "Carlo Alberto", 
        "id": "sg:person.0651507322.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651507322.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dipartimento di Scienze Biomediche ed Oncologia Umana, Cattedra di Statistica Medica, Universit\u00e0 degli Studi Aldo Moro, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trerotoli", 
        "givenName": "Paolo", 
        "id": "sg:person.01356402343.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356402343.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bari Aldo Moro", 
          "id": "https://www.grid.ac/institutes/grid.7644.1", 
          "name": [
            "Dipartimento di Medicina Respiratoria e del Sonno, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pierucci", 
        "givenName": "Paola", 
        "id": "sg:person.0721665275.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721665275.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bari Aldo Moro", 
          "id": "https://www.grid.ac/institutes/grid.7644.1", 
          "name": [
            "Dipartimento dell\u2019Emergenza e Trapianti d\u2019Organo (DETO), Sezione di Chirurgia Veterinaria, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Staffieri", 
        "givenName": "Francesco", 
        "id": "sg:person.0712453647.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712453647.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bari Aldo Moro", 
          "id": "https://www.grid.ac/institutes/grid.7644.1", 
          "name": [
            "Dipartimento dell\u2019Emergenza e Trapianti d\u2019Organo (DETO), Sezione di Anestesiologia e Rianimazione, Ospedale Policlinico, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare 11, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bruno", 
        "givenName": "Francesco", 
        "id": "sg:person.01030455645.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030455645.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Department of Adult Critical Care, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, King\u2019s Health Partners, and Division of Centre of Human Applied Physiological Sciences, King\u2019s College London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Camporota", 
        "givenName": "Luigi", 
        "id": "sg:person.0625347051.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625347051.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bari Aldo Moro", 
          "id": "https://www.grid.ac/institutes/grid.7644.1", 
          "name": [
            "Dipartimento dell\u2019Emergenza e Trapianti d\u2019Organo (DETO), Sezione di Anestesiologia e Rianimazione, Ospedale Policlinico, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare 11, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grasso", 
        "givenName": "Salvatore", 
        "id": "sg:person.0726713663.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726713663.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2015-207962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000633837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2015-207962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000633837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4187/respcare.02358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001544427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-015-0763-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002250523", 
          "https://doi.org/10.1186/s13054-015-0763-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-015-0763-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002250523", 
          "https://doi.org/10.1186/s13054-015-0763-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-015-0763-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002250523", 
          "https://doi.org/10.1186/s13054-015-0763-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/71012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006785474", 
          "https://doi.org/10.1038/71012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-011-2354-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008384679", 
          "https://doi.org/10.1007/s00134-011-2354-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm/138.6.1625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008639844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.164.3.2009018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010680062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-015-1178-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013299842", 
          "https://doi.org/10.1186/s13054-015-1178-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.2107138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013441079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc12865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013613296", 
          "https://doi.org/10.1186/cc12865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201402-0364oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014671682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e31827caba0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017108085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e31827caba0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017108085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e31827caba0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017108085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2016.2711", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019317523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.14-2871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025551949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-016-4277-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026891034", 
          "https://doi.org/10.1007/s00134-016-4277-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-009-1587-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029354365", 
          "https://doi.org/10.1007/s00134-009-1587-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-009-1587-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029354365", 
          "https://doi.org/10.1007/s00134-009-1587-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-009-1587-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029354365", 
          "https://doi.org/10.1007/s00134-009-1587-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-016-4470-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030802942", 
          "https://doi.org/10.1007/s00134-016-4470-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-016-4470-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030802942", 
          "https://doi.org/10.1007/s00134-016-4470-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4187/respcare.03423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031190238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201206-1117cp", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035132016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1503326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035211734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1748-1716.1974.tb05753.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037415749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-012-2700-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039396994", 
