Anemia prevalence and incidence and red blood cell transfusion practices in aneurysmal subarachnoid hemorrhage: results of a multicenter cohort study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-07-04

AUTHORS

Shane W. English, Michaël Chassé, Alexis F. Turgeon, François Lauzier, Donald Griesdale, Allan Garland, Dean Fergusson, Ryan Zarychanski, Carl van Walraven, Kaitlyn Montroy, Jennifer Ziegler, Raphael Dupont-Chouinard, Raphaëlle Carignan, Andy Dhaliwal, Ranjeeta Mallick, John Sinclair, Amélie Boutin, Giuseppe Pagliarello, Alan Tinmouth, Lauralyn McIntyre, V. McCredie, D. Scales

ABSTRACT

BACKGROUND: Whether a restrictive strategy for red blood cell (RBC) transfusion is applied to patients with aneurysmal subarachnoid hemorrhage (aSAH) is unclear. To inform the design and conduct of a future clinical trial, we sought to describe transfusion practices, hemoglobin (Hb) triggers, and predictors of RBC transfusion in patients with aSAH. METHODS: This is a retrospective cohort study of all consecutively admitted adult patients with aSAH at four tertiary care centers from January 1, 2012, to December 31, 2013. Patients were identified from hospital administrative discharge records and existing local aSAH databases. Data collection by trained abstractors included demographic data, aSAH characteristics, Hb and transfusion data, other major aSAH cointerventions, and outcomes using a pretested case report form with standardized procedures. Descriptive statistics were used to summarize data, and regression models were used to identify associations between anemia, transfusion, and other relevant predictors and outcome. RESULTS: A total of 527 patients met inclusion eligibility. Mean (±SD) age was 57 ± 13 years, and 357 patients (67.7%) were female. The median modified Fisher grade was 4 (IQR 3-4). Mean nadir Hb was 98 ± 20 g/L and occurred on median admission day 4 (IQR 2-11). RBC transfusion occurred in 100 patients (19.0%). Transfusion rates varied across centers (12.1-27.4%, p = 0.02). Patients received a median of 1 RBC unit (IQR 1-2) per transfusion episode and a median total of 2 units (IQR 1-4). Median pretransfusion Hb for first transfusion was 79 g/L (IQR 74-93) and did not vary substantially across centers (78-82 g/L, p = 0.37). Of patients with nadir Hb < 80 g/L, 66.3% received a transfusion compared with 2.0% with Hb nadir ≥ 100 g/L (p < 0.0001). Predictors of transfusion were history of oral anticoagulant use, anterior circulation aneurysm, neurosurgical clipping, and lower Hb. Controlling for numerous potential confounders, transfusion was not independently associated with poor outcome. CONCLUSIONS: We observed that moderate anemia remains very common early in admission following SAH. Only one-fifth of patients with SAH received RBC transfusions, mostly in cases of significant anemia (Hb < 80 g/L), and this did not appear to be associated with outcome. More... »

PAGES

169

References to SciGraph publications

  • 2010-08-18. Prospective, Randomized Trial of Higher Goal Hemoglobin after Subarachnoid Hemorrhage in NEUROCRITICAL CARE
  • 2012-08-30. Trajectory of Functional Recovery After Hospital Discharge for Subarachnoid Hemorrhage in NEUROCRITICAL CARE
  • 2011-07-19. Anemia and Transfusion After Subarachnoid Hemorrhage in NEUROCRITICAL CARE
  • 2009-09-24. Factors Associated with the Development of Anemia After Subarachnoid Hemorrhage in NEUROCRITICAL CARE
  • 2009-03-13. Transfusion increases infection without affecting neurologic outcome in spontaneous subarachnoid hemorrhage in CRITICAL CARE
  • 2012-09-11. Blood Transfusion is an Important Predictor of Hospital Mortality Among Patients with Aneurysmal Subarachnoid Hemorrhage in NEUROCRITICAL CARE
  • 2011-01-18. Red blood cell transfusion in patients with subarachnoid hemorrhage: a multidisciplinary North American survey in CRITICAL CARE
  • 2008-12-31. Relationship Between Hemoglobin Concentrations and Outcomes Across Subgroups of Patients with Aneurysmal Subarachnoid Hemorrhage in NEUROCRITICAL CARE
  • 2013-02-20. Red Blood Cell Transfusion Increases the Risk of Thrombotic Events in Patients with Subarachnoid Hemorrhage in NEUROCRITICAL CARE
  • 2011-07-20. Critical Care Management of Patients Following Aneurysmal Subarachnoid Hemorrhage: Recommendations from the Neurocritical Care Society’s Multidisciplinary Consensus Conference in NEUROCRITICAL CARE
  • 2010-02-22. Effect of different components of triple-H therapy on cerebral perfusion in patients with aneurysmal subarachnoid haemorrhage: a systematic review in CRITICAL CARE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13054-018-2089-7

    DOI

    http://dx.doi.org/10.1186/s13054-018-2089-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105305007

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29973245


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anemia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Canada", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cohort Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Erythrocyte Transfusion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Incidence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prevalence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Subarachnoid Hemorrhage", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Clinical Epidemiology Program (Centre for Transfusion Research), Ottawa Hospital Research Institute, Ottawa, ON Canada", 
              "id": "http://www.grid.ac/institutes/grid.412687.e", 
              "name": [
                "Department of Medicine (Critical Care), The Ottawa Hospital, Civic Campus Room F202, 1053 Carling Avenue, Ottawa, ON K1Y 4E9 Canada", 
                "Clinical Epidemiology Program (Centre for Transfusion Research), Ottawa Hospital Research Institute, Ottawa, ON Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "English", 
            "givenName": "Shane W.", 
