Simvastatin for patients with acute respiratory distress syndrome: long-term outcomes and cost-effectiveness from a randomised controlled trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-05-17

AUTHORS

A. Agus, C. Hulme, R. M. Verghis, C. McDowell, C. Jackson, C. M. O’Kane, J. G. Laffey, D. F. McAuley

ABSTRACT

BackgroundSimvastatin therapy for patients with acute respiratory distress syndrome (ARDS) has been shown to be safe and associated with minimal adverse effects, but it does not improve clinical outcomes. The aim of this research was to report on mortality and cost-effectiveness of simvastatin in patients with ARDS at 12 months.MethodsThis was a cost-utility analysis alongside a multicentre, double-blind, randomised controlled trial carried out in the UK and Ireland. Five hundred and forty intubated and mechanically ventilated patients with ARDS were randomly assigned (1:1) to receive once-daily simvastatin (at a dose of 80 mg) or identical placebo tablets enterally for up to 28 days.ResultsMortality was lower in the simvastatin group (31.8%, 95% confidence interval (CI) 26.1–37.5) compared to the placebo group (37.3%, 95% CI 31.6–43.0) at 12 months, although this was not significant. Simvastatin was associated with statistically significant quality-adjusted life year (QALY) gain (incremental QALYs 0.064, 95% CI 0.002–0.127) compared to placebo. Simvastatin was also less costly (incremental total costs –£3601, 95% CI –8061 to 859). At a willingness-to-pay threshold of £20,000 per QALY, the probability of simvastatin being cost-effective was 99%. Sensitivity analyses indicated that the results were robust to changes in methodological assumptions with the probability of cost-effectiveness never dropping below 90%.ConclusionSimvastatin was found to be cost-effective for the treatment of ARDS, being associated with both a significant QALY gain and a cost saving. There was no significant reduction in mortality at 12 months,Trial registrationISRCTN, 88244364. Registered 26 November 2010. More... »

PAGES

108

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13054-017-1695-0

DOI

http://dx.doi.org/10.1186/s13054-017-1695-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085379594

