Impact of prolonged assisted ventilation on diaphragmatic efficiency: NAVA versus PSV View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Rosa Di mussi, Savino Spadaro, Lucia Mirabella, Carlo Alberto Volta, Gabriella Serio, Francesco Staffieri, Michele Dambrosio, Gilda Cinnella, Francesco Bruno, Salvatore Grasso

ABSTRACT

BackgroundProlonged controlled mechanical ventilation depresses diaphragmatic efficiency. Assisted modes of ventilation should improve it. We assessed the impact of pressure support ventilation versus neurally adjusted ventilator assist on diaphragmatic efficiency.MethodPatients previously ventilated with controlled mechanical ventilation for 72 hours or more were randomized to be ventilated for 48 hours with pressure support ventilation (n =12) or neurally adjusted ventilatory assist (n = 13). Neuro-ventilatory efficiency (tidal volume/diaphragmatic electrical activity) and neuro-mechanical efficiency (pressure generated against the occluded airways/diaphragmatic electrical activity) were measured during three spontaneous breathing trials (0, 24 and 48 hours). Breathing pattern, diaphragmatic electrical activity and pressure time product of the diaphragm were assessed every 4 hours.ResultsIn patients randomized to neurally adjusted ventilator assist, neuro-ventilatory efficiency increased from 27 ± 19 ml/μV at baseline to 62 ± 30 ml/μV at 48 hours (p <0.0001) and neuro-mechanical efficiency increased from 1 ± 0.6 to 2.6 ± 1.1 cmH2O/μV (p = 0.033). In patients randomized to pressure support ventilation, these did not change. Electrical activity of the diaphragm, neural inspiratory time, pressure time product of the diaphragm and variability of the breathing pattern were significantly higher in patients ventilated with neurally adjusted ventilatory assist. The asynchrony index was 9.48 [6.38– 21.73] in patients ventilated with pressure support ventilation and 5.39 [3.78– 8.36] in patients ventilated with neurally adjusted ventilatory assist (p = 0.04).ConclusionAfter prolonged controlled mechanical ventilation, neurally adjusted ventilator assist improves diaphragm efficiency whereas pressure support ventilation does not.Trial registrationClinicalTrials.gov study registration: NCT0247317, 06/11/2015. More... »

PAGES

1

References to SciGraph publications

  • 2015-02-19. Asynchronies during mechanical ventilation are associated with mortality in INTENSIVE CARE MEDICINE
  • 2012-04-26. Clinical review: Respiratory monitoring in the ICU - a consensus of 16 in CRITICAL CARE
  • 2006-08-01. Patient-ventilator asynchrony during assisted mechanical ventilation in INTENSIVE CARE MEDICINE
  • 2013-06-21. Neurally adjusted ventilatory assist: letting the respiratory center take over control of ventilation in INTENSIVE CARE MEDICINE
  • 2015-08-08. Patient-ventilator synchrony in Neurally Adjusted Ventilatory Assist (NAVA) and Pressure Support Ventilation (PSV): a prospective observational study in BMC ANESTHESIOLOGY
  • 2010-09-25. Neurally adjusted ventilatory assist improves patient–ventilator interaction in INTENSIVE CARE MEDICINE
  • 2008-07-16. Physiologic response to varying levels of pressure support and neurally adjusted ventilatory assist in patients with acute respiratory failure in INTENSIVE CARE MEDICINE
  • 2012-07-31. Neuroventilatory efficiency and extubation readiness in critically ill patients in CRITICAL CARE
  • 2011-03-22. Daily titration of neurally adjusted ventilatory assist using the diaphragm electrical activity in INTENSIVE CARE MEDICINE
  • 2012-06-20. Clinical review: Update on neurally adjusted ventilatory assist - report of a round-table conference in CRITICAL CARE
  • 2015-12-01. Neurally adjusted ventilatory assist and proportional assist ventilation both improve patient-ventilator interaction in CRITICAL CARE
  • 1999-12. Neural control of mechanical ventilation in respiratory failure in NATURE MEDICINE
  • 2009-08-04. Evaluation of the catheter positioning for neurally adjusted ventilatory assist in INTENSIVE CARE MEDICINE
  • 2008-04-24. Reduction of patient-ventilator asynchrony by reducing tidal volume during pressure-support ventilation in INTENSIVE CARE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13054-015-1178-0

    DOI

    http://dx.doi.org/10.1186/s13054-015-1178-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013299842

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26728475


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Physiology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diaphragm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interactive Ventilatory Support", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Positive-Pressure Respiration", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Respiration, Artificial", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ventilator Weaning", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Dipartimento dell\u2019Emergenza e Trapianti d\u2019Organo (DETO), Sezione di Anestesiologia e Rianimazione, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare 11, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Dipartimento dell\u2019Emergenza e Trapianti d\u2019Organo (DETO), Sezione di Anestesiologia e Rianimazione, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare 11, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Di mussi", 
