Trauma-induced coagulopathy: impact of the early coagulation support protocol on blood product consumption, mortality and costs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Giuseppe Nardi, Vanessa Agostini, Beatrice Rondinelli, Emanuele Russo, Barbara Bastianini, Giovanni Bini, Simona Bulgarelli, Emiliano Cingolani, Alessia Donato, Giorgio Gambale, Giulia Ranaldi

ABSTRACT

INTRODUCTION: Hemorrhage is the principal cause of death in the first few hours following severe injury. Coagulopathy is a frequent complication of critical bleeding. A network of Italian trauma centers recently developed a protocol to prevent and treat trauma-induced coagulopathy. A pre-post cohort multicenter study was conducted to assess the impact of the early coagulation support (ECS) protocol on blood products consumption, mortality and treatment costs. METHODS: We prospectively collected data from all severely injured patients (Injury Severity Score (ISS) >15) admitted to two trauma centers in 2013 and compared these findings with the data for 2011. Patients transfused with at least 3 units of packed red blood cells (PRBCs) within 24 hours of an accident were included in the study. In 2011, patients with significant hemorrhaging were treated with early administration of plasma with the aim of achieving a high (≥1:2) plasma-to-PRBC ratio. In 2013, the ECS protocol was the treatment strategy. Outcome data, blood product consumption and treatment costs were compared between the two periods. RESULTS: The two groups were well matched for demographics, injury severity (ISS: 32.9 in 2011 versus 33.6 in 2013) and clinical and laboratory data on admission. In 2013, a 40% overall reduction in PRBCs was observed, together with a 65% reduction in plasma and a 52% reduction in platelets. Patients in the ECS group received fewer blood products: 6.51 units of PRBCs versus 8.14 units. Plasma transfusions decreased from 8.98 units to 4.21 units (P <0.05), and platelets fell from 4.14 units to 2.53 units (P <0.05). Mortality in 2013 was 13.5% versus 20% in 2011 (13 versus 26 hospital deaths, respectively) (nonsignificant). When costs for blood components, factors and point-of-care tests were compared, a €76,340 saving in 2013 versus 2011 (23%) was recorded. CONCLUSIONS: The introduction of the ECS protocol in two Italian trauma centers was associated with a marked reduction in blood product consumption, reaching statistical significance for plasma and platelets, and with a non-significant trend toward a reduction in early and 28-day mortality. The overall costs for transfusion and coagulation support (including point-of-care tests) decreased by 23% between 2011 and 2013. More... »

PAGES

83

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13054-015-0817-9

DOI

http://dx.doi.org/10.1186/s13054-015-0817-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047438634

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25880548


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Coagulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Coagulation Disorders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Component Transfusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemorrhage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hospital Mortality", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injury Severity Score", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Italy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Resuscitation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Ospedale San Camillo", 
          "id": "https://www.grid.ac/institutes/grid.416308.8", 
          "name": [
            "Department of Shock and Trauma Center, S Camillo-Forlanini Hospital, Circonvallazione Gianicolense 87, 00152, Roma, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nardi", 
        "givenName": "Giuseppe", 
        "id": "sg:person.01046526300.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046526300.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Maurizio Bufalini", 
          "id": "https://www.grid.ac/institutes/grid.414682.d", 
          "name": [
            "Departement of Clinical Pathology and Transfusion Medicine, Bufalini Hospital, Via Ghirotti 286, 45072, Cesena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Agostini", 
        "givenName": "Vanessa", 
        "id": "sg:person.01371444025.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371444025.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale San Camillo", 
          "id": "https://www.grid.ac/institutes/grid.416308.8", 
          "name": [
            "Department of Hematology and Transfusion Medicine, S Camillo-Forlanini Hospital, Circonvallazione Gianicolense 87, 00152, Roma, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rondinelli", 
        "givenName": "Beatrice", 
        "id": "sg:person.0600227765.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600227765.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Maurizio Bufalini", 
          "id": "https://www.grid.ac/institutes/grid.414682.d", 
          "name": [
            "Department of Anesthesia and ICU, Trauma Service, Bufalini Hospital, Via Ghirotti 286, 45072, Cesena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Russo", 
        "givenName": "Emanuele", 