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28511660


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cost-Benefit Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quality-Adjusted Life Years", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory Distress Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Simvastatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "State Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Northern Ireland Clinical Trials Unit, Elliot Dynes Building, The Royal Hospitals, Grosvenor Road, BT12 6BA, Belfast, UK", 
          "id": "http://www.grid.ac/institutes/grid.454053.3", 
          "name": [
            "Northern Ireland Clinical Trials Unit, Elliot Dynes Building, The Royal Hospitals, Grosvenor Road, BT12 6BA, Belfast, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Agus", 
        "givenName": "A.", 
        "id": "sg:person.010237457221.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010237457221.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academic Unit of Health Economics, University of Leeds, Charles Thackrah Building, Clarendon Road, LS2 9LJ, Leeds, UK", 
          "id": "http://www.grid.ac/institutes/grid.9909.9", 
          "name": [
            "Academic Unit of Health Economics, University of Leeds, Charles Thackrah Building, Clarendon Road, LS2 9LJ, Leeds, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hulme", 
        "givenName": "C.", 
        "id": "sg:person.01234300200.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234300200.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Infection and Immunity, Queen\u2019s University of Belfast, BT9 7AE, Belfast, UK", 
          "id": "http://www.grid.ac/institutes/grid.4777.3", 
          "name": [
            "Northern Ireland Clinical Trials Unit, Elliot Dynes Building, The Royal Hospitals, Grosvenor Road, BT12 6BA, Belfast, UK", 
            "Centre for Infection and Immunity, Queen\u2019s University of Belfast, BT9 7AE, Belfast, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verghis", 
        "givenName": "R. M.", 
        "id": "sg:person.0746152022.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746152022.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northern Ireland Clinical Trials Unit, Elliot Dynes Building, The Royal Hospitals, Grosvenor Road, BT12 6BA, Belfast, UK", 
          "id": "http://www.grid.ac/institutes/grid.454053.3", 
          "name": [
            "Northern Ireland Clinical Trials Unit, Elliot Dynes Building, The Royal Hospitals, Grosvenor Road, BT12 6BA, Belfast, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McDowell", 
        "givenName": "C.", 
        "id": "sg:person.01054064260.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054064260.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northern Ireland Clinical Trials Unit, Elliot Dynes Building, The Royal Hospitals, Grosvenor Road, BT12 6BA, Belfast, UK", 
          "id": "http://www.grid.ac/institutes/grid.454053.3", 
          "name": [
            "Northern Ireland Clinical Trials Unit, Elliot Dynes Building, The Royal Hospitals, Grosvenor Road, BT12 6BA, Belfast, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jackson", 
        "givenName": "C.", 
        "id": "sg:person.014066005357.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014066005357.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Infection and Immunity, Queen\u2019s University of Belfast, BT9 7AE, Belfast, UK", 
          "id": "http://www.grid.ac/institutes/grid.4777.3", 
          "name": [
            "Centre for Infection and Immunity, Queen\u2019s University of Belfast, BT9 7AE, Belfast, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Kane", 
        "givenName": "C. M.", 
        "id": "sg:person.0706061252.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706061252.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anesthesia, Centre for Critical Care Research, Keenan Research Centre for Biomedical Science, St. Michael\u2019s Hospital, University of Toronto, Toronto, Canada", 
          "id": "http://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Anaesthesia, School of Medicine, HRB Galway Clinical Research Facility, Clinical Sciences Institute, National University of Ireland, Galway, Ireland", 
            "Department of Anesthesia, Centre for Critical Care Research, Keenan Research Centre for Biomedical Science, St. Michael\u2019s Hospital, University of Toronto, Toronto, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laffey", 
        "givenName": "J. G.", 
        "id": "sg:person.01354366050.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354366050.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Regional Intensive Care Unit, The Royal Hospitals, Grosvenor Road, BT12 6BA, Belfast, UK", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Northern Ireland Clinical Trials Unit, Elliot Dynes Building, The Royal Hospitals, Grosvenor Road, BT12 6BA, Belfast, UK", 
            "Centre for Infection and Immunity, Queen\u2019s University of Belfast, BT9 7AE, Belfast, UK", 
            "Regional Intensive Care Unit, The Royal Hospitals, Grosvenor Road, BT12 6BA, Belfast, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McAuley", 
        "givenName": "D. F.", 
