The efficacy of recombinant human soluble thrombomodulin for obstetric disseminated intravascular coagulation: a retrospective study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Masato Yoshihara, Kaname Uno, Sho Tano, Michinori Mayama, Mayu Ukai, Shinya Kondo, Tetsuya Kokabu, Yasuyuki Kishigami, Hidenori Oguchi

ABSTRACT

INTRODUCTION: Recombinant human soluble thrombomodulin (rhTM) is a novel anti-coagulant agent that regulates the imbalanced coagulation system by reducing the excessive activation of thrombin. rhTM potentially reduces the morbidity and mortality in patients with sepsis-induced disseminated intravascular coagulation (DIC). However, the efficacy of rhTM in obstetric DIC has not yet been established. We performed this study to examine whether the administration of rhTM was a potentially effective treatment for DIC induced by one or more underlying obstetric disorders. METHODS: This is a single-center, retrospective cohort study conducted between January 2007 and February 2015 using the records of the Department of Obstetrics at the Perinatal Medical Center of TOYOTA Memorial Hospital, Aichi, Japan. The eligibility criteria were known or suspected obstetric DIC documented on the basis of clinical and laboratory data and association with one or more major underlying obstetric disorders. Baseline imbalance between patients with and without treatment of rhTM was adjusted using an inverse probability of treatment weighting using propensity scores composed of the following independent variables: severe postpartum hemorrhage, placental abruption, and preeclampsia/eclampsia, including hemolysis, elevated liver enzymes, and low platelet syndrome, initial platelet counts, D-dimer levels, fibrinogen levels, and prothrombin time-international normalized ratio (PT-INR). We evaluated laboratory changes and clinical outcomes in the early phase of obstetric DIC. RESULTS: In total, 66 of 4627 patients admitted to our department during the study period fulfilled the required criteria; of these, 37 and 29 patients were included in the rhTM and control group, respectively. After adjustment, treatment with rhTM was associated with significant improvements in platelet counts, D-dimer levels, fibrinogen levels, and PT-INR compared with the control group. The platelet concentrate transfusion volume was significantly lower in the rhTM treatment group (3.02 vs 6.03 units, P = 0.016). None of the adjusted group differences were statistically significant for all types of organ damage and failure. CONCLUSION: rhTM administration was associated with clinical and laboratory improvement in patients with DIC caused by underlying obstetric conditions. Further clinical research is needed to clarify the optimal application of rhTM in each of the causative obstetric disorders. More... »

PAGES

369

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13054-015-1086-3

DOI

http://dx.doi.org/10.1186/s13054-015-1086-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008131349