            "id": "sg:person.01036166574.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036166574.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, University of Montreal, Montreal, QC Canada", 
              "id": "http://www.grid.ac/institutes/grid.14848.31", 
              "name": [
                "Department of Medicine, University of Montreal, Montreal, QC Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chass\u00e9", 
            "givenName": "Micha\u00ebl", 
            "id": "sg:person.01033165762.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033165762.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Anesthesiology & Critical Care, Universit\u00e9 Laval, Quebec City, QC Canada", 
              "id": "http://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Department of Anesthesiology & Critical Care, Universit\u00e9 Laval, Quebec City, QC Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Turgeon", 
            "givenName": "Alexis F.", 
            "id": "sg:person.01253006352.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253006352.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Universit\u00e9 Laval, Quebec City, QC Canada", 
              "id": "http://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Department of Anesthesiology & Critical Care, Universit\u00e9 Laval, Quebec City, QC Canada", 
                "Department of Medicine, Universit\u00e9 Laval, Quebec City, QC Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lauzier", 
            "givenName": "Fran\u00e7ois", 
            "id": "sg:person.01066142337.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066142337.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Deparment of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC Canada", 
              "id": "http://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Deparment of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Griesdale", 
            "givenName": "Donald", 
            "id": "sg:person.01211667117.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211667117.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, University of Manitoba, Winnipeg, MB Canada", 
              "id": "http://www.grid.ac/institutes/grid.21613.37", 
              "name": [
                "Department of Medicine, University of Manitoba, Winnipeg, MB Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Garland", 
            "givenName": "Allan", 
            "id": "sg:person.0756503311.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756503311.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinical Epidemiology Program (Centre for Transfusion Research), Ottawa Hospital Research Institute, Ottawa, ON Canada", 
              "id": "http://www.grid.ac/institutes/grid.412687.e", 
              "name": [
                "Clinical Epidemiology Program (Centre for Transfusion Research), Ottawa Hospital Research Institute, Ottawa, ON Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fergusson", 
            "givenName": "Dean", 
            "id": "sg:person.01152765352.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152765352.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, University of Manitoba, Winnipeg, MB Canada", 
              "id": "http://www.grid.ac/institutes/grid.21613.37", 
              "name": [
                "Department of Medicine, University of Manitoba, Winnipeg, MB Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zarychanski", 
            "givenName": "Ryan", 
            "id": "sg:person.0617260043.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617260043.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, University of Ottawa, Ottawa, ON Canada", 
              "id": "http://www.grid.ac/institutes/grid.28046.38", 
              "name": [
                "Department of Medicine, University of Ottawa, Ottawa, ON Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van Walraven", 
            "givenName": "Carl", 
            "id": "sg:person.0636122731.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636122731.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinical Epidemiology Program (Centre for Transfusion Research), Ottawa Hospital Research Institute, Ottawa, ON Canada", 
              "id": "http://www.grid.ac/institutes/grid.412687.e", 
              "name": [
                "Clinical Epidemiology Program (Centre for Transfusion Research), Ottawa Hospital Research Institute, Ottawa, ON Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Montroy", 
            "givenName": "Kaitlyn", 
            "id": "sg:person.01120313137.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120313137.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, University of Manitoba, Winnipeg, MB Canada", 
              "id": "http://www.grid.ac/institutes/grid.21613.37", 
              "name": [
                "Department of Medicine, University of Manitoba, Winnipeg, MB Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ziegler", 
            "givenName": "Jennifer", 
            "id": "sg:person.01371774231.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371774231.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Anesthesiology & Critical Care, Universit\u00e9 Laval, Quebec City, QC Canada", 
              "id": "http://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Department of Anesthesiology & Critical Care, Universit\u00e9 Laval, Quebec City, QC Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dupont-Chouinard", 
            "givenName": "Raphael", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Anesthesiology & Critical Care, Universit\u00e9 Laval, Quebec City, QC Canada", 
              "id": "http://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Department of Anesthesiology & Critical Care, Universit\u00e9 Laval, Quebec City, QC Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carignan", 
            "givenName": "Rapha\u00eblle", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, University of Saskatchewan, Regina, SK Canada", 