        "id": "sg:person.013052706317.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013052706317.18"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00134-003-2022-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030320231", 
          "https://doi.org/10.1007/s00134-003-2022-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1745-6215-13-170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053650185", 
          "https://doi.org/10.1186/1745-6215-13-170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-006-0217-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045730573", 
          "https://doi.org/10.1007/s00134-006-0217-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-006-0080-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050889788", 
          "https://doi.org/10.1007/s00134-006-0080-2"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-05-17", 
    "datePublishedReg": "2017-05-17", 
    "description": "BackgroundSimvastatin therapy for patients with acute respiratory distress syndrome (ARDS) has been shown to be safe and associated with minimal adverse effects, but it does not improve clinical outcomes. The aim of this research was to report on mortality and cost-effectiveness of simvastatin in patients with ARDS at 12\u00a0months.MethodsThis was a cost-utility analysis alongside a multicentre, double-blind, randomised controlled trial carried out in the UK and Ireland. Five hundred and forty intubated and mechanically ventilated patients with ARDS were randomly assigned (1:1) to receive once-daily simvastatin (at a dose of 80\u00a0mg) or identical placebo tablets enterally for up to 28\u00a0days.ResultsMortality was lower in the simvastatin group (31.8%, 95% confidence interval (CI) 26.1\u201337.5) compared to the placebo group (37.3%, 95% CI 31.6\u201343.0) at 12\u00a0months, although this was not significant. Simvastatin was associated with statistically significant quality-adjusted life year (QALY) gain (incremental QALYs 0.064, 95% CI 0.002\u20130.127) compared to placebo. Simvastatin was also less costly (incremental total costs \u2013\u00a33601, 95% CI \u20138061 to 859). At a willingness-to-pay threshold of \u00a320,000 per QALY, the probability of simvastatin being cost-effective was 99%. Sensitivity analyses indicated that the results were robust to changes in methodological assumptions with the probability of cost-effectiveness never dropping below 90%.ConclusionSimvastatin was found to be cost-effective for the treatment of ARDS, being associated with both a significant QALY gain and a cost saving. There was no significant reduction in mortality at 12\u00a0months,Trial registrationISRCTN, 88244364. Registered 26 November 2010.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s13054-017-1695-0", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2784459", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.9042871", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.9712273", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1117766", 
        "issn": [
          "1364-8535", 
          "1466-609X"
        ], 
        "name": "Critical Care", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "keywords": [
      "acute respiratory distress syndrome", 
      "respiratory distress syndrome", 
      "distress syndrome", 
      "treatment of ARDS", 
      "quality-adjusted life-year gains", 
      "identical placebo tablets", 
      "significant QALY gains", 
      "long-term outcomes", 
      "life-year gains", 
      "minimal adverse effects", 
      "cost-utility analysis", 
      "daily simvastatin", 
      "placebo group", 
      "simvastatin group", 
      "clinical outcomes", 
      "placebo tablets", 
      "patients", 
      "QALY gain", 
      "simvastatin", 
      "adverse effects", 
      "months", 
      "syndrome", 
      "year gains", 
      "significant reduction", 
      "mortality", 
      "trials", 
      "outcomes", 
      "multicentre", 
      "placebo", 
      "MethodsThis", 
      "ResultsMortality", 
      "group", 
      "cost savings", 
      "therapy", 
      "QALY", 
      "treatment", 
      "days", 
      "aim", 
      "tablets", 
      "sensitivity analysis", 
      "gain", 
      "reduction", 
      "effect", 
      "analysis", 
      "changes", 
      "UK", 
      "threshold", 
      "willingness", 
      "probability", 
      "results", 
      "Ireland", 
      "research", 
      "savings", 
      "assumption", 
      "methodological assumptions"
    ], 
    "name": "Simvastatin for patients with acute respiratory distress syndrome: long-term outcomes and cost-effectiveness from a randomised controlled trial", 
    "pagination": "108", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1085379594"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13054-017-1695-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28511660"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13054-017-1695-0", 
      "https://app.dimensions.ai/details/publication/pub.1085379594"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_752.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s13054-017-1695-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13054-017-1695-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13054-017-1695-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13054-017-1695-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13054-017-1695-0'


