An international multicenter retrospective study of Pseudomonas aeruginosa nosocomial pneumonia: impact of multidrug resistance View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12-01

AUTHORS

Scott T Micek, Richard G Wunderink, Marin H Kollef, Catherine Chen, Jordi Rello, Jean Chastre, Massimo Antonelli, Tobias Welte, Bernard Clair, Helmut Ostermann, Esther Calbo, Antoni Torres, Francesco Menichetti, Garrett E Schramm, Vandana Menon

ABSTRACT

IntroductionPseudomonas aeruginosa nosocomial pneumonia (Pa-NP) is associated with considerable morbidity, prolonged hospitalization, increased costs, and mortality.MethodsWe conducted a retrospective cohort study of adult patients with Pa-NP to determine 1) risk factors for multidrug-resistant (MDR) strains and 2) whether MDR increases the risk for hospital death. Twelve hospitals in 5 countries (United States, n = 3; France, n = 2; Germany, n = 2; Italy, n = 2; and Spain, n = 3) participated. We compared characteristics of patients who had MDR strains to those who did not and derived regression models to identify predictors of MDR and hospital mortality.ResultsOf 740 patients with Pa-NP, 226 patients (30.5%) were infected with MDR strains. In multivariable analyses, independent predictors of multidrug-resistance included decreasing age (adjusted odds ratio [AOR] 0.91, 95% confidence interval [CI] 0.96-0.98), diabetes mellitus (AOR 1.90, 95% CI 1.21-3.00) and ICU admission (AOR 1.73, 95% CI 1.06-2.81). Multidrug-resistance, heart failure, increasing age, mechanical ventilation, and bacteremia were independently associated with in-hospital mortality in the Cox Proportional Hazards Model analysis.ConclusionsAmong patients with Pa-NP the presence of infection with a MDR strain is associated with increased in-hospital mortality. Identification of patients at risk of MDR Pa-NP could facilitate appropriate empiric antibiotic decisions that in turn could lead to improved hospital survival. More... »

PAGES

219

Journal

TITLE

Critical Care

ISSUE

1

VOLUME

19

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13054-015-0926-5

DOI

http://dx.doi.org/10.1186/s13054-015-0926-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013283271