        "id": "sg:person.01355415373.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355415373.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale San Camillo", 
          "id": "https://www.grid.ac/institutes/grid.416308.8", 
          "name": [
            "Department of Shock and Trauma Center, S Camillo-Forlanini Hospital, Circonvallazione Gianicolense 87, 00152, Roma, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bastianini", 
        "givenName": "Barbara", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Maurizio Bufalini", 
          "id": "https://www.grid.ac/institutes/grid.414682.d", 
          "name": [
            "Department of Anesthesia and ICU, Trauma Service, Bufalini Hospital, Via Ghirotti 286, 45072, Cesena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bini", 
        "givenName": "Giovanni", 
        "id": "sg:person.0754126042.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754126042.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Maurizio Bufalini", 
          "id": "https://www.grid.ac/institutes/grid.414682.d", 
          "name": [
            "Departement of Clinical Pathology and Transfusion Medicine, Bufalini Hospital, Via Ghirotti 286, 45072, Cesena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bulgarelli", 
        "givenName": "Simona", 
        "id": "sg:person.01030704765.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030704765.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale San Camillo", 
          "id": "https://www.grid.ac/institutes/grid.416308.8", 
          "name": [
            "Department of Shock and Trauma Center, S Camillo-Forlanini Hospital, Circonvallazione Gianicolense 87, 00152, Roma, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cingolani", 
        "givenName": "Emiliano", 
        "id": "sg:person.01213724723.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213724723.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Siena", 
          "id": "https://www.grid.ac/institutes/grid.9024.f", 
          "name": [
            "Department of Anesthesia and Intensive Care, University of Siena, Strada delle Scotte 14, 53100, Siena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Donato", 
        "givenName": "Alessia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Maurizio Bufalini", 
          "id": "https://www.grid.ac/institutes/grid.414682.d", 
          "name": [
            "Department of Anesthesia and ICU, Trauma Service, Bufalini Hospital, Via Ghirotti 286, 45072, Cesena, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gambale", 
        "givenName": "Giorgio", 
        "id": "sg:person.01361346407.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361346407.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale San Camillo", 
          "id": "https://www.grid.ac/institutes/grid.416308.8", 
          "name": [
            "Department of Shock and Trauma Center, S Camillo-Forlanini Hospital, Circonvallazione Gianicolense 87, 00152, Roma, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ranaldi", 
        "givenName": "Giulia", 
        "id": "sg:person.01261361765.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261361765.05"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/ta.0b013e3180324124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004166934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e3180324124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004166934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e3181826ddf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009471077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e3181826ddf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009471077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1423-0410.2008.01074.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010403618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13049-014-0073-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011097108", 
          "https://doi.org/10.1186/s13049-014-0073-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13049-014-0073-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011097108", 
          "https://doi.org/10.1186/s13049-014-0073-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e318160a57b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011365738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e318160a57b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011365738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc8948", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013644274", 
          "https://doi.org/10.1186/cc8948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc12816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014047188", 
          "https://doi.org/10.1186/cc12816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1537-2995.2009.02458.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015210752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1537-2995.2009.02458.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015210752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc11432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016736661", 