 

This table displays all metadata directly associated to this object as RDF triples.

255 TRIPLES      21 PREDICATES      97 URIs      85 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13054-017-1695-0 schema:about N06e6244db8a04e26a7993078dcaa1e61
2 N22a43e6c3dc24e50b0858771b092d48e
3 N415621015b1a4a9d9fc881aedb64a3f4
4 N653c5335645e435aafc1a69066a37c8a
5 N90efb35850a34f22817cd84efc2bfe7a
6 N91977af085f24d2a81642041e963cbb0
7 Nb2c3e72896cd4e3392eb51ff1dcbec67
8 Nb47ab39e2ae646edb1bd947e5b5ec23d
9 Nbb55737e4164495aaf545afb20fa9be8
10 Nd0a35d586f624c8e8935c22080c5fb03
11 Ne12fc9950d5f4e2da8fcd505e4e27f15
12 Ne3523e44cb52499394accb335c0a4593
13 Nfacbff61e3a248d5ac3ec38036c42f40
14 anzsrc-for:11
15 anzsrc-for:1103
16 schema:author Nef752ba2bb81470e880c5316a74786bb
17 schema:citation sg:pub.10.1007/s00134-003-2022-6
18 sg:pub.10.1007/s00134-006-0080-2
19 sg:pub.10.1007/s00134-006-0217-3
20 sg:pub.10.1186/1745-6215-13-170
21 schema:datePublished 2017-05-17
22 schema:datePublishedReg 2017-05-17
23 schema:description BackgroundSimvastatin therapy for patients with acute respiratory distress syndrome (ARDS) has been shown to be safe and associated with minimal adverse effects, but it does not improve clinical outcomes. The aim of this research was to report on mortality and cost-effectiveness of simvastatin in patients with ARDS at 12 months.MethodsThis was a cost-utility analysis alongside a multicentre, double-blind, randomised controlled trial carried out in the UK and Ireland. Five hundred and forty intubated and mechanically ventilated patients with ARDS were randomly assigned (1:1) to receive once-daily simvastatin (at a dose of 80 mg) or identical placebo tablets enterally for up to 28 days.ResultsMortality was lower in the simvastatin group (31.8%, 95% confidence interval (CI) 26.1–37.5) compared to the placebo group (37.3%, 95% CI 31.6–43.0) at 12 months, although this was not significant. Simvastatin was associated with statistically significant quality-adjusted life year (QALY) gain (incremental QALYs 0.064, 95% CI 0.002–0.127) compared to placebo. Simvastatin was also less costly (incremental total costs –£3601, 95% CI –8061 to 859). At a willingness-to-pay threshold of £20,000 per QALY, the probability of simvastatin being cost-effective was 99%. Sensitivity analyses indicated that the results were robust to changes in methodological assumptions with the probability of cost-effectiveness never dropping below 90%.ConclusionSimvastatin was found to be cost-effective for the treatment of ARDS, being associated with both a significant QALY gain and a cost saving. There was no significant reduction in mortality at 12 months,Trial registrationISRCTN, 88244364. Registered 26 November 2010.
24 schema:genre article
25 schema:isAccessibleForFree true
26 schema:isPartOf N8d2edfde6fc2401484e25552cbe2d998
27 N9536c66390584d4aaf641642636cac1b
28 sg:journal.1117766
29 schema:keywords Ireland
30 MethodsThis
31 QALY
32 QALY gain
33 ResultsMortality
34 UK
35 acute respiratory distress syndrome
36 adverse effects
37 aim
38 analysis
39 assumption
40 changes
41 clinical outcomes
42 cost savings
43 cost-utility analysis
44 daily simvastatin
45 days
46 distress syndrome
47 effect
48 gain
49 group
50 identical placebo tablets
51 life-year gains
52 long-term outcomes
53 methodological assumptions
54 minimal adverse effects
55 months
56 mortality
57 multicentre
58 outcomes
59 patients
60 placebo
61 placebo group
62 placebo tablets
63 probability
64 quality-adjusted life-year gains
65 reduction
66 research
67 respiratory distress syndrome
68 results
69 savings
70 sensitivity analysis
71 significant QALY gains
72 significant reduction
73 simvastatin
74 simvastatin group
75 syndrome
76 tablets
77 therapy
78 threshold
79 treatment
80 treatment of ARDS
81 trials
82 willingness
83 year gains
84 schema:name Simvastatin for patients with acute respiratory distress syndrome: long-term outcomes and cost-effectiveness from a randomised controlled trial
85 schema:pagination 108
86 schema:productId N14be03f6b78041bf966359634715fb10
87 N2a457547066d46deade16cf7589a0c32
88 Nd034b7169a6f416cbe488c0cc1b38a13
89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085379594
90 https://doi.org/10.1186/s13054-017-1695-0
91 schema:sdDatePublished 2022-12-01T06:37
92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
93 schema:sdPublisher N4001acb7161243e8b8a7a9c001ad607d