              "id": "http://www.grid.ac/institutes/grid.25152.31", 
              "name": [
                "Department of Medicine, University of Saskatchewan, Regina, SK Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dhaliwal", 
            "givenName": "Andy", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinical Epidemiology Program (Centre for Transfusion Research), Ottawa Hospital Research Institute, Ottawa, ON Canada", 
              "id": "http://www.grid.ac/institutes/grid.412687.e", 
              "name": [
                "Clinical Epidemiology Program (Centre for Transfusion Research), Ottawa Hospital Research Institute, Ottawa, ON Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mallick", 
            "givenName": "Ranjeeta", 
            "id": "sg:person.0657754474.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657754474.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery (Neurosurgery), University of Ottawa, Ottawa, ON Canada", 
              "id": "http://www.grid.ac/institutes/grid.28046.38", 
              "name": [
                "Department of Surgery (Neurosurgery), University of Ottawa, Ottawa, ON Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sinclair", 
            "givenName": "John", 
            "id": "sg:person.01331765645.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331765645.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Social and Preventive Medicine, Universit\u00e9 Laval, Quebec City, QC Canada", 
              "id": "http://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Department of Social and Preventive Medicine, Universit\u00e9 Laval, Quebec City, QC Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boutin", 
            "givenName": "Am\u00e9lie", 
            "id": "sg:person.01006113265.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006113265.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, University of Ottawa, Ottawa, ON Canada", 
              "id": "http://www.grid.ac/institutes/grid.28046.38", 
              "name": [
                "Department of Surgery, University of Ottawa, Ottawa, ON Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pagliarello", 
            "givenName": "Giuseppe", 
            "id": "sg:person.0711456336.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711456336.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinical Epidemiology Program (Centre for Transfusion Research), Ottawa Hospital Research Institute, Ottawa, ON Canada", 
              "id": "http://www.grid.ac/institutes/grid.412687.e", 
              "name": [
                "Clinical Epidemiology Program (Centre for Transfusion Research), Ottawa Hospital Research Institute, Ottawa, ON Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tinmouth", 
            "givenName": "Alan", 
            "id": "sg:person.01204673152.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204673152.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinical Epidemiology Program (Centre for Transfusion Research), Ottawa Hospital Research Institute, Ottawa, ON Canada", 
              "id": "http://www.grid.ac/institutes/grid.412687.e", 
              "name": [
                "Department of Medicine (Critical Care), The Ottawa Hospital, Civic Campus Room F202, 1053 Carling Avenue, Ottawa, ON K1Y 4E9 Canada", 
                "Clinical Epidemiology Program (Centre for Transfusion Research), Ottawa Hospital Research Institute, Ottawa, ON Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McIntyre", 
            "givenName": "Lauralyn", 
            "id": "sg:person.01115205001.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115205001.21"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "McCredie", 
            "givenName": "V.", 
            "id": "sg:person.01005111636.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005111636.47"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Scales", 
            "givenName": "D.", 
            "id": "sg:person.01110343356.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110343356.39"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s12028-013-9819-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032656755", 
              "https://doi.org/10.1007/s12028-013-9819-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc7264", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030802551", 
              "https://doi.org/10.1186/cc7264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12028-012-9777-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032140750", 
              "https://doi.org/10.1007/s12028-012-9777-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc9977", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032796563", 
              "https://doi.org/10.1186/cc9977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12028-009-9273-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031821288", 
              "https://doi.org/10.1007/s12028-009-9273-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12028-008-9171-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017503501", 
              "https://doi.org/10.1007/s12028-008-9171-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12028-011-9582-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034711250", 
              "https://doi.org/10.1007/s12028-011-9582-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12028-012-9772-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050479392", 
              "https://doi.org/10.1007/s12028-012-9772-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc8886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017673304", 
              "https://doi.org/10.1186/cc8886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12028-011-9605-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046372375", 
              "https://doi.org/10.1007/s12028-011-9605-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12028-010-9424-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051098664", 