          "https://doi.org/10.1186/cc11432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000337186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017793346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000337243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017806844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1209759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019126944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e318196c3ac", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025721289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e318196c3ac", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025721289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ta.0000069184.82147.06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028878571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ta.0000069184.82147.06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028878571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/asheducation-2013.1.664", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029213886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc12579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037728895", 
          "https://doi.org/10.1186/cc12579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2004.04868.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038079477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2012.04752.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039098992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc10078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039383270", 
          "https://doi.org/10.1186/cc10078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e31828fa3ed", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039841985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e31828fa3ed", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039841985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e31816c5c80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041062224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e31816c5c80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041062224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc8943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041305609", 
          "https://doi.org/10.1186/cc8943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(10)60835-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044378391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamcollsurg.2012.10.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045163877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc12685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046113313", 
          "https://doi.org/10.1186/cc12685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0000000000000146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051792393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0000000000000146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051792393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e31828fa43d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052567745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e31828fa43d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052567745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e3182051691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052793193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e3182051691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052793193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1423-0410.2011.01466.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053042885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0030-1265746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057229736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aln.0b013e318245c47b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060338765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aln.0b013e318245c47b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060338765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aln.0b013e318245c47b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060338765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7243/2049-9752-2-22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073672156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078854949", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "INTRODUCTION: Hemorrhage is the principal cause of death in the first few hours following severe injury. Coagulopathy is a frequent complication of critical bleeding. A network of Italian trauma centers recently developed a protocol to prevent and treat trauma-induced coagulopathy. A pre-post cohort multicenter study was conducted to assess the impact of the early coagulation support (ECS) protocol on blood products consumption, mortality and treatment costs.\nMETHODS: We prospectively collected data from all severely injured patients (Injury Severity Score (ISS) >15) admitted to two trauma centers in 2013 and compared these findings with the data for 2011. Patients transfused with at least 3 units of packed red blood cells (PRBCs) within 24\u00a0hours of an accident were included in the study. In 2011, patients with significant hemorrhaging were treated with early administration of plasma with the aim of achieving a high (\u22651:2) plasma-to-PRBC ratio. In 2013, the ECS protocol was the treatment strategy. Outcome data, blood product consumption and treatment costs were compared between the two periods.