            "givenName": "Rosa", 
            "id": "sg:person.0720267603.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720267603.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Sezione di Anestesiologia e Terapia Intensiva Universitaria, Universit\u00e0 degli studi di Ferrara, Ferrara, Italy", 
              "id": "http://www.grid.ac/institutes/grid.8484.0", 
              "name": [
                "Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Sezione di Anestesiologia e Terapia Intensiva Universitaria, Universit\u00e0 degli studi di Ferrara, Ferrara, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Spadaro", 
            "givenName": "Savino", 
            "id": "sg:person.0707071472.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707071472.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dipartimento di Anestesia e Rianimazione, Universit\u00e0 di Foggia, Foggia, Italy", 
              "id": "http://www.grid.ac/institutes/grid.10796.39", 
              "name": [
                "Dipartimento di Anestesia e Rianimazione, Universit\u00e0 di Foggia, Foggia, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mirabella", 
            "givenName": "Lucia", 
            "id": "sg:person.0650051746.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650051746.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Sezione di Anestesiologia e Terapia Intensiva Universitaria, Universit\u00e0 degli studi di Ferrara, Ferrara, Italy", 
              "id": "http://www.grid.ac/institutes/grid.8484.0", 
              "name": [
                "Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Sezione di Anestesiologia e Terapia Intensiva Universitaria, Universit\u00e0 degli studi di Ferrara, Ferrara, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Volta", 
            "givenName": "Carlo Alberto", 
            "id": "sg:person.0651507322.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651507322.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dipartimento di Scienze Biomediche ed Oncologia Umana, Cattedra di Statistica Medica, Universit\u00e0 degli Studi Aldo Moro, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Dipartimento di Scienze Biomediche ed Oncologia Umana, Cattedra di Statistica Medica, Universit\u00e0 degli Studi Aldo Moro, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Serio", 
            "givenName": "Gabriella", 
            "id": "sg:person.014601246460.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014601246460.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dipartimento dell\u2019Emergenza e Trapianti d\u2019Organo (DETO), Sezione di Chirurgia Veterinaria, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Dipartimento dell\u2019Emergenza e Trapianti d\u2019Organo (DETO), Sezione di Chirurgia Veterinaria, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Staffieri", 
            "givenName": "Francesco", 
            "id": "sg:person.0712453647.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712453647.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dipartimento di Anestesia e Rianimazione, Universit\u00e0 di Foggia, Foggia, Italy", 
              "id": "http://www.grid.ac/institutes/grid.10796.39", 
              "name": [
                "Dipartimento di Anestesia e Rianimazione, Universit\u00e0 di Foggia, Foggia, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dambrosio", 
            "givenName": "Michele", 
            "id": "sg:person.01061714607.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061714607.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dipartimento di Anestesia e Rianimazione, Universit\u00e0 di Foggia, Foggia, Italy", 
              "id": "http://www.grid.ac/institutes/grid.10796.39", 
              "name": [
                "Dipartimento di Anestesia e Rianimazione, Universit\u00e0 di Foggia, Foggia, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cinnella", 
            "givenName": "Gilda", 
            "id": "sg:person.01010335337.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010335337.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dipartimento dell\u2019Emergenza e Trapianti d\u2019Organo (DETO), Sezione di Anestesiologia e Rianimazione, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare 11, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Dipartimento dell\u2019Emergenza e Trapianti d\u2019Organo (DETO), Sezione di Anestesiologia e Rianimazione, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare 11, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bruno", 
            "givenName": "Francesco", 
            "id": "sg:person.01030455645.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030455645.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dipartimento dell\u2019Emergenza e Trapianti d\u2019Organo (DETO), Sezione di Anestesiologia e Rianimazione, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare 11, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Dipartimento dell\u2019Emergenza e Trapianti d\u2019Organo (DETO), Sezione di Anestesiologia e Rianimazione, Universit\u00e0 degli Studi di Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare 11, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grasso", 
            "givenName": "Salvatore", 
