Advances in antibiotic therapy in the critically ill View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-05-17

AUTHORS

Jean-Louis Vincent, Matteo Bassetti, Bruno François, George Karam, Jean Chastre, Antoni Torres, Jason A. Roberts, Fabio S. Taccone, Jordi Rello, Thierry Calandra, Daniel De Backer, Tobias Welte, Massimo Antonelli

ABSTRACT

Infections occur frequently in critically ill patients and their management can be challenging for various reasons, including delayed diagnosis, difficulties identifying causative microorganisms, and the high prevalence of antibiotic-resistant strains. In this review, we briefly discuss the importance of early infection diagnosis, before considering in more detail some of the key issues related to antibiotic management in these patients, including controversies surrounding use of combination or monotherapy, duration of therapy, and de-escalation. Antibiotic pharmacodynamics and pharmacokinetics, notably volumes of distribution and clearance, can be altered by critical illness and can influence dosing regimens. Dosing decisions in different subgroups of patients, e.g., the obese, are also covered. We also briefly consider ventilator-associated pneumonia and the role of inhaled antibiotics. Finally, we mention antibiotics that are currently being developed and show promise for the future. More... »

PAGES

133

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  • Journal

    TITLE

    Critical Care

    ISSUE

    1

    VOLUME

    20

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13054-016-1285-6

    DOI

    http://dx.doi.org/10.1186/s13054-016-1285-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052958411

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27184564


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