\nRESULTS: The two groups were well matched for demographics, injury severity (ISS: 32.9 in 2011 versus 33.6 in 2013) and clinical and laboratory data on admission. In 2013, a 40% overall reduction in PRBCs was observed, together with a 65% reduction in plasma and a 52% reduction in platelets. Patients in the ECS group received fewer blood products: 6.51 units of PRBCs versus 8.14 units. Plasma transfusions decreased from 8.98 units to 4.21 units (P <0.05), and platelets fell from 4.14 units to 2.53 units (P <0.05). Mortality in 2013 was 13.5% versus 20% in 2011 (13 versus 26 hospital deaths, respectively) (nonsignificant). When costs for blood components, factors and point-of-care tests were compared, a \u20ac76,340 saving in 2013 versus 2011 (23%) was recorded.\nCONCLUSIONS: The introduction of the ECS protocol in two Italian trauma centers was associated with a marked reduction in blood product consumption, reaching statistical significance for plasma and platelets, and with a non-significant trend toward a reduction in early and 28-day mortality. The overall costs for transfusion and coagulation support (including point-of-care tests) decreased by 23% between 2011 and 2013.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13054-015-0817-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1117766", 
        "issn": [
          "1364-8535", 
          "1466-609X"
        ], 
        "name": "Critical Care", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Trauma-induced coagulopathy: impact of the early coagulation support protocol on blood product consumption, mortality and costs", 
    "pagination": "83", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e1fb8d51f8c2fe7cd66161ed408352c3a36c22be89bd1c297e514727b4883aab"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25880548"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9801902"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13054-015-0817-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047438634"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13054-015-0817-9", 
      "https://app.dimensions.ai/details/publication/pub.1047438634"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88221_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs13054-015-0817-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-0817-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-0817-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-0817-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-0817-9'


 

This table displays all metadata directly associated to this object as RDF triples.

319 TRIPLES      21 PREDICATES      79 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13054-015-0817-9 schema:about N10f6bd3a100f4c9a85409ffc06b4fd60
2 N14d7993129b24cebae02b77a1a41178b
3 N23f3ffc4cc9748dca2fd7ef83cc9cc66
4 N2ab37a49b23f4eee84e16124d6899c32
5 N2f3ff6c622884e359bc0b66e014ca7fb
6 N388f829e8f1b41fcb62928415b58a8a4
7 N40fa4c6bcbca4c198baa95d722ae0ee6
8 N5a2084aafbb54eebbc6f0e1302a5de32
9 N6b7fb83023a045bebd48e59ce3840e34
10 N8625abd09706418cbe08166f6abde8bb
11 N8e49fdce89e5470fb53d4e040c2492dc
12 N956235bb6a3c4abca533ef7313920f59
13 Nb2aff7ef51104a10825bcdf8d3a8a426
14 Ndfc0ac4caba54d049ae1a045399d1666
15 Nf1010996d06046a2bb934a441f25b0e9
16 Nf4feeca78866452f98ad92fa61d4a059
17 Nfa8d824639bd48ef973222d98b7bf9dd
18 anzsrc-for:11
19 anzsrc-for:1102
20 schema:author N99309ab2d8d5451a8e974ea4e456aa7d
21 schema:citation sg:pub.10.1186/cc10078
22 sg:pub.10.1186/cc11432
23 sg:pub.10.1186/cc12579
24 sg:pub.10.1186/cc12685
25 sg:pub.10.1186/cc12816
26 sg:pub.10.1186/cc8943
27 sg:pub.10.1186/cc8948
28 sg:pub.10.1186/s13049-014-0073-z
29 https://app.dimensions.ai/details/publication/pub.1078854949
30 https://doi.org/10.1016/j.jamcollsurg.2012.10.017
31 https://doi.org/10.1016/s0140-6736(10)60835-5
32 https://doi.org/10.1055/s-0030-1265746
33 https://doi.org/10.1056/nejmoa1209759
34 https://doi.org/10.1097/01.ta.0000069184.82147.06
35 https://doi.org/10.1097/aln.0b013e318245c47b
36 https://doi.org/10.1097/ta.0000000000000146
37 https://doi.org/10.1097/ta.0b013e3180324124
38 https://doi.org/10.1097/ta.0b013e318160a57b
39 https://doi.org/10.1097/ta.0b013e31816c5c80
40 https://doi.org/10.1097/ta.0b013e3181826ddf
41 https://doi.org/10.1097/ta.0b013e318196c3ac
42 https://doi.org/10.1097/ta.0b013e3182051691
43 https://doi.org/10.1097/ta.0b013e31828fa3ed
44 https://doi.org/10.1097/ta.0b013e31828fa43d
45 https://doi.org/10.1111/j.1365-2141.2004.04868.x
46 https://doi.org/10.1111/j.1423-0410.2008.01074.x
47 https://doi.org/10.1111/j.1423-0410.2011.01466.x
48 https://doi.org/10.1111/j.1537-2995.2009.02458.x
49 https://doi.org/10.1111/j.1538-7836.2012.04752.x
50 https://doi.org/10.1159/000337186
51 https://doi.org/10.1159/000337243
52 https://doi.org/10.1182/asheducation-2013.1.664
53 https://doi.org/10.7243/2049-9752-2-22
54 schema:datePublished 2015-12
55 schema:datePublishedReg 2015-12-01