          "https://doi.org/10.1007/s00134-012-2700-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e3182282a5a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040611927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e3182282a5a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040611927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.317.7161.798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042534665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm/143.3.469", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046211467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4187/respcare.04026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047046786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.95.08111901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047810005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2016.14194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049419537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc11451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052726709", 
          "https://doi.org/10.1186/cc11451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.00584.2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063198673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078577981", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201605-0916oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079381308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2016-209673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079396783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2016-209673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079396783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2016-209673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079396783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1966.21.2.527", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081452529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082178694", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1993.75.3.1364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082710734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1996.81.3.1434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082988437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1998.85.3.1123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083313533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201701-0006ed", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085099430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15412555.2017.1315715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085304905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-017-4890-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090936249", 
          "https://doi.org/10.1007/s00134-017-4890-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-017-4890-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090936249", 
          "https://doi.org/10.1007/s00134-017-4890-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.02426-2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091408467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.02426-2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091408467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-018-5091-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101293627", 
          "https://doi.org/10.1007/s00134-018-5091-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-018-5091-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101293627", 
          "https://doi.org/10.1007/s00134-018-5091-2"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: The physiological effects of high-flow nasal cannula O2 therapy (HFNC) have been evaluated mainly in patients with hypoxemic respiratory failure. In this study, we compared the effects of HFNC and conventional low-flow O2 therapy on the neuroventilatory drive and work of breathing postextubation in patients with a background of chronic obstructive pulmonary disease (COPD) who had received mechanical ventilation for hypercapnic respiratory failure.\nMETHODS: This was a single center, unblinded, cross-over study on 14 postextubation COPD patients who were recovering from an episode of acute hypercapnic respiratory failure of various etiologies. After extubation, each patient received two 1-h periods of HFNC (HFNC1 and HFNC2) alternated with 1 h of conventional low-flow O2 therapy via a face mask. The inspiratory fraction of oxygen was titrated to achieve an arterial O2 saturation target of 88-92%. Gas exchange, breathing pattern, neuroventilatory drive (electrical diaphragmatic activity (EAdi)) and work of breathing (inspiratory trans-diaphragmatic pressure-time product per minute (PTPDI/min)) were recorded.\nRESULTS: EAdi peak increased from a mean (\u00b1SD) of 15.4 \u00b1 6.4 to 23.6 \u00b1 10.5 \u03bcV switching from HFNC1 to conventional O2, and then returned to 15.2 \u00b1 6.4 \u03bcV during HFNC2 (conventional O2: p\u2009<\u20090.05 versus HFNC1 and HFNC2). Similarly, the PTPDI/min increased from 135 \u00b1 60 to 211 \u00b1 70 cmH2O/s/min, and then decreased again during HFNC2 to 132 \u00b1 56 (conventional O2: p\u2009<\u20090.05 versus HFNC1 and HFNC2).\nCONCLUSIONS: In patients with COPD, the application of HFNC postextubation significantly decreased the neuroventilatory drive and work of breathing compared with conventional O2 therapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13054-018-2107-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1117766", 
        "issn": [
          "1364-8535", 
          "1466-609X"
        ], 
        "name": "Critical Care", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "name": "High-flow nasal cannula oxygen therapy decreases postextubation neuroventilatory drive and work of breathing in patients with chronic obstructive pulmonary disease", 
    "pagination": "180", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "baa6804401a96835fd18668df7a758bd7c2672cfa4568ea91e15889667ea433c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30071876"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9801902"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13054-018-2107-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105969953"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13054-018-2107-9", 
      "https://app.dimensions.ai/details/publication/pub.1105969953"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87115_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13054-018-2107-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2107-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2107-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2107-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2107-9'


 

This table displays all metadata directly associated to this object as RDF triples.