94 schema:url https://doi.org/10.1186/s13054-017-1695-0
95 sgo:license sg:explorer/license/
96 sgo:sdDataset articles
97 rdf:type schema:ScholarlyArticle
98 N06e6244db8a04e26a7993078dcaa1e61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Middle Aged
100 rdf:type schema:DefinedTerm
101 N0712615a575d4716834c65336216c773 rdf:first sg:person.014066005357.42
102 rdf:rest Nff447192a3584a31bcd9c33bfe18260e
103 N082b035b0c2b4277bd69c09e7a8f688b rdf:first sg:person.01234300200.37
104 rdf:rest Nf0e7194b6b69428da8f2fbfae3b65148
105 N0ef9e7182c0b460d9fbd8d1302950ae2 rdf:first sg:person.01354366050.28
106 rdf:rest Nda57ed1b291b41fda0dad5621c579ffd
107 N14be03f6b78041bf966359634715fb10 schema:name doi
108 schema:value 10.1186/s13054-017-1695-0
109 rdf:type schema:PropertyValue
110 N22a43e6c3dc24e50b0858771b092d48e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Aged
112 rdf:type schema:DefinedTerm
113 N2a457547066d46deade16cf7589a0c32 schema:name pubmed_id
114 schema:value 28511660
115 rdf:type schema:PropertyValue
116 N4001acb7161243e8b8a7a9c001ad607d schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 N415621015b1a4a9d9fc881aedb64a3f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Time
120 rdf:type schema:DefinedTerm
121 N653c5335645e435aafc1a69066a37c8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Cost-Benefit Analysis
123 rdf:type schema:DefinedTerm
124 N8d2edfde6fc2401484e25552cbe2d998 schema:issueNumber 1
125 rdf:type schema:PublicationIssue
126 N90efb35850a34f22817cd84efc2bfe7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Quality-Adjusted Life Years
128 rdf:type schema:DefinedTerm
129 N91977af085f24d2a81642041e963cbb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Respiratory Distress Syndrome
131 rdf:type schema:DefinedTerm
132 N9536c66390584d4aaf641642636cac1b schema:volumeNumber 21
133 rdf:type schema:PublicationVolume
134 Na280a115c6be4a5c97cc85ef94bc27e6 rdf:first sg:person.01054064260.56
135 rdf:rest N0712615a575d4716834c65336216c773
136 Nb2c3e72896cd4e3392eb51ff1dcbec67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Male
138 rdf:type schema:DefinedTerm
139 Nb47ab39e2ae646edb1bd947e5b5ec23d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Humans
141 rdf:type schema:DefinedTerm
142 Nbb55737e4164495aaf545afb20fa9be8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Double-Blind Method
144 rdf:type schema:DefinedTerm
145 Nd034b7169a6f416cbe488c0cc1b38a13 schema:name dimensions_id
146 schema:value pub.1085379594
147 rdf:type schema:PropertyValue
148 Nd0a35d586f624c8e8935c22080c5fb03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name State Medicine
150 rdf:type schema:DefinedTerm
151 Nda57ed1b291b41fda0dad5621c579ffd rdf:first sg:person.013052706317.18
152 rdf:rest rdf:nil
153 Ne12fc9950d5f4e2da8fcd505e4e27f15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Female
155 rdf:type schema:DefinedTerm
156 Ne3523e44cb52499394accb335c0a4593 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Simvastatin
158 rdf:type schema:DefinedTerm
159 Nef752ba2bb81470e880c5316a74786bb rdf:first sg:person.010237457221.38
160 rdf:rest N082b035b0c2b4277bd69c09e7a8f688b
161 Nf0e7194b6b69428da8f2fbfae3b65148 rdf:first sg:person.0746152022.63
162 rdf:rest Na280a115c6be4a5c97cc85ef94bc27e6
163 Nfacbff61e3a248d5ac3ec38036c42f40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Adult
165 rdf:type schema:DefinedTerm
166 Nff447192a3584a31bcd9c33bfe18260e rdf:first sg:person.0706061252.72
167 rdf:rest N0ef9e7182c0b460d9fbd8d1302950ae2
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
172 schema:name Clinical Sciences
173 rdf:type schema:DefinedTerm
174 sg:grant.2784459 http://pending.schema.org/fundedItem sg:pub.10.1186/s13054-017-1695-0
175 rdf:type schema:MonetaryGrant
176 sg:grant.9042871 http://pending.schema.org/fundedItem sg:pub.10.1186/s13054-017-1695-0
177 rdf:type schema:MonetaryGrant
178 sg:grant.9712273 http://pending.schema.org/fundedItem sg:pub.10.1186/s13054-017-1695-0
179 rdf:type schema:MonetaryGrant
180 sg:journal.1117766 schema:issn 1364-8535
181 1466-609X
182 schema:name Critical Care
183 schema:publisher Springer Nature
184 rdf:type schema:Periodical
185 sg:person.010237457221.38 schema:affiliation grid-institutes:grid.454053.3
186 schema:familyName Agus
187 schema:givenName A.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010237457221.38
189 rdf:type schema:Person