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26481315


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disseminated Intravascular Coagulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy Complications", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Propensity Score", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sepsis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thrombomodulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Toyota Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417248.c", 
          "name": [
            "Department of Obstetrics, Perinatal Medical Center, TOYOTA Memorial Hospital, 1-1, Heiwa-cho, Toyota, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshihara", 
        "givenName": "Masato", 
        "id": "sg:person.0606725715.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606725715.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Toyota Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417248.c", 
          "name": [
            "Department of Obstetrics, Perinatal Medical Center, TOYOTA Memorial Hospital, 1-1, Heiwa-cho, Toyota, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uno", 
        "givenName": "Kaname", 
        "id": "sg:person.0655041115.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655041115.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Toyota Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417248.c", 
          "name": [
            "Department of Obstetrics, Perinatal Medical Center, TOYOTA Memorial Hospital, 1-1, Heiwa-cho, Toyota, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tano", 
        "givenName": "Sho", 
        "id": "sg:person.0723154315.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723154315.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Toyota Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417248.c", 
          "name": [
            "Department of Obstetrics, Perinatal Medical Center, TOYOTA Memorial Hospital, 1-1, Heiwa-cho, Toyota, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mayama", 
        "givenName": "Michinori", 
        "id": "sg:person.0703112330.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703112330.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Toyota Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417248.c", 
          "name": [
            "Department of Obstetrics, Perinatal Medical Center, TOYOTA Memorial Hospital, 1-1, Heiwa-cho, Toyota, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ukai", 
        "givenName": "Mayu", 
        "id": "sg:person.01037402715.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037402715.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Toyota Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417248.c", 
          "name": [
            "Department of Obstetrics, Perinatal Medical Center, TOYOTA Memorial Hospital, 1-1, Heiwa-cho, Toyota, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kondo", 
        "givenName": "Shinya", 
        "id": "sg:person.01105516115.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105516115.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Toyota Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417248.c", 
          "name": [
            "Department of Obstetrics, Perinatal Medical Center, TOYOTA Memorial Hospital, 1-1, Heiwa-cho, Toyota, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kokabu", 
        "givenName": "Tetsuya", 
        "id": "sg:person.013526334721.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013526334721.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Toyota Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417248.c", 
          "name": [
            "Department of Obstetrics, Perinatal Medical Center, TOYOTA Memorial Hospital, 1-1, Heiwa-cho, Toyota, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kishigami", 
        "givenName": "Yasuyuki", 
        "id": "sg:person.01221744515.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221744515.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Toyota Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417248.c", 
          "name": [
            "Department of Obstetrics, Perinatal Medical Center, TOYOTA Memorial Hospital, 1-1, Heiwa-cho, Toyota, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oguchi", 
        "givenName": "Hidenori", 
        "id": "sg:person.01270057715.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270057715.89"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/cc10228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002455315", 
          "https://doi.org/10.1186/cc10228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2326-12-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002694933", 
          "https://doi.org/10.1186/1471-2326-12-10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.5991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003771929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1208626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008946453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jog.12426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008956300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1527-3466.2000.tb00055.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009418410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1527-3466.2000.tb00055.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009418410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/med.21294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009583628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e31828e9b03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009866786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e31828e9b03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009866786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1076029612443305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019858296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1076029612443305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019858296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.thromres.2011.10.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022841961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00281-011-0282-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029049275", 