56 schema:description INTRODUCTION: Hemorrhage is the principal cause of death in the first few hours following severe injury. Coagulopathy is a frequent complication of critical bleeding. A network of Italian trauma centers recently developed a protocol to prevent and treat trauma-induced coagulopathy. A pre-post cohort multicenter study was conducted to assess the impact of the early coagulation support (ECS) protocol on blood products consumption, mortality and treatment costs. METHODS: We prospectively collected data from all severely injured patients (Injury Severity Score (ISS) >15) admitted to two trauma centers in 2013 and compared these findings with the data for 2011. Patients transfused with at least 3 units of packed red blood cells (PRBCs) within 24 hours of an accident were included in the study. In 2011, patients with significant hemorrhaging were treated with early administration of plasma with the aim of achieving a high (≥1:2) plasma-to-PRBC ratio. In 2013, the ECS protocol was the treatment strategy. Outcome data, blood product consumption and treatment costs were compared between the two periods. RESULTS: The two groups were well matched for demographics, injury severity (ISS: 32.9 in 2011 versus 33.6 in 2013) and clinical and laboratory data on admission. In 2013, a 40% overall reduction in PRBCs was observed, together with a 65% reduction in plasma and a 52% reduction in platelets. Patients in the ECS group received fewer blood products: 6.51 units of PRBCs versus 8.14 units. Plasma transfusions decreased from 8.98 units to 4.21 units (P <0.05), and platelets fell from 4.14 units to 2.53 units (P <0.05). Mortality in 2013 was 13.5% versus 20% in 2011 (13 versus 26 hospital deaths, respectively) (nonsignificant). When costs for blood components, factors and point-of-care tests were compared, a €76,340 saving in 2013 versus 2011 (23%) was recorded. CONCLUSIONS: The introduction of the ECS protocol in two Italian trauma centers was associated with a marked reduction in blood product consumption, reaching statistical significance for plasma and platelets, and with a non-significant trend toward a reduction in early and 28-day mortality. The overall costs for transfusion and coagulation support (including point-of-care tests) decreased by 23% between 2011 and 2013.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N6d1c3c81cca340c489f687dd82eea259
61 Nd56a4a9203564c4493b946746c843682
62 sg:journal.1117766
63 schema:name Trauma-induced coagulopathy: impact of the early coagulation support protocol on blood product consumption, mortality and costs
64 schema:pagination 83
65 schema:productId N2b14e5e80e824f849ab854f6d95306fd
66 N455079d2012a4b31a933b12cd65f4251
67 Na34500fd43ef4805b19db1f240016ece
68 Nde11b73ad2dc448e905ad807b1a489e2
69 Ndf7b1d3c35574a8cb0fc46951dfed651
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047438634
71 https://doi.org/10.1186/s13054-015-0817-9
72 schema:sdDatePublished 2019-04-11T13:07
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N77ba52da71ff44f2aea8395567a921fc
75 schema:url http://link.springer.com/10.1186%2Fs13054-015-0817-9
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N10f6bd3a100f4c9a85409ffc06b4fd60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Injury Severity Score
81 rdf:type schema:DefinedTerm
82 N14d7993129b24cebae02b77a1a41178b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Resuscitation
84 rdf:type schema:DefinedTerm
85 N23f3ffc4cc9748dca2fd7ef83cc9cc66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Prospective Studies
87 rdf:type schema:DefinedTerm
88 N2ab37a49b23f4eee84e16124d6899c32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Female
90 rdf:type schema:DefinedTerm
91 N2b14e5e80e824f849ab854f6d95306fd schema:name dimensions_id
92 schema:value pub.1047438634
93 rdf:type schema:PropertyValue
94 N2f3ff6c622884e359bc0b66e014ca7fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Middle Aged
96 rdf:type schema:DefinedTerm
97 N388f829e8f1b41fcb62928415b58a8a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Italy
99 rdf:type schema:DefinedTerm
100 N3939dbfc3c3e4984abeb46ee60d9f0a7 rdf:first sg:person.01361346407.53
101 rdf:rest Nbe861da52adf4a30bfd91b58cf0c7cf2
102 N40fa4c6bcbca4c198baa95d722ae0ee6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Hospital Mortality
104 rdf:type schema:DefinedTerm
105 N415fd1d7c4144d209abf9e2be9b9edde schema:affiliation https://www.grid.ac/institutes/grid.416308.8
106 schema:familyName Bastianini
107 schema:givenName Barbara
108 rdf:type schema:Person
109 N455079d2012a4b31a933b12cd65f4251 schema:name doi
110 schema:value 10.1186/s13054-015-0817-9
111 rdf:type schema:PropertyValue
112 N486cccbc386c44f9a99cb191920ae8ea rdf:first sg:person.01355415373.23
113 rdf:rest N653b595c4bf54671bfb1caddc9c311d1
114 N5a2084aafbb54eebbc6f0e1302a5de32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Hemorrhage
116 rdf:type schema:DefinedTerm
117 N5c7cf995dd64401caf628054acc957a3 rdf:first sg:person.0600227765.34
118 rdf:rest N486cccbc386c44f9a99cb191920ae8ea
119 N5eb5599f2c2a4568b3822444f58a2fbf schema:affiliation https://www.grid.ac/institutes/grid.9024.f
120 schema:familyName Donato
121 schema:givenName Alessia
122 rdf:type schema:Person
123 N653b595c4bf54671bfb1caddc9c311d1 rdf:first N415fd1d7c4144d209abf9e2be9b9edde
124 rdf:rest Nd963f805fe9441a292b77426ee44cf11
125 N6b7fb83023a045bebd48e59ce3840e34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Blood Coagulation
127 rdf:type schema:DefinedTerm
128 N6d1c3c81cca340c489f687dd82eea259 schema:volumeNumber 19
129 rdf:type schema:PublicationVolume
130 N77ba52da71ff44f2aea8395567a921fc schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 N77e566dccade45989f1a1a116c9cd1ac rdf:first sg:person.01030704765.39
133 rdf:rest N929f65a9e40f4169bd30078b0a8ff5eb