281 TRIPLES      21 PREDICATES      72 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13054-018-2107-9 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author N9904a10a9cdb44fdacfff31e466f44ea
4 schema:citation sg:pub.10.1007/s00134-009-1587-0
5 sg:pub.10.1007/s00134-011-2354-6
6 sg:pub.10.1007/s00134-012-2700-3
7 sg:pub.10.1007/s00134-016-4277-8
8 sg:pub.10.1007/s00134-016-4470-9
9 sg:pub.10.1007/s00134-017-4890-1
10 sg:pub.10.1007/s00134-018-5091-2
11 sg:pub.10.1038/71012
12 sg:pub.10.1186/cc11451
13 sg:pub.10.1186/cc12865
14 sg:pub.10.1186/s13054-015-0763-6
15 sg:pub.10.1186/s13054-015-1178-0
16 https://app.dimensions.ai/details/publication/pub.1078577981
17 https://app.dimensions.ai/details/publication/pub.1082178694
18 https://doi.org/10.1001/jama.2016.14194
19 https://doi.org/10.1001/jama.2016.2711
20 https://doi.org/10.1056/nejmoa1503326
21 https://doi.org/10.1080/15412555.2017.1315715
22 https://doi.org/10.1097/ccm.0b013e3182282a5a
23 https://doi.org/10.1097/ccm.0b013e31827caba0
24 https://doi.org/10.1111/j.1748-1716.1974.tb05753.x
25 https://doi.org/10.1136/bmj.317.7161.798
26 https://doi.org/10.1136/thoraxjnl-2015-207962
27 https://doi.org/10.1136/thoraxjnl-2016-209673
28 https://doi.org/10.1152/jappl.1966.21.2.527
29 https://doi.org/10.1152/jappl.1993.75.3.1364
30 https://doi.org/10.1152/jappl.1996.81.3.1434
31 https://doi.org/10.1152/jappl.1998.85.3.1123
32 https://doi.org/10.1152/japplphysiol.00584.2016
33 https://doi.org/10.1164/ajrccm.164.3.2009018
34 https://doi.org/10.1164/ajrccm/138.6.1625
35 https://doi.org/10.1164/ajrccm/143.3.469
36 https://doi.org/10.1164/rccm.201206-1117cp
37 https://doi.org/10.1164/rccm.201402-0364oc
38 https://doi.org/10.1164/rccm.201605-0916oc
39 https://doi.org/10.1164/rccm.201701-0006ed
40 https://doi.org/10.1164/rccm.2107138
41 https://doi.org/10.1183/09031936.95.08111901
42 https://doi.org/10.1183/13993003.02426-2016
43 https://doi.org/10.1378/chest.14-2871
44 https://doi.org/10.4187/respcare.02358
45 https://doi.org/10.4187/respcare.03423
46 https://doi.org/10.4187/respcare.04026
47 schema:datePublished 2018-12
48 schema:datePublishedReg 2018-12-01
49 schema:description BACKGROUND: The physiological effects of high-flow nasal cannula O2 therapy (HFNC) have been evaluated mainly in patients with hypoxemic respiratory failure. In this study, we compared the effects of HFNC and conventional low-flow O2 therapy on the neuroventilatory drive and work of breathing postextubation in patients with a background of chronic obstructive pulmonary disease (COPD) who had received mechanical ventilation for hypercapnic respiratory failure. METHODS: This was a single center, unblinded, cross-over study on 14 postextubation COPD patients who were recovering from an episode of acute hypercapnic respiratory failure of various etiologies. After extubation, each patient received two 1-h periods of HFNC (HFNC1 and HFNC2) alternated with 1 h of conventional low-flow O2 therapy via a face mask. The inspiratory fraction of oxygen was titrated to achieve an arterial O2 saturation target of 88-92%. Gas exchange, breathing pattern, neuroventilatory drive (electrical diaphragmatic activity (EAdi)) and work of breathing (inspiratory trans-diaphragmatic pressure-time product per minute (PTPDI/min)) were recorded. RESULTS: EAdi peak increased from a mean (±SD) of 15.4 ± 6.4 to 23.6 ± 10.5 μV switching from HFNC1 to conventional O2, and then returned to 15.2 ± 6.4 μV during HFNC2 (conventional O2: p < 0.05 versus HFNC1 and HFNC2). Similarly, the PTPDI/min increased from 135 ± 60 to 211 ± 70 cmH2O/s/min, and then decreased again during HFNC2 to 132 ± 56 (conventional O2: p < 0.05 versus HFNC1 and HFNC2). CONCLUSIONS: In patients with COPD, the application of HFNC postextubation significantly decreased the neuroventilatory drive and work of breathing compared with conventional O2 therapy.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree true
53 schema:isPartOf N3791c2c984f845c58a8f253adc0dd574
54 N93c889169f964a27815f0d5ad94a7807
55 sg:journal.1117766
56 schema:name High-flow nasal cannula oxygen therapy decreases postextubation neuroventilatory drive and work of breathing in patients with chronic obstructive pulmonary disease
57 schema:pagination 180
58 schema:productId N0a96f133277c4846a42223d2916d3083
59 N3464f16f7277416086b8596b14008a78
60 N819be8e683d045fb963da3ffa3b56f9f