190 sg:person.01054064260.56 schema:affiliation grid-institutes:grid.454053.3
191 schema:familyName McDowell
192 schema:givenName C.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054064260.56
194 rdf:type schema:Person
195 sg:person.01234300200.37 schema:affiliation grid-institutes:grid.9909.9
196 schema:familyName Hulme
197 schema:givenName C.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234300200.37
199 rdf:type schema:Person
200 sg:person.013052706317.18 schema:affiliation grid-institutes:None
201 schema:familyName McAuley
202 schema:givenName D. F.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013052706317.18
204 rdf:type schema:Person
205 sg:person.01354366050.28 schema:affiliation grid-institutes:grid.17063.33
206 schema:familyName Laffey
207 schema:givenName J. G.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354366050.28
209 rdf:type schema:Person
210 sg:person.014066005357.42 schema:affiliation grid-institutes:grid.454053.3
211 schema:familyName Jackson
212 schema:givenName C.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014066005357.42
214 rdf:type schema:Person
215 sg:person.0706061252.72 schema:affiliation grid-institutes:grid.4777.3
216 schema:familyName O’Kane
217 schema:givenName C. M.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706061252.72
219 rdf:type schema:Person
220 sg:person.0746152022.63 schema:affiliation grid-institutes:grid.4777.3
221 schema:familyName Verghis
222 schema:givenName R. M.
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746152022.63
224 rdf:type schema:Person
225 sg:pub.10.1007/s00134-003-2022-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030320231
226 https://doi.org/10.1007/s00134-003-2022-6
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/s00134-006-0080-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050889788
229 https://doi.org/10.1007/s00134-006-0080-2
230 rdf:type schema:CreativeWork
231 sg:pub.10.1007/s00134-006-0217-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045730573
232 https://doi.org/10.1007/s00134-006-0217-3
233 rdf:type schema:CreativeWork
234 sg:pub.10.1186/1745-6215-13-170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053650185
235 https://doi.org/10.1186/1745-6215-13-170
236 rdf:type schema:CreativeWork
237 grid-institutes:None schema:alternateName Regional Intensive Care Unit, The Royal Hospitals, Grosvenor Road, BT12 6BA, Belfast, UK
238 schema:name Centre for Infection and Immunity, Queen’s University of Belfast, BT9 7AE, Belfast, UK
239 Northern Ireland Clinical Trials Unit, Elliot Dynes Building, The Royal Hospitals, Grosvenor Road, BT12 6BA, Belfast, UK
240 Regional Intensive Care Unit, The Royal Hospitals, Grosvenor Road, BT12 6BA, Belfast, UK
241 rdf:type schema:Organization
242 grid-institutes:grid.17063.33 schema:alternateName Department of Anesthesia, Centre for Critical Care Research, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, University of Toronto, Toronto, Canada
243 schema:name Department of Anaesthesia, School of Medicine, HRB Galway Clinical Research Facility, Clinical Sciences Institute, National University of Ireland, Galway, Ireland
244 Department of Anesthesia, Centre for Critical Care Research, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, University of Toronto, Toronto, Canada
245 rdf:type schema:Organization
246 grid-institutes:grid.454053.3 schema:alternateName Northern Ireland Clinical Trials Unit, Elliot Dynes Building, The Royal Hospitals, Grosvenor Road, BT12 6BA, Belfast, UK
247 schema:name Northern Ireland Clinical Trials Unit, Elliot Dynes Building, The Royal Hospitals, Grosvenor Road, BT12 6BA, Belfast, UK
248 rdf:type schema:Organization
249 grid-institutes:grid.4777.3 schema:alternateName Centre for Infection and Immunity, Queen’s University of Belfast, BT9 7AE, Belfast, UK
250 schema:name Centre for Infection and Immunity, Queen’s University of Belfast, BT9 7AE, Belfast, UK
251 Northern Ireland Clinical Trials Unit, Elliot Dynes Building, The Royal Hospitals, Grosvenor Road, BT12 6BA, Belfast, UK
252 rdf:type schema:Organization
253 grid-institutes:grid.9909.9 schema:alternateName Academic Unit of Health Economics, University of Leeds, Charles Thackrah Building, Clarendon Road, LS2 9LJ, Leeds, UK
254 schema:name Academic Unit of Health Economics, University of Leeds, Charles Thackrah Building, Clarendon Road, LS2 9LJ, Leeds, UK
255 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...