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25944081


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Bacterial Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross Infection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Multiple, Bacterial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hospital Mortality", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hospitalization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Internationality", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mortality", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pneumonia, Bacterial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pseudomonas Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pseudomonas aeruginosa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "St. Louis College of Pharmacy, 4588 Parkview Place, 63110-1088, St. Louis, MO, USA", 
          "id": "http://www.grid.ac/institutes/grid.419579.7", 
          "name": [
            "St. Louis College of Pharmacy, 4588 Parkview Place, 63110-1088, St. Louis, MO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Micek", 
        "givenName": "Scott T", 
        "id": "sg:person.0641701632.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641701632.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northwestern University Feinberg School of Medicine, McGaw Pavilion Suite M-300, 240 E Huron, 60611, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Northwestern University Feinberg School of Medicine, McGaw Pavilion Suite M-300, 240 E Huron, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wunderink", 
        "givenName": "Richard G", 
        "id": "sg:person.0664057206.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664057206.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8052, 63110, St. Louis, MO, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8052, 63110, St. Louis, MO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kollef", 
        "givenName": "Marin H", 
        "id": "sg:person.01157100146.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157100146.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8052, 63110, St. Louis, MO, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8052, 63110, St. Louis, MO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Catherine", 
        "id": "sg:person.0715341505.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715341505.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vall d\u2019Hebron University Hospital, Passeig Vall d\u2019Hebron, 119, 08035, Barcelona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.411083.f", 
          "name": [
            "Vall d\u2019Hebron University Hospital, Passeig Vall d\u2019Hebron, 119, 08035, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rello", 
        "givenName": "Jordi", 
        "id": "sg:person.01051715513.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051715513.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de R\u00e9animation M\u00e9dicale, Institut de Cardiologie, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 boulevard de l\u2019H\u00f4pital, 75651, Paris, Cedex 13, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, Institut de Cardiologie, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 boulevard de l\u2019H\u00f4pital, 75651, Paris, Cedex 13, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chastre", 
        "givenName": "Jean", 
        "id": "sg:person.0714077601.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714077601.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico Universitario A Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy", 
          "id": "http://www.grid.ac/institutes/grid.411075.6", 
          "name": [
            "Policlinico Universitario A Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Antonelli", 
        "givenName": "Massimo", 
        "id": "sg:person.01231157073.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231157073.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medizinische Hochschule, Carl-Neuberg-Str. 1, 30625, Hannover, Germany", 
          "id": "http://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Medizinische Hochschule, Carl-Neuberg-Str. 1, 30625, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Welte", 
        "givenName": "Tobias", 
        "id": "sg:person.01200122325.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200122325.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Raymond Poincar\u00e9, 104 boulevard Raymond Poincar\u00e9, 92380, Garches, France", 
          "id": "http://www.grid.ac/institutes/grid.414291.b", 
          "name": [
            "H\u00f4pital Raymond Poincar\u00e9, 104 boulevard Raymond Poincar\u00e9, 92380, Garches, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clair", 
        "givenName": "Bernard", 
        "id": "sg:person.0704712477.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704712477.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, University Hospital Grosshadern, Marchioninistr 15, D-81377, Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411095.8", 
          "name": [
            "Department of Hematology, University Hospital Grosshadern, Marchioninistr 15, D-81377, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ostermann", 
        "givenName": "Helmut", 
        "id": "sg:person.0720704077.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720704077.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitari M\u00fatuaTerrassa, Pla\u00e7a Dr. Robert, 5, 08221, Terrassa, Spain", 
          "id": "http://www.grid.ac/institutes/grid.414875.b", 
          "name": [
            "Hospital Universitari M\u00fatuaTerrassa, Pla\u00e7a Dr. Robert, 5, 08221, Terrassa, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calbo", 
        "givenName": "Esther", 
        "id": "sg:person.01134537734.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134537734.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pneumology Department, Clinic Institute of Thorax, Villarroel 170, 08036, Barcelona, Spain", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Pneumology Department, Clinic Institute of Thorax, Villarroel 170, 08036, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Torres", 
        "givenName": "Antoni", 