61 Nbf09229d364b4e81b5cd706cdcc31140
62 Ne3ace2f3aac848deb9776ae139498f17
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105969953
64 https://doi.org/10.1186/s13054-018-2107-9
65 schema:sdDatePublished 2019-04-11T12:27
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N32426cb746604e2cb062d42c76141461
68 schema:url https://link.springer.com/10.1186%2Fs13054-018-2107-9
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N0a96f133277c4846a42223d2916d3083 schema:name pubmed_id
73 schema:value 30071876
74 rdf:type schema:PropertyValue
75 N0b45e477364746f48b23d416e988308b rdf:first sg:person.0707071472.05
76 rdf:rest Ned9558b383b9457fb1ce04a464378cbd
77 N32426cb746604e2cb062d42c76141461 schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 N3464f16f7277416086b8596b14008a78 schema:name nlm_unique_id
80 schema:value 9801902
81 rdf:type schema:PropertyValue
82 N3791c2c984f845c58a8f253adc0dd574 schema:volumeNumber 22
83 rdf:type schema:PublicationVolume
84 N38810d3eeca040da804aacea52ba34cc rdf:first sg:person.0651507322.63
85 rdf:rest Ne96cbd805e314574a04f6c9d7b4469af
86 N761b84bd462c4783abce71185edb08ab schema:name Dipartimento di Scienze Biomediche ed Oncologia Umana, Cattedra di Statistica Medica, Università degli Studi Aldo Moro, Bari, Italy
87 rdf:type schema:Organization
88 N7fd9e880025f4d7a94a4ea4525cdb971 rdf:first sg:person.01030455645.40
89 rdf:rest N8df366c25bce4e2c82bf888ab0812085
90 N819be8e683d045fb963da3ffa3b56f9f schema:name readcube_id
91 schema:value baa6804401a96835fd18668df7a758bd7c2672cfa4568ea91e15889667ea433c
92 rdf:type schema:PropertyValue
93 N8736c916339e4c5b98ffb21b6a777de7 rdf:first sg:person.0726713663.34
94 rdf:rest rdf:nil
95 N8df366c25bce4e2c82bf888ab0812085 rdf:first sg:person.0625347051.76
96 rdf:rest N8736c916339e4c5b98ffb21b6a777de7
97 N93c889169f964a27815f0d5ad94a7807 schema:issueNumber 1
98 rdf:type schema:PublicationIssue
99 N9904a10a9cdb44fdacfff31e466f44ea rdf:first sg:person.0720267603.04
100 rdf:rest N0b45e477364746f48b23d416e988308b
101 Nb580dacedcea46da94a51dd402a6f258 rdf:first sg:person.0712453647.23
102 rdf:rest N7fd9e880025f4d7a94a4ea4525cdb971
103 Nbf09229d364b4e81b5cd706cdcc31140 schema:name dimensions_id
104 schema:value pub.1105969953
105 rdf:type schema:PropertyValue
106 Ncaa975e3ca3b46c39575932b05bf4eda rdf:first sg:person.0721665275.17
107 rdf:rest Nb580dacedcea46da94a51dd402a6f258
108 Ne3ace2f3aac848deb9776ae139498f17 schema:name doi
109 schema:value 10.1186/s13054-018-2107-9
110 rdf:type schema:PropertyValue
111 Ne96cbd805e314574a04f6c9d7b4469af rdf:first sg:person.01356402343.38
112 rdf:rest Ncaa975e3ca3b46c39575932b05bf4eda
113 Ned9558b383b9457fb1ce04a464378cbd rdf:first sg:person.01133041663.91
114 rdf:rest N38810d3eeca040da804aacea52ba34cc
115 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
116 schema:name Medical and Health Sciences
117 rdf:type schema:DefinedTerm
118 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
119 schema:name Cardiorespiratory Medicine and Haematology
120 rdf:type schema:DefinedTerm
121 sg:journal.1117766 schema:issn 1364-8535
122 1466-609X
123 schema:name Critical Care
124 rdf:type schema:Periodical
125 sg:person.01030455645.40 schema:affiliation https://www.grid.ac/institutes/grid.7644.1
126 schema:familyName Bruno
127 schema:givenName Francesco
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030455645.40
129 rdf:type schema:Person
130 sg:person.01133041663.91 schema:affiliation https://www.grid.ac/institutes/grid.7644.1
131 schema:familyName Stripoli
132 schema:givenName Tania
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133041663.91
134 rdf:type schema:Person
135 sg:person.01356402343.38 schema:affiliation N761b84bd462c4783abce71185edb08ab
136 schema:familyName Trerotoli
137 schema:givenName Paolo
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356402343.38
139 rdf:type schema:Person
140 sg:person.0625347051.76 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
141 schema:familyName Camporota
142 schema:givenName Luigi
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625347051.76
144 rdf:type schema:Person
145 sg:person.0651507322.63 schema:affiliation https://www.grid.ac/institutes/grid.8484.0
146 schema:familyName Volta
147 schema:givenName Carlo Alberto
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651507322.63
149 rdf:type schema:Person