134 N8625abd09706418cbe08166f6abde8bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Male
136 rdf:type schema:DefinedTerm
137 N8b96f0afe52540059e8de5c9a5d99198 rdf:first N5eb5599f2c2a4568b3822444f58a2fbf
138 rdf:rest N3939dbfc3c3e4984abeb46ee60d9f0a7
139 N8e49fdce89e5470fb53d4e040c2492dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Plasma
141 rdf:type schema:DefinedTerm
142 N929f65a9e40f4169bd30078b0a8ff5eb rdf:first sg:person.01213724723.03
143 rdf:rest N8b96f0afe52540059e8de5c9a5d99198
144 N956235bb6a3c4abca533ef7313920f59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Treatment Outcome
146 rdf:type schema:DefinedTerm
147 N99309ab2d8d5451a8e974ea4e456aa7d rdf:first sg:person.01046526300.45
148 rdf:rest Neb28b5a4b7f0441fadcc69c78a4558b6
149 Na34500fd43ef4805b19db1f240016ece schema:name readcube_id
150 schema:value e1fb8d51f8c2fe7cd66161ed408352c3a36c22be89bd1c297e514727b4883aab
151 rdf:type schema:PropertyValue
152 Nb2aff7ef51104a10825bcdf8d3a8a426 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Adult
154 rdf:type schema:DefinedTerm
155 Nbe861da52adf4a30bfd91b58cf0c7cf2 rdf:first sg:person.01261361765.05
156 rdf:rest rdf:nil
157 Nd56a4a9203564c4493b946746c843682 schema:issueNumber 1
158 rdf:type schema:PublicationIssue
159 Nd963f805fe9441a292b77426ee44cf11 rdf:first sg:person.0754126042.67
160 rdf:rest N77e566dccade45989f1a1a116c9cd1ac
161 Nde11b73ad2dc448e905ad807b1a489e2 schema:name nlm_unique_id
162 schema:value 9801902
163 rdf:type schema:PropertyValue
164 Ndf7b1d3c35574a8cb0fc46951dfed651 schema:name pubmed_id
165 schema:value 25880548
166 rdf:type schema:PropertyValue
167 Ndfc0ac4caba54d049ae1a045399d1666 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Blood Coagulation Disorders
169 rdf:type schema:DefinedTerm
170 Neb28b5a4b7f0441fadcc69c78a4558b6 rdf:first sg:person.01371444025.24
171 rdf:rest N5c7cf995dd64401caf628054acc957a3
172 Nf1010996d06046a2bb934a441f25b0e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Blood Component Transfusion
174 rdf:type schema:DefinedTerm
175 Nf4feeca78866452f98ad92fa61d4a059 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Survival Analysis
177 rdf:type schema:DefinedTerm
178 Nfa8d824639bd48ef973222d98b7bf9dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Humans
180 rdf:type schema:DefinedTerm
181 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
182 schema:name Medical and Health Sciences
183 rdf:type schema:DefinedTerm
184 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
185 schema:name Cardiorespiratory Medicine and Haematology
186 rdf:type schema:DefinedTerm
187 sg:journal.1117766 schema:issn 1364-8535
188 1466-609X
189 schema:name Critical Care
190 rdf:type schema:Periodical
191 sg:person.01030704765.39 schema:affiliation https://www.grid.ac/institutes/grid.414682.d
192 schema:familyName Bulgarelli
193 schema:givenName Simona
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030704765.39
195 rdf:type schema:Person
196 sg:person.01046526300.45 schema:affiliation https://www.grid.ac/institutes/grid.416308.8
197 schema:familyName Nardi
198 schema:givenName Giuseppe
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046526300.45
200 rdf:type schema:Person
201 sg:person.01213724723.03 schema:affiliation https://www.grid.ac/institutes/grid.416308.8
202 schema:familyName Cingolani
203 schema:givenName Emiliano
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213724723.03
205 rdf:type schema:Person
206 sg:person.01261361765.05 schema:affiliation https://www.grid.ac/institutes/grid.416308.8
207 schema:familyName Ranaldi
208 schema:givenName Giulia
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261361765.05
210 rdf:type schema:Person
211 sg:person.01355415373.23 schema:affiliation https://www.grid.ac/institutes/grid.414682.d
212 schema:familyName Russo
213 schema:givenName Emanuele
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355415373.23
215 rdf:type schema:Person
216 sg:person.01361346407.53 schema:affiliation https://www.grid.ac/institutes/grid.414682.d
217 schema:familyName Gambale
218 schema:givenName Giorgio
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361346407.53
220 rdf:type schema:Person
221 sg:person.01371444025.24 schema:affiliation https://www.grid.ac/institutes/grid.414682.d
222 schema:familyName Agostini
223 schema:givenName Vanessa
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371444025.24
225 rdf:type schema:Person
226 sg:person.0600227765.34 schema:affiliation https://www.grid.ac/institutes/grid.416308.8
227 schema:familyName Rondinelli
228 schema:givenName Beatrice
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600227765.34
230 rdf:type schema:Person
231 sg:person.0754126042.67 schema:affiliation https://www.grid.ac/institutes/grid.414682.d
232 schema:familyName Bini
233 schema:givenName Giovanni
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754126042.67
235 rdf:type schema:Person
236 sg:pub.10.1186/cc10078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039383270
237 https://doi.org/10.1186/cc10078
238 rdf:type schema:CreativeWork
239 sg:pub.10.1186/cc11432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016736661
240 https://doi.org/10.1186/cc11432
241 rdf:type schema:CreativeWork
242 sg:pub.10.1186/cc12579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037728895
243 https://doi.org/10.1186/cc12579