        "id": "sg:person.013605501140.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013605501140.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Malattie Infettive, Az. Ospedaliera Universitaria Pisana, Via Paradisa 2 \u2013 Cisanello, 56100, Pisa, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Malattie Infettive, Az. Ospedaliera Universitaria Pisana, Via Paradisa 2 \u2013 Cisanello, 56100, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Menichetti", 
        "givenName": "Francesco", 
        "id": "sg:person.0732254030.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732254030.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pharmacy Services, Mayo Clinic, 200 First St SW, 55905, Rochester, MN, USA", 
          "id": "http://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Pharmacy Services, Mayo Clinic, 200 First St SW, 55905, Rochester, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schramm", 
        "givenName": "Garrett E", 
        "id": "sg:person.01041205104.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041205104.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cubist Pharmaceuticals, Inc., 65 Hayden Avenue, 02421, Lexington, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.417686.a", 
          "name": [
            "Cubist Pharmaceuticals, Inc., 65 Hayden Avenue, 02421, Lexington, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Menon", 
        "givenName": "Vandana", 
        "id": "sg:person.01315725060.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315725060.03"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/cc11862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017822371", 
          "https://doi.org/10.1186/cc11862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-012-1741-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038186055", 
          "https://doi.org/10.1007/s10096-012-1741-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-012-1758-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020359417", 
          "https://doi.org/10.1007/s10096-012-1758-8"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12-01", 
    "datePublishedReg": "2015-12-01", 
    "description": "IntroductionPseudomonas aeruginosa nosocomial pneumonia (Pa-NP) is associated with considerable morbidity, prolonged hospitalization, increased costs, and mortality.MethodsWe conducted a retrospective cohort study of adult patients with Pa-NP to determine 1) risk factors for multidrug-resistant (MDR) strains and 2) whether MDR increases the risk for hospital death. Twelve hospitals in 5 countries (United States, n = 3; France, n = 2; Germany, n = 2; Italy, n = 2; and Spain, n = 3) participated. We compared characteristics of patients who had MDR strains to those who did not and derived regression models to identify predictors of MDR and hospital mortality.ResultsOf 740 patients with Pa-NP, 226 patients (30.5%) were infected with MDR strains. In multivariable analyses, independent predictors of multidrug-resistance included decreasing age (adjusted odds ratio [AOR] 0.91, 95% confidence interval [CI] 0.96-0.98), diabetes mellitus (AOR 1.90, 95% CI 1.21-3.00) and ICU admission (AOR 1.73, 95% CI 1.06-2.81). Multidrug-resistance, heart failure, increasing age, mechanical ventilation, and bacteremia were independently associated with in-hospital mortality in the Cox Proportional Hazards Model analysis.ConclusionsAmong patients with Pa-NP the presence of infection with a MDR strain is associated with increased in-hospital mortality. Identification of patients at risk of MDR Pa-NP could facilitate appropriate empiric antibiotic decisions that in turn could lead to improved hospital survival.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s13054-015-0926-5", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1117766", 
        "issn": [
          "1364-8535", 
          "1466-609X"
        ], 
        "name": "Critical Care", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "hospital mortality", 
      "nosocomial pneumonia", 
      "multidrug resistance", 
      "Cox proportional hazards model analysis", 
      "international multicenter retrospective study", 
      "proportional hazards model analysis", 
      "improved hospital survival", 
      "retrospective cohort study", 
      "characteristics of patients", 
      "multicenter retrospective study", 
      "hazards model analysis", 
      "identification of patients", 
      "presence of infection", 
      "PA-NP", 
      "ConclusionsAmong patients", 
      "hospital death", 
      "ICU admission", 
      "hospital survival", 
      "cohort study", 
      "adult patients", 
      "antibiotic decisions", 
      "considerable morbidity", 
      "independent predictors", 
      "diabetes mellitus", 
      "heart failure", 
      "multivariable analysis", 
      "mechanical ventilation", 
      "retrospective study", 
      "risk factors", 
      "MDR strains", 
      "patients", 
      "mortality", 
      "MDR", 
      "pneumonia", 
      "regression models", 
      "age", 
      "risk", 
      "predictors", 
      "hospitalization", 
      "mellitus", 
      "morbidity", 
      "bacteremia", 
      "admission", 
      "hospital", 
      "infection", 
      "MethodsWe", 
      "ventilation", 
      "death", 
      "survival", 
      "study", 
      "model analysis", 
      "failure", 
      "factors", 
      "analysis", 
      "resistance", 
      "strains", 
      "presence", 
      "identification", 
      "impact", 
      "countries", 
      "characteristics", 
      "decisions", 
      "turn", 
      "model", 
      "cost"
    ], 
    "name": "An international multicenter retrospective study of Pseudomonas aeruginosa nosocomial pneumonia: impact of multidrug resistance", 
    "pagination": "219", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013283271"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13054-015-0926-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25944081"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13054-015-0926-5", 
      "https://app.dimensions.ai/details/publication/pub.1013283271"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_684.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s13054-015-0926-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-0926-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-0926-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-0926-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-0926-5'