              "https://doi.org/10.1007/s12028-010-9424-4"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-07-04", 
        "datePublishedReg": "2018-07-04", 
        "description": "BACKGROUND: Whether a restrictive strategy for red blood cell (RBC) transfusion is applied to patients with aneurysmal subarachnoid hemorrhage (aSAH) is unclear. To inform the design and conduct of a future clinical trial, we sought to describe transfusion practices, hemoglobin (Hb) triggers, and predictors of RBC transfusion in patients with aSAH.\nMETHODS: This is a retrospective cohort study of all consecutively admitted adult patients with aSAH at four tertiary care centers from January 1, 2012, to December 31, 2013. Patients were identified from hospital administrative discharge records and existing local aSAH databases. Data collection by trained abstractors included demographic data, aSAH characteristics, Hb and transfusion data, other major aSAH cointerventions, and outcomes using a pretested case report form with standardized procedures. Descriptive statistics were used to summarize data, and regression models were used to identify associations between anemia, transfusion, and other relevant predictors and outcome.\nRESULTS: A total of 527 patients met inclusion eligibility. Mean (\u00b1SD) age was 57\u2009\u00b1\u200913\u00a0years, and 357 patients (67.7%) were female. The median modified Fisher grade was 4 (IQR 3-4). Mean nadir Hb was 98\u2009\u00b1\u200920\u00a0g/L and occurred on median admission day 4 (IQR 2-11). RBC transfusion occurred in 100 patients (19.0%). Transfusion rates varied across centers (12.1-27.4%, p\u2009=\u20090.02). Patients received a median of 1 RBC unit (IQR 1-2) per transfusion episode and a median total of 2\u00a0units (IQR 1-4). Median pretransfusion Hb for first transfusion was 79\u00a0g/L (IQR 74-93) and did not vary substantially across centers (78-82\u00a0g/L, p\u2009=\u20090.37). Of patients with nadir Hb\u2009<\u200980\u00a0g/L, 66.3% received a transfusion compared with 2.0% with Hb nadir \u2265\u2009100\u00a0g/L (p\u2009<\u20090.0001). Predictors of transfusion were history of oral anticoagulant use, anterior circulation aneurysm, neurosurgical clipping, and lower Hb. Controlling for numerous potential confounders, transfusion was not independently associated with poor outcome.\nCONCLUSIONS: We observed that moderate anemia remains very common early in admission following SAH. Only one-fifth of patients with SAH received RBC transfusions, mostly in cases of significant anemia (Hb <\u200980\u00a0g/L), and this did not appear to be associated with outcome.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s13054-018-2089-7", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1117766", 
            "issn": [
              "1364-8535", 
              "1466-609X"
            ], 
            "name": "Critical Care", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "22"
          }
        ], 
        "keywords": [
          "aneurysmal subarachnoid hemorrhage", 
          "RBC transfusion", 
          "cohort study", 
          "transfusion practice", 
          "subarachnoid hemorrhage", 
          "red blood cell transfusion practices", 
          "red blood cell transfusion", 
          "admission day 4", 
          "predictors of transfusion", 
          "blood cell transfusion", 
          "retrospective cohort study", 
          "oral anticoagulant use", 
          "multicenter cohort study", 
          "tertiary care center", 
          "anterior circulation aneurysms", 
          "future clinical trials", 
          "case report forms", 
          "numerous potential confounders", 
          "hemoglobin trigger", 
          "aSAH database", 
          "transfusion episodes", 
          "nadir Hb", 
          "cell transfusion", 
          "transfusion rate", 
          "first transfusion", 
          "anticoagulant use", 
          "adult patients", 
          "Fisher grade", 
          "neurosurgical clipping", 
          "significant anemia", 
          "anemia prevalence", 
          "poor outcome", 
          "mean age", 
          "potential confounders", 
          "moderate anemia", 
          "transfusion data", 
          "pretransfusion Hb", 
          "clinical trials", 
          "care center", 
          "inclusion eligibility", 
          "transfusion", 
          "patients", 
          "day 4", 
          "demographic data", 
          "median total", 
          "restrictive strategy", 
          "RBC units", 
          "anemia", 
          "discharge records", 
          "report forms", 
          "outcomes", 
          "hemorrhage", 
          "predictors", 
          "descriptive statistics", 
          "Hb", 
          "regression models", 
          "median", 
          "SAH", 
          "one-fifth", 
          "standardized procedures", 
          "total", 
          "relevant predictors", 
          "cointerventions", 
          "confounders", 
          "admission", 
          "aneurysms", 
          "prevalence", 
          "incidence", 
          "trials", 
          "center", 
          "eligibility", 
          "age", 
          "episodes", 
          "study", 
          "association", 
          "abstractors", 
          "data collection", 
          "grade", 
          "clipping", 
          "years", 
          "data", 
          "practice", 
          "triggers", 
          "records", 
          "history", 
          "cases", 
          "database", 
          "units", 
          "rate", 
          "procedure", 
          "use", 
          "strategies", 
          "results", 
          "characteristics", 
          "collection", 
          "statistics", 
          "conduct", 
          "form", 
          "model", 
          "design", 
          "hospital administrative discharge records", 
          "administrative discharge records", 
          "local aSAH databases", 