          "https://doi.org/10.1007/s00281-011-0282-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-013-2822-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029963833", 
          "https://doi.org/10.1007/s00134-013-2822-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-013-2822-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029963833", 
          "https://doi.org/10.1007/s00134-013-2822-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-015-0810-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031147176", 
          "https://doi.org/10.1186/s13054-015-0810-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-015-0810-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031147176", 
          "https://doi.org/10.1186/s13054-015-0810-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.2003.04790.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035498459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1523-1755.2005.00316.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038737644", 
          "https://doi.org/10.1111/j.1523-1755.2005.00316.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00096.2013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042245627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2015.03.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043971910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1447-0756.1987.tb00001.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044433759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)61230-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046827380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.blre.2009.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051750611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0146-0005(03)00022-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052617805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semnephrol.2010.10.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052976407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01621459.1984.10478078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058303004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1160/th06-07-0387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063290902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0037-1614900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074568224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/http://10.1097/aog.0b013e31826d60c5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078637905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0038-1649597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082726236"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "INTRODUCTION: Recombinant human soluble thrombomodulin (rhTM) is a novel anti-coagulant agent that regulates the imbalanced coagulation system by reducing the excessive activation of thrombin. rhTM potentially reduces the morbidity and mortality in patients with sepsis-induced disseminated intravascular coagulation (DIC). However, the efficacy of rhTM in obstetric DIC has not yet been established. We performed this study to examine whether the administration of rhTM was a potentially effective treatment for DIC induced by one or more underlying obstetric disorders.\nMETHODS: This is a single-center, retrospective cohort study conducted between January 2007 and February 2015 using the records of the Department of Obstetrics at the Perinatal Medical Center of TOYOTA Memorial Hospital, Aichi, Japan. The eligibility criteria were known or suspected obstetric DIC documented on the basis of clinical and laboratory data and association with one or more major underlying obstetric disorders. Baseline imbalance between patients with and without treatment of rhTM was adjusted using an inverse probability of treatment weighting using propensity scores composed of the following independent variables: severe postpartum hemorrhage, placental abruption, and preeclampsia/eclampsia, including hemolysis, elevated liver enzymes, and low platelet syndrome, initial platelet counts, D-dimer levels, fibrinogen levels, and prothrombin time-international normalized ratio (PT-INR). We evaluated laboratory changes and clinical outcomes in the early phase of obstetric DIC.\nRESULTS: In total, 66 of 4627 patients admitted to our department during the study period fulfilled the required criteria; of these, 37 and 29 patients were included in the rhTM and control group, respectively. After adjustment, treatment with rhTM was associated with significant improvements in platelet counts, D-dimer levels, fibrinogen levels, and PT-INR compared with the control group. The platelet concentrate transfusion volume was significantly lower in the rhTM treatment group (3.02 vs 6.03 units, P\u2009=\u20090.016). None of the adjusted group differences were statistically significant for all types of organ damage and failure.\nCONCLUSION: rhTM administration was associated with clinical and laboratory improvement in patients with DIC caused by underlying obstetric conditions. Further clinical research is needed to clarify the optimal application of rhTM in each of the causative obstetric disorders.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13054-015-1086-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1117766", 
        "issn": [
          "1364-8535", 
          "1466-609X"
        ], 
        "name": "Critical Care", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "The efficacy of recombinant human soluble thrombomodulin for obstetric disseminated intravascular coagulation: a retrospective study", 
    "pagination": "369", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "26bd2888276233040da0a48cfdd49e4559f3ab13d4ad5d43d70c99f20aede0dd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26481315"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9801902"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13054-015-1086-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008131349"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13054-015-1086-3", 
      "https://app.dimensions.ai/details/publication/pub.1008131349"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs13054-015-1086-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-1086-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-1086-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-1086-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-1086-3'