            "id": "sg:person.0726713663.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726713663.34"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00134-008-1208-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052333233", 
              "https://doi.org/10.1007/s00134-008-1208-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-008-1121-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050480887", 
              "https://doi.org/10.1007/s00134-008-1121-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12871-015-0091-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035898502", 
              "https://doi.org/10.1186/s12871-015-0091-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-010-2052-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015084725", 
              "https://doi.org/10.1007/s00134-010-2052-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc11146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023352793", 
              "https://doi.org/10.1186/cc11146"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/71012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006785474", 
              "https://doi.org/10.1038/71012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-011-2209-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038695858", 
              "https://doi.org/10.1007/s00134-011-2209-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-009-1587-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029354365", 
              "https://doi.org/10.1007/s00134-009-1587-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-015-0763-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002250523", 
              "https://doi.org/10.1186/s13054-015-0763-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-013-2953-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046058748", 
              "https://doi.org/10.1007/s00134-013-2953-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-015-3692-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034103763", 
              "https://doi.org/10.1007/s00134-015-3692-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc11297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053219696", 
              "https://doi.org/10.1186/cc11297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-006-0301-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014901079", 
              "https://doi.org/10.1007/s00134-006-0301-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc11451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052726709", 
              "https://doi.org/10.1186/cc11451"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-12", 
        "datePublishedReg": "2015-12-01", 
        "description": "BackgroundProlonged controlled mechanical ventilation depresses diaphragmatic efficiency. Assisted modes of ventilation should improve it. We assessed the impact of pressure support ventilation versus neurally adjusted ventilator assist on diaphragmatic efficiency.MethodPatients previously ventilated with controlled mechanical ventilation for 72\u00a0hours or more were randomized to be ventilated for 48\u00a0hours with pressure support ventilation (n =12) or neurally adjusted ventilatory assist (n\u2009=\u200913). Neuro-ventilatory efficiency (tidal volume/diaphragmatic electrical activity) and neuro-mechanical efficiency (pressure generated against the occluded airways/diaphragmatic electrical activity) were measured during three spontaneous breathing trials (0, 24 and 48\u00a0hours). Breathing pattern, diaphragmatic electrical activity and pressure time product of the diaphragm were assessed every 4\u00a0hours.ResultsIn patients randomized to neurally adjusted ventilator assist, neuro-ventilatory efficiency increased from 27\u2009\u00b1\u200919\u00a0ml/\u03bcV at baseline to 62\u2009\u00b1\u200930\u00a0ml/\u03bcV at 48\u00a0hours (p\u2009<0.0001) and neuro-mechanical efficiency increased from 1\u2009\u00b1\u20090.6 to 2.6\u2009\u00b1\u20091.1 cmH2O/\u03bcV (p\u2009=\u20090.033). In patients randomized to pressure support ventilation, these did not change. Electrical activity of the diaphragm, neural inspiratory time, pressure time product of the diaphragm and variability of the breathing pattern were significantly higher in patients ventilated with neurally adjusted ventilatory assist. The asynchrony index was 9.48 [6.38\u2013 21.73] in patients ventilated with pressure support ventilation and 5.39 [3.78\u2013 8.36] in patients ventilated with neurally adjusted ventilatory assist (p\u2009=\u20090.04).ConclusionAfter prolonged controlled mechanical ventilation, neurally adjusted ventilator assist improves diaphragm efficiency whereas pressure support ventilation does not.Trial registrationClinicalTrials.gov study registration: NCT0247317, 06/11/2015.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s13054-015-1178-0", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1117766", 
            "issn": [
              "1364-8535", 
              "1466-609X"
            ], 
            "name": "Critical Care", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "20"
          }
        ], 
        "keywords": [
          "pressure support ventilation", 
          "support ventilation", 
          "pressure-time product", 
          "diaphragmatic efficiency", 