 

This table displays all metadata directly associated to this object as RDF triples.

342 TRIPLES      21 PREDICATES      110 URIs      99 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13054-015-0926-5 schema:about N0757e0f793c040969b2019fa65d1c0d3
2 N09b3eb3106484b70a52740d169e7f012
3 N171cba291bab4e9b8549a984a3c4f33f
4 N1eca241be98f4c9ea29a32f2ae648bb6
5 N3c7fff7cb0c84bb48a47fc4ce5441a30
6 N3d616e8a1eba40d7b2c610ef028bd80e
7 N480a425accab48b3be3a7b7ece7e8ea9
8 N58addb891dc34d61bca5d62dd5ca62b4
9 N6fa0c8022eb540ff929fbc8d0d2a28aa
10 N96b11aca91e0481994d70c8ba70a93f0
11 N9a187a9ad4c3456f8e5e2665cec17e6d
12 Nb01e9dfc35a1437db6f12e1f000b8693
13 Nb16e091dc67840f09fc9951b6f309433
14 Nbde60fcc55d94c48bea5c02d993e4fab
15 Ne361989376284c0f9e122f97310664e5
16 Ne4cbcd2ea36e498fbe65710fea7ddc86
17 Nfbcdeeeb3f9c40b4833d65363c77defa
18 anzsrc-for:11
19 anzsrc-for:1102
20 schema:author N4ee3fc565cf14ba1af3f3ae585090901
21 schema:citation sg:pub.10.1007/s10096-012-1741-4
22 sg:pub.10.1007/s10096-012-1758-8
23 sg:pub.10.1186/cc11862
24 schema:datePublished 2015-12-01
25 schema:datePublishedReg 2015-12-01
26 schema:description IntroductionPseudomonas aeruginosa nosocomial pneumonia (Pa-NP) is associated with considerable morbidity, prolonged hospitalization, increased costs, and mortality.MethodsWe conducted a retrospective cohort study of adult patients with Pa-NP to determine 1) risk factors for multidrug-resistant (MDR) strains and 2) whether MDR increases the risk for hospital death. Twelve hospitals in 5 countries (United States, n = 3; France, n = 2; Germany, n = 2; Italy, n = 2; and Spain, n = 3) participated. We compared characteristics of patients who had MDR strains to those who did not and derived regression models to identify predictors of MDR and hospital mortality.ResultsOf 740 patients with Pa-NP, 226 patients (30.5%) were infected with MDR strains. In multivariable analyses, independent predictors of multidrug-resistance included decreasing age (adjusted odds ratio [AOR] 0.91, 95% confidence interval [CI] 0.96-0.98), diabetes mellitus (AOR 1.90, 95% CI 1.21-3.00) and ICU admission (AOR 1.73, 95% CI 1.06-2.81). Multidrug-resistance, heart failure, increasing age, mechanical ventilation, and bacteremia were independently associated with in-hospital mortality in the Cox Proportional Hazards Model analysis.ConclusionsAmong patients with Pa-NP the presence of infection with a MDR strain is associated with increased in-hospital mortality. Identification of patients at risk of MDR Pa-NP could facilitate appropriate empiric antibiotic decisions that in turn could lead to improved hospital survival.
27 schema:genre article
28 schema:isAccessibleForFree true
29 schema:isPartOf N74e560c5224e487d90df10609b8a1091
30 Na545705703c44d43b225cd605ff97e49
31 sg:journal.1117766
32 schema:keywords ConclusionsAmong patients
33 Cox proportional hazards model analysis
34 ICU admission
35 MDR
36 MDR strains
37 MethodsWe
38 PA-NP
39 admission
40 adult patients
41 age
42 analysis
43 antibiotic decisions
44 bacteremia
45 characteristics
46 characteristics of patients
47 cohort study
48 considerable morbidity
49 cost
50 countries
51 death
52 decisions
53 diabetes mellitus
54 factors
55 failure
56 hazards model analysis
57 heart failure
58 hospital
59 hospital death
60 hospital mortality
61 hospital survival
62 hospitalization
63 identification
64 identification of patients
65 impact
66 improved hospital survival
67 independent predictors
68 infection
69 international multicenter retrospective study
70 mechanical ventilation
71 mellitus
72 model
73 model analysis
74 morbidity
75 mortality
76 multicenter retrospective study
77 multidrug resistance
78 multivariable analysis
79 nosocomial pneumonia
80 patients
81 pneumonia
82 predictors
83 presence
84 presence of infection
85 proportional hazards model analysis
86 regression models
87 resistance
88 retrospective cohort study
89 retrospective study
90 risk
91 risk factors
92 strains
93 study
94 survival
95 turn
96 ventilation
97 schema:name An international multicenter retrospective study of Pseudomonas aeruginosa nosocomial pneumonia: impact of multidrug resistance
98 schema:pagination 219
99 schema:productId N3d924b9309be4d8284d3645cc2b92491
100 Nd3d148e1f77c46c6aea5cd69af3544f8
101 Nf057c1985d1e487194b9f5aae624feb2
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013283271
103 https://doi.org/10.1186/s13054-015-0926-5