 

This table displays all metadata directly associated to this object as RDF triples.

264 TRIPLES      21 PREDICATES      69 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13054-015-1086-3 schema:about N1132315739724bf7b50dd5b4a8dc23a1
2 N8795706ebd0147b285187dac01a713c3
3 Na0c400d9049845dd8c13dffa42ff18af
4 Na3522a16ec0441c99121b2aa3eb0d34a
5 Na9f08300fd8f48959d9fd7025add2bef
6 Nb6f5dbe637134a9dbc5708f535055190
7 Nc7e2548ebadc46cfb3e004f261d360fd
8 Ncab083d766ed48dc90ca0493bb7439a2
9 Ndbdfeb769892464fa3906d8c9f815a5b
10 Ne40dabb746554fdaae1bdf4dc54432eb
11 Nf5b5114548394bf189646f9218490134
12 Nf7df9d542e224978a5123dd5a5357f70
13 Nfbc93bf889504c18be9fd5ff15e56efd
14 anzsrc-for:11
15 anzsrc-for:1103
16 schema:author Nd679c3d22efc44c59d592d3d23fa97d8
17 schema:citation sg:pub.10.1007/s00134-013-2822-2
18 sg:pub.10.1007/s00281-011-0282-8
19 sg:pub.10.1111/j.1523-1755.2005.00316.x
20 sg:pub.10.1186/1471-2326-12-10
21 sg:pub.10.1186/cc10228
22 sg:pub.10.1186/s13054-015-0810-3
23 https://doi.org/10.1002/med.21294
24 https://doi.org/10.1002/sim.5991
25 https://doi.org/10.1016/j.ajog.2015.03.054
26 https://doi.org/10.1016/j.blre.2009.04.002
27 https://doi.org/10.1016/j.semnephrol.2010.10.004
28 https://doi.org/10.1016/j.thromres.2011.10.031
29 https://doi.org/10.1016/s0002-9440(10)61230-8
30 https://doi.org/10.1016/s0146-0005(03)00022-3
31 https://doi.org/10.1046/j.1365-2141.2003.04790.x
32 https://doi.org/10.1055/s-0037-1614900
33 https://doi.org/10.1055/s-0038-1649597
34 https://doi.org/10.1056/nejmra1208626
35 https://doi.org/10.1080/01621459.1984.10478078
36 https://doi.org/10.1097/ccm.0b013e31828e9b03
37 https://doi.org/10.1111/j.1447-0756.1987.tb00001.x
38 https://doi.org/10.1111/j.1527-3466.2000.tb00055.x
39 https://doi.org/10.1111/jog.12426
40 https://doi.org/10.1152/ajpheart.00096.2013
41 https://doi.org/10.1160/th06-07-0387
42 https://doi.org/10.1177/1076029612443305
43 https://doi.org/http:/10.1097/aog.0b013e31826d60c5
44 schema:datePublished 2015-12
45 schema:datePublishedReg 2015-12-01
46 schema:description INTRODUCTION: Recombinant human soluble thrombomodulin (rhTM) is a novel anti-coagulant agent that regulates the imbalanced coagulation system by reducing the excessive activation of thrombin. rhTM potentially reduces the morbidity and mortality in patients with sepsis-induced disseminated intravascular coagulation (DIC). However, the efficacy of rhTM in obstetric DIC has not yet been established. We performed this study to examine whether the administration of rhTM was a potentially effective treatment for DIC induced by one or more underlying obstetric disorders. METHODS: This is a single-center, retrospective cohort study conducted between January 2007 and February 2015 using the records of the Department of Obstetrics at the Perinatal Medical Center of TOYOTA Memorial Hospital, Aichi, Japan. The eligibility criteria were known or suspected obstetric DIC documented on the basis of clinical and laboratory data and association with one or more major underlying obstetric disorders. Baseline imbalance between patients with and without treatment of rhTM was adjusted using an inverse probability of treatment weighting using propensity scores composed of the following independent variables: severe postpartum hemorrhage, placental abruption, and preeclampsia/eclampsia, including hemolysis, elevated liver enzymes, and low platelet syndrome, initial platelet counts, D-dimer levels, fibrinogen levels, and prothrombin time-international normalized ratio (PT-INR). We evaluated laboratory changes and clinical outcomes in the early phase of obstetric DIC. RESULTS: In total, 66 of 4627 patients admitted to our department during the study period fulfilled the required criteria; of these, 37 and 29 patients were included in the rhTM and control group, respectively. After adjustment, treatment with rhTM was associated with significant improvements in platelet counts, D-dimer levels, fibrinogen levels, and PT-INR compared with the control group. The platelet concentrate transfusion volume was significantly lower in the rhTM treatment group (3.02 vs 6.03 units, P = 0.016). None of the adjusted group differences were statistically significant for all types of organ damage and failure. CONCLUSION: rhTM administration was associated with clinical and laboratory improvement in patients with DIC caused by underlying obstetric conditions. Further clinical research is needed to clarify the optimal application of rhTM in each of the causative obstetric disorders.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree true
50 schema:isPartOf N65ff74d664a842e6bce1e9424ad00628
51 Nfd1f0dbdc82341f893e574cf92fdc6d9
52 sg:journal.1117766
53 schema:name The efficacy of recombinant human soluble thrombomodulin for obstetric disseminated intravascular coagulation: a retrospective study
54 schema:pagination 369
55 schema:productId N26e3a725e8624021b63cca0542d43aa3
56 N3b98223912514d938ec2cd15fa171ab6
57 N577654d543c1432ba1c25beaca87020f
58 Nc14b2ab842fe42d3a53ca8e0f0581a47
59 Nf2b061f9e20c4371976ae1f64f9c3120
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008131349
61 https://doi.org/10.1186/s13054-015-1086-3
62 schema:sdDatePublished 2019-04-11T01:06
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N7560393f633f40c2b603331695cf5671