          "ventilator assist", 
          "ventilatory assist", 
          "mechanical ventilation", 
          "breathing pattern", 
          "spontaneous breathing trial", 
          "diaphragmatic electrical activity", 
          "electrical activity", 
          "neural inspiratory time", 
          "breathing trial", 
          "ResultsIn patients", 
          "assisted ventilation", 
          "inspiratory time", 
          "asynchrony index", 
          "patients", 
          "diaphragm efficiency", 
          "ventilation", 
          "time product", 
          "hours", 
          "diaphragm", 
          "assisted mode", 
          "MethodPatients", 
          "ConclusionAfter", 
          "BackgroundProlonged", 
          "trials", 
          "baseline", 
          "PSV", 
          "activity", 
          "NAVA", 
          "assists", 
          "patterns", 
          "index", 
          "impact", 
          "\u03bcV", 
          "registration", 
          "time", 
          "variability", 
          "products", 
          "mode", 
          "efficiency"
        ], 
        "name": "Impact of prolonged assisted ventilation on diaphragmatic efficiency: NAVA versus PSV", 
        "pagination": "1", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1013299842"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13054-015-1178-0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26728475"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13054-015-1178-0", 
          "https://app.dimensions.ai/details/publication/pub.1013299842"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T20:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_676.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s13054-015-1178-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-1178-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-1178-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-1178-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-1178-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    282 TRIPLES      21 PREDICATES      95 URIs      73 LITERALS      19 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13054-015-1178-0 schema:about N251e225c4a9b464fa27685ca469544c0
    2 N39f354d22b1d4ca5963382f7416a4910
    3 N445e52a00f4f4647b56a0193e9a1e8cd
    4 N51060669b5c244a1ac1afdbe51ef01a5
    5 N680a836fb71d4d2c9df5d659f748a852
    6 N757d8b730e0149c398b4f79dc5e4ede8
    7 N96bbf5395e9d409ca05539c2886a74f2
    8 Na70ca057b5724d73b58a566600e5218f
    9 Nac6c6a0941b24423babb9e1610bae840
    10 Nae043719e4774fc78a94a8bfac0f4a0b
    11 Nb0f20ac61f13469da2eb0d641f2c29ce
    12 Nc4553ba271d34bb68188940503e9e768
    13 anzsrc-for:11
    14 anzsrc-for:1116
    15 schema:author N59f4de4476e04199a8de0bca4858b225
    16 schema:citation sg:pub.10.1007/s00134-006-0301-8
    17 sg:pub.10.1007/s00134-008-1121-9
    18 sg:pub.10.1007/s00134-008-1208-3
    19 sg:pub.10.1007/s00134-009-1587-0
    20 sg:pub.10.1007/s00134-010-2052-9
    21 sg:pub.10.1007/s00134-011-2209-1
    22 sg:pub.10.1007/s00134-013-2953-5
    23 sg:pub.10.1007/s00134-015-3692-6
    24 sg:pub.10.1038/71012
    25 sg:pub.10.1186/cc11146
    26 sg:pub.10.1186/cc11297
    27 sg:pub.10.1186/cc11451
    28 sg:pub.10.1186/s12871-015-0091-z
    29 sg:pub.10.1186/s13054-015-0763-6
    30 schema:datePublished 2015-12
    31 schema:datePublishedReg 2015-12-01
    32 schema:description BackgroundProlonged controlled mechanical ventilation depresses diaphragmatic efficiency. Assisted modes of ventilation should improve it. We assessed the impact of pressure support ventilation versus neurally adjusted ventilator assist on diaphragmatic efficiency.MethodPatients previously ventilated with controlled mechanical ventilation for 72 hours or more were randomized to be ventilated for 48 hours with pressure support ventilation (n =12) or neurally adjusted ventilatory assist (n = 13). Neuro-ventilatory efficiency (tidal volume/diaphragmatic electrical activity) and neuro-mechanical efficiency (pressure generated against the occluded airways/diaphragmatic electrical activity) were measured during three spontaneous breathing trials (0, 24 and 48 hours). Breathing pattern, diaphragmatic electrical activity and pressure time product of the diaphragm were assessed every 4 hours.ResultsIn patients randomized to neurally adjusted ventilator assist, neuro-ventilatory efficiency increased from 27 ± 19 ml/μV at baseline to 62 ± 30 ml/μV at 48 hours (p <0.0001) and neuro-mechanical efficiency increased from 1 ± 0.6 to 2.6 ± 1.1 cmH2O/μV (p = 0.033). In patients randomized to pressure support ventilation, these did not change. Electrical activity of the diaphragm, neural inspiratory time, pressure time product of the diaphragm and variability of the breathing pattern were significantly higher in patients ventilated with neurally adjusted ventilatory assist. The asynchrony index was 9.48 [6.38– 21.73] in patients ventilated with pressure support ventilation and 5.39 [3.78– 8.36] in patients ventilated with neurally adjusted ventilatory assist (p = 0.04).ConclusionAfter prolonged controlled mechanical ventilation, neurally adjusted ventilator assist improves diaphragm efficiency whereas pressure support ventilation does not.Trial registrationClinicalTrials.gov study registration: NCT0247317, 06/11/2015.