150 sg:person.0707071472.05 schema:affiliation https://www.grid.ac/institutes/grid.8484.0
151 schema:familyName Spadaro
152 schema:givenName Savino
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707071472.05
154 rdf:type schema:Person
155 sg:person.0712453647.23 schema:affiliation https://www.grid.ac/institutes/grid.7644.1
156 schema:familyName Staffieri
157 schema:givenName Francesco
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712453647.23
159 rdf:type schema:Person
160 sg:person.0720267603.04 schema:affiliation https://www.grid.ac/institutes/grid.7644.1
161 schema:familyName Di mussi
162 schema:givenName Rosa
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720267603.04
164 rdf:type schema:Person
165 sg:person.0721665275.17 schema:affiliation https://www.grid.ac/institutes/grid.7644.1
166 schema:familyName Pierucci
167 schema:givenName Paola
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721665275.17
169 rdf:type schema:Person
170 sg:person.0726713663.34 schema:affiliation https://www.grid.ac/institutes/grid.7644.1
171 schema:familyName Grasso
172 schema:givenName Salvatore
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726713663.34
174 rdf:type schema:Person
175 sg:pub.10.1007/s00134-009-1587-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029354365
176 https://doi.org/10.1007/s00134-009-1587-0
177 rdf:type schema:CreativeWork
178 sg:pub.10.1007/s00134-011-2354-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008384679
179 https://doi.org/10.1007/s00134-011-2354-6
180 rdf:type schema:CreativeWork
181 sg:pub.10.1007/s00134-012-2700-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039396994
182 https://doi.org/10.1007/s00134-012-2700-3
183 rdf:type schema:CreativeWork
184 sg:pub.10.1007/s00134-016-4277-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026891034
185 https://doi.org/10.1007/s00134-016-4277-8
186 rdf:type schema:CreativeWork
187 sg:pub.10.1007/s00134-016-4470-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030802942
188 https://doi.org/10.1007/s00134-016-4470-9
189 rdf:type schema:CreativeWork
190 sg:pub.10.1007/s00134-017-4890-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090936249
191 https://doi.org/10.1007/s00134-017-4890-1
192 rdf:type schema:CreativeWork
193 sg:pub.10.1007/s00134-018-5091-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101293627
194 https://doi.org/10.1007/s00134-018-5091-2
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/71012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006785474
197 https://doi.org/10.1038/71012
198 rdf:type schema:CreativeWork
199 sg:pub.10.1186/cc11451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052726709
200 https://doi.org/10.1186/cc11451
201 rdf:type schema:CreativeWork
202 sg:pub.10.1186/cc12865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013613296
203 https://doi.org/10.1186/cc12865
204 rdf:type schema:CreativeWork
205 sg:pub.10.1186/s13054-015-0763-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002250523
206 https://doi.org/10.1186/s13054-015-0763-6
207 rdf:type schema:CreativeWork
208 sg:pub.10.1186/s13054-015-1178-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013299842
209 https://doi.org/10.1186/s13054-015-1178-0
210 rdf:type schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1078577981 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1082178694 schema:CreativeWork
213 https://doi.org/10.1001/jama.2016.14194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049419537
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1001/jama.2016.2711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019317523
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1056/nejmoa1503326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035211734
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1080/15412555.2017.1315715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085304905
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1097/ccm.0b013e3182282a5a schema:sameAs https://app.dimensions.ai/details/publication/pub.1040611927
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1097/ccm.0b013e31827caba0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017108085
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1111/j.1748-1716.1974.tb05753.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037415749