104 schema:sdDatePublished 2022-10-01T06:41
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher N409ceb0b922c4ac4a8a3864cc9b5cc50
107 schema:url https://doi.org/10.1186/s13054-015-0926-5
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N0616b4392aa04901ab154a9155d9581c rdf:first sg:person.01157100146.48
112 rdf:rest N699a98e0a2ac43da8e8facc8cefee709
113 N0757e0f793c040969b2019fa65d1c0d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Aged
115 rdf:type schema:DefinedTerm
116 N09b3eb3106484b70a52740d169e7f012 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Drug Resistance, Multiple, Bacterial
118 rdf:type schema:DefinedTerm
119 N171cba291bab4e9b8549a984a3c4f33f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Pseudomonas Infections
121 rdf:type schema:DefinedTerm
122 N1724766392aa4199a4817ea33cc3954a rdf:first sg:person.0732254030.49
123 rdf:rest Ne7a8f627f5514df499908239e084cdfa
124 N192f16bee35c449c94977a36fb02645b rdf:first sg:person.01200122325.47
125 rdf:rest Nc4750f6372e5496297a2f53d4af57176
126 N1eca241be98f4c9ea29a32f2ae648bb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Middle Aged
128 rdf:type schema:DefinedTerm
129 N3c7fff7cb0c84bb48a47fc4ce5441a30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Pneumonia, Bacterial
131 rdf:type schema:DefinedTerm
132 N3d616e8a1eba40d7b2c610ef028bd80e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Humans
134 rdf:type schema:DefinedTerm
135 N3d924b9309be4d8284d3645cc2b92491 schema:name doi
136 schema:value 10.1186/s13054-015-0926-5
137 rdf:type schema:PropertyValue
138 N3e37561d02ab49f0880583d7db087068 rdf:first sg:person.0720704077.45
139 rdf:rest N95020725947a4160887cdcf81a7a99f9
140 N409ceb0b922c4ac4a8a3864cc9b5cc50 schema:name Springer Nature - SN SciGraph project
141 rdf:type schema:Organization
142 N480a425accab48b3be3a7b7ece7e8ea9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Pseudomonas aeruginosa
144 rdf:type schema:DefinedTerm
145 N4ee3fc565cf14ba1af3f3ae585090901 rdf:first sg:person.0641701632.88
146 rdf:rest Naa5da233a5fd4cf9836d7f90ee4bfc94
147 N58addb891dc34d61bca5d62dd5ca62b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cross Infection
149 rdf:type schema:DefinedTerm
150 N648736c4a887483aacd62a820d829ead rdf:first sg:person.01051715513.34
151 rdf:rest Nf40f5f78657f43129f7527e6ff7367c4
152 N699a98e0a2ac43da8e8facc8cefee709 rdf:first sg:person.0715341505.05
153 rdf:rest N648736c4a887483aacd62a820d829ead
154 N6fa0c8022eb540ff929fbc8d0d2a28aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Female
156 rdf:type schema:DefinedTerm
157 N74e560c5224e487d90df10609b8a1091 schema:volumeNumber 19
158 rdf:type schema:PublicationVolume
159 N8c3732f9cb8a4623aedf73dee945357a rdf:first sg:person.01315725060.03
160 rdf:rest rdf:nil
161 N95020725947a4160887cdcf81a7a99f9 rdf:first sg:person.01134537734.76
162 rdf:rest Ncdaf32a6203440739d6264cc722dd4ee
163 N96b11aca91e0481994d70c8ba70a93f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Internationality
165 rdf:type schema:DefinedTerm
166 N9a187a9ad4c3456f8e5e2665cec17e6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Mortality
168 rdf:type schema:DefinedTerm
169 Na545705703c44d43b225cd605ff97e49 schema:issueNumber 1
170 rdf:type schema:PublicationIssue
171 Naa5da233a5fd4cf9836d7f90ee4bfc94 rdf:first sg:person.0664057206.49
172 rdf:rest N0616b4392aa04901ab154a9155d9581c
173 Nb01e9dfc35a1437db6f12e1f000b8693 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Hospitalization
175 rdf:type schema:DefinedTerm
176 Nb16e091dc67840f09fc9951b6f309433 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Adult
178 rdf:type schema:DefinedTerm
179 Nbde60fcc55d94c48bea5c02d993e4fab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Male
181 rdf:type schema:DefinedTerm
182 Nc4750f6372e5496297a2f53d4af57176 rdf:first sg:person.0704712477.99
183 rdf:rest N3e37561d02ab49f0880583d7db087068
184 Ncdaf32a6203440739d6264cc722dd4ee rdf:first sg:person.013605501140.89
185 rdf:rest N1724766392aa4199a4817ea33cc3954a
186 Nd3d148e1f77c46c6aea5cd69af3544f8 schema:name dimensions_id
187 schema:value pub.1013283271
188 rdf:type schema:PropertyValue
189 Ne361989376284c0f9e122f97310664e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Anti-Bacterial Agents
191 rdf:type schema:DefinedTerm
192 Ne4cbcd2ea36e498fbe65710fea7ddc86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Hospital Mortality
194 rdf:type schema:DefinedTerm
195 Ne7a8f627f5514df499908239e084cdfa rdf:first sg:person.01041205104.63