    33 schema:genre article
    34 schema:isAccessibleForFree true
    35 schema:isPartOf Nd551cd73e43b4949993dd867f0b555c3
    36 Nebbbd898e699446082db3360f5802e4b
    37 sg:journal.1117766
    38 schema:keywords BackgroundProlonged
    39 ConclusionAfter
    40 MethodPatients
    41 NAVA
    42 PSV
    43 ResultsIn patients
    44 activity
    45 assisted mode
    46 assisted ventilation
    47 assists
    48 asynchrony index
    49 baseline
    50 breathing pattern
    51 breathing trial
    52 diaphragm
    53 diaphragm efficiency
    54 diaphragmatic efficiency
    55 diaphragmatic electrical activity
    56 efficiency
    57 electrical activity
    58 hours
    59 impact
    60 index
    61 inspiratory time
    62 mechanical ventilation
    63 mode
    64 neural inspiratory time
    65 patients
    66 patterns
    67 pressure support ventilation
    68 pressure-time product
    69 products
    70 registration
    71 spontaneous breathing trial
    72 support ventilation
    73 time
    74 time product
    75 trials
    76 variability
    77 ventilation
    78 ventilator assist
    79 ventilatory assist
    80 μV
    81 schema:name Impact of prolonged assisted ventilation on diaphragmatic efficiency: NAVA versus PSV
    82 schema:pagination 1
    83 schema:productId N72a27e0d455c45adbf9e60860a719f90
    84 Na517f97f71f343ceaecfa7c177fb691c
    85 Nb8bd4e6cd06440e4ba7d65704cf5aa8d
    86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013299842
    87 https://doi.org/10.1186/s13054-015-1178-0
    88 schema:sdDatePublished 2022-11-24T20:59
    89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    90 schema:sdPublisher N7b1faf9375854684bb7ed11166e863f2
    91 schema:url https://doi.org/10.1186/s13054-015-1178-0
    92 sgo:license sg:explorer/license/
    93 sgo:sdDataset articles
    94 rdf:type schema:ScholarlyArticle
    95 N11bc954ac7bd4047bb273a5ed45658fa rdf:first sg:person.014601246460.69
    96 rdf:rest N9812657a98e3420c860f75e64d0a2e22
    97 N251e225c4a9b464fa27685ca469544c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Positive-Pressure Respiration
    99 rdf:type schema:DefinedTerm
    100 N385b673b28fd4e07b5f9515d603b8046 rdf:first sg:person.0726713663.34
    101 rdf:rest rdf:nil
    102 N39f354d22b1d4ca5963382f7416a4910 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Adult
    104 rdf:type schema:DefinedTerm
    105 N445e52a00f4f4647b56a0193e9a1e8cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Humans
    107 rdf:type schema:DefinedTerm
    108 N51060669b5c244a1ac1afdbe51ef01a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Aged
    110 rdf:type schema:DefinedTerm
    111 N52ee05bce8fb49f38f02a87d8f847657 rdf:first sg:person.01030455645.40
    112 rdf:rest N385b673b28fd4e07b5f9515d603b8046
    113 N59f4de4476e04199a8de0bca4858b225 rdf:first sg:person.0720267603.04
    114 rdf:rest Ne16b43dbbf4a4909b17fffc8fe7ef8ec
    115 N680a836fb71d4d2c9df5d659f748a852 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Diaphragm
    117 rdf:type schema:DefinedTerm
    118 N72a27e0d455c45adbf9e60860a719f90 schema:name pubmed_id
    119 schema:value 26728475
    120 rdf:type schema:PropertyValue
    121 N757d8b730e0149c398b4f79dc5e4ede8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Male
    123 rdf:type schema:DefinedTerm
    124 N7b1faf9375854684bb7ed11166e863f2 schema:name Springer Nature - SN SciGraph project
    125 rdf:type schema:Organization
    126 N96bbf5395e9d409ca05539c2886a74f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Aged, 80 and over
    128 rdf:type schema:DefinedTerm
    129 N9812657a98e3420c860f75e64d0a2e22 rdf:first sg:person.0712453647.23
    130 rdf:rest Nfbf2eb29252f481bb103b0650c9ad74d
    131 Na517f97f71f343ceaecfa7c177fb691c schema:name dimensions_id
    132 schema:value pub.1013299842
    133 rdf:type schema:PropertyValue
    134 Na70ca057b5724d73b58a566600e5218f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Respiration, Artificial
    136 rdf:type schema:DefinedTerm
    137 Na7b0ac5ee472432984527e3557584a42 rdf:first sg:person.0651507322.63
    138 rdf:rest N11bc954ac7bd4047bb273a5ed45658fa
    139 Nabae4100e94d47dfb2a4f71f081c0144 rdf:first sg:person.0650051746.50
    140 rdf:rest Na7b0ac5ee472432984527e3557584a42
