Antibiotic strategies in the era of multidrug resistance View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-06-22

AUTHORS

George Karam, Jean Chastre, Mark H. Wilcox, Jean-Louis Vincent

ABSTRACT

The rapid emergence and dissemination of antibiotic-resistant microorganisms in ICUs worldwide threaten adequate antibiotic coverage of infected patients in this environment. The causes of this problem are multifactorial, but the core issues are clear: the emergence of antibiotic resistance is highly correlated with selective pressure resulting from inappropriate use of these drugs. Because a significant increase in mortality is observed when antibiotic therapy is delayed in infected ICU patients, initial therapy should be broad enough to cover all likely pathogens. Receipt of unnecessary prolonged broad-spectrum antibiotics, however, should be avoided. Local microbiologic data are extremely important to predict the type of resistance that may be present for specific causative bacteria, as is prior antibiotic exposure, and antibiotic choices should thus be made at an individual patient level. More... »

PAGES

136

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13054-016-1320-7

DOI

http://dx.doi.org/10.1186/s13054-016-1320-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038854400

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27329228


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