196 rdf:rest N8c3732f9cb8a4623aedf73dee945357a
197 Nf04d47499a48449b96d00a33b4cda1a6 rdf:first sg:person.01231157073.12
198 rdf:rest N192f16bee35c449c94977a36fb02645b
199 Nf057c1985d1e487194b9f5aae624feb2 schema:name pubmed_id
200 schema:value 25944081
201 rdf:type schema:PropertyValue
202 Nf40f5f78657f43129f7527e6ff7367c4 rdf:first sg:person.0714077601.27
203 rdf:rest Nf04d47499a48449b96d00a33b4cda1a6
204 Nfbcdeeeb3f9c40b4833d65363c77defa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Retrospective Studies
206 rdf:type schema:DefinedTerm
207 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
208 schema:name Medical and Health Sciences
209 rdf:type schema:DefinedTerm
210 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
211 schema:name Cardiorespiratory Medicine and Haematology
212 rdf:type schema:DefinedTerm
213 sg:journal.1117766 schema:issn 1364-8535
214 1466-609X
215 schema:name Critical Care
216 schema:publisher Springer Nature
217 rdf:type schema:Periodical
218 sg:person.01041205104.63 schema:affiliation grid-institutes:grid.66875.3a
219 schema:familyName Schramm
220 schema:givenName Garrett E
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041205104.63
222 rdf:type schema:Person
223 sg:person.01051715513.34 schema:affiliation grid-institutes:grid.411083.f
224 schema:familyName Rello
225 schema:givenName Jordi
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051715513.34
227 rdf:type schema:Person
228 sg:person.01134537734.76 schema:affiliation grid-institutes:grid.414875.b
229 schema:familyName Calbo
230 schema:givenName Esther
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134537734.76
232 rdf:type schema:Person
233 sg:person.01157100146.48 schema:affiliation grid-institutes:grid.4367.6
234 schema:familyName Kollef
235 schema:givenName Marin H
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157100146.48
237 rdf:type schema:Person
238 sg:person.01200122325.47 schema:affiliation grid-institutes:grid.10423.34
239 schema:familyName Welte
240 schema:givenName Tobias
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200122325.47
242 rdf:type schema:Person
243 sg:person.01231157073.12 schema:affiliation grid-institutes:grid.411075.6
244 schema:familyName Antonelli
245 schema:givenName Massimo
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231157073.12
247 rdf:type schema:Person
248 sg:person.01315725060.03 schema:affiliation grid-institutes:grid.417686.a
249 schema:familyName Menon
250 schema:givenName Vandana
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315725060.03
252 rdf:type schema:Person
253 sg:person.013605501140.89 schema:affiliation grid-institutes:None
254 schema:familyName Torres
255 schema:givenName Antoni
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013605501140.89
257 rdf:type schema:Person
258 sg:person.0641701632.88 schema:affiliation grid-institutes:grid.419579.7
259 schema:familyName Micek
260 schema:givenName Scott T
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641701632.88
262 rdf:type schema:Person
263 sg:person.0664057206.49 schema:affiliation grid-institutes:grid.16753.36
264 schema:familyName Wunderink
265 schema:givenName Richard G
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664057206.49
267 rdf:type schema:Person
268 sg:person.0704712477.99 schema:affiliation grid-institutes:grid.414291.b
269 schema:familyName Clair
270 schema:givenName Bernard
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704712477.99
272 rdf:type schema:Person
273 sg:person.0714077601.27 schema:affiliation grid-institutes:grid.411439.a
274 schema:familyName Chastre
275 schema:givenName Jean
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714077601.27
277 rdf:type schema:Person
278 sg:person.0715341505.05 schema:affiliation grid-institutes:grid.4367.6
279 schema:familyName Chen
280 schema:givenName Catherine
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715341505.05
282 rdf:type schema:Person
283 sg:person.0720704077.45 schema:affiliation grid-institutes:grid.411095.8
284 schema:familyName Ostermann
285 schema:givenName Helmut
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720704077.45
287 rdf:type schema:Person
288 sg:person.0732254030.49 schema:affiliation grid-institutes:None
289 schema:familyName Menichetti
290 schema:givenName Francesco
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732254030.49
292 rdf:type schema:Person