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1136/bmj.317.7161.798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042534665
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1136/thoraxjnl-2015-207962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000633837
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1136/thoraxjnl-2016-209673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079396783
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1152/jappl.1966.21.2.527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081452529
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1152/jappl.1993.75.3.1364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082710734
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1152/jappl.1996.81.3.1434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082988437
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1152/jappl.1998.85.3.1123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083313533
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1152/japplphysiol.00584.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063198673
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1164/ajrccm.164.3.2009018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010680062
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1164/ajrccm/138.6.1625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008639844
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1164/ajrccm/143.3.469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046211467
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1164/rccm.201206-1117cp schema:sameAs https://app.dimensions.ai/details/publication/pub.1035132016
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1164/rccm.201402-0364oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1014671682
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1164/rccm.201605-0916oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1079381308
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1164/rccm.201701-0006ed schema:sameAs https://app.dimensions.ai/details/publication/pub.1085099430
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1164/rccm.2107138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013441079
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1183/09031936.95.08111901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047810005
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1183/13993003.02426-2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091408467
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1378/chest.14-2871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025551949
264 rdf:type schema:CreativeWork
265 https://doi.org/10.4187/respcare.02358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001544427
266 rdf:type schema:CreativeWork
267 https://doi.org/10.4187/respcare.03423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031190238
268 rdf:type schema:CreativeWork
269 https://doi.org/10.4187/respcare.04026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047046786
270 rdf:type schema:CreativeWork
271 https://www.grid.ac/institutes/grid.13097.3c schema:alternateName King's College London
272 schema:name Department of Adult Critical Care, Guy’s and St Thomas’ NHS Foundation Trust, King’s Health Partners, and Division of Centre of Human Applied Physiological Sciences, King’s College London, London, UK
273 rdf:type schema:Organization
274 https://www.grid.ac/institutes/grid.7644.1 schema:alternateName University of Bari Aldo Moro
275 schema:name Dipartimento dell’Emergenza e Trapianti d’Organo (DETO), Sezione di Anestesiologia e Rianimazione, Ospedale Policlinico, Università degli Studi di Bari “Aldo Moro”, Piazza Giulio Cesare 11, Bari, Italy
276 Dipartimento dell’Emergenza e Trapianti d’Organo (DETO), Sezione di Chirurgia Veterinaria, Università degli Studi di Bari “Aldo Moro”, Bari, Italy
277 Dipartimento di Medicina Respiratoria e del Sonno, Università degli Studi di Bari “Aldo Moro”, Bari, Italy
278 rdf:type schema:Organization
279 https://www.grid.ac/institutes/grid.8484.0 schema:alternateName University of Ferrara
280 schema:name Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Sezione di Anestesiologia e Terapia Intensiva Universitaria, Università degli studi di Ferrara, Ferrara, Italy
281 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...