Gut–kidney crosstalk in septic acute kidney injury View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Jingxiao Zhang, Ghada Ankawi, Jian Sun, Kumar Digvijay, Yongjie Yin, Mitchell H. Rosner, Claudio Ronco

ABSTRACT

Sepsis is the leading cause of acute kidney injury (AKI) in the intensive care unit (ICU). Septic AKI is a complex and multifactorial process that is incompletely understood. During sepsis, the disruption of the mucus membrane barrier, a shift in intestinal microbial flora, and microbial translocation may lead to systemic inflammation, which further alters host immune and metabolic homeostasis. This altered homeostasis may promote and potentiate the development of AKI. As part of this vicious cycle, when AKI develops, the clearance of inflammatory mediators and metabolic products is decreased. This will lead to further gut injury and breakdown in mucous membrane barriers. Thus, changes in the gut during sepsis can initiate and propagate septic AKI. This deleterious gut-kidney crosstalk may be a potential target for therapeutic maneuvers. This review analyses the underlying mechanisms in gut-kidney crosstalk in septic AKI. More... »

PAGES

117

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13054-018-2040-y

    DOI

    http://dx.doi.org/10.1186/s13054-018-2040-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103786381

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29724256


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