    141 Nac6c6a0941b24423babb9e1610bae840 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Middle Aged
    143 rdf:type schema:DefinedTerm
    144 Nae043719e4774fc78a94a8bfac0f4a0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Ventilator Weaning
    146 rdf:type schema:DefinedTerm
    147 Nb0f20ac61f13469da2eb0d641f2c29ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Female
    149 rdf:type schema:DefinedTerm
    150 Nb8bd4e6cd06440e4ba7d65704cf5aa8d schema:name doi
    151 schema:value 10.1186/s13054-015-1178-0
    152 rdf:type schema:PropertyValue
    153 Nc4553ba271d34bb68188940503e9e768 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Interactive Ventilatory Support
    155 rdf:type schema:DefinedTerm
    156 Nc5cba2c74a7e4254a72b3c04f6f86d95 rdf:first sg:person.01010335337.22
    157 rdf:rest N52ee05bce8fb49f38f02a87d8f847657
    158 Nd551cd73e43b4949993dd867f0b555c3 schema:volumeNumber 20
    159 rdf:type schema:PublicationVolume
    160 Ne16b43dbbf4a4909b17fffc8fe7ef8ec rdf:first sg:person.0707071472.05
    161 rdf:rest Nabae4100e94d47dfb2a4f71f081c0144
    162 Nebbbd898e699446082db3360f5802e4b schema:issueNumber 1
    163 rdf:type schema:PublicationIssue
    164 Nfbf2eb29252f481bb103b0650c9ad74d rdf:first sg:person.01061714607.95
    165 rdf:rest Nc5cba2c74a7e4254a72b3c04f6f86d95
    166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    167 schema:name Medical and Health Sciences
    168 rdf:type schema:DefinedTerm
    169 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
    170 schema:name Medical Physiology
    171 rdf:type schema:DefinedTerm
    172 sg:journal.1117766 schema:issn 1364-8535
    173 1466-609X
    174 schema:name Critical Care
    175 schema:publisher Springer Nature
    176 rdf:type schema:Periodical
    177 sg:person.01010335337.22 schema:affiliation grid-institutes:grid.10796.39
    178 schema:familyName Cinnella
    179 schema:givenName Gilda
    180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010335337.22
    181 rdf:type schema:Person
    182 sg:person.01030455645.40 schema:affiliation grid-institutes:grid.7644.1
    183 schema:familyName Bruno
    184 schema:givenName Francesco
    185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030455645.40
    186 rdf:type schema:Person
    187 sg:person.01061714607.95 schema:affiliation grid-institutes:grid.10796.39
    188 schema:familyName Dambrosio
    189 schema:givenName Michele
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061714607.95
    191 rdf:type schema:Person
    192 sg:person.014601246460.69 schema:affiliation grid-institutes:None
    193 schema:familyName Serio
    194 schema:givenName Gabriella
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014601246460.69
    196 rdf:type schema:Person
    197 sg:person.0650051746.50 schema:affiliation grid-institutes:grid.10796.39
    198 schema:familyName Mirabella
    199 schema:givenName Lucia
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650051746.50
    201 rdf:type schema:Person
    202 sg:person.0651507322.63 schema:affiliation grid-institutes:grid.8484.0
    203 schema:familyName Volta
    204 schema:givenName Carlo Alberto
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651507322.63
    206 rdf:type schema:Person
    207 sg:person.0707071472.05 schema:affiliation grid-institutes:grid.8484.0
    208 schema:familyName Spadaro
    209 schema:givenName Savino
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707071472.05
    211 rdf:type schema:Person
    212 sg:person.0712453647.23 schema:affiliation grid-institutes:grid.7644.1
    213 schema:familyName Staffieri
    214 schema:givenName Francesco
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712453647.23
    216 rdf:type schema:Person
    217 sg:person.0720267603.04 schema:affiliation grid-institutes:grid.7644.1
    218 schema:familyName Di mussi
    219 schema:givenName Rosa
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720267603.04
    221 rdf:type schema:Person
    222 sg:person.0726713663.34 schema:affiliation grid-institutes:grid.7644.1
    223 schema:familyName Grasso
    224 schema:givenName Salvatore
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726713663.34
    226 rdf:type schema:Person
    227 sg:pub.10.1007/s00134-006-0301-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014901079
