Surrogate endpoints and competing risk of death in cardiac arrest research View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Victoria A. McCredie, Damon C. Scales

ABSTRACT

We urgently need new therapies to improve outcomes after cardiac arrest. Initial studies typically target surrogate endpoints, and these studies help to inform subsequent larger trials that are powered to measure more patient-orientated clinical outcomes such as survival. The competing risk of death and premature assessment of neurological prognosis pose significant challenges to measuring these surrogate endpoints after cardiac arrest. More... »

PAGES

189

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13054-016-1345-y

DOI

http://dx.doi.org/10.1186/s13054-016-1345-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002004966

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27353499


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