65 schema:url http://link.springer.com/10.1186%2Fs13054-015-1086-3
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N05a8b6af37ac4c5ba8ea258b013ee9ec rdf:first sg:person.013526334721.47
70 rdf:rest N2542a79bf2b8496f8aa2edb101541ac2
71 N1132315739724bf7b50dd5b4a8dc23a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Female
73 rdf:type schema:DefinedTerm
74 N17b30caa959247eca0e11fea6117ac57 rdf:first sg:person.0703112330.60
75 rdf:rest Nffaff9be19174dd5ac349f24958f61b3
76 N2542a79bf2b8496f8aa2edb101541ac2 rdf:first sg:person.01221744515.13
77 rdf:rest Nccf909cdb51549b196e36da32742214e
78 N26e3a725e8624021b63cca0542d43aa3 schema:name dimensions_id
79 schema:value pub.1008131349
80 rdf:type schema:PropertyValue
81 N3b98223912514d938ec2cd15fa171ab6 schema:name readcube_id
82 schema:value 26bd2888276233040da0a48cfdd49e4559f3ab13d4ad5d43d70c99f20aede0dd
83 rdf:type schema:PropertyValue
84 N577654d543c1432ba1c25beaca87020f schema:name nlm_unique_id
85 schema:value 9801902
86 rdf:type schema:PropertyValue
87 N65ff74d664a842e6bce1e9424ad00628 schema:volumeNumber 19
88 rdf:type schema:PublicationVolume
89 N7560393f633f40c2b603331695cf5671 schema:name Springer Nature - SN SciGraph project
90 rdf:type schema:Organization
91 N8795706ebd0147b285187dac01a713c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Thrombomodulin
93 rdf:type schema:DefinedTerm
94 Na0c400d9049845dd8c13dffa42ff18af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Humans
96 rdf:type schema:DefinedTerm
97 Na3522a16ec0441c99121b2aa3eb0d34a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Retrospective Studies
99 rdf:type schema:DefinedTerm
100 Na9f08300fd8f48959d9fd7025add2bef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Sepsis
102 rdf:type schema:DefinedTerm
103 Nb6f5dbe637134a9dbc5708f535055190 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Pregnancy Complications
105 rdf:type schema:DefinedTerm
106 Nbb3354102223443085679e5f527e2ef7 rdf:first sg:person.0655041115.09
107 rdf:rest Nfe5b60dc1cb74f30a5303a010c07f1a0
108 Nc14b2ab842fe42d3a53ca8e0f0581a47 schema:name doi
109 schema:value 10.1186/s13054-015-1086-3
110 rdf:type schema:PropertyValue
111 Nc7e2548ebadc46cfb3e004f261d360fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Recombinant Proteins
113 rdf:type schema:DefinedTerm
114 Ncab083d766ed48dc90ca0493bb7439a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Pregnancy
116 rdf:type schema:DefinedTerm
117 Nccf909cdb51549b196e36da32742214e rdf:first sg:person.01270057715.89
118 rdf:rest rdf:nil
119 Nd679c3d22efc44c59d592d3d23fa97d8 rdf:first sg:person.0606725715.79
120 rdf:rest Nbb3354102223443085679e5f527e2ef7
121 Ndbdfeb769892464fa3906d8c9f815a5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Propensity Score
123 rdf:type schema:DefinedTerm
124 Ne40dabb746554fdaae1bdf4dc54432eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Disseminated Intravascular Coagulation
126 rdf:type schema:DefinedTerm
127 Nf2b061f9e20c4371976ae1f64f9c3120 schema:name pubmed_id
128 schema:value 26481315
129 rdf:type schema:PropertyValue
130 Nf5b5114548394bf189646f9218490134 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Cohort Studies
132 rdf:type schema:DefinedTerm
133 Nf7df9d542e224978a5123dd5a5357f70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Survival Analysis
135 rdf:type schema:DefinedTerm
136 Nfbc93bf889504c18be9fd5ff15e56efd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Treatment Outcome
138 rdf:type schema:DefinedTerm
139 Nfcba50af25e0486eaaefd451aa7ec721 rdf:first sg:person.01105516115.65
140 rdf:rest N05a8b6af37ac4c5ba8ea258b013ee9ec
141 Nfd1f0dbdc82341f893e574cf92fdc6d9 schema:issueNumber 1
142 rdf:type schema:PublicationIssue
143 Nfe5b60dc1cb74f30a5303a010c07f1a0 rdf:first sg:person.0723154315.69
144 rdf:rest N17b30caa959247eca0e11fea6117ac57
145 Nffaff9be19174dd5ac349f24958f61b3 rdf:first sg:person.01037402715.42
146 rdf:rest Nfcba50af25e0486eaaefd451aa7ec721
147 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
148 schema:name Medical and Health Sciences
149 rdf:type schema:DefinedTerm
150 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
151 schema:name Clinical Sciences
152 rdf:type schema:DefinedTerm
153 sg:journal.1117766 schema:issn 1364-8535
154 1466-609X
155 schema:name Critical Care
156 rdf:type schema:Periodical
157 sg:person.01037402715.42 schema:affiliation https://www.grid.ac/institutes/grid.417248.c
158 schema:familyName Ukai
159 schema:givenName Mayu
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037402715.42
161 rdf:type schema:Person
162 sg:person.01105516115.65 schema:affiliation https://www.grid.ac/institutes/grid.417248.c
163 schema:familyName Kondo
164 schema:givenName Shinya
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105516115.65
166 rdf:type schema:Person
167 sg:person.01221744515.13 schema:affiliation https://www.grid.ac/institutes/grid.417248.c
168 schema:familyName Kishigami
169 schema:givenName Yasuyuki
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221744515.13
171 rdf:type schema:Person
172 sg:person.01270057715.89 schema:affiliation https://www.grid.ac/institutes/grid.417248.c
173 schema:familyName Oguchi
174 schema:givenName Hidenori
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270057715.89
176 rdf:type schema:Person
177 sg:person.013526334721.47 schema:affiliation https://www.grid.ac/institutes/grid.417248.c