293 sg:pub.10.1007/s10096-012-1741-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038186055
294 https://doi.org/10.1007/s10096-012-1741-4
295 rdf:type schema:CreativeWork
296 sg:pub.10.1007/s10096-012-1758-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020359417
297 https://doi.org/10.1007/s10096-012-1758-8
298 rdf:type schema:CreativeWork
299 sg:pub.10.1186/cc11862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017822371
300 https://doi.org/10.1186/cc11862
301 rdf:type schema:CreativeWork
302 grid-institutes:None schema:alternateName Malattie Infettive, Az. Ospedaliera Universitaria Pisana, Via Paradisa 2 – Cisanello, 56100, Pisa, Italy
303 Pneumology Department, Clinic Institute of Thorax, Villarroel 170, 08036, Barcelona, Spain
304 schema:name Malattie Infettive, Az. Ospedaliera Universitaria Pisana, Via Paradisa 2 – Cisanello, 56100, Pisa, Italy
305 Pneumology Department, Clinic Institute of Thorax, Villarroel 170, 08036, Barcelona, Spain
306 rdf:type schema:Organization
307 grid-institutes:grid.10423.34 schema:alternateName Medizinische Hochschule, Carl-Neuberg-Str. 1, 30625, Hannover, Germany
308 schema:name Medizinische Hochschule, Carl-Neuberg-Str. 1, 30625, Hannover, Germany
309 rdf:type schema:Organization
310 grid-institutes:grid.16753.36 schema:alternateName Northwestern University Feinberg School of Medicine, McGaw Pavilion Suite M-300, 240 E Huron, 60611, Chicago, IL, USA
311 schema:name Northwestern University Feinberg School of Medicine, McGaw Pavilion Suite M-300, 240 E Huron, 60611, Chicago, IL, USA
312 rdf:type schema:Organization
313 grid-institutes:grid.411075.6 schema:alternateName Policlinico Universitario A Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy
314 schema:name Policlinico Universitario A Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy
315 rdf:type schema:Organization
316 grid-institutes:grid.411083.f schema:alternateName Vall d’Hebron University Hospital, Passeig Vall d’Hebron, 119, 08035, Barcelona, Spain
317 schema:name Vall d’Hebron University Hospital, Passeig Vall d’Hebron, 119, 08035, Barcelona, Spain
318 rdf:type schema:Organization
319 grid-institutes:grid.411095.8 schema:alternateName Department of Hematology, University Hospital Grosshadern, Marchioninistr 15, D-81377, Munich, Germany
320 schema:name Department of Hematology, University Hospital Grosshadern, Marchioninistr 15, D-81377, Munich, Germany
321 rdf:type schema:Organization
322 grid-institutes:grid.411439.a schema:alternateName Service de Réanimation Médicale, Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, 47-83 boulevard de l’Hôpital, 75651, Paris, Cedex 13, France
323 schema:name Service de Réanimation Médicale, Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, 47-83 boulevard de l’Hôpital, 75651, Paris, Cedex 13, France
324 rdf:type schema:Organization
325 grid-institutes:grid.414291.b schema:alternateName Hôpital Raymond Poincaré, 104 boulevard Raymond Poincaré, 92380, Garches, France
326 schema:name Hôpital Raymond Poincaré, 104 boulevard Raymond Poincaré, 92380, Garches, France
327 rdf:type schema:Organization
328 grid-institutes:grid.414875.b schema:alternateName Hospital Universitari MútuaTerrassa, Plaça Dr. Robert, 5, 08221, Terrassa, Spain
329 schema:name Hospital Universitari MútuaTerrassa, Plaça Dr. Robert, 5, 08221, Terrassa, Spain
330 rdf:type schema:Organization
331 grid-institutes:grid.417686.a schema:alternateName Cubist Pharmaceuticals, Inc., 65 Hayden Avenue, 02421, Lexington, MA, USA
332 schema:name Cubist Pharmaceuticals, Inc., 65 Hayden Avenue, 02421, Lexington, MA, USA
333 rdf:type schema:Organization
334 grid-institutes:grid.419579.7 schema:alternateName St. Louis College of Pharmacy, 4588 Parkview Place, 63110-1088, St. Louis, MO, USA
335 schema:name St. Louis College of Pharmacy, 4588 Parkview Place, 63110-1088, St. Louis, MO, USA
336 rdf:type schema:Organization
337 grid-institutes:grid.4367.6 schema:alternateName Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8052, 63110, St. Louis, MO, USA
338 schema:name Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8052, 63110, St. Louis, MO, USA
339 rdf:type schema:Organization
340 grid-institutes:grid.66875.3a schema:alternateName Pharmacy Services, Mayo Clinic, 200 First St SW, 55905, Rochester, MN, USA
341 schema:name Pharmacy Services, Mayo Clinic, 200 First St SW, 55905, Rochester, MN, USA
342 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...