Optimizing sedation in patients with acute brain injury View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Mauro Oddo, Ilaria Alice Crippa, Sangeeta Mehta, David Menon, Jean-Francois Payen, Fabio Silvio Taccone, Giuseppe Citerio

ABSTRACT

Daily interruption of sedative therapy and limitation of deep sedation have been shown in several randomized trials to reduce the duration of mechanical ventilation and hospital length of stay, and to improve the outcome of critically ill patients. However, patients with severe acute brain injury (ABI; including subjects with coma after traumatic brain injury, ischaemic/haemorrhagic stroke, cardiac arrest, status epilepticus) were excluded from these studies. Therefore, whether the new paradigm of minimal sedation can be translated to the neuro-ICU (NICU) is unclear. In patients with ABI, sedation has 'general' indications (control of anxiety, pain, discomfort, agitation, facilitation of mechanical ventilation) and 'neuro-specific' indications (reduction of cerebral metabolic demand, improved brain tolerance to ischaemia). Sedation also is an essential therapeutic component of intracranial pressure therapy, targeted temperature management and seizure control. Given the lack of large trials which have evaluated clinically relevant endpoints, sedative selection depends on the effect of each agent on cerebral and systemic haemodynamics. Titration and withdrawal of sedation in the NICU setting has to be balanced between the risk that interrupting sedation might exacerbate brain injury (e.g. intracranial pressure elevation) and the potential benefits of enhanced neurological function and reduced complications. In this review, we provide a concise summary of cerebral physiologic effects of sedatives and analgesics, the advantages/disadvantages of each agent, the comparative effects of standard sedatives (propofol and midazolam) and the emerging role of alternative drugs (ketamine). We suggest a pragmatic approach for the use of sedation-analgesia in the NICU, focusing on some practical aspects, including optimal titration and management of sedation withdrawal according to ABI severity. More... »

PAGES

128

References to SciGraph publications

  • 2000-12. Randomized placebo‐controlled trial of the activity of the morphine glucuronides in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2009-10. Effects of the Neurological Wake-Up Test on Intracranial Pressure and Cerebral Perfusion Pressure in Brain-Injured Patients in NEUROCRITICAL CARE
  • 2004-08. Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCTN50308308] in CRITICAL CARE
  • 2014-04. Neurological examination of critically ill patients: a pragmatic approach. Report of an ESICM expert panel in INTENSIVE CARE MEDICINE
  • 2012-08. Guidelines for the Evaluation and Management of Status Epilepticus in NEUROCRITICAL CARE
  • 2014-12. Clinical Monitoring Scales in Acute Brain Injury: Assessment of Coma, Pain, Agitation, and Delirium in NEUROCRITICAL CARE
  • 2012-12. Effects of the neurological wake-up test on clinical examination, intracranial pressure, brain metabolism and brain tissue oxygenation in severely brain-injured patients in CRITICAL CARE
  • 2004-04. Changes in Drug Plasma Concentrations of an Extensively Bound and Highly Extracted Drug, Propofol, in Response to Altered Plasma Binding in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2011-08. Sedation Confounds Outcome Prediction in Cardiac Arrest Survivors Treated with Hypothermia in NEUROCRITICAL CARE
  • 2006-02. Propofol for sedation in neuro-intensive care in NEUROCRITICAL CARE
  • 2012-12. Volatile isoflurane sedation in cerebrovascular intensive care patients using AnaConDa®: effects on cerebral oxygenation, circulation, and pressure in INTENSIVE CARE MEDICINE
  • 2014-09. What’s new in status epilepticus? in INTENSIVE CARE MEDICINE
  • 2011-08. Dexmedetomidine Controls Agitation and Facilitates Reliable, Serial Neurological Examinations in a Non-Intubated Patient with Traumatic Brain Injury in NEUROCRITICAL CARE
  • 2004-02. Comparative Tolerability of Sedative Agents in Head-Injured Adults in DRUG SAFETY
  • 2015-02. Moderate-Dose Sedation and Analgesia During Targeted Temperature Management After Cardiac Arrest in NEUROCRITICAL CARE
  • 2002-04. Isoflurane does not further impair microvascular vasomotion in a rat model of subarachnoid hemorrhage in JOURNAL CANADIEN D'ANESTHÉSIE
  • 2003-02. Offset of pharmacodynamic effects and safety of remifentanil in intensive care unit patients with various degrees of renal impairment in CRITICAL CARE
  • 2010-04. A systematic review of the impact of sedation practice in the ICU on resource use, costs and patient safety in CRITICAL CARE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13054-016-1294-5

    DOI

    http://dx.doi.org/10.1186/s13054-016-1294-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010805636

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27145814


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