178 schema:familyName Kokabu
179 schema:givenName Tetsuya
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013526334721.47
181 rdf:type schema:Person
182 sg:person.0606725715.79 schema:affiliation https://www.grid.ac/institutes/grid.417248.c
183 schema:familyName Yoshihara
184 schema:givenName Masato
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606725715.79
186 rdf:type schema:Person
187 sg:person.0655041115.09 schema:affiliation https://www.grid.ac/institutes/grid.417248.c
188 schema:familyName Uno
189 schema:givenName Kaname
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655041115.09
191 rdf:type schema:Person
192 sg:person.0703112330.60 schema:affiliation https://www.grid.ac/institutes/grid.417248.c
193 schema:familyName Mayama
194 schema:givenName Michinori
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703112330.60
196 rdf:type schema:Person
197 sg:person.0723154315.69 schema:affiliation https://www.grid.ac/institutes/grid.417248.c
198 schema:familyName Tano
199 schema:givenName Sho
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723154315.69
201 rdf:type schema:Person
202 sg:pub.10.1007/s00134-013-2822-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029963833
203 https://doi.org/10.1007/s00134-013-2822-2
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/s00281-011-0282-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029049275
206 https://doi.org/10.1007/s00281-011-0282-8
207 rdf:type schema:CreativeWork
208 sg:pub.10.1111/j.1523-1755.2005.00316.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038737644
209 https://doi.org/10.1111/j.1523-1755.2005.00316.x
210 rdf:type schema:CreativeWork
211 sg:pub.10.1186/1471-2326-12-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002694933
212 https://doi.org/10.1186/1471-2326-12-10
213 rdf:type schema:CreativeWork
214 sg:pub.10.1186/cc10228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002455315
215 https://doi.org/10.1186/cc10228
216 rdf:type schema:CreativeWork
217 sg:pub.10.1186/s13054-015-0810-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031147176
218 https://doi.org/10.1186/s13054-015-0810-3
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1002/med.21294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009583628
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1002/sim.5991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003771929
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.ajog.2015.03.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043971910
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.blre.2009.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051750611
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.semnephrol.2010.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052976407
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.thromres.2011.10.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022841961
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0002-9440(10)61230-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046827380
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0146-0005(03)00022-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052617805
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1046/j.1365-2141.2003.04790.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035498459
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1055/s-0037-1614900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074568224
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1055/s-0038-1649597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082726236
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1056/nejmra1208626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008946453
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1080/01621459.1984.10478078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058303004
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1097/ccm.0b013e31828e9b03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009866786
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1111/j.1447-0756.1987.tb00001.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044433759
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1111/j.1527-3466.2000.tb00055.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009418410
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1111/jog.12426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008956300
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1152/ajpheart.00096.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042245627
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1160/th06-07-0387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063290902
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1177/1076029612443305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019858296
259 rdf:type schema:CreativeWork
260 https://doi.org/http:/10.1097/aog.0b013e31826d60c5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078637905
261 rdf:type schema:CreativeWork
262 https://www.grid.ac/institutes/grid.417248.c schema:alternateName Toyota Memorial Hospital
263 schema:name Department of Obstetrics, Perinatal Medical Center, TOYOTA Memorial Hospital, 1-1, Heiwa-cho, Toyota, Aichi, Japan
264 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...