    228 https://doi.org/10.1007/s00134-006-0301-8
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1007/s00134-008-1121-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050480887
    231 https://doi.org/10.1007/s00134-008-1121-9
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1007/s00134-008-1208-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052333233
    234 https://doi.org/10.1007/s00134-008-1208-3
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1007/s00134-009-1587-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029354365
    237 https://doi.org/10.1007/s00134-009-1587-0
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1007/s00134-010-2052-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015084725
    240 https://doi.org/10.1007/s00134-010-2052-9
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1007/s00134-011-2209-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038695858
    243 https://doi.org/10.1007/s00134-011-2209-1
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1007/s00134-013-2953-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046058748
    246 https://doi.org/10.1007/s00134-013-2953-5
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1007/s00134-015-3692-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034103763
    249 https://doi.org/10.1007/s00134-015-3692-6
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/71012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006785474
    252 https://doi.org/10.1038/71012
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1186/cc11146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023352793
    255 https://doi.org/10.1186/cc11146
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1186/cc11297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053219696
    258 https://doi.org/10.1186/cc11297
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1186/cc11451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052726709
    261 https://doi.org/10.1186/cc11451
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1186/s12871-015-0091-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1035898502
    264 https://doi.org/10.1186/s12871-015-0091-z
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1186/s13054-015-0763-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002250523
    267 https://doi.org/10.1186/s13054-015-0763-6
    268 rdf:type schema:CreativeWork
    269 grid-institutes:None schema:alternateName Dipartimento di Scienze Biomediche ed Oncologia Umana, Cattedra di Statistica Medica, Università degli Studi Aldo Moro, Bari, Italy
    270 schema:name Dipartimento di Scienze Biomediche ed Oncologia Umana, Cattedra di Statistica Medica, Università degli Studi Aldo Moro, Bari, Italy
    271 rdf:type schema:Organization
    272 grid-institutes:grid.10796.39 schema:alternateName Dipartimento di Anestesia e Rianimazione, Università di Foggia, Foggia, Italy
    273 schema:name Dipartimento di Anestesia e Rianimazione, Università di Foggia, Foggia, Italy
    274 rdf:type schema:Organization
    275 grid-institutes:grid.7644.1 schema:alternateName Dipartimento dell’Emergenza e Trapianti d’Organo (DETO), Sezione di Anestesiologia e Rianimazione, Università degli Studi di Bari “Aldo Moro”, Piazza Giulio Cesare 11, Bari, Italy
    276 Dipartimento dell’Emergenza e Trapianti d’Organo (DETO), Sezione di Chirurgia Veterinaria, Università degli Studi di Bari “Aldo Moro”, Bari, Italy
    277 schema:name Dipartimento dell’Emergenza e Trapianti d’Organo (DETO), Sezione di Anestesiologia e Rianimazione, Università degli Studi di Bari “Aldo Moro”, Piazza Giulio Cesare 11, Bari, Italy
    278 Dipartimento dell’Emergenza e Trapianti d’Organo (DETO), Sezione di Chirurgia Veterinaria, Università degli Studi di Bari “Aldo Moro”, Bari, Italy
    279 rdf:type schema:Organization
    280 grid-institutes:grid.8484.0 schema:alternateName Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Sezione di Anestesiologia e Terapia Intensiva Universitaria, Università degli studi di Ferrara, Ferrara, Italy
    281 schema:name Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Sezione di Anestesiologia e Terapia Intensiva Universitaria, Università degli studi di Ferrara, Ferrara, Italy
    282 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...