244 rdf:type schema:CreativeWork
245 sg:pub.10.1186/cc12685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046113313
246 https://doi.org/10.1186/cc12685
247 rdf:type schema:CreativeWork
248 sg:pub.10.1186/cc12816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014047188
249 https://doi.org/10.1186/cc12816
250 rdf:type schema:CreativeWork
251 sg:pub.10.1186/cc8943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041305609
252 https://doi.org/10.1186/cc8943
253 rdf:type schema:CreativeWork
254 sg:pub.10.1186/cc8948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013644274
255 https://doi.org/10.1186/cc8948
256 rdf:type schema:CreativeWork
257 sg:pub.10.1186/s13049-014-0073-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1011097108
258 https://doi.org/10.1186/s13049-014-0073-z
259 rdf:type schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1078854949 schema:CreativeWork
261 https://doi.org/10.1016/j.jamcollsurg.2012.10.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045163877
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/s0140-6736(10)60835-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044378391
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1055/s-0030-1265746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057229736
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1056/nejmoa1209759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019126944
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1097/01.ta.0000069184.82147.06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028878571
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1097/aln.0b013e318245c47b schema:sameAs https://app.dimensions.ai/details/publication/pub.1060338765
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1097/ta.0000000000000146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051792393
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1097/ta.0b013e3180324124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004166934
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1097/ta.0b013e318160a57b schema:sameAs https://app.dimensions.ai/details/publication/pub.1011365738
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1097/ta.0b013e31816c5c80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041062224
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1097/ta.0b013e3181826ddf schema:sameAs https://app.dimensions.ai/details/publication/pub.1009471077
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1097/ta.0b013e318196c3ac schema:sameAs https://app.dimensions.ai/details/publication/pub.1025721289
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1097/ta.0b013e3182051691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052793193
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1097/ta.0b013e31828fa3ed schema:sameAs https://app.dimensions.ai/details/publication/pub.1039841985
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1097/ta.0b013e31828fa43d schema:sameAs https://app.dimensions.ai/details/publication/pub.1052567745
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1111/j.1365-2141.2004.04868.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038079477
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1111/j.1423-0410.2008.01074.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010403618
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1111/j.1423-0410.2011.01466.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053042885
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1111/j.1537-2995.2009.02458.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015210752
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1111/j.1538-7836.2012.04752.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039098992
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1159/000337186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017793346
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1159/000337243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017806844
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1182/asheducation-2013.1.664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029213886
306 rdf:type schema:CreativeWork
307 https://doi.org/10.7243/2049-9752-2-22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073672156
308 rdf:type schema:CreativeWork
309 https://www.grid.ac/institutes/grid.414682.d schema:alternateName Ospedale Maurizio Bufalini
310 schema:name Departement of Clinical Pathology and Transfusion Medicine, Bufalini Hospital, Via Ghirotti 286, 45072, Cesena, Italy
311 Department of Anesthesia and ICU, Trauma Service, Bufalini Hospital, Via Ghirotti 286, 45072, Cesena, Italy
312 rdf:type schema:Organization
313 https://www.grid.ac/institutes/grid.416308.8 schema:alternateName Ospedale San Camillo
314 schema:name Department of Hematology and Transfusion Medicine, S Camillo-Forlanini Hospital, Circonvallazione Gianicolense 87, 00152, Roma, Italy
315 Department of Shock and Trauma Center, S Camillo-Forlanini Hospital, Circonvallazione Gianicolense 87, 00152, Roma, Italy
316 rdf:type schema:Organization
317 https://www.grid.ac/institutes/grid.9024.f schema:alternateName University of Siena
318 schema:name Department of Anesthesia and Intensive Care, University of Siena, Strada delle Scotte 14, 53100, Siena, Italy
319 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...