          "aSAH characteristics", 
          "major aSAH cointerventions", 
          "aSAH cointerventions", 
          "median admission day 4", 
          "Median pretransfusion Hb", 
          "circulation aneurysm", 
          "blood cell transfusion practices", 
          "cell transfusion practices"
        ], 
        "name": "Anemia prevalence and incidence and red blood cell transfusion practices in aneurysmal subarachnoid hemorrhage: results of a multicenter cohort study", 
        "pagination": "169", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1105305007"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13054-018-2089-7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29973245"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13054-018-2089-7", 
          "https://app.dimensions.ai/details/publication/pub.1105305007"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-12-01T19:42", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_793.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s13054-018-2089-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2089-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2089-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2089-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13054-018-2089-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    442 TRIPLES      22 PREDICATES      162 URIs      143 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13054-018-2089-7 schema:about N00cb7cd71f4841f09980c08965c20d7a
    2 N0538c6a8e8eb4696ae9c7c8cd6c9eea5
    3 N1446604f4e444869ac38d83a52c75677
    4 N2d1ef004dd714291bf86364f45d76fb9
    5 N556186fae7c74fbfa348258603d23a4c
    6 N596a6ed9c3fa4d46bd563d7a49fbf97b
    7 N76bc1a6df52f44d5a189cac6f9c84263
    8 N82649215a55d48c2b6bf646faf7b695f
    9 N87f836cd47f04134ac0e0b2590abf3b4
    10 N8ef3731277a24299a52332ca3d2e0590
    11 Nc1d1b0042ca9492f8af1b69809c2df0d
    12 Nd25ba76d9a59470f83bb4b7f96003392
    13 Neaa83b1e05b045dfb9315596af19fd0e
    14 Ned5c404b9fb741eebd77de6282289e35
    15 anzsrc-for:11
    16 anzsrc-for:1102
    17 schema:author N8160ce84092a4295b65a8564fd9eba9e
    18 schema:citation sg:pub.10.1007/s12028-008-9171-y
    19 sg:pub.10.1007/s12028-009-9273-1
    20 sg:pub.10.1007/s12028-010-9424-4
    21 sg:pub.10.1007/s12028-011-9582-z
    22 sg:pub.10.1007/s12028-011-9605-9
    23 sg:pub.10.1007/s12028-012-9772-3
    24 sg:pub.10.1007/s12028-012-9777-y
    25 sg:pub.10.1007/s12028-013-9819-0
    26 sg:pub.10.1186/cc7264
    27 sg:pub.10.1186/cc8886
    28 sg:pub.10.1186/cc9977
    29 schema:datePublished 2018-07-04
    30 schema:datePublishedReg 2018-07-04
    31 schema:description BACKGROUND: Whether a restrictive strategy for red blood cell (RBC) transfusion is applied to patients with aneurysmal subarachnoid hemorrhage (aSAH) is unclear. To inform the design and conduct of a future clinical trial, we sought to describe transfusion practices, hemoglobin (Hb) triggers, and predictors of RBC transfusion in patients with aSAH. METHODS: This is a retrospective cohort study of all consecutively admitted adult patients with aSAH at four tertiary care centers from January 1, 2012, to December 31, 2013. Patients were identified from hospital administrative discharge records and existing local aSAH databases. Data collection by trained abstractors included demographic data, aSAH characteristics, Hb and transfusion data, other major aSAH cointerventions, and outcomes using a pretested case report form with standardized procedures. Descriptive statistics were used to summarize data, and regression models were used to identify associations between anemia, transfusion, and other relevant predictors and outcome. RESULTS: A total of 527 patients met inclusion eligibility. Mean (±SD) age was 57 ± 13 years, and 357 patients (67.7%) were female. The median modified Fisher grade was 4 (IQR 3-4). Mean nadir Hb was 98 ± 20 g/L and occurred on median admission day 4 (IQR 2-11). RBC transfusion occurred in 100 patients (19.0%). Transfusion rates varied across centers (12.1-27.4%, p = 0.02). Patients received a median of 1 RBC unit (IQR 1-2) per transfusion episode and a median total of 2 units (IQR 1-4). Median pretransfusion Hb for first transfusion was 79 g/L (IQR 74-93) and did not vary substantially across centers (78-82 g/L, p = 0.37). Of patients with nadir Hb < 80 g/L, 66.3% received a transfusion compared with 2.0% with Hb nadir ≥ 100 g/L (p < 0.0001). Predictors of transfusion were history of oral anticoagulant use, anterior circulation aneurysm, neurosurgical clipping, and lower Hb. Controlling for numerous potential confounders, transfusion was not independently associated with poor outcome. CONCLUSIONS: We observed that moderate anemia remains very common early in admission following SAH. Only one-fifth of patients with SAH received RBC transfusions, mostly in cases of significant anemia (Hb < 80 g/L), and this did not appear to be associated with outcome.
    32 schema:genre article
    33 schema:inLanguage en
    34 schema:isAccessibleForFree true
    35 schema:isPartOf N4f8d54868b2d4421abbd641f3abf6629
    36 Nc029de2ec2354887b78caaf6b6f9d760
    37 sg:journal.1117766
    38 schema:keywords Fisher grade
    39 Hb
    40 Median pretransfusion Hb
    41 RBC transfusion
    42 RBC units
    43 SAH
    44 aSAH characteristics
    45 aSAH cointerventions
    46 aSAH database
    47 abstractors
    48 administrative discharge records
    49 admission
    50 admission day 4
    51 adult patients
    52 age
    53 anemia
    54 anemia prevalence
    55 aneurysmal subarachnoid hemorrhage
    56 aneurysms
    57 anterior circulation aneurysms
    58 anticoagulant use
    59 association
    60 blood cell transfusion
    61 blood cell transfusion practices
    62 care center
    63 case report forms
    64 cases
    65 cell transfusion
    66 cell transfusion practices
    67 center
    68 characteristics
    69 circulation aneurysm
    70 clinical trials
    71 clipping
    72 cohort study
    73 cointerventions
    74 collection
    75 conduct
    76 confounders
    77 data
    78 data collection
    79 database
    80 day 4
    81 demographic data
    82 descriptive statistics
    83 design
    84 discharge records
    85 eligibility
    86 episodes
    87 first transfusion
    88 form
    89 future clinical trials
    90 grade
    91 hemoglobin trigger
    92 hemorrhage
    93 history
    94 hospital administrative discharge records
    95 incidence
    96 inclusion eligibility
    97 local aSAH databases
    98 major aSAH cointerventions
    99 mean age
    100 median
    101 median admission day 4
    102 median total
    103 model
    104 moderate anemia
    105 multicenter cohort study
    106 nadir Hb
    107 neurosurgical clipping
    108 numerous potential confounders
    109 one-fifth
    110 oral anticoagulant use
    111 outcomes
    112 patients
    113 poor outcome
    114 potential confounders
    115 practice
    116 predictors
    117 predictors of transfusion
    118 pretransfusion Hb
    119 prevalence
    120 procedure
    121 rate
    122 records
    123 red blood cell transfusion
    124 red blood cell transfusion practices
    125 regression models
    126 relevant predictors
    127 report forms
    128 restrictive strategy
    129 results
    130 retrospective cohort study
    131 significant anemia
    132 standardized procedures
    133 statistics
    134 strategies
    135 study
    136 subarachnoid hemorrhage
    137 tertiary care center
    138 total
    139 transfusion
    140 transfusion data
    141 transfusion episodes
    142 transfusion practice
    143 transfusion rate
    144 trials
    145 triggers
    146 units
    147 use
    148 years
    149 schema:name Anemia prevalence and incidence and red blood cell transfusion practices in aneurysmal subarachnoid hemorrhage: results of a multicenter cohort study
    150 schema:pagination 169
    151 schema:productId N0635bf3316ff4bdcb7ad7bc9dee2d7a4
    152 N9738ae04576c43c295730247dab2ed4c
    153 Nb0c9078909ae45379491b725a51e6994
    154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105305007
    155 https://doi.org/10.1186/s13054-018-2089-7
    156 schema:sdDatePublished 2021-12-01T19:42
    157 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    158 schema:sdPublisher Nd04bea57535b402dae463e0313531b7d
    159 schema:url https://doi.org/10.1186/s13054-018-2089-7
    160 sgo:license sg:explorer/license/
    161 sgo:sdDataset articles
    162 rdf:type schema:ScholarlyArticle
    163 N00cb7cd71f4841f09980c08965c20d7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Incidence
    165 rdf:type schema:DefinedTerm
    166 N0538c6a8e8eb4696ae9c7c8cd6c9eea5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Adult
    168 rdf:type schema:DefinedTerm
    169 N0635bf3316ff4bdcb7ad7bc9dee2d7a4 schema:name pubmed_id
    170 schema:value 29973245
    171 rdf:type schema:PropertyValue
    172 N06cde11daac74bf98ea8dcb1f82c7047 rdf:first sg:person.01204673152.64
    173 rdf:rest N66abd863192a4b0485dd912c8d263207
    174 N0b2d00f231914ca29d9b78f779c71828 rdf:first Nc8fdef84705d4f5798f66ff6dea983b6
    175 rdf:rest N4453383811fb4b1ba775b9d61bba3841
    176 N0deb3abf55a843bcb1e03c0bb8cd9eab schema:affiliation grid-institutes:grid.23856.3a
    177 schema:familyName Dupont-Chouinard
    178 schema:givenName Raphael
    179 rdf:type schema:Person
    180 N1446604f4e444869ac38d83a52c75677 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Anemia
    182 rdf:type schema:DefinedTerm
    183 N240553e0ddd145fd8970c2724737c082 rdf:first sg:person.01120313137.85
    184 rdf:rest N2fe608b984f44ba797e97bfaeb228001
    185 N2d1ef004dd714291bf86364f45d76fb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Canada
    187 rdf:type schema:DefinedTerm
    188 N2fe608b984f44ba797e97bfaeb228001 rdf:first sg:person.01371774231.85
    189 rdf:rest N7c668a9aedcc4487a6914f1c0d0e8fca
    190 N4453383811fb4b1ba775b9d61bba3841 rdf:first sg:person.0657754474.04
    191 rdf:rest N7106c30b2124470c823ad00f83d2e835
    192 N4f8d54868b2d4421abbd641f3abf6629 schema:issueNumber 1
    193 rdf:type schema:PublicationIssue
    194 N548097db8f2f4a39b63cade01798f480 rdf:first sg:person.01006113265.10
    195 rdf:rest N78d2a8a219ca4c1dacde988b9cc2f5d5
    196 N556186fae7c74fbfa348258603d23a4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Retrospective Studies
    198 rdf:type schema:DefinedTerm
    199 N55f74e336dcd4dcd9d1ff3fad4cb77e4 rdf:first sg:person.01211667117.10
    200 rdf:rest N92cbbce0a3394f75a028b31e9e194db6
    201 N594143d9ebe24f84ab115e13cf8234da rdf:first sg:person.0636122731.59
    202 rdf:rest N240553e0ddd145fd8970c2724737c082
    203 N596a6ed9c3fa4d46bd563d7a49fbf97b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Cohort Studies
    205 rdf:type schema:DefinedTerm
    206 N5d2596c1bc184e898b2532970b5c947b rdf:first sg:person.01005111636.47
    207 rdf:rest N7b8fedacde9f42b3afdeeaefde62b511
    208 N66abd863192a4b0485dd912c8d263207 rdf:first sg:person.01115205001.21
    209 rdf:rest N5d2596c1bc184e898b2532970b5c947b
    210 N698651be277c4e0f8b8f65e016fa1d02 rdf:first sg:person.01152765352.19
    211 rdf:rest N81f953736b584b5a867d7d4582edff54
    212 N7106c30b2124470c823ad00f83d2e835 rdf:first sg:person.01331765645.35
    213 rdf:rest N548097db8f2f4a39b63cade01798f480
    214 N72ffcb4a36664f819ad0795edc59971f rdf:first sg:person.01066142337.60
    215 rdf:rest N55f74e336dcd4dcd9d1ff3fad4cb77e4
    216 N76bc1a6df52f44d5a189cac6f9c84263 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name Humans
    218 rdf:type schema:DefinedTerm
    219 N78d2a8a219ca4c1dacde988b9cc2f5d5 rdf:first sg:person.0711456336.53
    220 rdf:rest N06cde11daac74bf98ea8dcb1f82c7047
    221 N7b8fedacde9f42b3afdeeaefde62b511 rdf:first sg:person.01110343356.39
    222 rdf:rest rdf:nil
    223 N7c668a9aedcc4487a6914f1c0d0e8fca rdf:first N0deb3abf55a843bcb1e03c0bb8cd9eab
    224 rdf:rest Nc4406d472690411bb33a3c697c59d9f3
    225 N8160ce84092a4295b65a8564fd9eba9e rdf:first sg:person.01036166574.42
    226 rdf:rest Nac7c1e4c711d414da43d34e3a2829e18
    227 N81f953736b584b5a867d7d4582edff54 rdf:first sg:person.0617260043.47
    228 rdf:rest N594143d9ebe24f84ab115e13cf8234da
    229 N82649215a55d48c2b6bf646faf7b695f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    230 schema:name Subarachnoid Hemorrhage
    231 rdf:type schema:DefinedTerm
    232 N87f836cd47f04134ac0e0b2590abf3b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    233 schema:name Prevalence
    234 rdf:type schema:DefinedTerm
    235 N8ef3731277a24299a52332ca3d2e0590 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    236 schema:name Female
    237 rdf:type schema:DefinedTerm
    238 N92cbbce0a3394f75a028b31e9e194db6 rdf:first sg:person.0756503311.81
    239 rdf:rest N698651be277c4e0f8b8f65e016fa1d02
    240 N9738ae04576c43c295730247dab2ed4c schema:name doi
    241 schema:value 10.1186/s13054-018-2089-7
    242 rdf:type schema:PropertyValue
    243 N9a4fcb2173a446baa3beae7800e8ec83 rdf:first sg:person.01253006352.94
    244 rdf:rest N72ffcb4a36664f819ad0795edc59971f
    245 Nac7c1e4c711d414da43d34e3a2829e18 rdf:first sg:person.01033165762.06
    246 rdf:rest N9a4fcb2173a446baa3beae7800e8ec83
    247 Nb0c9078909ae45379491b725a51e6994 schema:name dimensions_id
    248 schema:value pub.1105305007
    249 rdf:type schema:PropertyValue
    250 Nc003a4d0e75d4e6985d65279faa1948a schema:affiliation grid-institutes:grid.23856.3a
    251 schema:familyName Carignan
    252 schema:givenName Raphaëlle
    253 rdf:type schema:Person
    254 Nc029de2ec2354887b78caaf6b6f9d760 schema:volumeNumber 22
    255 rdf:type schema:PublicationVolume
    256 Nc1d1b0042ca9492f8af1b69809c2df0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    257 schema:name Middle Aged
    258 rdf:type schema:DefinedTerm
    259 Nc4406d472690411bb33a3c697c59d9f3 rdf:first Nc003a4d0e75d4e6985d65279faa1948a
    260 rdf:rest N0b2d00f231914ca29d9b78f779c71828
    261 Nc8fdef84705d4f5798f66ff6dea983b6 schema:affiliation grid-institutes:grid.25152.31
    262 schema:familyName Dhaliwal
    263 schema:givenName Andy
    264 rdf:type schema:Person
    265 Nd04bea57535b402dae463e0313531b7d schema:name Springer Nature - SN SciGraph project
    266 rdf:type schema:Organization
    267 Nd25ba76d9a59470f83bb4b7f96003392 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    268 schema:name Risk Factors
    269 rdf:type schema:DefinedTerm
    270 Neaa83b1e05b045dfb9315596af19fd0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    271 schema:name Male
    272 rdf:type schema:DefinedTerm
    273 Ned5c404b9fb741eebd77de6282289e35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    274 schema:name Erythrocyte Transfusion
    275 rdf:type schema:DefinedTerm
    276 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    277 schema:name Medical and Health Sciences
    278 rdf:type schema:DefinedTerm
    279 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    280 schema:name Cardiorespiratory Medicine and Haematology
    281 rdf:type schema:DefinedTerm
    282 sg:journal.1117766 schema:issn 1364-8535
    283 1466-609X
    284 schema:name Critical Care
    285 schema:publisher Springer Nature
    286 rdf:type schema:Periodical
    287 sg:person.01005111636.47 schema:familyName McCredie
    288 schema:givenName V.
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005111636.47
    290 rdf:type schema:Person
    291 sg:person.01006113265.10 schema:affiliation grid-institutes:grid.23856.3a
    292 schema:familyName Boutin
    293 schema:givenName Amélie
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006113265.10
    295 rdf:type schema:Person
    296 sg:person.01033165762.06 schema:affiliation grid-institutes:grid.14848.31
    297 schema:familyName Chassé
    298 schema:givenName Michaël
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033165762.06
    300 rdf:type schema:Person
    301 sg:person.01036166574.42 schema:affiliation grid-institutes:grid.412687.e
    302 schema:familyName English
    303 schema:givenName Shane W.
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036166574.42
    305 rdf:type schema:Person
    306 sg:person.01066142337.60 schema:affiliation grid-institutes:grid.23856.3a
    307 schema:familyName Lauzier
    308 schema:givenName François
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066142337.60
    310 rdf:type schema:Person
    311 sg:person.01110343356.39 schema:familyName Scales
    312 schema:givenName D.
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110343356.39
    314 rdf:type schema:Person
    315 sg:person.01115205001.21 schema:affiliation grid-institutes:grid.412687.e
    316 schema:familyName McIntyre
    317 schema:givenName Lauralyn
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115205001.21
    319 rdf:type schema:Person
    320 sg:person.01120313137.85 schema:affiliation grid-institutes:grid.412687.e
    321 schema:familyName Montroy
    322 schema:givenName Kaitlyn
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120313137.85
    324 rdf:type schema:Person
    325 sg:person.01152765352.19 schema:affiliation grid-institutes:grid.412687.e
    326 schema:familyName Fergusson
    327 schema:givenName Dean
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152765352.19
    329 rdf:type schema:Person
    330 sg:person.01204673152.64 schema:affiliation grid-institutes:grid.412687.e
    331 schema:familyName Tinmouth
    332 schema:givenName Alan
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204673152.64
    334 rdf:type schema:Person
    335 sg:person.01211667117.10 schema:affiliation grid-institutes:grid.17091.3e
    336 schema:familyName Griesdale
    337 schema:givenName Donald
    338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211667117.10
    339 rdf:type schema:Person
    340 sg:person.01253006352.94 schema:affiliation grid-institutes:grid.23856.3a
    341 schema:familyName Turgeon
    342 schema:givenName Alexis F.
    343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253006352.94
    344 rdf:type schema:Person
    345 sg:person.01331765645.35 schema:affiliation grid-institutes:grid.28046.38
    346 schema:familyName Sinclair
    347 schema:givenName John
    348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331765645.35
    349 rdf:type schema:Person
    350 sg:person.01371774231.85 schema:affiliation grid-institutes:grid.21613.37
    351 schema:familyName Ziegler
    352 schema:givenName Jennifer
    353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371774231.85
    354 rdf:type schema:Person
    355 sg:person.0617260043.47 schema:affiliation grid-institutes:grid.21613.37
    356 schema:familyName Zarychanski
    357 schema:givenName Ryan
    358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617260043.47
    359 rdf:type schema:Person
    360 sg:person.0636122731.59 schema:affiliation grid-institutes:grid.28046.38
    361 schema:familyName van Walraven
    362 schema:givenName Carl
    363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636122731.59
    364 rdf:type schema:Person
    365 sg:person.0657754474.04 schema:affiliation grid-institutes:grid.412687.e
    366 schema:familyName Mallick
    367 schema:givenName Ranjeeta
    368 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657754474.04
    369 rdf:type schema:Person
    370 sg:person.0711456336.53 schema:affiliation grid-institutes:grid.28046.38
    371 schema:familyName Pagliarello
    372 schema:givenName Giuseppe
    373 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711456336.53
    374 rdf:type schema:Person
    375 sg:person.0756503311.81 schema:affiliation grid-institutes:grid.21613.37
    376 schema:familyName Garland
    377 schema:givenName Allan
    378 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756503311.81
    379 rdf:type schema:Person
    380 sg:pub.10.1007/s12028-008-9171-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1017503501
    381 https://doi.org/10.1007/s12028-008-9171-y
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1007/s12028-009-9273-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031821288
    384 https://doi.org/10.1007/s12028-009-9273-1
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1007/s12028-010-9424-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051098664
    387 https://doi.org/10.1007/s12028-010-9424-4
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1007/s12028-011-9582-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1034711250
    390 https://doi.org/10.1007/s12028-011-9582-z
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1007/s12028-011-9605-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046372375
    393 https://doi.org/10.1007/s12028-011-9605-9
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1007/s12028-012-9772-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050479392
    396 https://doi.org/10.1007/s12028-012-9772-3
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1007/s12028-012-9777-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1032140750
    399 https://doi.org/10.1007/s12028-012-9777-y
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1007/s12028-013-9819-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032656755
    402 https://doi.org/10.1007/s12028-013-9819-0
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1186/cc7264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030802551
    405 https://doi.org/10.1186/cc7264
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1186/cc8886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017673304
    408 https://doi.org/10.1186/cc8886
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1186/cc9977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032796563
    411 https://doi.org/10.1186/cc9977
    412 rdf:type schema:CreativeWork
    413 grid-institutes:grid.14848.31 schema:alternateName Department of Medicine, University of Montreal, Montreal, QC Canada
    414 schema:name Department of Medicine, University of Montreal, Montreal, QC Canada
    415 rdf:type schema:Organization
    416 grid-institutes:grid.17091.3e schema:alternateName Deparment of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC Canada
    417 schema:name Deparment of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC Canada
    418 rdf:type schema:Organization
    419 grid-institutes:grid.21613.37 schema:alternateName Department of Medicine, University of Manitoba, Winnipeg, MB Canada
    420 schema:name Department of Medicine, University of Manitoba, Winnipeg, MB Canada
    421 rdf:type schema:Organization
    422 grid-institutes:grid.23856.3a schema:alternateName Department of Anesthesiology & Critical Care, Université Laval, Quebec City, QC Canada
    423 Department of Medicine, Université Laval, Quebec City, QC Canada
    424 Department of Social and Preventive Medicine, Université Laval, Quebec City, QC Canada
    425 schema:name Department of Anesthesiology & Critical Care, Université Laval, Quebec City, QC Canada
    426 Department of Medicine, Université Laval, Quebec City, QC Canada
    427 Department of Social and Preventive Medicine, Université Laval, Quebec City, QC Canada
    428 rdf:type schema:Organization
    429 grid-institutes:grid.25152.31 schema:alternateName Department of Medicine, University of Saskatchewan, Regina, SK Canada
    430 schema:name Department of Medicine, University of Saskatchewan, Regina, SK Canada
    431 rdf:type schema:Organization
    432 grid-institutes:grid.28046.38 schema:alternateName Department of Medicine, University of Ottawa, Ottawa, ON Canada
    433 Department of Surgery (Neurosurgery), University of Ottawa, Ottawa, ON Canada
    434 Department of Surgery, University of Ottawa, Ottawa, ON Canada
    435 schema:name Department of Medicine, University of Ottawa, Ottawa, ON Canada
    436 Department of Surgery (Neurosurgery), University of Ottawa, Ottawa, ON Canada
    437 Department of Surgery, University of Ottawa, Ottawa, ON Canada
    438 rdf:type schema:Organization
    439 grid-institutes:grid.412687.e schema:alternateName Clinical Epidemiology Program (Centre for Transfusion Research), Ottawa Hospital Research Institute, Ottawa, ON Canada
    440 schema:name Clinical Epidemiology Program (Centre for Transfusion Research), Ottawa Hospital Research Institute, Ottawa, ON Canada
    441 Department of Medicine (Critical Care), The Ottawa Hospital, Civic Campus Room F202, 1053 Carling Avenue, Ottawa, ON K1Y 4E9 Canada
    442 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...